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| 1 | Global overview of research progress and development of precision maize planters显示文摘Maize is the most important crop for food and widely used for industrial materials,leading to its increasing demand all over the world.Precision planting is the effective method to increase maize yield.To meet the agronomic requirement of precision planting,different kinds of precision maize planters were developed.However,because of the difference of geographical environment,cropping system,farm scale and economic status among different countries,types of maize planters are various and the technologies involved are at different levels.This paper summarizes the precision maize planters currently available in the world and classifies them into four types:precision planters for tilled-land,minimum/no tilled-land,hilly&small land,and cold&arid land.Detailed characteristics have been provided for some typical precision planters and comparisons were made as to their suitability under particular working conditions.High-efficiency and high-accuracy are the main features of precision planters for tilled-land,while the ability to clean residue from seed rows and prevent planters to be blocked are the important function of precision planters for minimum/no tilled-land.To fit for hilly&small land,planters should be light-weighted and small-sized,and to warm up soil and keep moisture,planters for cold&arid land should be equipped with plastic-film mulching mechanism.Finally,developing trend of precision planting technology was analyzed and suggestions,including policy support and technical improvement,were made for developing countries to make suitable precision maize planters according to the local geographical conditions and cropping systems. | Yang Li Yan Bingxin Cui Tao Yu Yiming He Xiantao Liu Quanwei Liang Zhijie Yin Xiaowei Zhang Dongxing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 17 |
| 2 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 3 | Effects of a conversion from grassland to cropland on the different soil organic carbon fractions in Inner Mongolia, China显示文摘耕作是除放牧以外影响草地生态系统的最重要的人的活动之一,但是它土壤上的影响总计器官的碳(C) ,特别在有倾向的器官的 C 部分上还充分没被理解。在这份报纸,在土壤收割不同部分的器官的 C 水池的角色在中国,和在不同 C 部分之间的关系的内部蒙古在一个草地大草原区域被调查也被讨论。结果显示在大草原和栽培土地的不同 C 部分的集中都与土壤深度日益增多地减少了。在到为 36 年的春天小麦地的从大草原的变换以后,在 0~100 厘米土壤深度的全部的器官的碳( TOC )集中在12.3%~28.2%减少了,并且表面土壤地平线的 TOC ,特别那些更显著地 030 厘米减少了( p < 0.01 )。溶解的器官的碳(文档) 和在 040 厘米的深度的微生物引起的生物资源碳(MBC ) 被发现分别地在 66.7% ~ 77.1% 和 36.5% ~ 42.4% 减少了。在 S。baicalensis 大草原,春天小麦地里的到 TOC 的文档在 0.52% 和 0.60% 之间改变了的土壤的比率,和那些仅仅在 0.18%0.20% 的范围。在春天小麦的微生物引起的商(qMBs ) 回答,从 1.11% ~ 1.40% 变化,也是比在 S 的那些低的。baicalensis 大草原,它在 1.50%1.63% 的范围。文档的变化对耕作骚乱更敏感。土壤 TOC,文档,和 MBC 是显著地积极的在 S 与对方一起相关。baicalensis 大草原,但是在春天小麦地里,在文档之间的相互关系和在文档和 MBC 之间的 TOC 和那没到达 0.05 的意义水平。 | QI Yuchun DONG Yunshe PENG Qin XIAO Shengsheng HE Yating LIU Xinchao SUN Liangjie JIA Junqiang YANG Zhijie | 2012 | Journal of Geographical Sciences2012，22，2： | 13 |
| 4 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 5 | Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants——China,May 21,2021-February 28,2022显示文摘Summary What is already known about this topic?Compared with the international mRNA and adenovirus-vectored coronavirus disease 2019(COVID-19)vaccines,there is less real-world research data about breakthrough cases in people vaccinated with China-made COVID-19 vaccines.Analyses of clinical outcomes of breakthrough cases will be an important supplement to the clinical trial efficacy and observational effectiveness data of China-made COVID-19 vaccines. | Mingshuang Li Qianqian Liu Dan Wu Lin Tang Xiaoqi Wang Tingting Yan Zhijie An Zundong Yin Geroge F.Gao Fuzhen Wang Hui Zheng | 2022 | China CDC weekly2022，4，14： | 10 |
| 6 | Effect of heat treatment on structure and gasification reactivity of petroleum coke显示文摘 | Chao Li Xin Liu Zhijie Zhou Zhenghua Dai Ji Yan Fuchen Wang | 2016 | International Journal of Coal Science & Technology2016，3，1： | 9 |
