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| 1 | 3D bioprinting: an emerging technology full of opportunities and challenges显示文摘 | Bin Zhang Yichen Luo Liang Ma Lei Gao Yuting Li Qian Xue Huayong Yang Zhanfeng Cui | 2018 | Bio-Design and Manufacturing2018，1，1： | 13 |
| 2 | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography-mass spectrometry显示文摘Pesticide residue analysis plays an important role in the quality control of Chinese materia medica.This paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of Chinese materia medica.Sample preparation utilized the QuEChERS method with acetonitrile:1% aqueous acetic acid(9:1,v/v)as extraction solvent followed by sample clean-up by dispersive solid phase extraction using primary secondary amine sorbent and graphitized carbon black.Extracts were then analysed by gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring mode.Limit of detection(LOD)and limit of quantitation(LOQ)values were in the ranges 0.5-50 ng/g and 1-100 ng/g,respectively.The recoveries of the 39 pesticides were in the range 75-112% with precision(as relative standard deviation,RSD)<15%.The results show that the modified QuEChERS method allows rapid and sensitive analysis of multiple pesticide residues in Chinese materia medica. | Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang Cao | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 11 |
| 3 | High-performance Zn battery with transition metal ions co-regulated electrolytic MnO_(2)显示文摘Electrolytic MnO_(2)/Zn batteries have attracted extensive attention for use in large-scale energy storage applications due to their low cost,high output voltage,safety,and environmental friendliness.However,the poor electrical conductivity of MnO_(2)limits its deposition and dissolution at large capacities,which leads to sluggish reaction kinetics and drastic capacity decay.Here,we report a theory-guided design principle for an electrolytic MnO_(2)/Zn battery co-regulated with transition metal ions that has improved electrochemical performance in terms of deposition and stripping chemistries.We start with first-principles calculations to predict the electrolytic effects of regulating transition metal ions in the deposition/stripping chemistry of the MnO_(2)cathode.The results indicate that with the simultaneous incorporation of strongly electronegative Co and Ni,the MnO_(2)cathode tends to possess more active electron states,faster charge-transfer kinetics,and better electrical conductivity than either MnO_(2)regulated with Co or Ni on their own,or pristine MnO_(2);hence,this co-regulation is beneficial for the cathode solid/liquid MnO_(2)/Mn2t reactions.We then fabricate and demonstrate a novel Co2t and Ni2t coregulated MnO_(2)/Zn(Co-Ni-MnO_(2)/Zn)battery that yields significantly better electrochemical performance,finding that the synergistic regulation of Co and Ni on MnO_(2)can significantly increase its intrinsic conductivity and achieve high rates and Coulombic efficiencies at large capacities.The aqueous Co-Ni-MnO_(2)/Zn battery exhibits a high rate(10C,100 mA cm^(-2)),high Coulombic efficiency(91.89%),and excellent cycling stability(600 cycles without decay)at a large areal capacity of 10 mAh cm^(-2).Our proposed strategy of co-regulation with transition metal ions offers a versatile approach for improving the electrochemical performance of aqueous electrolytic MnO_(2)/Zn batteries in large-scale energy storage applications. | Mingyan Chuai Jinlong Yang Mingming Wang Yuan Yuan Zaichun Liu Yan Xu Yichen Yin Jifei Sun Xinhua Zheng Na Chen Wei Chen | 2021 | eScience2021，1，2： | 8 |
| 4 | Au nanorods decorated TiO_(2)nanobelts with enhanced full solar spectrum photocatalytic antibacterial activity and the sterilization file cabinet application显示文摘TiO_(2)photocatalysts have been widely studied and applied for removing bacteria,but its antibacterial efficiency is limited to the ultraviolet(UV)range of the solar spectrum.In this work,we use the gold(Au)nanorods to enhance the visible and near-infrared(NIR)light absorption of TiO_(2)NBs,a typical UV light photocatalyst,thus the enhancement of its full solar spectrum(UV,visible and NIR)photocatalytic antibacterial properties is achieved.Preliminary surface plasmon resonance(SPR)enhancement photocatalytic antibacterial mechanism is