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| 1 | Gut microbiota derived metabolites in cardiovascular health and disease显示文摘微生物的万亿从摄取的食物,而且表明分子维持健康并且得到疾病的生产新陈代谢的 bioactive 住在人的内脏,不是仅仅提供的营养素和精力到主人,例如心血管的疾病(CVD ) 。CVD 是世界范围的死亡的领先的原因。在这评论,我们介绍了导出的代谢物处于心血管的健康和疾病包含了的内脏 microbiota,包括 trimethylamine-N-oxide (TMAO ) ,尿毒症的毒素,短链丰满的酸(SCFA ) , phytoestrogens, anthocyanins,胆汁酸和 lipopolysaccharide。这些内脏 microbiota 导出代谢物玩在维持健康心血管的功能的关键角色,并且如果 dysregulated,有原因地潜在地连接了到 CVD。功能的更好的理解和内脏 microbiota 的动力学导出代谢物抓住伟人诺言向机械学表语 CVD biomarker 发现和精确干预。 | Zeneng Wang Yongzhong Zhao | 2018 | Protein & Cell2018，9，5： | 39 |
| 2 | Determination of 20(S)-protopanaxadiol in human plasma by HPLC–MS/MS:application to a pharmacokinetic study显示文摘A rapid,specific and sensitive HPLC-MS/MS method was developed and validated for the determination of 20(S)-protopanaxadiol(PPD)in human plasma.PPD and the internal standard PD were extracted from plasma by liquid-liquid extraction with cyclohexane-methylene dichloride(2:1,v/v).The separation was performed on a HyPURIYTY C18 column using methanol-5 mM ammonium formate(90:10,v/v)as mobile phase at a flow rate of 0.35 mL/min.Mass spectrometric detection was carried out by electrospray ionization(ESI)in the positive ion mode using multiple reaction monitoring(MRM).The monitored transitions were m/z 425.4-217.2 for PPD and at m/z 461.4-425.5 for PD.The method was linear over the range 0.512-100 ng/mL with a lower limit of quantification(LLOQ)of 0.512 ng/mL.The mean extraction recovery of PPD was greater than 78.2%and no significant matrix effect was detected.The intra-and inter-day precisions were less than 10%and the biases below 4%for PPD.The validated method was applied to a three-level single-dose clinical pharmacokinetics study of 12 healthy Chinese volunteers and the main pharmacokinetic parameters of PPD were obtained. | Feifan Xie Sanwang Li Zeneng Cheng Xingling Liu Hong Zhang Peijiong Li Zhi Liu Xin Guo Peng Yu | 2013 | Acta Pharmaceutica Sinica B2013，3，6： | 3 |
| 3 | Positional distribution of fatty acids on the glycerol backbone during the biosyn-thesis of glycerolipids in Ectocarpus fasciculatus显示文摘The biosynthesis of glycolipids in E.fascicula-tus was studied by 14C label and chase. The fatty acids in sulphoquinovosyl diacylglycerol (SQDG) were almost 16-car-bon and 18-carbon ones. In addition to the two fatty acids, monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG) contained 8.5 mol% and 31.0 mol% of eicosapentaenoic acid (20 : 5), respectively, and this fatty acid was usually distributed in the sn-1 position of the glyc-erol backbone. When plants were incubated with [2-14C] acetate, differences existed in the positional distribution of the labeled fatty acids in sn-1 and sn-2 among the three glycerolipids. In SQDG, 14C-labeled fatty acids were distributed uniformly in the sn-1 and sn-2 positions. In DGDG, 14C-labeled fatty acids were mainly distributed in the sn-2 position. In MGDG, the radioactivity of fatty acids in sn-1 position was far greater than that in sn-2 position after a 30 min pulse label, and the difference in radioactivity between the two positions | XU Yinong WANG Zeneng VAN Xiaojun LIN Wei LI Liangbi KUANG Tingyun | 2002 | Chinese Science Bulletin2002，47，21： | 3 |
| 4 | Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects显示文摘The aim of this study was to apply the reference-scaled average bioequivalence(RSABE)approach to evaluate the bioequivalence of 2 formulations of agomelatine,and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects.This was performed in a single-dose,randomized-sequence,open-label,four-way crossover study with a one-day washout period between doses.Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation.The formulations were considered bioequivalent if 90% confidence intervals(CIs)for the log-transformed ratios and ratio of geometric means(GMR)of AUC and C_(max) of agomelatine were within the predetermined bioequivalence range based on RSABE method.Results showed that both of the90% CIs for the log-transformed ratios of AUC and C_(max) of 7-desmethyl-agomelatine and 3-hydroxyagomelatine were within the predetermined bioequivalence range.The 90% CIs for natural logtransformed ratios of C_(max) ,AUC_(0–t)and AUC_(0–∞) of agomelatine(104.42–139.86,101.33–123.83 and97.90–117.94)were within the RSABE acceptance limits,and 3-hydroxy-agomelatine(105.55–123.03,101.95–109.10 and 101.72–108.70)and 7-desmethyl-agomelatine(104.50–125.23,102.36–111.50 and101.62–110.64)were within the FDA bioequivalence definition intervals(0.80–1.25 for AUC and0.75–1.33 for C_(max)).The RSABE approach was successful in evaluating the bioequivalence of these two formulations. | Fang Tang Rui Zhou Zeneng Cheng Guoping Yang Aiqiao Chen Zhi Liu Hongyi Tan Shuang Yang Sanwang Li Lingli Mu Peng Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 2 |