| 7 | Identification and characterization of Argonaute gene family and meiosis-enriched Argonaute during sporogenesis in maize显示文摘Argonaute(AGO) proteins play a key role in regulation of gene expression through small RNA‐directed RNA cleavage and translational repression, and are essential for multiple developmental processes. In the present study, 17 AGO genes of maize(Zea mays L., ZmAGOs) were identified using a Hidden Markov Model and validated by rapid amplification of cDNA ends assay. Subsequently, quantitative PCR revealed that expressions of these genes were higher in reproductive than in vegetative tissues. AGOs presented five temporal and spatial expression patterns, which were likely modulated by DNA methylation, 50‐untranslated exons and microRNA‐mediated feedback loops. Intriguingly, ZmAGO18 b was highly expressed in tassels during meiosis. Furthermore, in situ hybridization and immunofluorescence showed that ZmAResearchGO18b was enriched in the tapetum and germ cells in meiotic anthers. We hypothesized that ZmAGOs are highly expressed in reproductive tissues, and that ZmAGO18 b is a tapetum and germ cell‐specific member of the AGO family in maize. | Lihong Zhai Wei Sun Ke Zhang Haitao Jia Lei Liu Zhijie Liu Feng Teng Zuxin Zhang | 2014 | Journal of Integrative Plant Biology2014，56，11： | 8 |
| 8 | African Swine Fever Virus MGF-110-9L-deficient Mutant Has Attenuated Virulence in Pigs显示文摘African swine fever virus(ASFV)is the etiological agent of African swine fever(ASF),an often lethal disease in domestic and wild pigs.ASF represents a major threat to the swine industry worldwide.Currently,no commercial vaccine is available because of the complexity of ASFV or biosecurity concerns.Live attenuated viruses that are naturally isolated or genetically manipulated have demonstrated reliable protection against homologous ASFV strain challenge.In the present study,a mutant ASFV strain with the deletion of ASFV MGF-110-9L(ASFV-D9L)was generated from a highly virulent ASFV CN/GS/2018 parental strain,a genotypeⅡASFV.Relative to the parental ASFV isolate,deletion of the MGF-110-9L gene significantly decreased the ability of ASFV-D9L to replicate in vitro in primary swine macrophage cell cultures.The majority of animals inoculated intramuscularly with a low dose of ASFV-D9L(10 HAD50)remained clinically normal during the 21-day observational period.Three of five ASFV-D9L-infected animals displayed low viremia titers and low virus shedding and developed a strong virus-specific antibody response,indicating partial attenuation of the ASFV-D9L strain in pigs.The findings imply the potential usefulness of the ASFV-D9L strain for further development of ASF control measures. | Dan Li Yinguang Liu Xiaolan Qi Yuan Wen Pan Li Zhao Ma Yongjie Liu Haixue Zheng Zhijie Liu | 2021 | Virologica Sinica2021，36，2： | 8 |
| 9 | Directly patterned substrate-free plasmonic “nanograter” structures with unusual Fano resonances显示文摘The application of three-dimensional(3D)plasmonic nanostructures as metamaterials(MMs),nano-antennas,and other devices faces challenges in producing metallic nanostructures with easily definable orientations,sophisticated shapes,and smooth surfaces that are operational in the optical regime and beyond.Here,we demonstrate that complex 3D nanostructures can be readily achieved with focused-ion-beam irradiation-induced folding and examine the optical characteristics of plasmonic“nanograter”structures that are composed of free-standing Au films.These 3D nanostructures exhibit interesting 3D hybridization in current flows and exhibit unusual and well-scalable Fano resonances at wavelengths ranging from 1.6 to 6.4 mm.Upon the introduction of liquids of various refractive indices to the structures,a strong dependence of the Fano resonance is observed,with spectral sensitivities of 1400 nm and 2040 nm per refractive index unit under figures of merit of 35.0 and 12.5,respectively,for low-order and high-order resonance in the near-infrared region.This work indicates the exciting,increasing relevance of similarly constructed 3D free-standing nanostructures in the research and development of photonics and MMs. | Ajuan Cui Zhe Liu Jiafang Li Tiehan H Shen Xiaoxiang Xia Zhiyuan Li Zhijie Gong Hongqiang Li Benli Wang Junjie Li Haifang Yang Wuxia Li Changzhi Gu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 10 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 11 | Novel roll effector based on zero-mass-flux dual synthetic jets and its flight test显示文摘The autonomous and controllable Dual Synthetic Jet Actuator(DSJA)is firstly integrated into the Unmanned Aerial Vehicle(UAV),and flight tests without the deflection of rudders are carried out to verify the viability of DSJA to control the attitudes of UAV during cruising.DSJA is improved into an actuator with