suggested.On one hand,transverse and longitudinal SPR of Au NRs is beneficial for visible and NIR light utilization.On the other hand,Au NRs combined with TiO_(2)NBs to form the heterostructure,which can improve the photogenerated carrier separation and direct electron transfer increases the hot electron concentration while Au NRs as the electron channel can well restrain charge recombination.finally produces the high yield of radical oxygen species and exhibits a superior antibacterial efficiency.Furthermore,we design a sterilization file cabinet with Au NR/TiO_(2)NB heterostructures as the photocatalytic coating plates.Our study reveals that Au NR/TiO_(2)NB heterostructure is a potential candidate for sterilization of bacteria and archives protection. | Yingying Qin Yichen Guo Zhangqian Liang Yanjun Xue Xiaoli Zhang Lei Yang Jian Tian | 2021 | Chinese Chemical Letters2021，32，4： | 6 |
| 5 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 6 | 3D Bioprinting:A Novel Avenue for Manufacturing Tissues and Organs显示文摘Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of biomaterials,cells,and biomolecules in a layer-by-layer fashion,with precisely controlled spatial distribution.This technology is expected to address the organ-shortage issue in the future.In this review,we first introduce three categories of 3D bioprinting strategies:inkjet-based printing(IBP),extrusion-based printing(EBP),and light-based printing(LBP).Biomaterials and cells,which are normally referred to as“bioinks,”are then discussed.We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures,including cartilage,bone,skin,muscle,vascular network,and so on.The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well.Finally,the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed. | Bin Zhang Lei Gao Liang Ma Yichen Luo Huayong Yang Zhanfeng Cui | 2019 | Engineering2019，5，4： | 5 |
| 7 | Facile one-step synthesis of graphitic carbon nitride-modified biochar for the removal of reactive red 120 through adsorption and photocatalytic degradation显示文摘Converting waste biomass into value-added biochar has been considered as a green and sustainable strategy for resource management and pollution control.In this study,graphitic carbon nitride(g-C_(3)N_(4))modified biochars(BCs)were produced through one-pot pyrolysis of urea and hickory chips in differential ratios at 520℃.The resulting BC/g-C_(3)N_(4)composites were evaluated in laboratory for their physicochemical,adsorptive,and photocatalytic properties.The characterization tests showed the successful synthesis of the BC/g-C_(3)N_(4)composites that introduced g-C_(3)N_(4)structure,N-containing surface func-tional groups,reduced surface area,and better thermal stability to the biochar.After modification,the BC/g-C_(3)N_(4)composites showed better adsorption ability to reactive red 120(RR120)than the pristine BC,due to the strong electrostatic attrition between N-containing functional groups of g-C_(3)N_(4)on biochar surface and anionic RR120.The BC/g-C_(3)N_(4)composites also inherited g-C_(3)N_(4)’s photocatalytic activity,which is visible light responsive to generate free radicals for RR120 degradation.In addition,the composites with higher urea modification ratios were more effective in the degradation of RR120.Overall,this study demonstrates the feasibility and promising potential of combining biochar and photocatalyst for the removal of aqueous dye.Because of the synergistic adsorption and photodegradation ability,BC/g-C_(3)N_(4)composites present a novel and cost-effective solution for the removal of aqueous dye and other photodegradable contaminants under natural conditions. | Yulin Zheng Yichen Yang Yue Zhang Weixin Zou Yidan Luo Lin Dong Bin Gao | 2019 | Biochar2019，1，1： | 5 |
