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| 1 | 3D bioprinting: an emerging technology full of opportunities and challenges显示文摘 | Bin Zhang Yichen Luo Liang Ma Lei Gao Yuting Li Qian Xue Huayong Yang Zhanfeng Cui | 2018 | Bio-Design and Manufacturing2018，1，1： | 13 |
| 2 | Bright-field holography:cross-modality deep learning enables snapshot 3D imaging with bright-field contrast using a single hologram显示文摘Digital holographic microscopy enables the 3D reconstruction of volumetric samples from a single-snapshot hologram.However,unlike a conventional bright-field microscopy image,the quality of holographic reconstructions is compromised by interference fringes as a result of twin images and out-of-plane objects.Here,we demonstrate that cross-modality deep learning using a generative adversarial network(GAN)can endow holographic images of a sample volume with bright-field microscopy contrast,combining the volumetric imaging capability of holography with the speckle-and artifact-free image contrast of incoherent bright-field microscopy.We illustrate the performance of this“bright-field holography”method through the snapshot imaging of bioaerosols distributed in 3D,matching the artifact-free image contrast and axial sectioning performance of a high-NA bright-field microscope.This data-driven deep-learning-based imaging method bridges the contrast gap between coherent and incoherent imaging,and enables the snapshot 3D imaging of objects with bright-field contrast from a single hologram,benefiting from the wave-propagation framework of holography. | Yichen Wu Yilin Luo Gunvant Chaudhari Yair Rivenson Ayfer Calis Kevin de Haan Aydogan Ozcan | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 3 | Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer(NSCLC)显示文摘Purpose: A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in advanced non-small-cell lung cancer(NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.Patients and methods: EGFR gene typing in 33 advanced NSCLC patients received gefitinib(250 mg/day) were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively.Results: The overall objective response rate(ORR) and median progression-free survival(PFS) in the 33 patients treated by gefitinib were 45.5% and 3.0(2.0-4.0) months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients(P<0.01). Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients(P<0.05, P<0.01, respectively). However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR(P<0.01). Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS(P<0.05). Conclusions: EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients. | Lian Chen Rui Chen Zhe Zhu Yichen Zhang Zhengwei Wen Yun Li Xiaoming Li Yuwen Luo Liyu Ma Shuguang Lin Xin Chen | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 4 | 3D Bioprinting:A Novel Avenue for Manufacturing Tissues and Organs显示文摘Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of biomaterials,cells,and biomolecules in a layer-by-layer fashion,with precisely controlled spatial distribution.This technology is expected to address the organ-shortage issue in the future.In this review,we first introduce three categories of 3D bioprinting strategies:inkjet-based printing(IBP),extrusion-based printing(EBP),and light-based printing(LBP).Biomaterials and cells,which are normally referred to as“bioinks,”are then discussed.We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures,including cartilage,bone,skin,muscle,vascular network,and so on.The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well.Finally,the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed. | Bin Zhang Lei Gao Liang Ma Yichen Luo Huayong Yang Zhanfeng Cui | 2019 | Engineering2019，5，4： | 5 |
| 5 | Facile one-step synthesis of graphitic carbon nitride-modified biochar for the removal of reactive red 120 through adsorption and photocatalytic degradation显示文摘Converting waste biomass into value-added biochar has been considered as a green and sustainable strategy for resource management and pollution control.In this study,graphitic carbon nitride(g-C_(3)N_(4))modified biochars(BCs)were produced through one-pot pyrolysis of urea and hickory chips in differential ratios at 520℃.The resulting BC/g-C_(3)N_(4)composites were evaluated in laboratory for their physicochemical,adsorptive,and photocatalytic properties.The characterization tests showed the successful synthesis of the BC/g-C_(3)N_(4)composites that introduced g-C_(3)N_(4)structure,N-containing surface func-tional groups,reduced surface area,and better thermal stability to the biochar.After modification,the BC/g-C_(3)N_(4)composites showed better adsorption ability to reactive red 120(RR120)than the pristine BC,due to the strong electrostatic attrition between N-containing functional groups of g-C_(3)N_(4)on biochar surface and anionic RR120.The BC/g-C_(3)N_(4)composites also inherited g-C_(3)N_(4)’s photocatalytic activity,which is visible light responsive to generate free radicals for RR120 degradation.In addition,the composites with higher urea modification ratios were more effective in the degradation of RR120.Overall,this study demonstrates the feasibility and promising potential of combining biochar and photocatalyst for the removal of aqueous dye.Because of the synergistic adsorption and photodegradation ability,BC/g-C_(3)N_(4)composites present a novel and cost-effective solution for the removal of aqueous dye and other photodegradable contaminants under natural conditions. | Yulin Zheng Yichen Yang Yue Zhang Weixin Zou Yidan Luo Lin Dong Bin Gao | 2019 | Biochar2019，1，1： | 5 |
