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| 1 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 2 | Methanation of carbon dioxide on Ni/ZrO_2-Al_2O_3 catalysts:Effects of ZrO_2 promoter and preparation method of novel ZrO_2-Al_2O_3 carrier显示文摘The novel nickel-based catalysts with a nickel content of 12 wt% were prepared with the zirconia-alumina composite as the supports. The new carriers, ZrO2 improved alumina, were synthesized by three methods, i.e., impregnation-precipitation, co-precipitation, and impregnation method. The catalytic properties of these catalysts were investigated in the methanation of carbon dioxide, and the samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscope (XPS), temperature-programmed reduction (TPR) and temperature-programmed desorption (TPD) techniques. The new catalysts showed higher catalytic activity and better stability than Ni/γ-Al2O3. Furthermore, as a support for new nickel catalyst, the ZrO2-Al2O3 composite prepared by the impregnation-precipitation method was more efficient than the other supports in the methanation of carbon dioxide. The highly dispersed zirconium oxide on the surface of γ-Al2O3 inhibited the formation of nickel aluminate-like phase, which was responsible for the better dispersion of Ni species and easier reduction of NiO species, leading to the enhanced catalytic performance of corresponding catalyst. | Mengdie Cai Jie Wen Wei Chu Xueqing Cheng Zejun Li | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 33 |
| 3 | Effect of China's rapid development on its iconic giant panda显示文摘Anthropogenic factors affect biodiversity and have led to the contraction or extinction of animal populations worldwide.Here,we use historical demographic data,spanning the past 300 years,to show that a rapid distributional contraction of giant pandas took place during the 18th and 19th centuries alongside the increase in human population.Land-use also underwent a significant change across the areas where giant pandas were found because of government agricultural policy and the introduction of new crops.The impact of social development on giant pandas includes habitat loss and fragmentation,and range reductions.Our findings would facilitate the design of effective conservation strategies that seek to conserve and increase current habitats of this iconic species,especially in areas that our analysis has identified as places where pandas have suffered from high human pressure. | ZHU LiFeng HU YiBo ZHANG ZeJun WEI FuWen | 2013 | Chinese Science Bulletin2013，58，17： | 8 |
| 4 | Genetic Analysis and Fine Mapping of a Novel Semidominant Dwarfing Gene LB4D in Rice显示文摘一个矮子变异的、指明的 LB4D,在回交的子孙之中被获得到一根野米饭基因渗入线。LB4D 的基因分析显示矮子显型被使基因相形见绌的单个 semidominant 控制,它被称为 LB4D。异种根据 internode 减小的模式作为 dn 类型矮子异种被分类。另外,赤霉素(GA ) 反应测试证明 LB4D 植物对 GA 既不缺乏也不感觉迟钝。这研究发现由 LB4D 植物的那 tiller 形成被 40% 与野类型相比减少,与被识别了的另外的主导的矮子异种相对照,显示不同相形见绌机制可能涉及 LB4D 主导的异种。在 F1 植物的植物高度的减小在不同基因背景从 27.9% ~ 38.1%,证明 LB4D 施加了更强壮的主导的相形见绌效果。用从在异质接合的 LB4D 和装饰用的梨树栽培变种 Nipponbare 之间的一个十字导出的大 F2 和 F3 人口, LB4D 基因在染色体 11 的短手臂上对在标记 Indel 4 和 Indel G 之间的 46 kb 区域局部性,并且四预言的基因在目标区域作为候选人被识别。 | Fei Liang Xiaoyun Xin Zejun Hu Jiandi Xu Gang Wei Xiaoyin Qian Jinshui Yang Haohua He Xiaojin Luo | 2011 | Journal of Integrative Plant Biology2011，53，4： | 6 |
| 5 | Blind reconnaissance of the pseudo-random sequence in DS/SS signal with negative SNR显示文摘This paper introduces a new theory and algorithm that can be used in blind detection of the carrier wave signal and the pseudo-random sequence of the direct sequence spread spectrum (DS/SS) signal with negative SNR. First, without any a priori knowledge of the DS/SS signal, the carrier wave signal can be detected from DS/SS signal with negative SNR by using stochastic differential equations and energy detection method. Based on this, the pseudo-random sequence can also be blindly detected in DS/SS signal with negative SNR by reducing noise of the nonlinear signal and the algorithm of wavelet multiscale decomposition algorithm. Finally, the computer simulation shows that we can detect the carrier wave signal with SNR=-27 dB and the pseudo-random sequence under error code ratio 10-4 with SNR =-10 dB. | HUANG XianGao HUANG Wei WANG Chao LU ZeJun HU YanHua | 2007 | Science in China(Series F)2007，50，3： | 6 |
