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| 1 | Stepwise-Nanocavity-Assisted Transmissive Color Filter Array Microprints显示文摘Visible-light color flters using patterned nanostructures have attracted much interest due to their various advantages such as compactness,enhanced stability,and environmental friendliness compared with traditional pigment or dye-based optical flters.While most existing studies are based on planar nanostructures with lateral variation in size,shape,and arrangement,the vertical dimension of structures is a long-ignored degree of freedom for the structural colors.Herein,we demonstrate a synthetic platform for transmissive color flter array by coordinated manipulations between height-varying nanocavities and their lateral flling fractions.Te thickness variation of those nanocavities has been fully deployed as an alternative degree of freedom,yielding vivid colors with wide gamut and excellent saturation.Experimental results show that the color-rendering capability of the pixelated nanocavities can be still retained as pixels are miniaturized to 500 nm.Crosstalk between closely spaced pixels of a Bayer color flter arrangement was calculated,showing minimal crosstalk for 1μm2 square subpixels.Our work provides an approach to designing and fabricating ultracompact color flter arrays for various potential applications including stained-glass microprints,microspectrometers,and high-resolution image sensing systems. | Yasi Wang Mengjie Zheng Qifeng Ruan Yanming Zhou Yiqin Chen Peng Dai Zhengmei Yang Zihao Lin Yuxiang Long Ying Li Na Liu Cheng-Wei Qiu Joel K.W.Yang Huigao Duan | 2018 | Research2018，，1： | 8 |
| 2 | Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers显示文摘It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices.Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes.Our recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide polymers.Here we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide groups.The peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in vitro.Furthermore,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and cytotoxicity.In vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU surfaces.We further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial membrane.These results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices. | Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu | 2021 | Bioactive Materials2021，6，12： | 5 |
| 3 | Biological receptor-inspired flexible artificial synapse based on ionic dynamics显示文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 4 | 3D shape retrieval based on Laplace operator and joint Bayesian model显示文摘Feature analysis plays a significant role in computer vision and computer graphics.In the task of shape retrieval,shape descriptor is indispensable.In recent years,feature extraction based on deep learning becomes very popular,but the design of geometric shape descriptor is still meaningful due to the contained intrinsic information and interpretability.This paper proposes an effective and robust descriptor of 3D models.The descriptor is constructed based on the probability distribution of the normalized eigenfunctions of the Laplace–Beltrami operator on the surface,and a spectrum method for dimensionality reduction.The distance metric of the descriptor space is learned by utilizing the joint Bayesian model,and we introduce a matrix regularization in the training stage to re-estimate the covariance matrix.Finally,we apply the descriptor to 3D shape retrieval on a public benchmark.Experiments show that our method is robust and has good retrieval performance. | Wang Zihao Lin Hongwei | 2020 | Visual Informatics2020，4，3： | 2 |
| 5 | Molecular Cloning,Bioinformatics Analysis and Transcriptional Expression of Virulence-related Gene(exsA)of Vibrio alginolyticus显示文摘[Objectives]The purpose was to investigate the function and mechanism of exsA gene in type III secretion system of Vibrio alginolyticus.[Methods]The full length of exsA was cloned using molecular biology techniques to analyze its biological information.Fluorescence quantitative PCR technology was used to analyze the expression of exsA after different media stress.[Results]The exsA gene contains an open reading frame(ORF)of 861 bp,encoding 286 amino acids.The physico-chemical analysis shows that the molecular structural formula is C1442H2267N393O441S12,the theoretical molecular weight is 32.549 kD,the theoretical pI value is 6.0,and the protein is non-hydrophilic and unstable.The gene does not contain a transmembrane region,and there is no obvious signal peptide.The prediction result of protein subcellular localization shows that the protein is inside the cell.The deduced amino acid sequence and constructed phylogenetic tree show that V.alginolyticus has a close relationship with Vibrio antiquarius.The qPCR results show that the expression level of exsA in different media is different,highest in TSB medium containing bile salts,followed by DMEM medium,and lowest in ordinary TSB medium.[Conclusions]The gene sequence,molecular structure and isoelectric point of exsA,as well as its expression in three different media were obtained. | Weijie ZHANG Liangchuan CHEN Lin LIN Shihui ZHOU Zihao HE Yanqiu LIANG Huanying PANG | 2021 | Asian Agricultural Research2021，13，1： | 2 |