| 6 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 7 | Efficacy of catgut embedding in Baihui(GV20)and Feishu(BL13)and Pishu(BL20)on lung tissue,brain tissue and blood related indexes in rats with allergic rhinitis of lung deficiency type显示文摘OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency type.METHODS:Forty-five female Sprague-Dawley rats were randomly divided for two times.The first time,they were randomly divided into model group and blank group(Group C)according to 2∶1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1∶1.15 in each group.For Group A and Group B,the lung deficiency model was made by'sulfur–moxa fumigation',and then the allergic rhinitis model was established by'ovalbumin(OVA)sensitization'.Then catgut embedding was performed at acupoints in Group A and not in Group B.After 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and TLR-2.RESULTS:IgE level(μg/m L)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P<0.001).IL-4 level(pg/mL)was(14.2±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P<0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810±0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P<0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still continued.To achieve further treatment,prolonging the catgut embedding time is necessary. | HUANG Heyin WANG Yichen ZHANG Qinxiu WU Xiaojuan WANG Jiang Li Xiangyu PANG Rui FAN Li CAO Liu TANG Luo | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 1 |
| 8 | Immunomodulating Activities of Polysaccharides from ZhuQin Formula and Atractylodes in Hypoimmune Mice显示文摘[Objectives] To investigate the infrared identification of ZhuQin Formula and Atractylodes polysaccharides and its effect on immune function in immunocompromised mice. [Methods] In this experiment,the structure of polysaccharides was analyzed by Fourier transform infrared spectroscopy. The experiment was divided into the polysaccharide groups of high,medium and low dose of ZhuQin,the extraction group of ZhuQin,the polysaccharide group of Atractylodes,the positive drug group,the blank group and the model group. The model of immunosuppressed mice was established by intraperitoneal injection of cyclophosphamide. The carbon clearance index,immune organ index,serum hemolysin,spleen T and B lymphocyte transformation rate were determined. [Results]The results show that the polysaccharides have obvious absorption peaks of polysaccharides; Formula extracts and polysaccharides can enhance the immune function of immunosuppressive mice at a certain dose level,and the effect of formula polysaccharide is better than that of extract and single traditional Chinese medicine polysaccharides. [Conclusions] The results suggest that the polysaccharides of ZhuQin Formula and Atractylodes may be acidic polysaccharides containing pyran ring and furan ring. ZhuQin Formula polysaccharide may play an immunomodulatory role mainly by improving the specific immunity of the organism. | Min PANG Yichen LUO Yongfeng HAO Xin YUE Zhaorong ZHU Juan LIU | 2018 | Medicinal Plant2018，9，1： | 1 |
| 9 | Research lab on 3D bioprinting of Zhejiang University显示文摘 | Lei Gao Bin Zhang Liang Ma Yichen Luo Qian Xue Zhanfeng Cui Huayong Yang | 2018 | Bio-Design and Manufacturing2018，1，3： | 1 |
| 10 | Corporate incentives to disclose carbon information: Evidence from the CDP Global 500 Report 显示文摘 | Luo Le Lan Yichen Tang Qingliang | 2012 | Journal of International Financial Management & Accounting2012，23，2： | 1 |
| 11 | 3D bioprinted hyaluronic acid‑based cell‑laden scaffold for brain microenvironment simulation显示文摘Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent years.Understanding the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in vitro.Here,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment models.The study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study. | Liang Ma Yuting Li Yutong Wu Mengfei Yu Abdellah Aazmi Lei Gao Qian Xue Yichen Luo Hongzhao Zhou Bin Zhang Huayong Yang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 12 | A social computing method for energy safety显示文摘Information and communication technologies enable the transformation of traditional energy systems into cyber-physical energy systems(CPESs),but such systems have also become popular targets of cyberattacks.Currently,available methods for evaluating the impacts of cyberattacks suffer from limited resilience,efficacy,and practical value.To mitigate their potentially disastrous consequences,this study suggests a two-stage,discrepancy-based optimization approach that considers both preparatory actions and response measures,integrating concepts from social computing.The proposed Kullback-Leibler divergence-based,distributionally robust optimization(KDR)method has a hierarchical,two-stage objective function that incorporates the operating costs of both system infrastructures(e.g.,energy