| 6 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 7 | Wildlife conservation and management in China:achievements,challenges and perspectives显示文摘Dramatic global changes to the environment have wrought unprecedented reductions in biodiversity, with>28%species assessed by the International Union for Conservation of Nature(IUCN) under the threat of extinction[1]. China, as one of the world’s megadiverse countries, plays a critical role in global biodiversity conservation. | Guangping Huang Xiaoge Ping Weihua Xu Yibo Hu Jiang Chang Ronald R.Swaisgood Jiang Zhou Xiangjiang Zhan Zejun Zhang Yonggang Nie Jie Cui Michael Bruford Zhihe Zhang Baoguo Li Li Zhang Zhi Lv Fuwen Wei | 2021 | National Science Review2021，8，7： | 4 |
| 8 | A putative bHLH transcription factor is a candidate gene for male sterile 32,a locus affecting pollen and tapetum development in tomato显示文摘The tomato(Solanum lycopersicum)male sterile 32(ms32)mutant has been used in hybrid seed breeding programs largely because it produces no pollen and has exserted stigmas.In this study,histological examination of anthers revealed dysfunctional pollen and tapetum development in the ms32 mutant.The ms32 locus was fine mapped to a 28.5 kb interval that encoded four putative genes.Solyc01g081100,a homolog of Arabidopsis bHLH10/89/90 and rice EAT1,was proposed to be the candidate gene of MS32 because it contained a single nucleotide polymorphism(SNP)that led to the formation of a premature stop codon.A codominant derived cleaved amplified polymorphic sequence(dCAPS)marker,MS32D,was developed based on the SNP.Real-time quantitative reverse-transcription PCR showed that most of the genes,which were proposed to be involved in pollen and tapetum development in tomato,were downregulated in the ms32 mutant.These findings may aid in marker-assisted selection of ms32 in hybrid breeding programs and facilitate studies on the regulatory mechanisms of pollen and tapetum development in tomato. | Xiaoyan Liu Mengxia Yang Xiaolin Liu Kai Wei Xue Cao Xiaotian Wang Xiaoxuan Wang Yanmei Guo Yongchen Du Junming Li Lei Liu Jinshuai Shu Yong Qin Zejun Huang | 2019 | Horticulture Research2019，6，1： | 3 |
| 9 | Chinese Antarctic Magnetometer Chain at the Cusp Latitude显示文摘A Chinese Antarctic Magnetometer(CAM) chain from Zhongshan Station(ZHS) to Dome-A(DMA) has been established since February 2009.A regular magnetometer is operated at ZHS,and four low power magnetometers are operated along the interior route from ZHS to DMA in the cusp latitude,extending over a distance of 1260 km.These stations fill an important void in the Antarctic magnetometer network.Furthermore,the CAM chain is magnetically conjugated with the Arctic region reaching from the Svalbard archipelago to Daneborg,on the east coast of Greenland.Conjugate measurements using the Arctic and Antarctic magnetometers provide excellent opportunities to investigate phenomena related to the coupling of the solar wind to the magnetosphere and ionosphere,such as magnetic impulse events,flux transfer events,traveling convection vortices and ultra-low frequency waves. | LIU Yonghua HU Hongqiao YANG Huigen ZHANG Beichen SUN Bo WEI Fuhai LIU Yang LIU Jianjun WANG Rui CHEN Zhuotian HU Zejun HAN Desheng SHI Guitao HU Zhengyi WANG Tao AN Chunlei Mike Rose | 2016 | Advances in Polar Science2016，27，2： | 2 |
| 10 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 11 | Ecological scale and seasonal heterogeneity in the spatial behaviors of giant pandas显示文摘We report on the first study to track the spatial behaviors of wild giant pandas(Ailuropoda melanoleuca)using high-resolution global positioning system(GPS)telemetry.Between 2008 and 2009,4 pandas(2 male and 2 fe-male)were tracked in Foping Reserve,China for an average of 305 days(±54.8 SE).Panda home ranges were larger than those of previous very high frequency tracking studies,with a bimodal distribution of space-use and distinct winter and summer centers of activity.Home range sizes were larger in winter than in summer,although there was considerable individual variability.All tracked pandas exhibited individualistic,unoriented and multi-phasic movement paths,with a high level of tortuosity within seasonal core habitats and directed,linear,large-scale movements between habitats.Pandas moved from low elevation winter habitats to high elevation(>2000 m)summer habitats in May,when temperatures averaged 17.5°C(±0.3 SE),and these large-scale movements took<1 month to complete.The peak in panda mean elevation occurred in Jul,after which they began slow,large-scale movements back to winter habitats that were completed in Nov.An adult female panda made 2 long-distance movements during the mating season.Pandas remain close to rivers and streams during winter,possi-bly reflecting the elevated water requirements to digest their high-fiber food.Panda movement path tortuosity and first-passage-time as a function of spatial scale indicated a mean peak in habitat search effort and patch use of approximately 700 m.Despite a high degree of spatial overlap between panda home ranges,particularly in winter,we detected neither avoidance nor attraction behavior between conspecifics. | Zejun ZHANG James K.SHEPPARD Ronald R.SWAISGOOD Guan WANG Yonggang NIE Wei WEI Naxun ZHAO Fuwen WEI | 2014 | Integrative Zoology2014，9，1： | 1 |