| 5 | Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease显示文摘 | Zeneng W Elizabeth K Brian B | 2011 | Nature2011，472，7341： | 1 |
| 6 | Determination of nifeviroc, a novel CCR5 antagonist: Application to a pharmacokinetic study显示文摘 | Wei Wu Dong Xie Zeneng Cheng Zhi Liu Liling Ran Zhenkun Gu Peng Yu | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，3： | 1 |
| 7 | Biology of LPA in health and disease显示文摘 | Saubhik Sengupta Zeneng Wang Russell Tipps Yan Xu | 2004 | Seminars in Cell and Developmental Biology2004，，5： | 1 |
| 8 | Numerical investigations on gas-solid flow in circulating fluidized bed risers using a new cluster-based drag model显示文摘A cluster-based drag model is proposed for the gas-solid circulating fluidized bed(CFB)riser by including the cluster information collected from image processing and wavelet analysis into the calculation of system drag.The performance of the proposed drag model is compared with some commonly used drag models.A good agreement with the experimental data is achieved by the proposed cluster-based drag model.Error analysis of the proposed cluster-based drag model based on the local distributions of solids holdup and particle velocity is conducted.The clustering phenomenon in the low-density and high-density CFB risers and the effect of the cluster size on the simulation accuracy are also numerically studied by the proposed drag model. | Zeneng Sun Chao Zhang Jesse Zhu | 2022 | Particuology2022，20，4： | 1 |
| 9 | Biology of LPA in health and disease显示文摘 | SAUBHIK S WANG Zeneng RUSSELL T | 2004 | Seminars in Cell and Developmental Biology2004，15，5： | 1 |
| 10 | Gut flora metabolism of phosphatidyl- choline promo~s cardiovascular disease显示文摘 | Zeneng W Klipfell E Bennett BJ | 2011 | Nature2011，472，7341： | 1 |
| 11 | Depletion of phosphatidyl-glycerol head-group induces changes in oxygen evolution and protein secondary structures of photosystem Ⅱ显示文摘The techniques of oxygen electrode polarogra-phy and Fourier transform infrared (FT-IR) spectroscopy were employed to explore the roles of polar head-group of phosphatidylglycerol (PG) molecules in the functional and structural aspects of photosystem Ⅱ (PS Ⅱ) through enzymatic approach. It was shown that the depletion of PG by treatment of phospholipase C (PLC) on PS Ⅱ particles caused the inhibition of oxygen evolving activity in PS Ⅱ. This effect also gave rise to changes in the protein secondary structures of PS Ⅱ, that is, an increase in a-helical conformation which is compensated by the loss of p-strand structures. It revealed that the head-group of PG molecules plays an important structural role in the maintenance of normal structure of PS Ⅱ proteins, which is required to maintain the appropriate physiological activity of the PS Ⅱ complex such as the oxygen evolving activity. It is suggested that there most probably exist hydrogen-bonding interactions between PG molecules and PS Ⅱ proteins. | YANG Zhenle, WANG Zeneng, JIANG Guizhen, XU Yinong, LI Liangbi & KUANG TingyunPhotosynthesis Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China | 2002 | Chinese Science Bulletin2002，47，10： | 1 |
| 12 | Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine- N -Oxide in Patients With Heart Failure显示文摘 | W.H. Wilson Tang Zeneng Wang Yiying Fan Bruce Levison Jennie E. Hazen Lillian M. Donahue Yuping Wu Stanley L. Hazen | 2014 | Journal of the American College of Cardiology2014，，18： | 1 |
| 13 | Measurement of trimethylamine- N -oxide by stable isotope dilution liquid chromatography tandem mass spectrometry显示文摘 | Zeneng Wang Bruce S. Levison Jennie E. Hazen Lillian Donahue Xin-Min Li Stanley L. Hazen | 2014 | Analytical Biochemistry2014，，： | 1 |