| 6 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
| 7 | Study of Pressure Balance for Press-Pack IGBTs and Its Influence on Temperature Distribution显示文摘Pressure balance is a key technology for Press-Pack IGBT packaging,and is studied in this paper with its influence on the temperature distribution discussed in further when the device is turned on.By establishing the physical model of the Press-Pack IGBT device in the finite element simulation software,the influence of the internal flatness condition on the pressure balance is analyzed,and the variation of the average pressure difference with the flatness in different parallel scale of the chips is obtained.The thermal contact resistance and the electrical contact resistance parameters,which are dependent on the pressure,are then imported to perform the multi-field coupling,further investigating the effect of different pressure distributions on temperature distribution.The junction-case thermal resistance of the device with different flatness is compared experimentally.The results have demonstrated the influence of the flatness on the thermal resistance of the Press-Pack IGBT device. | Zihao Zhao Lin Liang Lubin Han | 2018 | Chinese Journal of Electrical Engineering2018，4，4： | 2 |
| 8 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 9 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 10 | Bio-inspired flexible artificial synapses for pain perception and nerve injuries显示文摘Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 11 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 12 | Transcriptome Analysis Provides New Insights into Host Response to Hepatopancreatic Necrosis Disease in the Black Tiger Shrimp Penaeus monodon显示文摘The hepatopancreatic necrosis disease(HPND)is a common shrimp disease.Aquaculture of the black tiger shrimp Penaeus monodon has suffered with the frequent outbreak of HPND.Understanding the molecular mechanisms of host response to HPND is of pivotal importance for improving its farming performance.In this study,the RNA-Seq platform was utilized to investigate transcriptomic changes of the hepatopancreas in pond-cultured P.monodon with HPND symptoms.A total of 62071 genes with an average length of 953 bp were obtained,and a lot of simple sequence repeat(SSR)loci related to these genes were identified.Totally,5204 differentially expressed genes(DEGs)were detected between healthy shrimp and HPND shrimp,with 3399 genes upregulated and 1,805 genes down-regulated.These genes had a wide range of biological functions,and several well-known immunerelated genes including integrin alpha 5,integrin beta 1,C type lectin and catalase were among the DEGs.Cell signaling pathways including the extracellular matrix(ECM)receptor interaction,phagosome and lysosome pathways were significantly upregulated in HPND-infected shrimps,indicating their involvement in the immune responses of shrimp against HPND.The data obtained in this study offers new insights into the molecular mechanisms of shrimp host response to HPND disease,and provides a resource for molecular marker development and genetic breeding studies of P.monodon. | ZHAO Jichen CHEN Xieyan HE Zihao CHEN Guoliang LIN Zhaojian LIU Yongkui SUN Chengbo WANG Wei | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 13 | A computational model of topological and geometric recovery for visual curve completion显示文摘Visual curve completion is a fundamental problem in understanding the principles of the human visual system. This problem is usually divided into two problems: a grouping problem and a shape problem.On one hand, though perception of the visually completed curve is clearly a global task(for example,a human perceives the Kanizsa triangle only when seeing all three black objects), conventional methods for solving the grouping problem are generally based on local Gestalt laws. On the other hand, the shape of the visually completed curve is usually recovered by minimizing shape energy in existing methods.However, not only do these methods lack mechanisms to adjust the shape of the recovered visual curve using perceptual, psychophysical, and neurophysiological knowledge, but it is also difficult to calculate an explicit representation of the visually completed curve. In this paper, we present a systematic computational model for generating a visually completed curve. Firstly, based on recent studies of perception, psychophysics, and neurophysiology, we formulate a grouping procedure based on the human visual system by seeking a minimum Hamiltonian cycle in a graph, solving the grouping problem in a global manner. Secondly, we employ a B′ezier curve-based model to represent the visually completed curve. Not only is an explicit representation deduced, but we also present a means to integrate knowledge from related areas, such as perception, psychophysics, and neurophysiology, and so on. The proposed computational model has been validated using many modal and amodal completion examples, and desirable results were obtained. | Hongwei Lin Zihao Wang Panpan Feng Xingjiang Lu Jinhui Yu | 2016 | Computational Visual Media2016，2，4： | 1 |