two diaphragms and three cavities,which has higher energy levels.Actuators,differentially distributed on both sides of the wings,are installed on the trailing edge close to the wing tips.Flight tests,containing Differential Circulation Control(DCC)using double-side actuators,Positive Circulation Control(PCC)using left-side actuators and Negative Circulation Control(NCC)using right-side actuators,are implemented at cruising speed of 25 m/s.Results show that roll attitude control without rudders could be realized by DSJAs.DCC and NCC can generate the rightward roll and yaw angular velocity,prompting UAV to turn right.The stronger controlling ability can be achieved by DCC,with the maximum roll angular velocity of 15.62(°)/s.PCC can generate a rightward roll moment,but a leftward yaw moment will be produced at the same time.Leftward yaw induces the leftward rolling moment,which weakens the roll control effect,making UAV keep to yaw to the left with a small slope. | Zhenbing LUO Zhijie ZHAO Jiefu LIU Xiong DENG Mu ZHENG Hang YANG Qingyang CHEN Shiqing LI | 2022 | Chinese Journal of Aeronautics2022，35，8： | 7 |
| 12 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 13 | Variational method based robust adaptive control for a guided spinning rocket显示文摘In this paper,a robust adaptive controller is designed for a guided spinning rocket,whose dynamics presents the characteristics of pitch-yaw cross coupling,fast time-varying aerodynamics parameters and wide flight envelop.First,a coupled nonlinear six-degree-of-freedom equation of motion for a guided spinning rocket is developed,and the lateral acceleration motion is modeled as a control plant with time-varying matched uncertainties and unmodeled dynamics.Then,a robust adaptive control method is proposed by combining Bregman divergence and variational method to achieve fast adaption and maintain bounded tracking.The stability of the resulting closed-loop system is proved,and the ultimate bound and convergence rate are also analyzed.Finally,numerical simulations are performed for a single operating point and the whole flight trajectory to show the robustness and adaptability of the proposed method with respect to timevarying uncertainties and unmodeled dynamics. | Zhongjiao Shi Liangyu Zhao Zhijie Liu | 2021 | Chinese Journal of Aeronautics2021，34，3： | 6 |
| 14 | The application of perovskite materials in solar water splitting显示文摘Solar water splitting is a promising strategy for sustainable production of renewable hydrogen,and solving the crisis of energy and environment in the world.However,large-scale application of this method is hampered by the efficiency and the expense of the solar water splitting systems.Searching for non-toxic,low-cost,efficient and stable photocatalysts is an important way for solar water splitting.Due to the simplicity of structure and the flexibility of composition,perovskite based photocatalysts have recently attracted widespread attention for application in solar water splitting.In this review,the recent developments of perovskite based photocatalysts for water splitting are summarized.An introduction including the structures and properties of perovskite materials,and the fundamentals of solar water splitting is first provided.Then,it specifically focuses on the strategies for designing and modulating perovskite materials to improve their photocatalytic performance for solar water splitting.The current challenges and perspectives of perovskite materials in solar water splitting are also reviewed.The aim of this review is to summarize recent findings and developments of perovskite based photocatalysts and provide some useful guidance for the future research on the design and development of highly efficient perovskite based photocatalysts and the relevant systems for water splitting. | Yanbin Huang Jun Liu Yanchun Deng Yuanyuan Qian Xiaohao Jia Mengmeng Ma Cheng Yang Kong Liu Zhijie Wang Shengchun Qu Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，1： | 6 |
| 15 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 16 | An efficient method for privacy preserving location queries显示文摘最近,保存地点询问的隐私的问题吸引了许多研究。然而,有很少工作,集中于在地点隐私保藏和地点质问信息收集之间的折衷。处理这种折衷,我们建议坚持的隐私地点质问(PLQ ) ,保存地点质问处理的有效隐私框架。没有揭示用户地点信息,这个框架能启用基于地点的质问。框架能也便于基于地点的服务供应商关于基于的地点收集一些信息查询,它在实践是有用的。也就是, PLQ 由三个关键部件组成在顾客方面,在服务器方面的隐私询问处理器,和连接顾客和服务器的另外的信任第三方的地点 anonymizer。地点 anonymizer 基于一个地图层次模糊用户地点进一个 cloaked 区域。地图层次包含根据真实地形被划分的精确区域。隐私质问处理器处理请求近邻居(NN ) 地点基于质问。多角形(CHP ) 的新凸的壳算法用一个多角形 cloaked 区域为近邻居的询问被建议。我们高效地,进程地点基于的算法罐头查询的试验性的结果表演。 | Yubao LIU Xiuwei CHEN Zhan LI Zhijie LI Raymond Chi-Wing WONG | 2012 | Frontiers of Computer Science2012，6，4： | 5 |
