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| 1 | Radiolabeling and Biodistribution of a Nasopharyngeal Carcinoma-targeting Peptide Identified by in vivo Phage Display显示文摘指向 CEN-1 人的鼻咽的癌(NPC ) 的 dodecapeptide EDIKPKTSLAFR 配体被识别由在 vivo 噬菌体显示。二 tridecapeptides 和他们的衍生物,命名 YR13 ( YEDIKPKTSLAFR ), EY13 ( EDIKPKTSLAFRY ), EY13-NH_2 ( EDIKPKTSLAFRY-NH_2 ) andFmoc-YR13 ( Fmoc-YEDIKPKTSLAFR ),被综合,无线电用^( 131 )标记 I.The 稳定性 invitro ,在忍受 NPC 肿瘤的老鼠的选择噬菌体粒子的简历分发和织物分发被决定,并且无线电的血浆代谢物分析把肽标记被带 out.AlthoughFmoc 和 NH_2 组能保护肽免受 deiodination 的伤害,仅仅 Fmoc 组禁止了 Fmoc-YR13 的绑定到 NPC 肿瘤。复合 EY13-NH_2 ,肽 EY13 的C终端酰胺,有最大的浆液稳定性,最少的 deiodination ,并且证明有利肿瘤/血 ratios.Theselected 噬菌体粒子(噬菌体 3 或噬菌体 5 )是比控制噬菌体(起始的噬菌体显示器肽图书馆)在 NPC 肿瘤集中的更多 .EY13 能也禁止选择噬菌体粒子的绑定到肿瘤。结果显示 EDIKPKTSLAFR 是在诊断、治疗学的 NPC 的一个好候选人。 | Liyan SUN Taiwei CHU Yi WANG Xiangyun WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 5 |
| 2 | On the Application of Surface Cmnplexatian Models to Ionic Adsorption显示文摘 | TAO ZUYI CHU TAIWEI LI WEUUAN | 2000 | Journal of Colloid and Interface Science2000，232，1： | 1 |
| 3 | Synthesis and Biological Results of the ^99mTc-la- beled 4-nitroimidazole for Imaging Tumor Hypoxia显示文摘 | CHU Taiwei HU Shaowen WEI Bing | 2004 | Bioorgan Med Chem lett2004，14，3： | 1 |
| 4 | Effect of Fulvic Acids on Sorption of UO2^2+ , Zn, Yb, I and Se(Ⅳ) Onto Oxides of Aluminum, Iron and Silicon显示文摘 | Tao Zuyi Chu Taiwei Du Jinzhou | 2000 | Appl Geochem2000，15，： | 1 |
| 5 | Radioiodination,biodistribution and pharmacokinetics of berberine in mice显示文摘 | Li Zejun Wei Yu Chu Taiwei | 2005 | Radioanalytical and Nuclear Chemistry2005，265，3： | 1 |
| 6 | Preparation and biodistribution of technetium-99m -labeled 1-( 2- nitroimidazole- 1-yl)-propanhydroxyiminoamide (N2IPA) as a tumor hypoxia marker显示文摘 | Chu Taiwei Li Rujun Hu Shaowen | 2004 | Nucl Med Biol2004，31，： | 1 |
| 7 | Synthesis and biological results of the technetium-99m- labeled 4- nitroimindazole for imaging tumor hypoxia显示文摘 | Chu Taiwei Hu Shaowen Wei Bing | 2004 | Bioorg Med Chem Lett2004，14，： | 1 |
| 8 | Directly radiolabeled phage with spleen-targeting specificity显示文摘Phage display technique is a powerful approach for discovering new tumor-and organ-targeting ligands,and radiolabeled phage has a potential to analyze the phage-binding sensitivity and specific imaging.In this study,phage Ⅱ (the spleen-targeting phage) in mice was isolated after three rounds biopanning,and labeled by 99mTc using mercaptoacetyltriglycine (MAG3) as chelator to evaluate their binding properties in vivo.The amount of phage Ⅱ eluted from spleen was enriched by plague assay each round.99mTc-MAG3-phage Ⅱ showed the less retention in blood at any time point than half that of 99mTc-MAG3-phage Ⅰ (the radiolabeled original Ph.D-12 phage as control).The accumulation in spleen between 99mTc-MAG3-phage Ⅰ and Ⅱ was of different tendency.The highest uptake of 99mTc-MAG3-phage Ⅱ in spleen was 24.80 %ID/g at 30 min;and of 99mTc-MAG3-phage I,30.93% ID/g at 5 min.After circulating 99mTc-MAG3-phage Ⅱ for 120 min,its accumulation in spleen decreased though higher than that of 99mTc-MAG3-phage Ⅰ.In other organs,the 99mTc-MAG3-phage Ⅱ showed low retention and high spleen-to-organ or tissue ratios.In conclusion,the radiolabeled phage Ⅱ is convenient for studying the binding and specificity of spleen-targeting peptides found via phage display in vivo. | SUN Liyan LIANG Kun WANG Xiangyun CHU Taiwei | 2011 | Nuclear Science and Techniques2011，22，4： | 0 |