| 14 | Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk显示文摘 | W.H. Wilson Tang Zeneng Wang Leslie Cho Danielle M. Brennan Stanley L. Hazen | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 15 | Gut Microbiota Community Shift with Severity of Coronary Artery Disease显示文摘Gut microbiota community shift with coronary artery disease(CAD)has been reported in several limited cohorts during the past several years.However,whether the enriched or decreased microbiota taxa with CAD can be reproducible deserves further investigation and validation.In this study,78 human subjects were recruited.Of these,19 were diagnosed without stenosis in coronary artery(control group,referred to herein as Ctrl),14 with stenosis less than 50%(LT50),and 45 with stenosis greater than 50%(GT50).Fecal samples were collected and DNA was extracted to perform 16S ribosomal RNA(rRNA)gene sequencing.The operational taxonomic units(OTUs)were analyzed to identify taxa specific to different groups;next,multivariate logistic regression was employed to test whether the defined taxa could independently predict CAD risk.We found that Deltaproteobacteria,Fusobacterium,Bilophila,Actinomyces,and Clostridium XIX were enriched in Ctrl;Prevotellaceae,Parabacteriodes,and Butyricicoccus were enriched in LT50;and Roseburia and Butyricimonas were enriched in GT50.Further analysis revealed that increased populations of Deltaproteobacteria,Fusobacterium,Bilophila,and Desulfovibrionaceae were associated with a 0.26-fold,0.21-fold,0.18-fold,and 0.26-fold decreased risk of CAD,respectively(p<0.05),and an increased Prevotellaceae population was associated with a 5.63-fold increased risk of CAD(p<0.01).A combination of the 20 microbial taxa achieved an area under the receiver operating characteristic(ROC)curve of higher than 0.88 for all discriminations between LT50 vs Ctrl,GT50 vs Ctrl,LT50+GT50 vs Ctrl,and GT50 vs Ctrl+LT50.However,the microbial taxa previously reported as enriched in CAD patients or healthy controls could not be observed in our cohort except for Bacteroides.In conclusion,CAD patients showed a different microbial taxa signature than the healthy controls.However,the non-reproducibility of the microbiota taxa enriched in CAD across different cohorts limits the use of this signature in early diagnosis and prevention.Only decreased Bacteroides abundance was found to be a reliable marker to indicate CAD progression. | Jia-Lu Hu Zhi-Feng Yao Min-Na Tang Chun Tang Xiao-Fan Zhao Xi Su Dan-Bo Lu Qiu-Rong Li Zhang-Sheng Wang Yan Yan Zeneng Wang | 2021 | Engineering2021，7，12： | 0 |
| 16 | FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population显示文摘The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels. | Haoran Wei Mingming Zhao Man Huang Chenze Li Jianing Gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 17 | Effects of internals and distributors on the distribution and growth of bubbles in the conventional gas-solid fluidized bed显示文摘The effects of internals and gas distributors on the local dynamics of the bubbles in the conventional gas-solid fluidized bed were studied.Mesh-type internals with different opening areas(50%,70%and 90%)and different arrangements(two-layer and four-layer);and a sintered plate with a smaller pore size(1μm)and a perforated plate with a larger pore size as distributors were investigated.Differential pressure drops and local solids holdups were measured under various superficial gas velocities to compare the performances of the different types of internals and distributors.The instantaneous solids holdup signals from the optical fibre probe were used to further examine the local bubble dynamics in detail.Smaller bubbles were found,with the installation of internals or using the sintered plate,resulting in lower pressure drops and a higher bed expansion.Internals with reduced opening area or distributor with smaller pore size further leads to a higher changeover rate between the bubbles and dense phase,both axially and radially,and hence a better gas-solid contacting and an earlier transition to the turbulent flow regime of the bed. | Haidong Zhang Zeneng Sun Chengguo Liu Shurui Dong Yuanyuan Shao Jesse Zhu | 2021 | Particuology2021，19，2： | 0 |