| 14 | Joint Model of Wind Speed and Corresponding Direction Based on Wind Rose for Wind Energy Exploitation显示文摘As a common and extensive datum to analyze wind,wind rose is one of the most important components of the meteorological elements.In this study,a model is proposed to establish the joint probability distribution of wind speed and direction using grouped data of wind rose.On the basis of the model,an algorithm is presented to generate pseudorandom numbers of wind speed and paired direction data.Afterward,the proposed model and algorithm are applied to two weather stations located in the Liaodong Gulf.With the models built for the two cases,a novel graph representing the continuous joint probability distribution of wind speed and direction is plotted,showing a strong correlation to the corresponding wind rose.Moreover,the joint probability distributions are utilized to evaluate wind energy potential successfully.In cooperation with Monte Carlo simulation,the model can approximately predict annual directional extreme wind speed under different return periods under the condition that the wind rose can represent the meteorological characters of the wind field well.The model is beneficial to design and install wind turbines. | YANG Zihao LIN Yifan DONG Sheng | 2022 | Journal of Ocean University of China2022，21，4： | 1 |
| 15 | Evolution of TCP Phase During Long Term Thermal Exposure in Several Re-Containing Single Crystal Superalloys显示文摘The application and component designs of single crystal superalloys are restricted by the precipitation of topologically closed packed(TCP)phases,which can deteriorate the microstructural stability of the alloys severely.Limited researches concerning the type and morphology evolution of TCP phases under elevated temperature conditions have been reported previously.In the present work,three Re-containing single crystal alloys were designed to investigate TCP phase evolution via long term isothermal exposure tests at 1120℃while the effects of Re on the microstructural characteristic and elements segregation were also clarified.The results showed that the addition of Re increased the instability of the alloys and the volume fraction of the TCP phases exceeded 5 vol%when the Re content reached 3 wt%.The increasing Re content had also raised the precipitation temperature of TCP phases but it did not change the type of them after long term aging;all the TCP particles were identified asμphase in this study.Moreover,the elements segregation became considerably serious as Re addition increased constantly,which brought about various morphologies of theμphase in the experimental alloys.In particular,the rod-like and needle-likeμphases demonstrated the typical orientation withinγmatrix while the blockyμphase was dispersedly distributed in the space.No specific orientation relationship could be observed in theμphase when the addition of Re exceeded certain threshold value. | Zihao Tan Lin Yang Xinguang Wang Yunling Du Lihua Ye Guichen Hou Yanhong Yang Jinlai Liu Jide Liu Jinguo Li Yizhou Zhou Xiaofeng Sun | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 1 |
| 16 | HMGB1 is necessary for the development of lamprey显示文摘High mobility group box protein 1(HMGB1)with a highly conserved structure in chromatin is an abundant nonhistone protein,which is involved in nucleosome folding and assembly,chromatin formation,DNA binding,V(D)J recombination,DNA replication,gene transfer,cell differentiation,cell migration,neurotransmitters,cell death,immune response,and other important processes[1–4].So,it has important biological functions in animals.The function of hmgb1 has been extensively studied in jawed vertebrates but little in lampreys.Lampreys are members of the living agnathans,the most basal group of vertebrates.Lamprey is a considerable model organism in vertebrate evolution and developmental biology because of its special phylogenetic position and critical stage closely related to other animals.Many aspects of the hmgb1 in lampreys have not been revealed,such as evolution,distribution,and role.Therefore,in this paper,the evolution of hmgb1 was carried out,and the function of hmgb1 in lampreys was investigated by the morpholine antisense oligonucleotide(MO)technique.The data provide the foundation for the study of origins,evolution,and the function of hmgb1 in a jawless vertebrate.Linking evolution to function can shed more light on the role of the hmgb1 gene involved in development. | Jingjing Lu Jun Li Zihao Yan Xiaokun Wang Feng Lin Qinghua Ma Huaixiu Liu Haoran Guan Yueying Xun Xiaoying Kang Peijie Luan Xiao Feng Yue Pang Qingwei Li Yinglun Han | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 17 | Soxllb regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish显示文摘The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye development.However,its function in retina regeneration remains elusive.Here we report that Sox11 b,a zebrafish Sox11 homolog,regulates the migration and fate determination of Müller glia-derived progenitors(MGPCs)in an adult zebrafish model of mechanical retinal injury.Following a stab injury,the expression of Sox11 b was induced in proliferating MGPCs in the retina.Sox11 b knockdown did not affect MGPC formation at 4 days post-injury,although the nuclear morphology and subsequent radial migration of MGPCs were alte red.At 7 days post-injury,Sox11 b knockdown res ulted in an increased proportion of MGPCs in the inner retina and a decreased propo rtion of