resources,reserve capacity)and real-time response measures(e.g.,load shedding,demand-side management,electric vehicle charging station management).By incorporating social computing principles,the optimization framework can also capture the social behavior and interactions of energy consumers in response to cyberattacks.The preparatory stage entails day-ahead operational decisions,leveraging insights from social computing to model and predict the behaviors of individuals and communities affected by potential cyberattacks.The mitigation stage generates responses designed to contain the consequences of the attack by directing and optimizing energy use from the demand side,taking into account the social context and preferences of energy consumers,to ensure resilient,economically efficient CPES operations.Our method can determine optimal schemes in both stages,accounting for the social dimensions of the problem.An original disaster mitigation model uses an abstract formulation to develop a risk-neutral model that characterizes cyberattacks through KDR,incorporating social computing techniques to enhance the understanding and response to cyber threats.This approach can mitigate the impacts more effectively than several existing methods,even with limited data availability.To extend this risk-neutral model,we incorporate conditional value at risk as an essential risk measure,capturing the uncertainty and diverse impact scenarios arising from social computing factors.The empirical results affirm that the KDR method,which is enriched with social computing considerations,produces resilient,economically efficient solutions for managing the impacts of cyberattacks on a CPES.By integrating social computing principles into the optimization framework,it becomes possible to better anticipate and address the social and behavioral aspects associated with cyberattacks on CPESs,ultimately improving the overall resilience and effectiveness of the system’s response measures. | Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu Daniel Dajun Zeng Da Xie Yichen Shen Jiangfeng Li Tianyi Luo | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
| 13 | Self-assembled Supramolecular Artificial Transmembrane Ion Channels:Recent Progress and Application显示文摘Natural protein channels have evolved with fantastic spatial structures,which play pivotal physiological functions in all living systems.Learning from nature,chemical scientists have developed a myriad of artificial transmembrane ion channels by using various chemical strategies,among which the non-covalent supramolecular ion channels exhibit remarkable advantages over other forms(e.g.,single-molecule ion channel),which exhibited facile preparation methods,easier structural modification and functionalization.In this review,we have systematically summarized the recent progress of supramolecular self-assembled artificial transmembrane ion channels,which were classified by different self-assembly mechanisms,such as hydrogen bonds,π-πinteractions,etc.Detailed preparation process and self-assembly strategies of the supramolecular ion channels have been described.Moreover,potential biomedical applications of the supramolecular ion channels have also been carefully discussed in this review.Finally,future opportunities and challenges facing this field were also elaborately discussed.It is anticipated that this review could provide a panoramic sketch and future directions towards the construction of novel artificial ion channels with novel functions and biomedical applications. | LUO Yichen ZHU Canhong ZHANG Tianlong YAN Tengfei LIU Junqiu | 2023 | Chemical Research in Chinese Universities2023，39，1： | 0 |
| 14 | Legal Regulation of Unfair Application User Agreements in China显示文摘With the increase in the content and specialization of user agreements,the vast majority of users seldom,if ever,read the user agreements of mobile applications.In the face of absolutely strong application providers,users are forced to accept user agreements out of necessity,which leaves an opportunity for application providers to stipulate unfair terms,and in the long run,users will fall into rational indifference to the defense of unfair user agreements.In order to solve the above problems,this paper proposes that for online platforms with a large number of users and a dominant position in the market,they should convert most of the contents in the application agreement into the legal provisions of the model contract,and display only the terms that the users are able to choose and those that modify the model contract when entering the application.Among the invalid blacklists in the model contract,the law should add new clauses that explicitly prohibit the set-off of uncertain liquidated damages in format contracts,unnecessary authorization of personal information,format jurisdiction,and unlimited copyright licenses to adequately protect the rights and interests of vulnerable users.In addition,the law should grant users the right of withdrawal and a certain degree of refusal in case of substantial obstruction,in order to balance the position and interests of application providers and users.Finally,the law should establish a public interest litigation system and a pre-censorship system to build a final line of defense for a comprehensive review of the fairness of user agreements. | LAN Zihang LUO Yichen YAN Yanru | 2023 | US-China Law Review2023，20，5： | 0 |
