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| 1 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 2 | Gastric motor abnormlities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and beyhanechol 显示文摘 | Malagelada JR Rees WDW Mazzetta LJ | 1980 | Gastroenterology1980，78，8： | 1 |
| 3 | The preva- lence of urinary incontinence in community-dwelling married women: a matter of definition 显示文摘 | Vandoninck V Bemelmans BL Mazzetta C | 2004 | BJU Int2004，94，9： | 1 |
| 4 | Establishment of a continuous tumor-cell line (panc-1)from a human carcinoma of the exocrine pancreas显示文摘 | Lieher M Mazzetta J Nelson-Rees W | 1975 | Int J Cancer1975，15，5： | 1 |
| 5 | The association between lower urinary tract symptoms and erectile dysfunction in four centres: the UrEpik study显示文摘 | Boyle P Robertson C Mazzetta C | 2003 | BJU Int2003，92，7： | 1 |
| 6 | CCR5 and CXCR4chemokine receptor expression and ~-chemokine production during early T cell repopulation induced by highly active anti-retroviral therapy显示文摘 | Giovannetti A Ensoli F Mazzetta F | 1999 | Clin Exp Immunol1999，118，1： | 1 |
| 7 | Transponder calibration of the Envisat RA-2 altimeter Ku band sigma naught显示文摘 | N. Pierdicca C. Bignami M. Roca P. Féménias M. Fascetti M. Mazzetta C.N. Loddo A. Martini S. Pinori | 2012 | Advances in Space Research2012，，： | 1 |
| 8 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Simone Rossi Del Monte Danilo Ranieri Francesca Mazzetta Andrea Kazemi Nava Salvatore Raffa Maria Rosaria Torrisi Vincenzo Ziparo | 2012 | J Surg Oncol2012，，1： | 1 |
| 9 | Finding dose-volume constraints to reduce late rectal toxicity fottowing3D-conformat radiotherapy (3D-CRT) of prostate cancer显示文摘 | Greco C Mazzetta C Cattani F | 2003 | Radiother Oncot2003，69，： | 1 |
| 10 | The association between lower urinary tract symptoms and erectile dysfunction in four centres:the UrEpik study显示文摘 | Boyle P Robertson C Mazzetta C | 2003 | BJU Int2003，92，7： | 1 |
| 11 | Mammaglobin Expression in Leukapheresis Products Is a Predictive Marker of Poor Prognosis in Woman with High-Risk Breast Cancer显示文摘 | Ferrucci P F Rabscio C Mazzetta C | 2004 | Clinical Cancer Research2004，10，： | 1 |
| 12 | The preva- lence of urinary incontinence in community-dwelling married women: A matter of definition显示文摘 | Vandoninck V Bemelmans BL Mazzetta C | 2004 | BJU lnt2004，94，9： | 1 |
| 13 | The association between lower urinary tract symptoms and erectile dysfunction in four centres:the UrEpik study显示文摘 | BOYLE P ROBERTSON C MAZZETTA C | 2003 | BJU Int2003，92，7： | 1 |
| 14 | Finding dose2volume constraintsto reduce late rectal toxicity following 3D2conformal radiotherapy (3D-CRT) of p rostate cancer显示文摘 | Greco C Mazzetta C Cattani F | 2003 | RadiotherOncol2003，69，： | 1 |
| 15 | Free peritoneal tu- mor ceils detection in gastric and colorectal cancer patients显示文摘 | Rossi Del Monte S Ranieri D Mazzetta F | 2012 | j Surg Oncol2012，106，1： | 1 |
| 16 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Simone Rossi Del Monte Danilo Ranieri Francesca Mazzetta Andrea Kazemi Nava Salvatore Raffa Maria Rosaria Torrisi Vincenzo Ziparo | 2012 | J. Surg. Oncol2012，，1： | 1 |
| 17 | Castric motor abnormalities in diabetic and postvagomy gastroparesis effect of metoclopramide and bethanechol显示文摘 | Malagelada JR Rees WDW Mazzetta Li | 1980 | Gastroenterology1980，78，3： | 1 |
| 18 | CCR5 and CXCR4 chemokine receptor expression and β-chemokine production during early T cell repopulation induced by highly active anti-retroviral therapy显示文摘 | Giovannetti A Ensoli F Mazzetta F | 1999 | Clin Exp Immunol1999，118，1： | 1 |
| 19 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Rossi Del Monte S Ranieri D Mazzetta F | 2012 | J Surg Oncol2012，106，1： | 1 |
| 20 | Establishment of a continuous tumor-cell line ( panc-1 ) from a human carcinoma of the exocrine pancreas 显示文摘 | Lieber M Mazzetta J Nelson-Rees W | 1975 | Int J Cancer1975，15，5： | 1 |
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