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| 1 | A leaf shape mutant provides insight into PINOID Serine/Threonine Kinase function in cucumber(Cucumis sativus L.)显示文摘Optimizing leaf shape is a major challenge in efforts to develop an ideal plant type. Cucumber leaf shapes are diverse;however, the molecular regulatory mechanisms underlying leaf shape formation are unknown. In this study, we obtained a round leaf mutant(rl) from an ethyl methanesulfonate-induced mutagenesis population. Genetic analysis revealed that a single recessive gene, rl, is responsible for this mutation. A modified Mut Map analysis combined linkage mapping identified a single nucleotide polymorphism within a candidate gene,Csa1 M537400, as the mutation underlying the trait.Csa1 M537400 encodes a PINOID kinase protein involved in auxin transport. Expression of Csa1 M537400 was significantly lower in the rl mutant than in wild type, and it displayed higher levels of IAA(indole-3-acetic acid) in several tissues. Treatment of wild-type plants with an auxin transport inhibitor induced the formation of round leaves,similar to those in the rl mutant. Altered expression patterns of several auxin-related genes in the rl mutant suggest that rl plays a key role in auxin biosynthesis,transport, and response in cucumber. These findings provide insight into the molecular mechanism underlying the regulation of auxin signaling pathways in cucumber,and will be valuable in the development of an ideal plant type. | Mengfei Song Feng Cheng Jing Wang Qingzhen Wei Wenyuan Fu Xiaqing Yu Ji Li Jinfeng Chen Qunfeng Lou | 2019 | Journal of Integrative Plant Biology2019，61，9： | 3 |
| 2 | A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19:The Artificial-Liver Blood-Purification System显示文摘The coronavirus disease 2019(COVID-19)pan-epidemic,resulting from infection with the 2019 novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is currently the source of public health concern worldwide;however,treatment of this infection has been clinically challenging in many patients[1].Importantly,2019-nCoV is the third fatal coronavirus that has emerged in the past two decades,following SARS-CoV and the Middle East respiratory syndrome(MERS)-CoV[2].The numbers of confirmed cases of COVID-19 infection and related deaths are still rising.As of 9 March 2020. | Yimin Zhang Liang Yu LingLing Tang Mengfei Zhu Yanqi Jin Zhouhan Wang Lanjuan Li | 2021 | Engineering2021，7，1： | 2 |
| 3 | Smart Manipulation of Gas Bubbles in Harsh Environments Via a Fluorinert-Infused Shape-Gradient Slippery Surface显示文摘Fundamental research and practical applications have examined the manipulation of gas bubbles on open surfaces in lowsurface-tension,high-pressure,and high-acidity,-alkalinity,or-salinity environments.However,to the best of our knowledge,effi cient and general approaches to achieve the smart manipulation of gas bubbles in these harsh environments are limited.Herein,a Fluorinert-infused shape-gradient slippery surface(FSSS)that could eff ectively regulate the behavior of gas bubbles in harsh environments was successfully fabricated.The unique capability of FSSS was mainly attributed to the properties of Fluorinert,which include chemical inertness and incompressibility.The shape-gradient morphology of FSSS could induce asymmetric driving forces to move gas bubbles directionally on open surfaces.Factors infl uencing gas bubble transport on FSSS,such as the apex angle of the slippery surface and the surface tension of the aqueous environment,were carefully investigated,and large apex angles were found to result in large initial transport velocities and short transport distances.Lowering the surface tension of the aqueous environment is unfavorable to bubble transport.Nevertheless,FSSS could transport gas bubbles in aqueous environments with surface tensions as low as 28.5±0.1 mN/m,which is lower than that of many organic solvents(e.g.,formamide,ethylene glycol,and dimethylformamide).In addition,FSSS could also realize the facile manipulation of gas bubbles in various aqueous environments,e.g.,high pressure(~6.8 atm),high acidity(1 mol/L H 2 SO 4),high alkalinity(1 mol/L NaOH),and high salinity(1 mol/L NaCl).The current fi ndings provide a source of knowledge and inspiration for studies on bubble-related interfacial phenomena and contribute to scientifi c and technological developments for controllable bubble manipulation in harsh environments. | Guoliang Liu Chunhui Zhang Mengfei Liu Ziwei Guo Xinsheng Wang Cunming Yu Moyuan Cao | 2020 | Transactions of Tianjin University2020，26，6： | 1 |
