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| 1 | Glioblastoma vaccine tumor therapy research progress显示文摘Glioblastoma(GBM)is the most common primary malignancy of the central nervous system in adults.The prognosis for late-stage glioblastoma(World Health Organization grade IV astrocytic glioma)is very poor.Novel treatment options are sought after and evaluated by clinicians and researchers,and remarkable advances have been made in surgical techniques,radiotherapy,and chemotherapy.However,the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few months.There has been notable progress in the field of immunotherapy,particularly with the use of tumor vaccines,for treating glioblastoma;especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell vaccines.However,the results of the current clinical trials for vaccination are not satisfactory.This article reviews the progress in the development of vaccines for glioblastoma. | Tong Zhao Chunwang Li Hongliang Ge Yuanxiang Lin Dezhi Kang | 2022 | Chinese Neurosurgical Journal2022，8，2： | 3 |
| 2 | Neural stem cell activation and glial proliferation in the hippocampal CA3 region of posttraumatic epileptic rats显示文摘The present study observed the dynamic expression of CD133,nuclear factor-κB and glial fibrillary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy.CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy,peaked at 7 days,and gradually decreased up to 14 days,as seen by double-immunohistochemical staining.Glial fibrillary acidic protein/nuclear factor-κB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy.Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density. | Yuanxiang Lin Kun Lin Dezhi Kang Feng Wang | 2011 | Neural Regeneration Research2011，6，16： | 1 |
| 3 | Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review显示文摘The brain parenchymal Langerhans cell histiocytosis(LCH) without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging(MRI) showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CD1a and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good. | Shanshan Cai Sheng Zhang Xueyong Liu Yuanxiang Lin Chunlin Wu Yupeng Chen Jianping Hu Xingfu Wang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 1 |
| 4 | Cognitive disorder and changes in cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury显示文摘BACKGROUND: Learning and memory damage is one of the most permanent and the severest symptoms of traumatic brain injury; it can seriously influence the normal life and work of patients. Some research has demonstrated that cognitive disorder is closely related to nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor. OBJECTIVE: To summarize the cognitive disorder and changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury. RETRIEVAL STRATEGY: A computer-based online search was conducted in PUBMED for English language publications containing the Keywords 'brain injured, cognitive handicap, acetylcholine, N-methyl-D aspartate receptors, neural cell adhesion molecule, brain-derived neurotrophic factor' from January 2000 to December 2007. There were 44 papers in total. Inclusion criteria: ① articles about changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury; ② articles in the same researching circle published in authoritative journals or recently published. Exclusion criteria: duplicated articles. LITERATURE EVALUATION: References were mainly derived from research on changes in these four factors following brain injury. The 20 included papers were clinical or basic experimental studies. DATA SYNTHESIS: After craniocerebral injury, changes in these four factors in brain were similar to those during recovery from cognitive disorder, to a certain degree. Some data have indicated that activation of nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor could greatly improve cognitive disorder following brain injury. However, there are still a lot of questions remaining; for example, how do these factors change at different time points after brain injury, and what is the relationship between associated factors and cognitive disorder. CONCLUSION: It is necessary to comprehensively study some associated factors, to analyze their changes and their relationship with cognitive disorder following brain injury, and to investigate their effects at different time points after brain injury. | Weiliang Zhao Dezhi Kang Yuanxiang Lin | 2008 | Neural Regeneration Research2008，3，3： | 0 |
| 5 | Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat显示文摘Studies have confirmed that iron induces epilepsy onset,and iron ion-induced epilepsy in animal models closely resembles the clinical situation.Models of post-traumatic epilepsy (PTE) were established by intracortical injection of FeCl2 using stereotactic techniques.Electron microscopy revealed neuronal degeneration,with shrinkage of the neuronal soma,hyperplasia of rough endoplasmic reticulum,ribosomal detachment from the endoplasmic reticulum,and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats.With prolonged time,injuries became more severe and neuronal apoptosis was observed.Synapses in the hippocampal neuropil significantly increased (primarily type I/excitatory synapses) at day 14 following injury.Type II synapses (inhibitory synapse) were observed in the rat hippocampus at day 30.Cortical neuronal degeneration,apoptosis,glial cell proliferation,and ultrastructural hippocampal changes,in particular changes in type of neuronal synapse,play an important role in PTE onset. | Yuanxiang Lin Feng Wang Ruxiang Xu Xiaodan Jiang Dezhi Kang Yiquan Ke Mouxuan Du Lishuang Xu | 2010 | Neural Regeneration Research2010，5，18： | 0 |
| 6 | Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors:an operative technique and short-term outcomes of 20 consecutive cases显示文摘Background:To present a surgical technique for the treatment of intradural extramedullary(IDEM)tumors by using endoscopically controlled surgery with open hemilaminectomy technique.Methods:In this study,20 patients with 22 IDEM tumors were enrolled.An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors.Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis.Results:All the tumors in 20 patients were well removed.The clinical symptoms were significantly reduced in all the patients as well.The short-term follow-up data showed that there was no tumor recurrence or spinal deformity.Conclusion:The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors.It may be an effective surgical method for treating IDEM tumors.Larger samples and longer follow-up data are needed to verify its long-term effectiveness. | Xiaorong Yan Huiqing Wang Cai Li Yuanxiang Lin Lin Lin Shinong Zhu Chenyang Wang Zhangya Lin Changzhen Jiang Dezhi Kang | 2021 | Chinese Neurosurgical Journal2021，7，2： | 0 |
| 7 | Exosomal circular RNAs inglioma:coexistenceof opportunitiesand challenges forapplication显示文摘Glioma is the most common primary tumor in the central nervous system.With the help of intercellular communication,glioma cells have the ability to survive in the tumor microenvironment(TME)and make it more suitable. | Xiaoyong Chen Jinyuan Chen Yue Chen Honghai You Yuanxiang Lin Zanyi Wu Dezhi Kang Chenyu Ding | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 8 | Safety and feasibility of curved lead simultaneously implanted into pedunculopontine nucleus and subthalamic nucleus显示文摘To the Editor:Combined nuclei stimulation may have a synergistic effect on controlling the symptoms of nervous system diseases and improving quality of life.[1]However,increasing of leads may increase costs and complications.[2]Therefore,our study aims to investigate the safety and feasibility of the single curved lead,which can simultaneously reach both subthalamic nucleus(STN)and pedunculopontine nucleus(PPN). | Wei Wang Xiaoyong Chen Deyuan Chen Yue Chen Lianghong Yu Yuanxiang Lin Dezhi Kang Xiangrong Chen Chenyu Ding | 2022 | Chinese Medical Journal2022，135，20： | 0 |
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