| 12 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 13 | A culture-free method for detection of Vibrio vulnif icus from coastal seawater based on loop-mediated isothermal amplification targeting vcgC gene显示文摘Vibrio vulnificus is an opportunistic pathogen widely distributed in estuarine and coastal seawaters.In this study,a culture-free method was developed to rapid detection of V.vulnificus in all seasons,based on loop-mediated isothermal amplification(LAMP) targeting virulent-correlated gene(vcg).The new assay method allows differentiation between the virulent and non-virulent strain of V.vulnificus accurately.This method also allows effective detection of the pathogeny in winter when the bacterium lives in the viable but non-culturable(VBNC) state.A total of 30 costal seawater samples collected in all seasons were used for the evaluation of this method.The results show that the method is sensitive,accurate and convenient. | LI Yongjun ZHENG Zejun ZHAO Yulong WEI Xiaona ZHU Lin HUANG Xitai | 2010 | Acta Oceanologica Sinica2010，29，2： | 1 |
| 14 | Radioiodination,biodistribution and pharmacokinetics of berberine in mice显示文摘 | Li Zejun Wei Yu Chu Taiwei | 2005 | Radioanalytical and Nuclear Chemistry2005，265，3： | 1 |
| 15 | On the sources of the anomalous moisture transport for the severe rainfall over the Mainland of Eastern China during summer显示文摘 | Wei Li Frank Schmidt Zejun Ren | | (Submitted to Science in China)0，，： | 1 |
| 16 | A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes显示文摘An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-L-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions. | ZOU ZhiQin DENG ZeJun YU XinHong ZHANG ManMan ZHAO SiHan LUO Ting YIN Xin XU Hui WANG Wei | 2012 | 中国科学:化学2012，42，2： | 0 |
| 17 | Space physics and astronomy research from Chinese polar stations: current and future directions显示文摘Space weather has a remarkable effect on modern human activities,e.g.,communication,navigation,space exploration etc.Space physics study from polar stations is as an important part of the entire solar-terrestrial space,and conducts quantitative research from the perspective of overall space plasma behavior.One of the most important issues is to identify the dominant processes that transfer plasma and momentum from the solar wind to Earth’s magnetosphere.Thus,it is necessary to carry out research for combination the observations from polar ground stations and spacecraft observations in the space.Observations at polar regions can be as a window to the space for satellite traffic controls.The operation of the observation chain―Zhongshan-Taishan-Kunlun Station could monitor polar space debris in a large area with high temporal and spatial resolution.Also,night-time measurements of astronomical seeing at Dome A in Antarctica make it less challenging to locate a telescope above it,thereby giving greater access to the free atmosphere because of a thinner boundary layer. | ZONG Qiugang HU Zejun LIU Jianjun JIANG Peng DU Yang ZHANG Wei | 2023 | Advances in Polar Science2023，34，4： | 0 |
| 18 | Need of a paradigm shift to conserve endangered species in China’s national park system显示文摘CHINAS EVOLVING NATIONAL PARK DESIGNATIONS AND SINGLE LARGE PROTECTED AREA OR SEVERAL SMALL PROTECTED AREAS(SLOSS)DEBATE As of 2021,the International Union for Conservation of Nature estimated that there are over 6,000 national parks(NPs)in more than 100 countries,most of which are strongly focused on endangered species.1 Over the past 6 years,China has invested US$20million in developing the Giant Panda National Park(GPNP)and a furtherUS$16million in establishing theNortheast China Tiger and Leopard National Park(NCTLNP). | Biao Yang Qiang Dai Yu Xu Christina D.Buesching Xiaodong Gu Zhisong Yang Zejun Zhang Fuwen Wei | 2023 | The Innovation2023，4，4： | 0 |
| 19 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 20 | A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes显示文摘An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-L-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions. | ZOU ZhiQin DENG ZeJun YU XinHong ZHANG ManMan ZHAO SiHan LUO Ting YIN Xin XU HUi WANG Wei | 2012 | Science China Chemistry2012，55，1： | 0 |
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