| 8 | Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge显示文摘The gut microbiota is involved in host responses to high altitude.However,the dynamics of intestinal microecology and their association with altitude-related illness are poorly understood.Here,we used a rat model of hypobaric hypoxia challenge to mimic plateau exposure and monitored the gut microbiome,short-chain fatty acids(SCFAs),and bile acids(BAs)over 28 d.We identified weight loss,polycythemia,and pathological cardiac hypertrophy in hypoxic rats,accompanied by a large compositional shift in the gut microbiota,which is mainly driven by the bacterial families of Prevotellaceae,Porphyromonadaceae,and Streptococcaceae.The aberrant gut microbiota was characterized by increased abundance of the Parabacteroides,Alistipes,and Lactococcus genera and a larger Bacteroides to Prevotella ratio.Trans-omics analyses showed that the gut microbiome was significantly correlated with the metabolic abnormalities of SCFAs and BAs in feces,suggesting an interaction network remodeling of the microbiome-metabolome after the hypobaric hypoxia challenge.Interestingly,the transplantation of fecal microbiota significantly increased the diversity of the gut microbiota,partially inhibited the increased abundance of the Bacteroides and Alistipes genera,restored the decrease of plasma propionate,and moderately ameliorated cardiac hypertrophy in hypoxic rats.Our results provide an insight into the longitudinal changes in intestinal microecology during the hypobaric hypoxia challenge.Abnormalities in the gut microbiota and microbial metabolites contribute to the development of high-altitude heart disease in rats. | Zhiyuan Pan Yichen Hu Zongyu Huang Ni Han Yan Li Xiaomei Zhuang Jiye Yin Hui Peng Quansheng Gao Wenpeng Zhang Yong Huang Yujun Cui Yujing Bi Zhenjiang Zech Xu Ruifu Yang | 2022 | Science China(Life Sciences)2022，65，10： | 5 |
| 9 | New Localities and Palaeoscolecid Worms from the Cambrian(Stage 4,Series 2)Guanshan Biota in Kunming,Yunnan,South China显示文摘The Guanshan Biota from the Cambrian Stage 4 Wulongqing Formation is a typical Burgess-shale type Lagerst?tte that had witnessed the Cambrian explosion. Here we report two new localities of the Guanshan Biota,which is located at Baimei village,south of Kunming and Xinglong village,Wuding County,Yunnan Province respectively. Both localities produce soft-body fossils and several new taxa,e.g. a new species of palaeoscolecidans(Palaeoscolex xinglongensis sp. nov.) reported herein. The comparative study of the new species with similar form not only indicates that there is a diversification of palaeoscolecid species in Guanshan Biota,but also strengthens the ties between the older Chengjiang Biota and the younger Kaili Biota(and also the coeval Burgess Shale community). Three paleoecological features,including high diversity,little disparity and richness of palaeoscolecid worms,are summarized as a case study to represent the differences between Guanshan and Chengjiang Biota. | LIU Jianni HAN Jian LI Jinshu WU Yichen PENG Jie QI Nan YANG Yiyao LI Juan | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 4 |
| 10 | ZbAGL11, a class D MADS-box transcription factor of Zanthoxylum bungeanum, is involved in sporophytic apomixis显示文摘Apomixis is a reproductive model that bypasses sexual reproduction,so it does not require the combination of paternal and maternal gametes but instead results in the production of offspring directly from maternal tissues.This reproductive mode results in the same genetic material in the mother and the offspring and has signi fi cant applications in agricultural breeding.Molecular and cytological methods were used to identify the reproductive type of Zanthoxylum bungeanum(ZB).Fluorescence detection of the ampli fi ed products of 12 pairs of polymorphic SSR primers showed consistent fl uorescence signals for mother and offspring,indicating that no trait separation occurred during reproduction.In addition,the cytological observation results showed differentiation of ZB embryos(2n)from nucellar cells(2n)to form inde fi nite embryonic primordia and then form adventitious embryos(2n),indicating that the apomictic type of ZB is sporophytic apomixis.The MADS-box transcription factor ZbAGLll was highly expressed during the critical period of nucellar embryo development in ZB.Unpollinated ZbAGLll-OE Arabidopsis produced fertile offspring and exhibited an apomictic phenotype.The overexpression of ZbAGL11 increased the callus induction rate of ZB tissue.In addition,the results of the yeast two-hybrid experiment showed that ZbAGL11 could interact with the ZbCYP450 and ZbCAD11 proteins.Our results demonstrate that ZbAGL11 can cause developmental disorders of Arabidopsis fl ower organs and result in apomixis-like phenotypes. | Xitong Fei Qianqian Shi Yichen Qi Shujie Wang Yu Lei Haichao Hu Yulin Liu Tuxi