| 9 | [(99m)~Tc(CO)_3]^+ labeled histidine derivative containing 4-nitroimidazole:Synthesis,biodistribution as a tumor hypoxia imaging agent显示文摘A novel histidine derivative containing 4-nitroimidazole,(S)-2-(4-((4-nitro-1H-imidazol-1-yl) methyl) benzamido)-3-(1H-imidazol-4-yl)propanoic acid (His-NI),was synthesized and labeled with [99mTc(CO)3(H2O)3]+.The tricarbonyl technetium complex,the 99mTc(CO)3-His-NI,showed a 99% yield under mild conditions at a low His-NI ligand concentration of 10-4 molL-1,and its biodistribution in mice bearing S180 tumor had a selective accumulation in tumor (2.01±0.40%ID/g at 1 h postinjection) and a slow clearance.The tumor/muscle ratio was 1.64 at 1 h,3.10 at 4 h,and 3.88 at 24 h,indicating that the 99mTc(CO)3-His-NI has a potential to image tumor hypoxia. | MEI Lei CHU Taiwei | 2011 | Nuclear Science and Techniques2011，22，2： | 0 |
| 10 | Screening tumor-targeting bacteriophage particles by pre-clearing phage display显示文摘Phage display technique provides a powerful approach for the discovery of new tumor-specific peptides.However,the peptides isolated through this technique usually did not possess high tumor-specific property.A pre-clearing step was introduced to increase the efficiency of biopanning by removal of particles that could interact with ubiquitously expressed cellular receptors in the non-target organs.The randomized Ph.D-CX7C phage library (Phage III) was first pre-cleared in normal mice to reduce vasculatureor organ-targeting phages to get the pre-cleared phage library,and then the tumor-targeting bacteriophage particles (Phage I) were screened from pre-clearing phage library in S180 tumor-bearing mice.The biodistribution results of 99mTc-labeled phages in mice bearing S180 tumor show that the uptake of 99mTc-labeled Phage I in tumor is high but low in normal organs,and the tumor-to-liver and tumor-to-spleen ratios of 99mTc-labeled Phage I are higher than those of 99mTc-labeled Phage II (tumor-specific phages screened from the original CX7C library) and Phage III (unscreened phages from the original CX7C library).It indicates that the yield of tumor-targeting bacteriophage particles could be improved and the non-specific binding in organs becomes weak.Consequently,the pre-clearing phage display method could improve the yield of positive hits by reducing the non-target organ accumulation of bacteriophage particles. | LIANG Kun LI Yao CHU Taiwei | 2012 | Nuclear Science and Techniques2012，23，1： | 0 |
| 11 | Tumor angiogenesis imaging agent:biodistribution of ^(131)I-YG5 and ^(131)I-Boc-YG5显示文摘The cyclic peptide YG5 and the t-butyloxycarbonyl(Boc)-modified analog(Boc-YG5) were labeled with radioiodine.The radiochemical purity of 131I-YG5 or 131I-Boc-YG5 was almost 100% after purification by RP-HPLC.Biodistribution in BALB/C nude mice bearing MCF-7 tumor was measured.After t-butyloxycarbonyl(Boc)-modification,the 131I-Boc-YG5 was quite resistant to deiodination in vivo,resulting in negligible radioactivity accumulation in thyroid.The radiotracer clearance in tumor became faster,the absolute tumor uptake decreased for 131I-Boc-YG5,but the tumor-to-tissue uptake ratios increased.The uptake ratios of tumor to muscle,blood,heart,and lung at 1 h post injection reached 4.73,1.70,4.09 and 1.70,respectively.It is demonstrated that Boc-group is an effective prosthetic one to prevent deiodination in vivo and improve tumor imaging for radioiodinated NGR. | SUN Xin CHU Taiwei WANG Xiangyun | 2010 | Nuclear Science and Techniques2010，21，5： | 0 |
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