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| 1 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 2 | Diffraction-limited imaging with monolayer 2D material-based ultrathin flat lenses显示文摘Ultrathin flat optics allow control of light at the subwavelength scale that is unmatched by traditional refractive optics.To approach the atomically thin limit,the use of 2D materials is an attractive possibility due to their high refractive indices.However,achievement of diffraction-limited focusing and imaging is challenged by their thickness-limited spatial resolution and focusing efficiency.Here we report a universal method to transform 2D monolayers into ultrathin flat lenses.Femtosecond laser direct writing was applied to generate local scattering media inside a monolayer,which overcomes the longstanding challenge of obtaining sufficient phase or amplitude modulation in atomically thin 2D materials.We achieved highly efficient 3D focusing with subwavelength resolution and diffractionlimited imaging.The high focusing performance even allows diffraction-limited imaging at different focal positions with varying magnifications.Our work paves the way for downscaling of optical devices using 2D materials and reports an unprecedented approach for fabricating ultrathin imaging devices. | Han Lin Zai-Quan Xu Guiyuan Cao Yupeng Zhang Jiadong Zhou Ziyu Wang Zhichen Wan Zheng Liu Kian Ping Loh Cheng-Wei Qiu Qiaoliang Bao Baohua Jia | 2020 | Light(Science & Applications)2020，9，1： | 9 |
| 3 | Recent Progress of Two-Dimensional Thermoelectric Materials显示文摘Thermoelectric generators have attracted a wide research interest owing to their ability to directly convert heat into electrical power.Moreover,the thermoelectric properties of traditional inorganic and organic materials have been significantly improved over the past few decades.Among these compounds,layered two-dimensional(2D)materials,such as graphene,black phosphorus,transition metal dichalcogenides,IVA–VIA compounds,and MXenes,have generated a large research attention as a group of potentially high-performance thermoelectric materials.Due to their unique electronic,mechanical,thermal,and optoelectronic properties,thermoelectric devices based on such materials can be applied in a variety of applications.Herein,a comprehensive review on the development of 2D materials for thermoelectric applications,as well as theoretical simulations and experimental preparation,is presented.In addition,nanodevice and new applications of 2D thermoelectric materials are also introduced.At last,current challenges are discussed and several prospects in this field are proposed. | Delong Li Youning Gong Yuexing Chen Jiamei Lin Qasim Khan Yupeng Zhang Yu Li Han Zhang Heping Xie | 2020 | Nano-Micro Letters2020，12，3： | 5 |
| 4 | Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune homeostasis against lipopolysaccharideinduced inflammatory responses in broilers显示文摘Background:Lactobacillus reuteri strains are widely used as probiotics to prevent and treat inflammatory bowel disease by modulating the host’s immune system.However,the underlying mechanisms by which they communicate with the host have not been clearly understood.Bacterial extracellular vesicles(EVs)have been considered as important mediators of host-pathogen interactions,but their potential role in commensals-host crosstalk has not been widely studied.Here,we investigated the regulatory actions of EVs produced by L.reuteri BBC3,a gut-associated commensal bacterium of Black-Bone chicken,in the development of lipopolysaccharide(LPS)-induced intestinal inflammation in a chicken model using both in vivo and in vitro experiments.Results:L.reuteri BBC3 produced nano-scale membrane vesicles with the size range of 60-250 nm.Biochemical and proteomic analyses showed that L.reuteri BBC3-derived EVs(LrEVs)carried DNA,RNA and several bioactive proteins previously described as mediators of other probiotics’beneficial effects such as glucosyltransferase,serine protease and elongation factor Tu.In vivo broiler experiments showed that administration of LrEVs exerted similar effects as L.reuteri BBC3 in attenuating LPS-induced inflammation by improving growth performance,reducing mortality and decreasing intestinal injury.LrEVs suppressed the LPS-induced expression of pro-inflammatory genes(TNF-α,IL-1β,IL-6,IL-17 