Yang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 11 | Diurnal and Seasonal Variations of Thermal Stratification and Vertical Mixing in a Shallow Fresh Water Lake显示文摘Among several influential factors, the geographical position and depth of a lake determine its thermal structure. In temperate zones, shallow lakes show significant differences in thermal stratification compared to deep lakes. Here,the variation in thermal stratification in Lake Taihu, a shallow fresh water lake, is studied systematically. Lake Taihu is a warm polymictic lake whose thermal stratification varies in short cycles of one day to a few days. The thermal stratification in Lake Taihu has shallow depths in the upper region and a large amplitude in the temperature gradient,the maximum of which exceeds 5°C m–1. The water temperature in the entire layer changes in a relatively consistent manner. Therefore, compared to a deep lake at similar latitude, the thermal stratification in Lake Taihu exhibits small seasonal differences, but the wide variation in the short term becomes important. Shallow polymictic lakes share the characteristic of diurnal mixing. Prominent differences on the duration and frequency of long-lasting thermal stratification are found in these lakes, which may result from the differences of local climate, lake depth, and fetch. A prominent response of thermal stratification to weather conditions is found, being controlled by the stratifying effect of solar radiation and the mixing effect of wind disturbance. Other than the diurnal stratification and convection, the representative responses of thermal stratification to these two factors with contrary effects are also discussed. When solar radiation increases, stronger wind is required to prevent the lake from becoming stratified. A daily average wind speed greater than 6 m s–1 can maintain the mixed state in Lake Taihu. Moreover, wind-induced convection is detected during thermal stratification. Due to lack of solar radiation, convection occurs more easily in nighttime than in daytime. Convection occurs frequently in fall and winter, whereas long-lasting and stable stratification causes less convection in summer. | Yichen YANG Yongwei WANG Zhen ZHANG Wei WANG Xia REN Yaqi GAO Shoudong LIU Xuhui LEE | 2018 | Journal of Meteorological Research2018，32，2： | 3 |
| 12 | Investigation of Nb Ox-based volatile switching device with self-rectifying characteristics显示文摘Dear editor,Resistive random access memory(RRAM),one of the most promising emerging non-volatile memory technologies,has been extensively investigated by researchers from both academia and industry due to its fast speed and excellent scalability for storage class memory(SCM)[1-3].To achieve large-scale integration in an RRAM array,each cell needs to contain a nonlinear device to eliminate the sneak path which may lead to false program and read-margin narrowing[2,3].Usually,transistors or selectors are serially connected to RRAM cells to act as the selective elements. | Yichen FANG Zongwei WANG Caidie CHENG Zhizhen YU Teng ZHANG Yuchao YANG Yimao CAI Ru HUANG | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 13 | Strong partitioning of soil bacterial community composition and co-occurrence networks along a small-scale elevational gradient on Zijin Mountain显示文摘The elevational distributions of bacterial communities in natural mountain forests,especially along large elevational gradients,have been studied for many years.However,the distributional patterns that underlie variations in soil bacterial communities along small-scale elevational gradients in urban ecosystems are not yet well understood.Using Illumina MiSeq DNA sequencing,we surveyed soil bacterial communities at three elevations on Zijin Mountain in Nanjing City:the hilltop(300 m a.s.l.),the hillside(150 m a.s.l.),and the foot of the hill(0 m a.s.l.).The results showed that edaphic properties differed significantly with elevation.Bacterial community composition,rather than alpha diversity,strongly differed among the three elevations(Adonis:R2=0.12,P<0.01).Adonis and DistLM analyses demonstrated that bacterial community composition was highly correlated with soil pH,elevation,total nitrogen(TN),and dissolved organic carbon(DOC).The degree scores,betweenness centralities,and composition of keystone species were distinct among the elevations.These results demonstrate strong elevational partitioning in the distributions of soil bacterial communities along the gradient on Zijin Mountain.Soil pH and elevation together drove the smallscale elevational distribution of soil bacterial communities.This study broadens our understanding of distribution patterns and biotic co-occurrence associations of soil bacterial communities from large elevational gradients to short elevational gradients. | Xu Liu Teng Yang Yu Shi Yichen Zhu Mulin He Yunke Zhao Jonathan MAdams Haiyan Chu | 2021 | Soil Ecology Letters2021，3，4： | 2 |