MGPCs in the outer nuclear layer,compared with controls.Furthermore,Sox11 b knockdown led to reduced photoreceptor regeneration,while it increased the numbe rs of newborn amacrines and retinal ganglion cells.Finally,quantitative polymerase chain reaction analysis revealed that Sox11 b regulated the expression of Notch signaling components in the retina,and Notch inhibition partially recapitulated the Sox11 b knockdown phenotype,indicating that Notch signaling functions downstream of Sox11 b.Our findings imply that Sox11 b plays key roles in MGPC migration and fate determination during retina regeneration in zebrafish,which may have critical im plications for future explorations of retinal repair in mammals. | Kaida Song Zihao Lin Lining Cao Bowen Lu Yuxi Chen Shuqiang Zhang Jianfeng Lu Hui Xu | 2023 | Neural Regeneration Research2023，18，2： | 0 |
| 18 | A Network Security Risk Assessment Method Based on a B_NAG Model显示文摘Computer networks face a variety of cyberattacks.Most network attacks are contagious and destructive,and these types of attacks can be harmful to society and computer network security.Security evaluation is an effective method to solve network security problems.For accurate assessment of the vulnerabilities of computer networks,this paper proposes a network security risk assessment method based on a Bayesian network attack graph(B_NAG)model.First,a new resource attack graph(RAG)and the algorithm E-Loop,which is applied to eliminate loops in the B_NAG,are proposed.Second,to distinguish the confusing relationships between nodes of the attack graph in the conversion process,a related algorithm is proposed to generate the B_NAG model.Finally,to analyze the reachability of paths in B_NAG,the measuring indexs such as node attack complexity and node state transition are defined,and an iterative algorithm for obtaining the probability of reaching the target node is presented.On this basis,the posterior probability of related nodes can be calculated.A simulation environment is set up to evaluate the effectiveness of the B_NAG model.The experimental results indicate that the B_NAG model is realistic and effective in evaluating vulnerabilities of computer networks and can accurately highlight the degree of vulnerability in a chaotic relationship. | Hui Wang Chuanhan Zhu Zihao Shen Dengwei Lin Kun Liu MengYao Zhao | 2021 | Computer Systems Science & Engineering2021，38，7： | 0 |
| 19 | A hybrid flexible gas sensory system with perceptual learning显示文摘Imbuing artificial sensory system with intelligence of the biological counterpart is limited by challenges in emulating perceptual learning ability at the device level.In biological systems,stimuli from the surrounding environment are detected,transmitted,and processed by receptor,afferent nerve,and brain,respectively.This process allows the living creatures to identify the potential hazards and improve their adaptability in various environments.Here,inspired by the biological olfaction system,a gas sensory system with perceptual learning is developed.As a proof-of-concept,H2S gas with various concentrations is used as the stimulation and the stimuli will be converted to pulse-like physiological signals in the designed system,which consists of a gas sensor,a flexible oscillator,and a memristor-type artificial synapse.Furthermore,the learning ability is implemented using a supervised learning method based on k-nearest neighbors(KNN)algorithm.The recognition accuracy can be enhanced by repeating training,illustrating a great potential to be used as the neuromorphic sensory system with a learning ability for the applications in robotics. | Qifeng Lu Fuqin Sun Yanbing Dai Yingyi Wang Lin Liu Zihao Wang Shuqi Wang Ting Zhang | 2022 | Nano Research2022，15，1： | 0 |
| 20 | Fiber-based quantum secure direct communication without active polarization compensation显示文摘Quantum secure direct communication(QSDC)that allows people to directly transmit confidential information through insecure channels is an important branch of quantum communication.The widespread adoption of the QSDC demands the development of simple and stable systems.However,most of the existent QSDC systems involve a complex self-alignment process at the initial stage and additional hardware to compensate environmental disturbance.In this study,we present a fiber-based QSDC system without active polarization compensation.Our system comprises a stable transmitter and a novel Sagnac-Mach-Zehnder interferometer for security detection.This robust system simplifies the self-alignment and is immune to environmental disturbance.The robustness of the system was theoretically and experimentally verified,and low bit error rates in a 12 min continuous operation with an active polarization scrambler were attained.In addition,we performed a proof-of-principle QSDC demonstration,and a secrecy capacity of 3.43 kbps over a 5 km fiber with a detection bit error rate of 0.85%±0.07%and a quantum bit error rate of 0.42%±0.05%were achieved.Experimental results confirm the viability of the proposed QSDC system for practical applications. | Xin Liu Di Luo Guangshen Lin Zihao Chen Chunfeng Huang Shizhuo Li Chengxian Zhang Zhenrong Zhang Kejin Wei | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 0 |
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