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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Microstructures and fatigue properties of electron beam welds with beam oscillation for heavy section TC4-DT alloy显示文摘With the development of the manufacturing technology, electron beam welding(EBW) is capable of producing titanium alloy large parts in aero fields. To increase the applications and improve the properties, EBW with beam oscillation was investigated on TC4-DT alloy with50 mm thickness. We detected the welding samples by X-ray NDT, observed the microstructures of the welds, and tested the fatigue properties of the joints. The results showed that EBW with beam oscillation improved the weld morphology as well as welding quality, and the microstructure homogeneity of the welds and HAZ along the weld penetration were also improved. The fatigue properties of the joints with beam oscillation were more excellent than those of conventional EBW, even equal to those of the base metal under high stresses. The influences of the processing and the microstructure on the properties with beam oscillation were discussed. | Fu Pengfei Mao Zhiyong Zuo Congjin Wang Yajun Wang Chunming | 2014 | Chinese Journal of Aeronautics2014，27，4： | 8 |
| 4 | Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity显示文摘The metabolic intermediate of acetaminophen(APAP)can cause severe hepatocyte necrosis,which triggers aberrant immune activation of liver non-parenchymal cells(NPC).Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury(AILI).Interleukin-1 receptor(IL-1R)signaling has been shown to play a critical role in various inflammatory conditions,but its precise role and underlying mechanism in AILI remain debatable.Herein,we show that NLRP3 inflammasome activation of IL-1βis dispensable to AILI,whereas IL-1α,the other ligand of IL-1R1,accounts for hepatic injury by a lethal dose of APAP.Furthermore,Kupffer cells function as a major source of activated IL-1αin the liver,which is activated by damaged hepatocytes through TLR4/MyD88 signaling.Finally,IL-1αis able to chemoattract and activate CD11b^(+)Gr-1^(+) myeloid cells,mostly neutrophils and inflammatory monocytes,to amplify deteriorated inflammation in the lesion.Therefore,this work identifies that MyD88-dependent activation of IL-1αin Kupffer cells plays a central role in the immunopathogenesis of AILI and implicates that IL-1αis a promising therapeutic target for AILI treatment. | Chao Zhang Jin Feng Jun Du Zhiyong Zhuo Shuo Yang Weihong Zhang Weihong Wang Shengyuan Zhang Yoichiro Iwakura Guangxun Meng Yang-Xin Fu Baidong Hou Hong Tang | 2018 | Cellular & Molecular Immunology2018，15，11： | 7 |
| 5 | The spatial variation of soil bacterial community assembly processes affects the accuracy of source tracking in ten major Chinese cities显示文摘Urban soils harbor billions of bacterial cells and millions of species.However,the distribution patterns and assembly processes of bacterial communities remain largely uncharacterized in urban soils.It is also unknown if we can use the bacteria to track soil sources to certain cities and districts.Here,Illumina MiSeq sequencing was used to survey soil bacterial communities from 529 random plots spanning 61 districts and 10 major cities in China.Over a 3,000 km range,community similarity declined with increasing geographic distance(Mantel r=0.62),and community composition was clustered by city(R^(2)=0.50).Within cities(<100 km),the aforementioned biogeographic patterns were weakened.Process analysis showed that homogenizing dispersal and dispersal limitation dominated soil bacterial assembly at small and large spatial scales,respectively.Accordingly,the probabilities of accurately tracking random soil sources to certain cities and districts were 90.0% and 66.7%,respectively.When the tested samples originated from cities that were more than 1,265 km apart,the soil sources could be identified with nearly 100% accuracy.Overall,this study demonstrates the strong distance-decay relationship and the clear geographic zoning of urban soil bacterial communities among cities.The