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| 1 | Possible biological and translational significance of mast cells density in colorectal cancer显示文摘Mast cells(MCs), located ubiquitously near blood vessels, are descended from CD34+ hematopoietic stem cells. Initially, although their role has been well defined in hypersensitivity reactions, the discovery of their sharing in both innate and adaptive immunity has allowed to redefine their crucial interplay on the regulatory function between inflammatory and tumor cells through the release of mediators granule-associated(mainly tryptase and vascular endothelial growth factor). In particular, in several animal and human malignancies it has been well demonstrated that activated c-Kit receptor(c-KitR) and tryptase(an agonist of the proteinase-activated receptor-2) take pivotal part in tumor angiogenesis after the MCs activation, contributing to tumor cells invasion and metastasis. In this review, we focused on crucial MCs density(MCD) role in colorectal cancer(CRC) development and progression angiogenesis-mediated; then, we will analyze the principal studies that have focused on MCD as possible prognostic factor. Finally, we will consider a possible role of MCD as novel therapeutic target mainly by c-KitR tyrosine kinase inhibitors(imatinib, masitinib) and tryptase inhibitors(gabexate and nafamostat mesylate) with the aim to prevent CRC progression. | Ilaria Marech Michele Ammendola Claudia Gadaleta Nicola Zizzo Caroline Oakley Cosmo Damiano Gadaleta Girolamo Ranieri | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 2 | Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum:Role of GABA(A) and GABA(c) reeeptors显示文摘 | Zizzo M G Mule F Serio R | 2007 | Neuropharmacology2007，52，8： | 1 |
| 3 | Racing with uncertainty: A patent race experiment 显示文摘 | Zizzo D | 2002 | International Journal of Industrial Organization2002，20，6： | 1 |
| 4 | Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis 显示文摘 | Zizzo G De Santis M Bosello S L | 2011 | Clin Immunol2011，138，1： | 1 |
| 5 | Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon显示文摘 | Mariangela Mastropaolo Maria Grazia Zizzo Michelangelo Auteri Flavia Mulè Rosa Serio | 2013 | Regulatory Peptides2013，，： | 1 |
| 6 | Mast Cells Density Positive to Tryptase Correlates with Angiogenesis in Pancreatic Ductal Adenocarcinoma Patients Having Undergone Surgery显示文摘 | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Maria Luposella Rosa Patruno Ilaria Marech Severino Montemurro Nicola Zizzo Cosmo Damiano Gadaleta Girolamo Ranieri Niccola Funel | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 7 | Masitinib (AB1010), from canine tumor model to human clinical development: Where we are?显示文摘 | Ilaria Marech Rosa Patruno Nicola Zizzo Claudia Gadaleta Marcello Introna Alfredo Francesco Zito Cosmo Damiano Gadaleta Girolamo Ranieri | 2013 | Critical Reviews in Oncology / Hematology2013，，： | 1 |
| 8 | A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies显示文摘 | G. Ranieri C.D. Gadaleta R. Patruno N. Zizzo M.G. Daidone M.G. Hansson A. Paradiso D. Ribatti | 2013 | Critical Reviews in Oncology / Hematology2013，，： | 1 |
| 9 | A1 receptors mediate adenosine inhibitory effects in mouse ileum via activation of potassium channels显示文摘 | Zizzo MG Bonomo A Belluardo N | | 0，，21： | 1 |
| 10 | The PPAR-',/antagonist GW9662 elicits differ- entiation of M2c-like cells and upregulation of the MerTK/Gas6 axis:a key role for PPAR- in human macrophage polarization 显示文摘 | Zizzo G Cohen PL | 2015 | J Inflamm (Land)2015，12，： | 1 |
| 11 | Traumatic pseudoaneurysm of the lateral plantar artery after endoscopic plantar fasciotomy 显示文摘 | Gentile AT Zizzo C J Dahukey A | 1997 | Foot Ankle int1997，18，： | 1 |
| 12 | Microvascular density and endothelial area correlate with ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneous mode 显示文摘 | Patrunol R Zizzo N Zito A F | 2006 | Leuk Lymphom2006，47，6： | 1 |
| 13 | Synovial fluid-derived T helper 17 ceils correlate with inflammatory activity in arthritis, irrespectively of diagnosis显示文摘 | Zizzo G De Santis M Bosello SL | 2011 | Clin Immunol2011，138，1： | 1 |
| 14 | Microvascular density and endothelial area correlate with Ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneousmode 显示文摘 | Patrunol R Zizzo N Zito AF | 2006 | Leuk Lymphom2006，47，6： | 1 |
| 15 | Automatic detection and imaging of ischemic changes during electrocardiogram monitoring 显示文摘 | Zizzo C Hassani A Turner D | 2008 | IEEE Trans Biomed Eng2008，55，3： | 1 |
| 16 | Microvascular density and endothelial area correlate with Ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneous model显示文摘 | Paruno R Zizzo N Zito AF | 2006 | Leukemia Lymphoma2006，47，： | 1 |
| 17 | Synovial fluid-derived T helper 17 cells correlate with inflam- matory activity in arthritis, irrespectively of diagnosis显示文摘 | Zizzo G De Santis M Bosello SL | 2011 | Clin Immunol2011，138，1： | 1 |
| 18 | Racing with uncertainty: A patent race ex- periment显示文摘 | Zizzo D J | 2001 | Economics2001，20，1： | 1 |
| 19 | Are People Willing to Pay to Reduce Others'Incomes?显示文摘 | Zizzo D Oswald A | 2001 | Annales D'' economic et de statistique2001，，63： | 1 |
| 20 | The potential role of Th17 in mediating the transition from acute to chronic au- toimmune inflammation: rheumatoid arthritis as a model显示文摘 | Ferraccioli G Zizzo G | 2011 | Discov Med2011，11，60： | 1 |
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