and IL-8),and improved the expression of anti-inflammatory genes(IL-10 and TGF-β)in the jejunum.LrEVs could be internalized by chicken macrophages.In vitro pretreatment with LrEVs reduced the gene expression of TNF-α,IL-1βand IL-6 by suppressing the NF-κB activity,and enhanced the gene expression of IL-10 and TGF-βin LPS-activated chicken macrophages.Additionally,LrEVs could inhibit Th1-and Th17-mediated inflammatory responses and enhance the immunoregulatory cells-mediated immunosuppression in splenic lymphocytes of LPS-challenged chickens through the activation of macrophages.Finally,we revealed that the reduced content of both vesicular proteins and nucleic acids attenuated the suppression of LrEVs on LPS-induced inflammatory responses in ex vivo experiments,suggesting that they are essential for the LrEVs-mediated immunoregulation.Conclusions:We revealed that LrEVs participated in maintaining intestinal immune homeostasis against LPSinduced inflammatory responses in a chicken model.Our findings provide mechanistic insight into how commensal and probiotic Lactobacillus species modulate the host’s immune system in pathogens-induced inflammation. | Rujiu Hu Hua Lin Mimi Wang Yuezhen Zhao Haojing Liu Yuna Min Xiaojun Yang Yupeng Gao Mingming Yang | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 5 |
| 5 | A Robust Authentication Scheme for Filtering of Injected False Data in Dynamic Wireless Sensor Networks显示文摘 | HU Yupeng LIN Yaping YU Jianping ZENG Weini YI Yeqing LI Xiaolong | 2007 | Chinese Journal of Electronics2007，16，3： | 4 |
| 6 | Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives显示文摘In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical properties.The influence of solvent polarity on the photophysical properties was investigated.Employing time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed. | KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU JieYing XUE ZhaoMing TIAN YuPeng | 2013 | Science China Chemistry2013，56，1： | 3 |
| 7 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 8 | Monolayer MoS_(2)-based transistors with low contact resistance by inserting ultrathin Al_(2)O_(3)interfacial layer显示文摘Transition metal dichalcogenides(TMDCs)are promising high performance electronic materials due to their interesting semiconductor properties.However,it is acknowledged that the effective electrical contact between TMDCs-layered materials and metals remains one of the major challenges.In this work,the homogeneous monolayer MoS_(2)films with high crystalline quality were prepared by chemical vapor deposition method on SiO2/Si substrates.The back-gate field-effect transistors(FETs)were fabricated by inserting an ultrathin Al_(2)O_(3)interlayer between the metal electrodes and MoS_(2)nanosheets.With the addition of an ultrathin 0.8 nm Al_(2)O_(3)interlayer,the contact resistance decreased dramatically from 59.9 to 1.3 kΩμm and the Schottky barrier height(SBH)dropped from 102 to 27 meV compared with devices without the Al_(2)O_(3)interlayer.At the same time,the switching ratio increased from~106to~108,and both the on-current and field-effect mobility were greatly improved.We find that the ultrathin Al_(2)O_(3)interlayer can not only reduce the SBH to alleviate the Fermi level pinning phenomenon at the interface,but also protect the channel materials from the influence of air and moisture as a covering layer.In addition,the lattice and band structures of Al_(2)O_(3)/MoS_(2)film were calculated and analyzed by first-principles calculation.It is found that the total density of states of the Al_(2)O_(3)/MoS_(2)film exhibits interfacial polarized metals property,which proves the higher carrier transport characteristics.FETs with Al_(2)O_(3)interlayers have excellent stability and repeatability,which can provide effective references for future low power and high performance electronic devices. | CHEN Gang LIN Xin LIU Yuan WANG Fang HU Kai SHAN Xin WU ZeYu ZHANG YuPeng NIE WeiCan ZHONG JiXiang REN TianLing ZHANG KaiLiang | 2023 | Science China(Technological Sciences)2023，66，6： | 2 |