| 4 | A hierarchical vascularized engineered bone inspired by intramembranous ossification for mandibular regeneration显示文摘Mandibular defects caused by injuries,tumors,and infections are common and can severely affect mandibular function and the patient's appearance.However,mandible reconstruction with a mandibular bionic structure remains challenging.Inspired by the process of intramembranous ossification in mandibular development,a hierarchical vascularized engineered bone consisting of angiogenesis and osteogenesis modules has been produced.Moreover,the hierarchical vascular network and bone structure generated by these hierarchical vascularized engineered bone modules match the particular anatomical structure of the mandible.The ultra-tough polyion complex has been used as the basic scaffold for hierarchical vascularized engineered bone for ensuring better reconstruction of mandible function.According to the results of in vivo experiments,the bone regenerated using hierarchical vascularized engineered bone is similar to the natural mandibular bone in terms of morphology and genomics.The sonic hedgehog signaling pathway is specifically activated in hierarchical vascularized engineered bone,indicating that the new bone in hierarchical vascularized engineered bone underwent a process of intramembranous ossification identical to that of mandible development.Thus,hierarchical vascularized engineered bone has a high potential for clinical application in mandibular defect reconstruction.Moreover,the concept based on developmental processes and bionic structures provides an effective strategy for tissue regeneration. | Xin Ye Jianxiang He Shaolong Wang Qianglong Han Dongqi You Bin Feng Feiya Zhao Jun Yin Mengfei Yu Huiming Wang Huayong Yang | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 5 | ALK5 transfection of bone marrow mesenchymal stem cells to repair osteoarthritis of knee joint显示文摘 | Danna Cao Liang Ma Xiaodong Han Lingqing Dong Mengfei Yu Bin Zhang Binbin Ying | 2018 | Bio-Design and Manufacturing2018，1，2： | 1 |
| 6 | 3D bioprinted hyaluronic acid‑based cell‑laden scaffold for brain microenvironment simulation显示文摘Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent years.Understanding the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in vitro.Here,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment models.The study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study. | Liang Ma Yuting Li Yutong Wu Mengfei Yu Abdellah Aazmi Lei Gao Qian Xue Yichen Luo Hongzhao Zhou Bin Zhang Huayong Yang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 7 | Electrolyte induced synergistic construction of cathode electrolyte interphase and capture of reactive free radicals for safer high energy density lithium-ion battery显示文摘As the energy density of battery increases rapidly,lithium-ion batteries(LIBs)are facing serious safety issue with thermal runaway,which largely limits the large-scale applications of high-energy-density LIBs.It is generally agreed that the chemical crosstalk between the cathode and anode leads to thermal runaway of LIBs.Herein,a multifunctional high safety electrolyte is designed with synergistic construction of cathode electrolyte interphase and capture of reactive free radicals to limit the intrinsic pathway of thermal runaway.The cathode electrolyte interphase not only resists the gas attack from the anode but suppresses the parasitic side reactions induced by electrolyte.And the function of free radical capture has the ability of reducing heat release from thermal runaway of battery.The dual strategy improves the intrinsic safety of battery prominently that the triggering temperature of thermal runaway is increased by 24.4℃and the maximum temperature is reduced by 177.7℃.Simultaneously,the thermal runaway propagation in module can be self-quenched.Moreover,the electrolyte design balances the trade-off of electrochemical and safety performance of high-energy batteries.The capacity retention of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)|graphite pouch cell has been significantly increased from 53.85%to 97.05%with higher coulombic efficiency of 99.94%at operating voltage extended up to 4.5 V for 200 cycles.Therefore,this work suggests a feasible strategy to mitigate the safety risk of high-energy-density LIBs without sacrificing electrochemical performances. | Mengfei Ding Xuning Feng Yong Peng Jing Jing Tong Bowen Hou Yalan Xing Weifeng Zhang Li Wang Yu Wu Jiabin Lv Chunyan