| 17 | Traditional Chinese Medicine syndrome elements of male infertility revealed by latent tree model analysis显示文摘OBJECTIVE: To explore the features of Traditional Chinese Medicine(TCM) syndromes in male infertility using computer-based analyses.METHODS: Latent class analysis was used to analyze the TCM syndrome data from 813 patients with male infertility and establish a latent tree model.RESULTS: A latent tree model with a Bayesian information criterion score of-11 263 was created.This model revealed that the characteristics of basic TCM syndromes in patients with male infertility were kidney Yang deficiency, kidney Qi deficiency,spleen Yang deficiency, liver Qi stagnation, Qi stagnation and blood stasis, and dump-heat; moreover,most patients with male infertility had complex syndromes(spleen-kidney Yang deficiency and liver Qi stagnation) rather than simple single syndromes.CONCLUSION: The hidden tree model analysis revealed the objective and quantitative complex relationships between the TCM symptoms of male infertility, and obtained the quantification and objective evidence of TCM syndromes in male infertility. | Zhang Zhijie Liu Shaoming Zhang Yueyang Yang Jingzhe Kong Tao Wang Chengli Ning Peng Chen Xiaochao Li Xuesong Jia Yusen Chen Xiaojun | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 5 |
| 18 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 19 | Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip显示文摘Studying the cytokine profiles in animal models or patients with sepsis provides an experimental basis for the identification of diagnostic biomarkers and therapeutic targets. In this study, we used a liquid protein chip(LiquiChip), also known as flexible multi-analyte profiling technology, to perform quantitative analyses of several cytokines and chemokines(e.g., IL-1β,IL-2,IL-4, IL-5, IL-6, IL-10, IL-12, TNF-α, IFN-γ, granulocyte-macrophage colony-stimulating factor, keratinocyte chemoattractant,monocyte chemoattractant protein, monokine induced by gamma interferon, IFN-y-inducible protein 10, and macrophage inflammatory protein 1 alpha). The levels of these cytokines and chemokines were determined both in the blood and in tissues,including the lung, liver, heart, kidney, spleen, brain, stomach, intestine and muscle, of mice challenged with LPS. Our data showed variable production levels of LPS-induced cytokines in different mouse organs, and the cytokine in the blood did not correlate with those in the organs. We also showed that the levels of most cytokines peaked within 1 to 6 h and decreased rapidly afterward. A variety of inflammatory cytokines might be related to the damage in different organs during septic shock. Our data also suggest that the spleen might be an important target organ in the development of systemic inflammatory response syndrome and sepsis. | jinghua liu juan wang haihua luo zhijie li tianyu zhong jing tang yong jiang | 2017 | Science China(Life Sciences)2017，60，11： | 5 |
| 20 | An in-pipe micro robot actuated by piezoelectric bimorphs显示文摘A novel in-pipe micro robot providing stable and accurate locomotion inside a tubular structure with diameters ranging from 16 mm to 18 mm is presented in this paper. Driven by impulsive voltages, deflections of the piezoelectric bimorphs are generated and then converted into translational locomotion by the principle of the Impact Drive Mechanism (IDM). Theoretical analysis of the proposed system is performed based on a simplified mechanical model. Then dynamic simulations of the dynamic behavior are performed. Finally, an experiment is conducted to investigate the moving ability of this device. The results demonstrate that a maximum translational velocity of 3.5 mm/s can be obtained under an impulsive driving voltage with peak value at 50 V and frequency of 1100 Hz. Both theoretical analysis and experimental trials prove that the principle of IDM actuated by piezoelectric bimorphs is feasible and robust for achieving accurate locomotion of the micro robot in pipes with diameters of less than 20 mm. | LIU PinKuan WEN ZhiJie SUN LiNing | 2009 | Chinese Science Bulletin2009，54，12： | 5 |
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