varied importance of different community assembly processes at multiple spatial scales strongly affects the accuracy of microbial source tracking. | Teng Yang Yu Shi Jun Zhu Chang Zhao Jianmei Wang Zhiyong Liu Xiao Fu Xu Liu Jiangwei Yan Meiqing Yuan Haiyan Chu | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 6 | Short-term link quality prediction using nonparametric time series analysis显示文摘Wireless link quality prediction(LQP) is the foundation for proactive operations and is therefore a key technique in alleviating network performance degradation. However, accurate LQP is difficult because of the dynamic nature of wireless environments. A recent study found that fluctuations in intermediate quality links often show dynamics on a sub-second granularity, making the task even more challenging. In order to leverage the intermediate links, as well as fine-tune upper-layer protocols, we propose to use nonparametric modeling in nonlinear time series analysis that predicts short-term link quality online. Unlike existing studies,we do not define any new experimental or hypothetical models, or train models using a set of training data.Functional-coefficient autoregression is employed to predict the link dynamics at high time resolutions. We apply our approach and a local linear regression-based LQP(a typical parametric modeling approach) to both NS-2 simulation and empirical packet traces. The results indicate that the proposed method has much higher prediction accuracy and convergence speed than the local linear regression-based LQP under dynamic network conditions. | WENG LiNa ZHANG Ping FENG ZhiYong CHENG HongWei LIAN Hao FU Bin | 2015 | Science China(Information Sciences)2015，58，8： | 4 |
| 7 | The Major Controlling Factors and Different Oolitic Shoal Reservoir Characteristics of the Triassic Feixianguan Formation,Eastern Longgang Area,NE Sichuan Basin,SW China显示文摘Based on comprehensive analyses of occurrence,petrological observation,pore structure and geochemistry,the different reservoir characteristics and reservoir evolutionary pathways between different oolitic shoal reservoir types of the Feixianguan Formation on the west side of the Kaijiang-Liangping Trough have been studied.There exist three stages of high-energy slope break belts in the Feixianguan period,the corresponding three stages of oolitic shoals gradually migrating in the direction of the trough.Three types of oolitic shoal reservoirs,namely,residual-oolitic dolomite,mold-oolitic dolomite and sparry oolitic limestone,were formed during sedimentary-diagenetic evolution,the pore types being intergranular dissolved pore,mold pore(or intragranular dissolved pore)and residual intergranular pore,respectively.The petrology,physical properties and pore structure of the different types of oolitic shoal reservoirs are quite different.Residual-oolitic dolomite reservoirs have the best quality,while sparry oolitic limestone reservoirs have the poorest.Combined with analyses of trace elements,rare earth elements and carbon-oxygen isotopes,it is suggested that the formation of residual-oolitic dolomite reservoirs is jointly controlled by penesaline seawater seepage-reflux dolomitization and hydrothermal dolomitization.Mold-pore oolitic dolomite reservoirs are controlled by penesaline seawater seepage-reflux dolomitization and meteoric water solution.The burial dissolution of organic acid not only further improves the reservoir qualities of previously formed oolitic dolomite reservoirs,but also preserves residual intergranular pores in the sparry oolitic limestone reservoirs. | GU Yifan JIANG Yuqiang LEI Xiaohua CHEN Zhiyong ZHOU Lu FU Yonghong JIANG Zengzheng | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 3 |
