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| 1 | Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer显示文摘Metformin is a widely prescribed hypoglycemic drug.Many studies have shown its anti-cancer properties.In the present study,we aimed to explore the effect of metformin on breast cancer and clarify the underlying mechanism.Our results showed that metformin induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression.Overexpression of miR-324-3p inhibited cancer cell viability.miR-324-3p inhibitor promoted cell viability.Further studies showed that the effect of miR-324-3p was mediated by directly targeting glutathione peroxidase 4(GPX4).miR-324-3p bound to the 3ʹ-UTR of GPX4 and led to the downregulation of GPX4.In vivo studies showed that metformin induced ferroptosis by upregulating miR-324-3p in the xenograft model of breast cancer in mice.Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR-324-3p/GPX4 axis.Metformin could act as a potential anti-cancer agent through the induction of ferroptosis. | Yifeng Hou Shuang Cai Shouyang Yu Hui Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 11 |
| 2 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 3 | Review of the biological and engineering aspects of algae to fuels approach显示文摘Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel demands.Oil producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil fuels.This review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels approach.The article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic assessment.Despite the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic constraints.Technological breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable. | Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang Blanca Martinez Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 9 |
| 4 | Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese显示文摘Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95% CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population. | Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu | 2009 | Journal of Genetics and Genomics2009，36，7： | 7 |
| 5 | Application of convolution perfectly matched layer in finite element method calculation for 2D acoustic wave显示文摘一个方法被介绍完美地扩大卷绕旋转匹配的层 CPML,它基于转移的复杂坐标转变和复杂频率拉长了 -- 并列度量标准,到 2D,声学的方程与方法计算了有限元素方法女性。这非物理的层在计算的边被使用一象 Ab- sorbing 边界条件 ABC 到女性截断无界的媒介。在这份报纸, CPML 方程在频率领域并且及时被介绍了领域,分别地并且计算在 COMSOL 的女性的软件被认识到。在古典 PML 层上的 CPML 的主要优点是它基于导致更稳定的、高度有效的吸收和一台更多的设备认识到的波浪地的 unsplit 部件。数字模拟的结果证明 CPML 比 PML 有更好的被吸收,它吸收 out^oin~ 精力更多的 effectivelv。 | LI Yifeng LIN Zhiqi LI Guofeng WANG Yun | 2012 | Chinese Journal of Acoustics2012，31，1： | 4 |
| 6 | Investigation on surface roughness,residual stress and fatigue property of milling in-situ TiB_2/7050Al metal matrix composites显示文摘For higher efficiency and precision manufacturing,more and more attentions are focused on the surface roughness and residual stress of machined parts to obtain a good fatigue life.At present,the in-situ TiB_2/7050 Al metal matrix composites are widely researched due to its attractive properties such as low density,good wear resistance and improved strength.It is of great significance to investigate the machined surface roughness,residual stress and fatigue life for higher efficiency and precision manufacturing of this new kind material.In this study,the surface roughness including two-dimensional and three-dimensional roughness,residual stress and fatigue life of milling in-situ TiB_2/7050 Al metal matrix composites were analyzed.It was found from comparative investigation that the three-dimensional surface roughness would be more appropriate to represent the machined surface profile of milling particle reinforced metal matrix composites.The cutting temperature played a great role on the residual stress.However,the effect of increasing cutting force could slow down the transformation from compressive stress to tensile stress under 270°C.An exponential relationship between three-dimensional roughness and fatigue life was established and the main fracture mechanism was brittle fracture with observation of obvious shellfish veins,river pattern veins and wave shaped veins in fracture surface. | Yifeng XIONG Wenhu WANG Yaoyao SHI Ruisong JIANG Chenwei SHAN Xiaofen LIU Kunyang LIN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 7 | The promoting effect of low-level sulfidation in PdCuS nanoparticles catalyzed alkyne semihydrogenation显示文摘硫来源的支持的效果是吸引人却糟糕听说的现象。此处,我们与硫粉末的不同数量学习了 PdCu 二金属的 nanoparticles (NP ) 的处理。低级 sulfidation 导致了由表面组成的 Pd30Cu10S9 NP 催化剂的产生充实的 Pd NP,电子缺乏的 Pd 和 Cu,以及零原子价硫。Pd30Cu10S9 NP 催化剂在炔属羟的 semihydrogenation 显示出显着地提高的活动和选择。我们的学习第一次在原子水平为硫的支持的效果揭示了一个可能的原因,建议在催化剂设计的新策略。 | Cai Wu Yifeng Chen Rongan Shen Wei Zhu Yue Gong Lin Gu Qing Peng Huifang Guo Wei He | 2018 | Nano Research2018，11，9： | 2 |