| 15 | Adult tiger beetles Cicindela gemmata modify their foraging strategy in different hunting contexts显示文摘Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but the extent of this trade-off is not yet clear.Tiger beetles display diversity in their diets and hunting strategies,and hence,they become an ideal system to address how self-security affects foraging efficiency.We addressed this question in captive adult tiger beetles Cicindela gemmata.By offering several types of arthropod and plant foods,we confirmed that C.gemmata is carnivorous.We found that C.gemmata hunt by either ambushing or chasing their prey,and that they switch between strategies based on differences in the number of prey,the prey status and encounter rate,and the number of predators.Ambushing success increased with the number of prey but decreased with prey encounter rate.Chasing success decreased as prey body size and encounter rate increased.Foraging Cicindela gemmata often gave up an attack when it was nonfatal.This active giving up of hunting may be a consequence of a trade-off between foraging efficiency and self-security.Therefore,it is an adaptive response to the risk of injury when hunting for larger live prey. | Shumin Wang Panshuai Fei Zifeng Wu Zeyi Luo Yichen Wu Ningning Sun Yujie Wang Shumei Zi Lifang Gao Bo Du | 2023 | Insect Science2023，30，6： | 0 |
| 16 | Design of a High Precision Multichannel 3D Bioprinter显示文摘Three-dimensional(3D)printing technology is expected to solve the organ shortage problem.However,owing to the accuracy limitations,it is difficult for the current bioprinting technology to achieve an accurate control of the spatial position and distribution of a single cell or single component droplet.In this study,to accurately achieve the directional deposition of different cells and biological materials in the spatial position for the construction of large transplantable tissues and organs,a high-precision multichannel 3D bioprinter with submicron-level motion accuracy is designed,and concurrent and synergistic printing methods are proposed.Based on the high-precision motion characteristics of the gantry structure and the requirements of concurrent and synergistic printing,a 3D bioprint-ing system with a set of 6 channels is designed to achieve six-in-one printing.Based on the Visual C++environ-ment,a control system software that integrates the programmable multi-axis controller(PMAC)motion,pneumatic,and temperature control subsystems was developed and designed.Finally,based on measurements and experiments,the 3D bioprinter and its control system was verified to fulfil the requirements of multichannel,concurrent,and syn-ergistic printing with submicron-level motion accuracy,significantly shortening the printing time and improving the printing efficiency.This study not only provides an equipment basis for printing complex heterogeneous tissue structures,but also improves the flexibility and functionality of bioprinting,and ultimately makes the construction of complex multicellular tissues or organs possible. | Jintao Li Bin Zhang Yichen Luo Huayong Yang | 2023 | Chinese Journal of Mechanical Engineering2023，36，6： | 0 |
| 17 | Practical continuous-variable quantum key distribution with feasible optimization parameters显示文摘Continuous-variable quantum key distribution(CV-QKD)offers an approach to achieve a potential high secret key rate(SKR)in metropolitan areas.There are several challenges in developing a practical CV-QKD system from the laboratory to the real world.One of the most significant points is that it is really hard to adapt different practical optical fiber conditions for CV-QKD systems with unified hardware.Thus,how to improve the performance of practical CV-QKD systems in the field without modification of the hardware is very important.Here,a systematic optimization method,combining the modulation variance and error correction matrix optimization,is proposed to improve the performance of a practical CV-QKD system with a restricted capacity of postprocessing.The effect of restricted postprocessing capacity on the SKR is modeled as a nonlinear programming problem with modulation variance as an optimization parameter,and the selection of an optimal error correction matrix is studied under the same scheme.The results show that the SKR of a CV-QKD system can be improved by 24%and 200%compared with previous frequently used optimization methods theoretically with a transmission distance of 50 km.Furthermore,the experimental results verify the feasibility and robustness of the proposed method,where the achieved optimal SKR achieved practically deviates<1.6%from the theoretical optimal value.Our results pave the way to deploy high-performance CV-QKD in the real world. | Li MA Jie YANG Tao ZHANG Yun SHAO Jinlu LIU Yujie LUO Heng WANG Wei HUANG Fan FAN Chuang ZHOU Liangliang ZHANG Shuai ZHANG Yichen ZHANG Yang LI Bingjie XU | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 18 | Three-Dimensional M-Shaped Resection for Nasal Alar Hypertrophy in Asian