| 9 | Excellent light-capture capability of trilobal SiNW for ultra-high JSC in single-nanowire solar cells显示文摘Single-.nanowire solar cells with a unique light-concentration property are expected to exceed the Shockley-Queisser limit.The architecture of single nanowire is an important factor to regulate its optical performance.We designed a trilobal silicon nanowire(SiNW)with two cquivalent scales that possesses superior light-absorption efficiency in the whole wavelength range and shows good tolerance for incident angle.The electric field distribution in this geometry is concentrated in the blade with small equivalent scale and pivot with large equivalent scale,respectively,in the short wavelength range and long wavelength range.Corresponding good light absorption of trilobal SiNW in the two wavelength ranges leads to stronger total light absorption capacity than that of cylindrical SiNW.Trilobal single nanowire solar cells can obtain a short-circuit current density(JSC)of 647 mA·cm^2,which provides a new choice for designing single nanowire with excellent light-capture capability. | ZHONGLIANG GAO GUILU Lin YUPENG ZHENG NA SANG YINGFENG LI LEI CHEN MEICHENG LI | 2020 | Photonics Research2020，8，6： | 2 |
| 10 | 会计师事务所合并与审计效率显示文摘得益于政策的鼓励,中国审计市场的集中度得以在短时间内大幅提升。以收入计算,中国本土最大的会计师事务所的市场份额从2006年的13.95%提升到2012年的36.12%,中国审计市场开始了由高度分散的审计市场向更加集中的审计市场的转变。已有关于会计师事务所合并的研究非常有限,其原因在于已有审计方面的研究均用审计费用来衡量审计投入。实际上,审计费用衡量的是审计服务的价格,而不是审计服务的投入成本。 | Qihui Gong Oliver Zhen Li Yupeng Lin Liansheng Wu | 2018 | 中国注册会计师2018，，7： | 2 |
| 11 | Increasingπ-electron availability in benzene ring incorporated graphitic carbon nitride for increased photocatalytic hydrogen generation显示文摘Increasing the availability ofπ-electron in graphitic carbon nitride(g-C_(3)N_(4))can reduce the band gap and thus enhance the photocatalytic hydrogen(H_(2))generation activity upon exposure to visible light,However,such strategy has not yet been largely applied to increase the H_(2)generation of g-C_(3)N_(4).Herein,we succes s fully increased the amount ofπ-electron in g-C_(3)N_(4)by incorporatingπ-electron-rich benzene rings through copolymerization of melamine and trimesic acid in air.The incorporation of benzene rings not only extends the light absorption of g-C_(3)N_(4)to 650 nm,but also improves the electrical conductivity due to delocalization ofπelectrons in benzene rings.As a result,a 3.4 times enhancement of photocatalytic H_(2)generation was achieved from the g-C_(3)N_(4)with benzene ring incorporation in comparing with that of pristine g-C_(3)N_(4).More interestingly,H_(2)generation still occurs under irradiation of the light ofλ≥490 nm,above the absorption edge of pristine g-C_(3)N_(4)(~460 nm),illustrating the positive effectiveness of incorporated benzene rings on enhancing the H_(2)generation capacity of g-C_(3)N_(4).The present work manifests the advantages of increasingπ-conjugated electrons on designing highly active g-C_(3)N_(4)photocatalysts. | Xiangang Lin Xiaojuan Hou Lixia Cui Shiqiang Zhao Hong Bi Haiwei Du Yupeng Yuan | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 12 | Complex‐Formation‐Enhanced Fluorescence Quenching Effect for Efficient Detection of Picric Acid显示文摘 | Aixiang Ding Longmei Yang Yuyang Zhang Gaobin Zhang Lin Kong Xuanjun Zhang Yupeng Tian Xutang Tao Jiaxiang Yang | 2014 | Chem. Eur. J2014，，38： | 1 |
| 13 | A novel blue light generation by frequency doubling of a diode-pumped Nd:YAG thin disk laser显示文摘 | Lin Xuechun Li Ruining | 2004 | Optics Communications2004，237，： | 1 |
| 14 | Synthesis,structure and nonlinear optical properties of two novel two-photon absorption chromophores显示文摘Two triphenylamine-based derivatives that can be used as two-photon absorption chromophore,tris{4-[4-(3-trifluoromethyl-3-oxopanoyl)]phenyl}amine (1) and tris{4-[4-(3-phenyl-3-oxopanoyl)] phenyl} amine (2) were successfully synthesized and fully characterized by elemental analysis,IR,1H NMR and MS. The single crystal X-ray diffraction analysis showed that the molecules possess D-(π-A)3 structures. One-and two-photon absorption and fluorescence in various solvents were experimentally investigated. A data recording experiment proved the potential application of these chromophores. | CHENG LeHua LI Lin SUN PingPing ZHOU HongPing TIAN YuPeng TANG HuoHong | 2009 | Science China Chemistry2009，52，4： | 1 |
| 15 | Efficient distributed skyline computation using dependency-based data partitioning显示文摘 | Bo Yin Siwang Zhou Yaping Lin Yonghe Liu Yupeng Hu | 2014 | The Journal of Systems & Software2014，，： | 1 |
