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| 1 | Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity显示文摘IL-15 is a promising cytokine to expand NK and CD8'T cells for cancer immunotherapy,but its application is limited by dose-limiting,on-target off-tumor toxicity.Here,we have developed a next-generation IL 15 that is activated inside the tumor microenvironment(TME).This pro-IL-15 has the extracellular domain of IL-15RP fused to the N-terminus of slL-15-Fc through a tumor-enriched Matrix Metalloproteinase(MMP)cleavable peptide linker to block its activity.Unlike slL-15-Fc,pro-IL-15 does not activate the peripheral expansion of NK cells and T cells,thus reducing systemic toxicity,but it still preserves efficient anti-tumor abilities.In various mouse tumors,the anti-tumor effect of pro-IL-15 depends on intratumoral CD8'T cells and IFN-y-Pro-IL-15 increases the stem-like TCF1^(+)Tim-3 CD8^(+)T cells within tumor tissue and helps overcome immune checkpoint blockade(ICB)resistance.Moreover,pro-IL-15 synergizes with current tyrosine kinase inhibitor(TKI)targeted-therapy in a poorly inflamed TUBO tumor model,suggesting that pro-IL-15 helps overcome targeted-therapy resistance.Our results demonstrate a next-generation IL-15 cytokine that can stimulate potent anti-tumor activity without severe toxicity. | Jingya Guo Yong Liang Diyuan Xue Jiao Shen Yueqi Cai Jiankun Zhu Yang-Xin Fu Hua Peng | 2021 | Cell Research2021，31，11： | 2 |
| 2 | Whole genome variants across 57 pig breeds enable comprehensive identification of genetic signatures that underlie breed features显示文摘Background:A large number of pig breeds are distributed around the world,their features and characteristics vary among breeds,and they are valuable resources.Understanding the underlying genetic mechanisms that explain across-breed variation can help breeders develop improved pig breeds.Results:In this study,we performed GWAS using a standard mixed linear model with three types of genome variants(SNP,InDel,and CNV)that were identified from public,whole-genome,sequencing data sets.We used 469 pigs of 57 breeds,and we identified and analyzed approximately 19 million SNPs,1.8 million InDels,and 18,016 CNVs.We defined six biological phenotypes by the characteristics of breed features to identify the associated genome variants and candidate genes,which included coat color,ear shape,gradient zone,body weight,body length,and body height.A total of 37 candidate genes was identified,which included 27 that were reported previously(e.g.,PLAG1 for body weight),but the other 10 were newly detected candidate genes(e.g.,ADAMTS9 for coat color).Conclusion:Our study indicated that using GWAS across a modest number of breeds with high density genome variants provided efficient mapping of complex traits. | Jingya Xu Yuhua Fu Yan Hu Lilin Yin Zhenshuang Tang Dong Yin Mengjin Zhu Mei Yu Xinyun Li Yang Zhou Shuhong Zhao Xiaolei Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 1 |
| 3 | Low Complexity Energy Optimization Algorithm for Massive MIMO systems显示文摘We consider the problem of nearly optimal energy efficiency in massive(Multiinput Multi-output) MIMO systems. Considering the correlated channel in practice, we derive the ergodic expression with zero-forcing precoding and analyze the simplified antennas selection method. Aiming at optimizing the energy efficiency, the closed form expressions of the nearly optimal number of transmit antennas and transmit power are given under the circuit consumption model. The joint solution of the number of transmit antennas and transmit power was replaced to only solve transmit power. Based on the expression only related with transmit power, we give an energy efficiency optimization algorithm. The simulation results show that the proposed algorithm can achieve nearly optimal energy efficiency with fast convergence speed. | YUAN Jingya LI Xiaohui HEI Yongqiang FU Weihong | 2015 | China Communications2015，12，S1： | 1 |
| 4 | A Review of Leakage and Dispersion of LNG on the Ground显示文摘Based on the analysis of the whole process of LNG spill on land,the research methods of LNG pool expansion and heavy gas diffusion are summarized and analyzed.This paper reviews the experimental and analytical work performed to data on spill of LNG.Specifically,experiments on the spill of LNG onshore,as well as experiments and numerical study on heavy gas dispersion.Pool boiling and turbulence model are described and discussed,as well as models used to predict dispersion.Although there have been significant progress in understanding the behavior of LNG spills,technical knowledge gaps to improve hazard prediction are still identified.Some of the gaps can be addressed with current modeling and testing capabilities.Finally,a discussion of the state of knowledge,and recommendations to further improvement the understanding of the behavior of LNG spills onshore. | Shi-er Dong Yiqing He Jingya Dong Zhouyu Peng Guohua Fu | 2021 | Energy Engineering2021，118，1： | 0 |
| 5 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 6 | Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein receptor显示文摘Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces encephalitis in rodents.Recently,the very-low-density lipoprotein receptor(VLDLR)was identified as the cellular receptor for SFV entry.In this study,we present the cryo-electron microscopy structure of SFV bound to human VLDLR.VLDLR targets E1-DIII region of SFV using its membrane-distal LDLR class A(LA)repeats.Structural and functional analyses emphasize the synergistic role of multiple VLDLR repeats in the SFV entry.Remarkably,VLDLR’s binding mode to SFV closely mirrors that of minor group human rhinoviruses but differs significantly from other alphaviruses’interactions with receptors in the canyon re-gion of the E protein.We also assessed SFV binding to VLDLR or apolipoprotein E receptor 2(ApoER2)proteins in horses and mosquitoes and revealed their use of multiple but different LA repeats for binding.Our findings illuminate SFV’s cross-species infectivity,offering insights into potential antiviral strategies against alphavirus infections. | Ying Li Zhennan Zhao Sheng Liu Haichen Wang Junqing Sun Yan Chai Jingya Zhou Yinuo Wang Yi Shi Hao Song George Fu Gao | 2023 | hLife2023，1，2： | 0 |
| 7 | Comments on‘Dietary intervention preservesβcell function in mice through CTCF-mediated transcriptional reprogramming’显示文摘Type 2 diabetes(T2D)has become a common chronic disease worldwide.Pancreaticβcell dysfunction,together with insulin resistance,is among the main causes for the pathogenesis of T2D.However,the dynamic changes in the number and function ofβcells and the molecular mechanism of irreversible damage in the pathogenesis of T2D are still unclear.A thorough analysis of the mechanism underlyingβcell dysfunction will provide a theoretical basis and molecular targets for the development of new and more effective individualized therapies for diabetes. | Ruo-Ran Wang Hongxing Fu Jingya Li Zhuo-Xian Meng | 2022 | Journal of Molecular Cell Biology2022，14，7： | 0 |
| 8 | Hydrodynamics in a new liquid–solid circulating conventional fluidized bed显示文摘A new type of liquid–solid fluidized bed,named circulating conventional fluidized bed(CCFB)which operates below particle terminal velocity was proposed and experimentally studied.The hydrodynamic behavior was systematically studied in a liquid–solid CCFB of 0.032 m I.D.and 4.5 m in height with five different types of particles.Liquid–solid fluidization with external particle circulation was experimentally realized below the particle terminal velocity.The axial distribution of local solids holdup was obtained and found to be fairly uniform in a wide range of liquid velocities and solids circulation rates.The average solids holdup is found to be significantly increased compared with conventional fluidization at similar conditions.The effect of particle properties and operating conditions on bed behavior was investigated as well.Results show that particles with higher terminal velocity have higher average solids holdup. | Jingya Fu Xinyu Pan Zeneng Sun Ruoting Liu Ying Zheng Jesse Zhu | 2022 | Particuology2022，，11： | 0 |
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