| 8 | Geochemical identification of coal-sourced oils and inter-bedded shale-sourced oils as revealed by compound specific carbon isotopic analysis显示文摘To date, questions remain as to how to differentiate between coal- and interbedded shale-sourced oils in coal measures. Based on the hypothesis that δ13C value of sedimentary organic matter is controlled by the depositional environment and productivities of biota grown in such depositional setting, this note examines compound specific carbon isotopic profiles from coal and interbedded shale extracts using the gas chromatography-isotope ratio mass spec-trometry technique (GC/IRMS). The results show that compound specific carbon isotope values from coal extracts are enriched in 13C relative to that of interbedded shale extracts, and provide useful information in characterizing coal- and interbedded shale-sourced oils in coal measures. An example for its successful application from the Turpan Basin, Northwestern China is presented. | SUN Yongge WANG Zhiyong SHENG Guoying ZHANG Shihuan PENG Ping’an FU Jiamo WANG Wuhe YUAN Mingshen | 2001 | Chinese Science Bulletin2001，46，20： | 2 |
| 9 | Observation of the novel “three-pointed star” cage-like (H_2O)_5cluster in a polymeric solid {[Ag_2(bpp)_2(H_2O)_2](chd)·9H_2O}_n显示文摘Coordination polymeric solid, {[Ag 2 (bpp) 2 (H 2 O) 2 ](chd)·9H 2 O} n (1) (bpp = 1,3-bis(4-pyridyl) propane, H 2 chd = 1,4-cyclo-hexanedicarboxylic acid), has been obtained by the solution phase ultrasonic synthesis techniques. The structure established through X-ray structural analysis shows that the compound traps an interesting 1D water tape built by the alternating 'three-pointed star' cage-like pentameric and D 2h tetrameric clusters (C2/c, Z = 4; a = 30.37(2) , b = 9.271(5) , and c = 18.89(1) ; β = 128.47°; V = 4164(4) 3 ). The novelty of the present complex is the rarely crystallographic example of the cage-shaped water pentamer, which is usually ascribed to a less-stable species. A first-principle density functional theory (DFT) calculation demonstrates that the interconnectivity between cage-like pentamers and D 2h tetramers is beneficial for contribution to the structural stabilization of these less-stable water cluster species. | LUO GengGeng XIONG HongBo FU ZhiYong DAI JingCao | 2012 | Science China Chemistry2012，55，10： | 2 |
| 10 | A novel range-Doppler imaging algorithm with OFDM radar显示文摘Traditional pulse Doppler radar estimates the Doppler frequency by taking advantage of Doppler modulation over different pulses and usually it requires a few pulses to estimate the Doppler frequency. In this paper, a novel range-Doppler imaging algorithm based on single pulse with orthogonal frequency division multiplexing(OFDM) radar is proposed, where the OFDM pulse is composed of phase coded symbols. The Doppler frequency is estimated using one single pulse by utilizing Doppler modulation over different symbols, which remarkably increases the data update rate. Besides, it is shown that the range and Doppler estimations are completely independent and the well-known range-Doppler coupling effect does not exist. The effects of target movement on the performances of the proposed algorithm are also discussed and the results show that the algorithm is not sensitive to velocity. Performances of the proposed algorithm as well as comparisons with other range-Doppler algorithms are demonstrated via simulation experiments. | Xia Yang Song Zhiyong Lu Zaiqi Fu Qiang | 2016 | Chinese Journal of Aeronautics2016，29，2： | 2 |
| 11 | Fast density peak-based clustering algorithm for multiple extended target tracking显示文摘The key challenge of the extended target probability hypothesis density (ET-PHD) filter is to reduce the computational complexity by using a subset to approximate the full set of partitions. In this paper, the influence for the tracking results of different partitions is analyzed, and the form of the most informative partition is obtained. Then, a fast density peak-based clustering (FDPC) partitioning algorithm is applied to the measurement set partitioning. Since only one partition of the measurement set is used, the ET-PHD filter based on FDPC partitioning has lower computational complexity than the other ET-PHD filters. As FDPC partitioning is able to remove the spatially close clutter-generated measurements, the ET-PHD filter based on FDPC partitioning has good tracking performance in the scenario with more clutter-generated measurements. The simulation results show that the proposed algorithm can get the most informative partition and obviously reduce computational burden without losing tracking performance. As the number of clutter-generated measurements increased, the ET-PHD filter based on FDPC partitioning has better tracking performance than other ET-PHD filters. The FDPC algorithm will play an important role in the engineering realization of the multiple extended target tracking filter. | SHEN Xinglin SONG Zhiyong FAN Hongqi FU Qiang | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 2 |
