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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Comparison of PM_(10) concentrations and metal content in three different sites of the Venice Lagoon: An analysis of possible aerosol sources显示文摘The Venice Lagoon is exposed to atmospheric pollutants from industrial activities, thermoelectric power plants, petrochemical plants, incinerator, domestic heating, ship traffic, glass factories and vehicular emissions on the mainland. In 2005, construction began on the mobile dams (MOSE), one dam for each channel connecting the lagoon to the Adriatic Sea as a barrier against high tide. These construction works could represent an additional source of pollutants. PM 10 samples were taken on random days between 2007 and 2010 at three different sites: Punta Sabbioni, Chioggia and Malamocco, located near the respective dam construction worksites. Chemical analyses of V, Cr, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, Tl and Pb in PM 10 samples were performed by Inductively coupled plasma-quadrupole mass spectrometry (ICP-QMS) and results were used to identify the main aerosol sources. The correlation of measured data with meteorology, and source apportionment, failed to highlight a contribution specifically associated to the emissions of the MOSE construction works. The comparison of the measurements at the three sites showed a substantial homogeneity of metal concentrations in the area. Source apportionment with principal component analysis (PCA) and positive matrix factorization (PMF) showed that a four principal factors model could describe the sources of metals in PM 10 . Three of them were assigned to specific sources in the area and one was characterised as a source of mixed origin (anthropogenic and crustal). A specific anthropogenic source of PM 10 rich in Ni and Cr, active at the Chioggia site, was also identified. | Daniele Contini Franco Belosi Andrea Gambaro Daniela Cesari Angela Maria Stortini Maria Chiara Bove | 2012 | Journal of Environmental Sciences2012，24，11： | 4 |
| 3 | 行人保护和车辆设计(英文)显示文摘首先介绍了行人保护方面的欧盟法规和Euro NCAP的改进以及最新的发展情况。通过事故再现方法,并基于当前的研究成果,研究和探索了改进行人保护的方法。其次,对主动安全(行人保护的行人探测、碰撞风险估计、紧急自动制动)和被动安全(车辆前端结构设计、主动式发动机罩、A柱和发动机罩前缘安全气囊)等方面的先进技术进行了讨论。最后,提出了改进行人保护的评价方法的指导方针。 | Dominique Cesari | 2011 | 汽车工程学报2011，1，4： | 3 |
| 4 | Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life显示文摘Orthostatic hypotension (OH)is a common condition in older persons.According to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH. | Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari | 2018 | Journal of Geriatric Cardiology2018，15，10： | 2 |
| 5 | Orthostatic hypertension and adverse clinical outcomes in adults and older people显示文摘Orthostatic hypertension(OHT)is a condition characterized by an increase in blood pressure after assuming the standing position.[1]Nowadays no consensus definition exists,thus OHT prevalence varies among studies(4%-20.3%). | Sarah Damanti Paolo D Rossi Matteo Cesari | 2021 | Journal of Geriatric Cardiology2021，18，9： | 2 |
| 6 | Precision Breeding Made Real with CRISPR: Illustration through Genetic Resistance to Pathogens显示文摘Since its discovery as a bacterial adaptive immune system and its development for genome editing in eukaryotes,the CRISPR technology has revolutionized plant research and precision crop breeding.The CRISPR toolbox holds great promise in the production of crops with genetic disease resistance to increase agriculture resilience and reduce chemical crop protection with a strong impact on the environment and public health.In this review,we provide an extensive overviewon recent breakthroughs in CRISPR technology,including the newly developed prime editing system that allows precision gene editing in plants.We present how each CRISPR tool can be selected for optimal use in accordance with its specific strengths and limitations,and illustrate how the CRISPR toolbox can foster the development of genetically pathogen-resistant crops for sustainable agriculture. | Florian Veillet Mickael Durand Thomas Kroj Stella Cesari Jean-Luc Gallois | 2020 | Plant Communications2020，1，5： | 2 |
| 7 | 显示文摘 | Cesari E Kokorin V V | 1995 | Scripta Met et Mat1995，33，： | 1 |
| 8 | Prospective evaluation of high-dose ifosfamide related nephrotoccity in young adult petients with recurrent osteosarcoma previously treated with cisplamtin,methotrexate and standard-dose ifosfamide显示文摘 | Fenari S Zolezzi C Cesari M | 1999 | Anticancer Drugs1999，10，： | 1 |
| 9 | On recent theorems in the theory of optimization显示文摘 | Cesari L Suryanarayana M B | 1980 | J of Optimization Theory and Appl1980，31，3： | 1 |
| 10 | Hemoglobin levels and skeletal muscle: results from the InCHIANTI study显示文摘 | Cesari M Penninx BW Lauretani F | 2004 | J Gerontol A BioI Sci Med Sci2004，59，3： | 1 |
| 11 | Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes显示文摘 | Carini R De Cesaris MG Splendore R | 2001 | Hepatology2001，33，1： | 1 |
| 12 | Hyperhomocystrinemia is inversely related with left ventricular ejection fraction and predicts cardiovascular mortality in high risk coronary artery disease hypertensive 显示文摘 | Cesari M Zanchetta M Burlian A | 2005 | Arterioscler Thromb Vasc Boil J2005，25，10： | 1 |
| 13 | The T-786C en- dothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study显示文摘 | Rossi GP Cesari M Zanchetta M | 2003 | J Am Coll Cardiol2003，41，6： | 1 |
| 14 | Continuing follow-up of malignant hypertension 显示文摘 | SCARPELLI P T GALLO M DE CESARIS F | 2002 | J Nephrol2002，15，4： | 1 |
| 15 | Inflammatory markers and onset of cardiovascular events: results from the Health ABC study显示文摘 | Cesari M Penninx BW Newman AB | 2003 | Circulation2003，108，19： | 1 |
| 16 | 查看详情显示文摘 | Chernenko VA Cesari E Kokorin VV | | 0，，08： | 1 |
| 17 | Transformation behaviour and martensite stabilization in the ferromagnetic Co-Ni-Ga Heusler alloy显示文摘 | CHERNENKO V A PONS J CESARI E | 2004 | Scripta Materialia2004，50，： | 1 |
| 18 | Interactions between endothelin - 1 and the renin - angiotensin - aldosterone system 显示文摘 | Rossi GP Sacchetto A Cesari M | 1999 | Cardiovasc Res1999，43，2： | 1 |
| 19 | Transformation behavior and martensite stabilization in the ferromagnetic Co-Ni-Ga Heusler alloy 显示文摘 | Chernenko V A Pons J Cesari E | 2004 | Scripta Materialia2004，50，2： | 1 |
| 20 | Parkin,a gene implicated in autosomal recessive juvenile parkinsonism,is a candidate tumor suppressor gene on chromosome 6q25-q27显示文摘 | Cesari R Martin ES Calin GA | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
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