| 14 | SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation显示文摘The nucleocapsid(N)protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation,which enables its incorporation into stress granules(SGs)of host cells.However,whether SG invasion by N protein occurs in the scenario of SARS-CoV-2 infection is unknow,neither do we know its con-sequence.Here,we used SARS-CoV-2 to infect mam-malian cells and observed the incorporation of N protein into SGs,which resulted in markedly impaired self-dis-assembly but stimulated cell cellular clearance of SGs.NMR experiments further showed that N protein binds to the SG-related amyloid proteins via non-specific tran-sient interactions,which not only expedites the phase transition of these proteins to aberrant amyloid aggre-gation in vitro,but also promotes the aggregation of FUS with ALS-associated P525L mutation in cells.In addition,we found that ACE2 is not necessary for the infection of SARS-CoV-2 to mammalian cells.Our work indicates that SARS-CoV-2 infection can impair the dis-assembly of host SGs and promote the aggregation of SG-related amyloid proteins,which may lead to an increased risk of neurodegeneration. | Yichen Li Shuaiyao Lu Jinge Gu Wencheng Xia Shengnan Zhang Shenqing Zhang Yan Wang Chong Zhang Yunpeng Sun Jian Lei Cong Liu Zhaoming Su Juntao Yang Xiaozhong Peng Dan Li | 2022 | Protein & Cell2022，13，8： | 1 |
| 15 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 16 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 17 | Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells 显示文摘 | Yang Hsinling Chang Wenhuei Chia Yichen | 2006 | Food and Chemical Toxicology2006，，44： | 1 |
| 18 | The Study of the Cable Failure Criteria Used in Fire PSA显示文摘 | YANG Yichen LI Qiang ZHANG Jiaqing | 2016 | Procedia Engineering2016，135，： | 1 |
| 19 | Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration显示文摘Varieties of pathological conditions,including diabetes,are closely related to oxidative stress(OS),but the osseointegration or bioadaptation of implants to OS and the related mechanism remain poorly explored.In this study,the antioxidation and osteoimmune regeneration of titanium implants with micro/nanotopographies were evaluated under H2O2-,lipopolysaccharide(LPS)-and hyperglycemia-mediated cellular OS models and in diabetic rats as a representative animal model of OS.TiO2 nanotube(TNT)coating on titanium implants directly induced superior osteogenic differentiation of bone mesenchymal stem cells(MSCs)and osseointegration compared with microscale sand blasted-acid etched topography(SLA)under OS,attributed to higher superoxide dismutase 2 activity,the neutralization of intracellular reactive oxygen species(ROS),and less apoptosis.Mechanistically,the oxidation resistance on TNT is driven by upregulated forkhead box transcription factor O1(FoxO1),which is abolished after knockdown of FoxO1 via shRNA in MSCs.Indirectly,TNT also alleviates OS in macrophages,therefore inducing a higher portion of the M2 phenotype under OS with increased secretion of the anti-inflammatory cytokine IL-10,further promoting the osseoimmunity capacity compared with SLA.The current study not only suggests the potential application of TiO2 nanotube-coated titanium implants in compromised conditions but also provides a systematic evaluation strategy for the future development of bone biomaterials. | Jingyan Huang Ruoqi Li Jinghong Yang Min Cai Yichen Lee Anxun Wang Bin Cheng Yan Wang | 2021 | Bioactive Materials2021，6，10： | 1 |
| 20 | Roles of thymosins in cancers and other organ systems显示文摘 | Chang Yichen Li Min Yang Hui | 2005 | World J Surg2005，29，3： | 1 |
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