| 12 | Self-assembled honokiol-loaded micelles based on poly(?-caprolactone)-poly(ethylene glycol)-poly(?-caprolactone) copolymer显示文摘 | XiaWei Wei ChangYang Gong Shuai Shi ShaoZhi Fu Ke Men Shi Zeng XiuLing Zheng MaLing Gou LiJuan Chen LiYan Qiu ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 13 | Bioaugmentation of Bromoamine Acid Degradation with Sphingomonas xenophaga QYY and DNA Fingerprint Analysis of Augmented Systems显示文摘 | Yuanyuan Qu Jiti Zhou Jing Wang Zhiyong Song Linlin Xing Xiang Fu | 2006 | Biodegradation2006，，1： | 1 |
| 14 | Filterless optical ox- ygen sensor based on a CMOS buried double junction photo- diode 显示文摘 | Zhan Zhiyong Zhou Bin Fu Zhenhong | 2013 | Sensors and Actuators B : Chemical2013，176，： | 1 |
| 15 | Fiherless Optical Oxygen Sensor Based on a CMOS Buried Double Junction Photodiode显示文摘 | Zhan Zhiyong Zhou Bin Fu Zhenhong et al | 2013 | Sensors and Actuators B: Chemical2013，176，： | 1 |
| 16 | Ontogeny of expression of transforming growth factor-βand its receptors and their possible relationship with scarless or scar-forming healing in human fetal and postnatal skins显示文摘Fetal eutaneous wounds that oeeur in earlygestation heal without sear formation.Althoughmueh work has been done to eharaeterize the roleof transforming growth | Chen Wei Fu Xiaobing Ge Shili~1 Sun Tongzhu Zhou Gang Jiang Duyin Sheng Zhiyong Research Department of Burn Institute,304th Hospital,Beijing 100037 Institute of Radiation Medicine,Academy of Military Medicine Sciences,Beijing 100850,People’s Republic of China | 2003 | 感染.炎症.修复2003，4，4： | 1 |
| 17 | Fractal detector design and application in maritime target detection显示文摘The fractal properties of sea clutter are proposed and applied to the maritime target detection. Calculation of the measured data shows that, the Hurst exponent of the sea clutter with targets and the sea clutter without targets are different, which enables us to detect low-observable targets within the sea clutter.This paper explains the reason why the Hurst exponent can distinguish the presence or absence of targets in theory and proposes a fractal detector based on the Hurst exponent. Comparing the fractal detector proposed in this paper to the energy detector by the detection results of 140 frames data of the real sea clutter, it is demonstrated that the fractal detection method has a better detection performance. In order to get systemic conclusions, the new sea clutter data with different signal-to-clutter ratios(SCRs) are constructed in the way that add the sea clutter data with targets to the pure sea clutter data. The results show that the fractal detection method has a better performance than the statistical method on detection of maritime targets, especially maritime weak targets with low SCR. | Xinglin Shen Zhiyong Song Yongfeng Zhu Qiang Fu | 2017 | Journal of Systems Engineering and Electronics2017，28，1： | 1 |
| 18 | Epide- miological study of chronic dermal ulcers in China显示文摘 | Fu Xiaobing Sheng Zhiyong Cherry GW Li Quanyue | 1998 | Wound Rep Reg1998，6，1： | 1 |
| 19 | Synthesis and Enhanced Electrochemical Catalytic Performance of Monolayer WS2(1– x )Se2 x with a Tunable Band Gap显示文摘 | Qi Fu Lei Yang Wenhui Wang Ali Han Jian Huang Pingwu Du Zhiyong Fan Jingyu Zhang Bin Xiang | 2015 | Adv. Mater2015，，32： | 1 |
| 20 | Healing of chronic cutaneous wounds by topical treatment with basic fibroblast growth factor 显示文摘 | Fu xiaobing Sheng zhiyong Guo zhenrong | 2002 | Clin Med J2002，115，： | 1 |
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