| 16 | Synthesis, crystal structures and electrochemical properties of two new metal-centered ferrocene complexes显示文摘Two new metal-centered ferrocene complexes Ni(SCN)2(L)4 (1) and Cu(OAc)2(L)2 (2) (L = 1-[1-ferro- cenylmethyl]imidazole) have been synthesized and characterized by elemental analysis, single crystal X-ray diffraction analysis, spectroscopic and cyclic voltammetric measurements. The geometry of Ni(Ⅱ) in 1 is octahedral, with four ligands in the equatorial plan and two thiocyanate anions at the axial site, while that of Cu(Ⅱ) in 2 is a distorted octahedron formed by two chealted OAc- and two ligands. Single crystal X-ray diffraction studies reveal that there is partial electron delocalization from ferrocene to imidazole in the two complexes. Electrochemical measurements exhibit that complexes 1 and 2 un-dergo similar reversible one electron redox processes, suggesting that the ferrocene moieties are equivalent and there are no interactions among them. | WANG XuChun WU JieYing ZHOU HongPing TIAN YuPeng LI Lin YANG JiaXiang JIN BaoKang ZHANG ShengYi | 2009 | Science China Chemistry2009，52，7： | 1 |
| 17 | Physics and astrophysics of strong magnetic field systems with eXTP显示文摘In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s. | Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef Jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li Lin Lin Roberto Mignani Nanda Rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit Paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 18 | Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review显示文摘The brain parenchymal Langerhans cell histiocytosis(LCH) without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging(MRI) showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CD1a and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good. | Shanshan Cai Sheng Zhang Xueyong Liu Yuanxiang Lin Chunlin Wu Yupeng Chen Jianping Hu Xingfu Wang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 1 |
| 19 | Applications of diffusion-weighted MRI in thoracic spinal cord injury without radiographic abnormality显示文摘 | Huiyong Shen Yong Tang Lin Huang Rui Yang Yanfeng Wu Peng Wang Yupeng Shi Xiaoyu He Hu Liu Jichao Ye | 2007 | International Orthopaedics2007，，3： | 1 |
| 20 | SH3P2,an SH3 domain-containing protein that interacts with both Pib and AvrPib,suppresses effector-triggered,Pib-mediated immunity in rice显示文摘Plants usually keep resistance(R)proteins in a static state under normal conditions to avoid autoimmunity and save energy for growth,but R proteins can be rapidly activated upon perceiving pathogen invasion.Pib,the first cloned blast disease R gene in rice,encoding a nucleotide-binding leucine-rich repeat(NLR)protein,mediates resistance to the blast fungal(Magnaporthe oryzae)isolates carrying the avirulence gene AvrPib.However,the molecular mechanisms about how Pib recognizes AvrPib and how it is inactivated and activated remain largely unclear.In this study,through map-based cloning and CRISPR-Cas9 gene editing,we proved that Pib contributes to the blast disease resistance of rice cultivar Yunyin(YY).Furthermore,an SH3 domain-containing protein,SH3P2,was found to associate with Pib mainly at clathrin-coated vesicles in rice cells,via direct binding with the coiled-coil(CC)domain of Pib.Interestingly,overexpression of SH3P2 in YY compromised Pib-mediated resistance to M.oryzae isolates carrying AvrPib and Pib-AvrPib recognition-induced cell death.SH3P2 competitively inhibits the self-association of the Pib CC domain in vitro,suggesting that binding of SH3P2 with Pib undermines its homodimerization.Moreover,SH3P2 can also interact with AvrPib and displays higher affinity to AvrPib than to Pib,which leads to dissociation of SH3P2 from Pib in the presence of AvrPib.Taken together,our results suggest that SH3P2 functions as a“protector”to keep Pib in a static state by direct interaction during normal growth but could be triggered off by the invasion of AvrPib-carrying M.oryzae isolates.Our study reveals a new mechanism about how an NLR protein is inactivated under normal conditions but is activated upon pathogen infection. | Yunjie Xie Yupeng Wang Xiangzhen Yu Yuelong Lin Yongsheng Zhu Jinwen Chen Hongguang Xie Qingqing Zhang Lanning Wang Yidong Wei Yanjia Xiao Qiuhua Cai Yanmei Zheng Mo Wang Huaan Xie Jianfu Zhang | 2022 | Molecular Plant2022，15，12： | 1 |
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