| 8 | AGAMOUS AND TERMINAL FLOWER controls floral organ identity and inflorescence development in Medicago truncatula显示文摘Angiosperms integrate a multitude of endogenous and environmental signals to control floral development,thereby ensuring reproductive success.Here,we report the identification of AGAMOUS AND TERMINAL FLOWER(AGTFL),a novel regulator of floral development in Medicago truncatula.Mutation of AGTFL led to the transformation of carpels and stamens into numerous sepals and petals and altered primary inflorescence identity.AGTFL encodes a nucleus-localized proteincontaining a putative Myb/SANT-like DNA-binding domain and a PKc kinase domain.Molecular and genetic analyses revealed that AGTFL regulates the transcription of MtAGs and MtTFL1 to control floral organ identity and inflorescence development. | Butuo Zhu Hui Li Yifeng Hou Pengcheng Zhang Xiuzhi Xia Na Wang Hui Wang Kirankumar S.Mysore Jiangqi Wen Yanxi Pei Lifang Niu Hao Lin | 2019 | Journal of Integrative Plant Biology2019，61，8： | 2 |
| 9 | Decoding psychosis:from national genome project to national brain project显示文摘The mind has puzzled humans for centuries,and its disorders,such as psychoses,have caused tremendous difficulties.However,relatively recent biotechnological breakthroughs,such as DNA technology and neuroimaging,have empowered scientists to explore the more fundamental aspects of psychosis.From searching for psychosis-causing genes to imaging the depths of the brain,scientists worldwide seek novel methods to understand the mind and the causes of its disorders.This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science. | Liya Sun Manfei Xu Yongyong Shi Yifeng Xu Jinghong Chen Lin He | 2022 | General Psychiatry2022，35，4： | 1 |
| 10 | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population显示文摘 | Jixia Liu Yongyong Shi Wei Tang Tingwei Guo Dawei Li Yifeng Yang Xinzhi Zhao Hongsheng Wang Xingwang Li Guoyin Feng Niufan Gu Shaomin Zhu Huijun Liu Yangling Guo Jianguo Shi Hong Sang Lijuan Yan Lin He | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 11 | Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells 显示文摘 | Guo Hongshen Lin Yifeng Zhang Hongwei | 2007 | BMC Mol Biol2007，8，1： | 1 |
| 12 | Cascade Classifier Using Combination of Histograms of Oriented Gradients for Rapid Pedestrian Detection显示文摘 | Li Wenhui Lin Yifeng Fu Bo | 2013 | Journal of Software2013，8，1： | 1 |
| 13 | Prediction of adolescent subjective well being: A machine learning approach显示文摘Background Subjective well-being(SWB),also known as happiness,plays an important role in evaluating both mental and physical health.Adolescents deserve specific attention because they are under a great variety of stresses and are at risk for mental disorders during adulthood.Aim The present paper aims to predict undergraduate students1 SWB by machine learning method.Methods Gradient Boosting Classifier which was an innovative yet validated machine learning approach was used to analyse data from 10518 Chinese adolescents.The online survey included 298 factors such as depression and personality.Quality control procedure was used to minimise biases due to online survey reports.We applied feature selection to achieve the balance between optimal prediction and result interpretation.Results The top 20 happiness risks and protective factors were finally brought into the predicting model.Approximately 90%individuals'SWB can be predicted correctly,and the sensitivity and specificity were about 92%and 90%,respectively.Conclusions This result identifies at-risk individuals according to new characteristics and established the foundation for adolescent prevention strategies. | Naixin Zhang Chuanxin Liu Zhixuan Chen Lin An Decheng Ren Fan Yuan Ruixue Yuan Lei Ji Yan Bi Zhenming Guo Gaini Ma Fei Xu Fengping Yang Liping Zhu Gabirel Robert Yifeng Xu Lin He Bo Bai Tao Yu Guang He | 2019 | General Psychiatry2019，32，5： | 1 |
| 14 | Protective effects of combined Astragalus membranaceus and magnesium ions on global brain ischemia显示文摘The traditional Chinese herb Astragalus membranaceus is a well-known treatment for neurological diseases and is considered to exhibit anti-dementia properties.This study investigated the synergistic effects of magnesium ions and Astragalus membranaceus on global brain ischemia in rats.4'-6-diamidino-2-phenylindole staining demonstrated that the number of living neurons was significantly greater in the rat hippocampus after administration of a combination of Astragalus membranaceus and magnesium,compared with a vehicle group,an Astragalus membranaceus alone group,and a magnesium alone group.Western blot assay revealed that cleaved Caspase-3 protein expression was significantly reduced in the rat hippocampus in the combined Astragalus membranaceus and magnesium group compared with the Astragalus membranaceus alone group and the magnesium alone group.The results suggested that the combination of Astragalus membranaceus and magnesium exhibits a stronger neuroprotective effect on global brain ischemia in rats compared with Astragalus membranaceus or magnesium alone.This effect was associated with decreased Caspase-3 expression. | Yifeng Miao Bing Li Yuchang Lin Xiaojie Lu Bin Wu Yongming Qiu | 2011 | Neural Regeneration Research2011，6，15： | 1 |
| 15 | Cascade Classifier Using Combination of Histograms of Oriented Gradients for Rapid Pedestrian Detection显示文摘 | Li Wenhui Lin Yifeng Fu Bo | 2013 | Journal of Software2013，8，1： | 1 |
