|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 2 | Research on operation and management muti-node model of mega city energy Internet显示文摘This paper conducts comprehensive analysis about operational characteristics, market value, stakeholders, and operating modes of a megacity energy Internet. An innovating 'one platform, two centers, and multiple nodes' operation management model is proposed. The study provides an in-depth explanation of the new operation and management model of the connotation and logical relationship. Building a comprehensive energy service platform, developing an integrated energy dispatch center, a market trading service center, communication, and other parts of the system needed to achieve benefits for all parties is including in the discussion. The proposed new model of operation and management has important guiding significance and reference for the development and construction of energy Internets in megacities. | Cheng Yao Zhang Zhang Jiancheng Yu Wei Feng Changxin Zhou Yiming Han | 2018 | Global Energy Interconnection2018，1，2： | 5 |
| 3 | Feature Selection via Maximizing Global InformationGain for Text Classification 显示文摘 | SHANG Changxin LI Ming FENG Shengzhong | 2013 | Knowledge-Based Systems2013，54，： | 1 |
| 4 | A chloride efflux transporter,BIG RICE GRAIN 1,is involved in mediating grain size and salt tolerance in rice显示文摘Grain size is determined by the size and number of cells in the grain.The regulation of grain size is crucial for improving crop yield;however,the genes and molecular mechanisms that control grain size remain elusive.Here,we report that a member of the detoxification efflux carrier/Multidrug and Toxic Compound Extrusion(DTX/MATE)family transporters,BIG RICE GRAIN 1(BIRG1),negatively influences grain size in rice(Oryza sativa L.).BIRG1 is highly expressed in reproductive organs and roots.In birg1 grain,the outer parenchyma layer cells of spikelet hulls are larger than in wild-type(WT)grains,but the cell number is unaltered.When expressed in Xenopus laevis oocytes,BIRG1 exhibits chloride efflux activity.Consistent with this role of BIRG1,the birg1 mutant shows reduced tolerance to salt stress at a toxic chloride level.Moreover,grains from birg1 plants contain a higher level of chloride than those of WT plants when grown under normal paddy field conditions,and the roots of birg1 accumulate more chloride than those of WT under saline conditions.Collectively,the data suggest that BIRG1 in rice functions as a chloride efflux transporter that is involved in mediating grain size and salt tolerance by controlling chloride homeostasis. | Zhijie Ren Fenglin Bai Jingwen Xu Li Wang Xiaohan Wang Qian Zhang Changxin Feng Qi Niu Liying Zhang Jiali Song Fang Bao Liangyu Liu Yikun He Ligeng Ma Wang Tian Congcong Hou Legong Li | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 5 | Smac蛋白在HCC组织的表达及其与凋亡和增殖的关系(英文)显示文摘Objective:The aim of the study was to investigate the expression of Smac protein in human hepatocarcinoma and their relationship with cell apoptosis and proliferation.Methods:The expressions of Smac and the proliferating cell nuclear antigen (PCNA) in 41 cancer tissues,41 adjacent cirrhosis tissues and 9 normal control tissues in hemangioma were assessed by two-step immunohistochemical method and apoptosis was detected by TUNEL method.Results:Smac protein was expressed in 14 (34.14%) of the 41 cases of hepatocarcinoma,in 23 (56.10%) of the 41 cases of the adjacent cirrhosis tissues,and in 7 (77.8%) of the normal tissues in hemangioma.Smac protein positive expression rate in hepatocarcinoma was significantly lower than that in the adjacent cirrhosis tissues and the normal control tissues,χ2 were 3.989 and 4.115,respectively,and P were 0.046 and 0.042,respectively.Smac protein expression in cancer was significantly correlated with the ratio of apoptotic index to proliferative index,t'=2.260,P<0.05,but was not with the clinicopathological indicators such as the age and the histological grade,P>0.05.Conclusion:The relatively lower level of the expression of Smac may in a certain extent break the dynamic balance between apoptosis and proliferation of hepatocarcinoma cells,and then plays an important role in the pathogenesis of hepatocarcinoma. | Changxin Li Zhenbo Feng | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，4： | 0 |
| 6 | Chicken QTL mapping by multiplex PCR | HUANG Yinhua HU Xiaoxiang DENG Xuemei XU Weizhuo LI Ning FENG Jidong SUN Han WU Changxin | 2002 | Progress in Natural Science:Materials International2002，12，1： | 0 |
| 7 | Magnetic Resonance Image-Based Modeling for Neurosurgical Interventions显示文摘Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain.Because placement affects performance,image guidance and robotic assistance techniques have been widely adopted.These methods require accurate prediction of brain deformation during and following implantation.In this study,a magnetic resonance(MR)image-based finite element(FE)model was proposed by using a coupled Eulerian-Lagrangian method.Anatomical accuracy was achieved by mapping image voxels directly to the volumetric mesh space.The potential utility was demonstrated by evaluating the effect of different surgical approaches on the deformation of the corpus callosum(CC)region.The results showed that the maximum displacement of the corpus callosum increase with an increase of interventional angle with respect to the midline.The maximum displacement of the corpus callosum for different interventional locations was predicted,which is related to the brain curvature and the distance between the interventional area and corpus callosum(CC).The estimated displacement magnitude of the CC region followed those obtained from clinical observations.The proposed method provided an automatic pipeline for generating realistic computational models for interventional surgery.Results also demonstrated the potential of constructing patient-specific models for image-guided,robotic neurological surgery. | Yongqiang Li Changxin Lai Chengchen Zhang Alexa Singer Suhao Qiu Boming Sun Michael S.Sacks Yuan Feng | 2019 | Molecular & Cellular Biomechanics2019，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员