| 18 | Hydrodynamics in a new liquid–solid circulating conventional fluidized bed显示文摘A new type of liquid–solid fluidized bed,named circulating conventional fluidized bed(CCFB)which operates below particle terminal velocity was proposed and experimentally studied.The hydrodynamic behavior was systematically studied in a liquid–solid CCFB of 0.032 m I.D.and 4.5 m in height with five different types of particles.Liquid–solid fluidization with external particle circulation was experimentally realized below the particle terminal velocity.The axial distribution of local solids holdup was obtained and found to be fairly uniform in a wide range of liquid velocities and solids circulation rates.The average solids holdup is found to be significantly increased compared with conventional fluidization at similar conditions.The effect of particle properties and operating conditions on bed behavior was investigated as well.Results show that particles with higher terminal velocity have higher average solids holdup. | Jingya Fu Xinyu Pan Zeneng Sun Ruoting Liu Ying Zheng Jesse Zhu | 2022 | Particuology2022，，11： | 0 |
| 19 | Metabolomics studies identify novel diagnostic and prognostic indicators in patients with alcoholic hepatitis显示文摘AIM: To identify plasma analytes using metabolomics that correlate with the diagnosis and severity of liver disease in patients with alcoholic hepatitis(AH).METHODS: We prospectively recruited patients with cirrhosis from AH(n = 23) and those with cirrhosis with acute decompensation(AD) from etiologies other than alcohol(n = 25). We used mass spectrometry to identify 29 metabolic compounds in plasma samples from fasted subjects. A receiver operating characteristics analysis was performed to assess the utility of biomarkers in distinguishing acute AH from alcoholic cirrhosis. Logistic regression analysis was performed to build a predictive model for AH based on clinical characteristics. A survival analysis was used to construct Kaplan Meier curves evaluating transplant-free survival.RESULTS: A comparison of model for end-stage liver disease(MELD)-adjusted metabolomics levels between cirrhosis patients who had AD or AH showed that patients with AH had significantly higher levels of betaine, and lower creatinine, phenylalanine, homocitrulline, citrulline, tyrosine, octenoyl-carnitine, and symmetric dimethylarginine. When considering combined levels, betaine and citrulline were highly accurate predictors for differentiation between AH and AD(area under receiver operating characteristics curve = 0.84). The plasma levels of carnitine [0.54(0.18, 0.91); P = 0.005], homocitrulline [0.66(0.34, 0.99); P < 0.001] and pentanoyl-carnitine [0.53(0.16, 0.90); P = 0.007] correlated with MELD scores in patients diagnosed with AH. Increased levels of many biomarkers(carnitine P = 0.005, butyrobetaine P = 0.32, homocitrulline P = 0.002, leucine P = 0.027, valine P = 0.024, phenylalanine P = 0.037, tyrosine P = 0.012, acetyl-carnitine P = 0.006, propionyl-carnitine P = 0.03, butyryl-carnitine P = 0.03, trimethyl-lisine P = 0.034, pentanoyl-carnitine P = 0.03, hexanoyl-carnitine P = 0.026) were associated with increased mortality in patients with AH. CONCLUSION: Metabolomics plasma analyte levels might be used to diagnose of AH or help predict patient prognoses. | Mona Ascha Zeneng Wang Mustafa S Ascha Raed Dweik Nizar N Zein David Grove J Mark Brown Stephanie Marshall Rocio Lopez Ibrahim A Hanouneh | 2016 | World Journal of Hepatology2016，8，10： | 0 |
| 20 | Study on Emergency Management of Geological and Meteorological Disasters显示文摘The damage caused by geological and meteorological disasters was pointed out in this paper through analyzing the features and causes of geological and meteorological disasters.To strengthen emergency management of geological and meteorological disasters,it is suggested to rigorously investigate potential geological hazard points,to strengthen observation and warning system,to take group prevention and group test as a supplementary to professional observation,to build up the last line of defense to geological and meteorological disasters,to set up functional cooperation mechanism,and to publicize disaster prevention and mitigation. | Guan Changgui Zuo Xiong He Zeneng | 2014 | Meteorological and Environmental Research2014，5，3： | 0 |
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