Patients显示文摘Background Nasal alarplasty is an important component of esthetic rhinoplasty in Asians.The two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and are associated with a high relapse rate.Methods We developed a new technique,called three-dimensional(3D)M-shaped resection,which corrects both the nasal alar height and length and simultaneously minimizes external scarring.We performed this procedure from January 2013 to September 2016 in 49 consecutive female patients diagnosed with saddle nose and nasal alar hypertrophy.Their mean age was 28.6(range,18–40)years.All patients had previously undergone simple rhinoplasty.Nasal alar length and height,nostril length and width,and maximal nose width were analyzed preoperatively and postoperatively from photographs.Results After a mean of 9(range,3–24)months of follow-up,surgery was considered successful in 46 women(94%)with good cosmetic effects.In three patients,nasal alar hypertrophy recurred(6 months postoperatively).There were no early complications such as hematomas,infections,skin or mucosal necrosis,or wound dehiscence.The mean reductions postoperatively were 1.7 mm and 0.9 mm for nasal alar length and height,respectively,1.6 mm for both nostril length and width,and 3.5 mm for nose width.Conclusion The 3D M-shaped resection for nasal alar hypertrophy effectively reduced hypertrophy in 94%of patients for up to 24 months,producing minimal external scars and good cosmetic effects.It is a simple and convenient technique that is an effective and safe option for nasal alarplasty. | Yiqing QIU Qingfang ZHAO Zhixiong CHEN Yichen SHEN Mengmeng LUO Qiaoyun QIU Jinghong XU | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 0 |
| 19 | Activation of peroxymonosulfate by FeVO_(3-x)for the degradation of carbamazepine:Vanadium mediated electron shuttle and oxygen vacancy modulated interface chemistry显示文摘Fast Fe(III)/Fe(II)circulation in heterogeneous peroxymonosulfate(PMS)activation remains as a bottleneck issue that restricts the development of PMS based advanced oxidation processes.Herein,we proposed a facile ammonia reduction strategy and synthesized a novel FeVO3-x catalysts to activate PMS for the degradation of a typical pharmaceutical,carbamazepine(CBZ).Rapid CBZ removal could be achieved within 10 min,which outperforms most of the other iron or vanadium-based catalysts.Electron paramagnetic resonance analysis and chemical probe experiments revealed SO_(4)^(·-),·OH,O_(2)^(·-)and high valent iron(Fe(IV))were all generated in this system,but SO4·-and Fe(IV)primarily contributed to the degradation of CBZ.Besides,X-ray photoelectron spectroscopy and X-ray adsorption spectroscopy indicated that both the generated low-valent V provides and oxygen vacancy acted as superior electron donors and accelerated internal electron transfer via the unsaturated V-O-Fe bond.Finally,the proposed system also exhibited satisfactory performance in practical applications.This work provides a promising platform in heterogeneous PMS activation. | Leiduo Lai Hongyu Zhou Yichen Hong Mengfan Luo Yang Shi Heng Zhang Zhaokun Xiong Gang Yao Bo Lai | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 20 | Identification of lipid metabolism-related genes as prognostic indicators in papillary thyroid cancer显示文摘Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also in the oncogenesis and progression of cancers.In this study,we investigated the prognostic value of lipid metabolism-related genes in papillary thyroid cancer(PTC).The recurrence predictive gene signature was developed and internally and externally validated based on PTC datasets including The Cancer Genome Atlas(TCGA)and GSE33630 datasets.Univariate,LASSO,and multivariate Cox regression analysis were applied to assess prognostic genes and build the prognostic gene signature.The expression profiles of prognostic genes were further determined by immunohistochemistry of tissue microarray using in-house cohorts,which enrolled 97 patients.Kaplan–Meier curve,time-dependent receiver operating characteristic curve,nomogram,and decision curve analyses were used to assess the performance of the gene signature.We identified four recurrence-related genes,PDZK1IP1,TMC3,LRP2 and KCNJ13,and established a four-gene signature recurrence risk model.The expression profiles of the four genes in the TCGA and in-house cohort indicated that stage T1/T2 PTC and locally advanced PTC exhibit notable associations not only with clinicopathological parameters but also with recurrence.Calibration analysis plots indicate the excellent predictive performance of the prognostic nomogram constructed based on the gene signature.Single-sample gene set enrichment analysis showed that high-risk cases exhibit changes in several important tumorigenesis-related pathways,such as the intestinal immune network and the p53 and Hedgehog signaling pathways.Our results indicate that lipid metabolism-related gene profiling represents a potential marker for prognosis and treatment decisions for PTC patients. | Shishuai Wen Yi Luo Weili Wu Tingting Zhang Yichen Yang Qinghai Ji Yijun Wu Rongliang Shi Ben Ma Midie Xu Ning Qu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
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