| 16 | Preparation of Macroporous Sol-Gel Bioglass Using PVA Particles as Pore Former显示文摘 | Qing Jie Kaili Lin Jipin Zhong Yifeng Shi Qin Li Jiang Chang Ruoding Wang | 2004 | Journal of Sol - Gel Science and Technology2004，，1： | 1 |
| 17 | How psychiatrists coordinate treatment for COVID-19: a retrospective study and experience from China显示文摘Background Patients with C0VID-19 are at high risk of developing mental health problems;however,the prevalence and management of mental disorders and how psychiatrists coordinate the treatment are unclear.Aims We aimed to investigate the mental health problems of patients infected with C0VID-19 and to identify the role of psychiatrists in the clinical treatment team during the pandemic.We also share the experience of psychiatric consultations of patients with COVID-19 in Shanghai,China.Methods We analysed data from the psychiatric medical records of 329 patients with COVID-19 in the Shanghai Public Health Clinical Center from 20 January to 8 March 2020.We collected information including sociodemographic characteristics,whether patients received psychiatric consultation,mental health symptoms,psychiatric diagnoses,psychiatric treatments and severity level of COVID-19.Results Psychiatric consultations were received by 84(25.5%)patients with COVID-19.The most common symptoms of mental health problems were sleep disorders(75%),anxiety(58.3%)and depressive symptoms(11.9%).The psychiatric consultation rate was highest in critically ill patients(69.2%),with affective symptoms or disturbed behaviour as their main mental health problems.Psychiatric diagnoses for patients who received consultation included acute stress reaction(39.3%),sleep disorders(33.3%),anxiety(15.5%),depression(7.1%)and delirium(4.8%).In terms of psychiatric treatments,86.9%of patients who received psychiatric consultation were treated with psychotropic medications,including non-benzodiazepine sedative-hypnotic agents(54.8%),antidepressants(26.2%),benzodiazepines(22.6%)and antipsychotics(10.7%).Among the 76 patients who were discharged from the hospital,79%had recovered from mental health problems and were not prescribed any psychotropic medications.The symptoms of the remaining 21%of patients had improved and they were prescribed medications to continue the treatment.Conclusions This is the first study to report psychiatric consultations for patients with COVID-19.Our study indicated that a considerable proportion of patients with COVID-19,especially critically ill cases,experienced mental health problems.Given the remarkable effect of psychiatric treatments,we recommend that psychiatrists be timely and actively involved in the treatment of COVID-19. | Ling Yue Jingyi Wang Mingliang Ju Yi Zhu Lianghu Chen Lin Shi Bohai Shi Jun Chen Yifeng Shen | 2020 | General Psychiatry2020，33，4： | 1 |
| 18 | HGF Proteets rat mesangial cells from high glueose-mediated oxidative stress显示文摘 | LI Hui JIANG Tao LIN Yifeng | | 0，，： | 1 |
| 19 | Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice显示文摘CHD8 is a candidate gene for autism spectrum disorders and neurological development delay.It has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively investigated.The potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not clear.In this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar development.Mice with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is detected.Genetic deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje neuron.However,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ablation.Single-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential mechanism.Importantly,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark tests.Taken together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations. | Xiang Chen Tong Chen Chen Dong Huiyao Chen Xinran Dong Lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye Yao Yu Xiong Man Xiong Yifeng Lin Wenhao Zhou | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 20 | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation显示文摘Targeted muscle reinnervation(TMR)is a microsurgical repair technique to reconstruct the anatomical structure between thedistal nerve and the muscle stump to provide more myoelectric information to the artificially intlligent prosthesis.Postoperative functional electrical stimulation treatment of the patient's denervated muscle or proximal nerve stump as well asnerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery.In this experiment,wesuccessfully established a TMR rat model and divided Sprague-Dawley(SD)adult male rats into IMR group,TMR+FESgroup,and TMR+NGF group acording to TMR and whether they received FES treatment or NGF injection after surgery.and the recovery ffect of rat neuromuscular function was assessed by analyzing EMG signals.Through the experiments,weconfrmed that growth factor supplementation and lowfrequency electrical stimulation can efectively promote theregeneration of the transplanted nerve as well as signifcantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve. | Siyang Zhong Zijun Zhang Huan Su Chenyang Li Yifeng Lin Wei Lu Zhendong Jiang Lin Yang | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
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