Luo Dejun Xiong Shichao Zhang Minggao Ouyang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 8 | Research on the Types of Cigarette Products Preferred by Consumers显示文摘Cigarette design and improvement according to consumer needs is an important basis for market-oriented management.The preferences of cigarette consumption such as cigarette product types,packaging styles,packaging colors and packaging materials were investigated and the real needs of cigarette consumers were figured out,in order to provide specific work guidance for the development of new cigarette products. | Mengfei JIANG Hongtao FENG Xuefeng HE Tao ZHANG Lei YANG Yu ZHONG Tiyuan XIA | 2022 | Asian Agricultural Research2022，14，4： | 0 |
| 9 | Diverse glasses revealed from Chang'E-5 lunar regolith显示文摘Lunar glasses with different origins act as snapshots of their formation processes,providing a rich archive of the Moon's formation and evolution.Here,we reveal diverse glasses from Chang'E-5(CE-5)lunar regolith,and clarify their physical origins of liquid quenching,vapor deposition and irradiation damage respectively.The series of quenched glasses,including rotation-featured particles,vesicular agglutinates and adhered melts,record multiple-scale impact events.Abundant micro-impact products,like micron-to nano-scale glass droplets or craters,highlight that the regolith is heavily reworked by frequent micrometeorite bombardment.Distinct from Apollo samples,the indigenous ultra-elongated glass fibers drawn from viscous melts and the widespread ultra-thin deposited amorphous rims without nanophase iron particles both indicate a relatively gentle impact environment at the CE-5 landing site.The clarification of multitype CE-5 glasses also provides a catalogue of diverse lunar glasses,meaning that more of the Moon's mysteries,recorded in glasses,could be deciphered in future. | Rui Zhao Laiquan Shen Dongdong Xiao Chao Chang Yao Huang Jihao Yu Huaping Zhang Ming Liu Shaofan Zhao Wei Yao Zhen Lu Baoan Sun Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2023 | National Science Review2023，10，12： | 0 |
| 10 | Constructing biomimetic liver models through biomaterials and vasculature engineering显示文摘The occurrence of various liver diseases can lead to organ failure of the liver,which is one of the leading causes of mortality worldwide.Liver tissue engineering see the potential for replacing liver transplantation and drug toxicity studies facing donor shortages.The basic elements in liver tissue engineering are cells and biomaterials.Both mature hepatocytes and differentiated stem cells can be used as themain source of cells to construct spheroids and organoids,achieving improved cell function.To mimic the extracellular matrix(ECM)environment,biomaterials need to be biocompatible and bioactive,which also help support cell proliferation and differentiation and allow ECM deposition and vascularized structures formation.In addition,advancedmanufacturing approaches are required to construct the extracellular microenvironment,and it has been proved that the structured three-dimensional culture system can help to improve the activity of hepatocytes and the characterization of specific proteins.In summary,we review biomaterials for liver tissue engineering,including natural hydrogels and synthetic polymers,and advanced processing techniques for building vascularized microenvironments,including bioassembly,bioprinting and microfluidic methods.We then summarize the application fields including transplant and regeneration,disease models and drug cytotoxicity analysis.In the end,we put the challenges and prospects of vascularized liver tissue engineering. | Weikang Lv Hongzhao Zhou Abdellah Aazmi Mengfei Yu Xiaobin Xu Huayong Yang Yan Yan Shery Huang Liang Ma | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 11 | Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration显示文摘Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts.Here,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects.Loose and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their biosafety.The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus.After internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium ions.Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications. | Jingyi Lu Miao Sun Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang | 2023 | Bio-Design and Manufacturing2023，6，5： | 0 |
| 12 | Pulmonary Vein Stenosis:A Review显示文摘Pulmonary vein stenosis(PVS)is an extremely rare and lethal disease caused by multiple etiologies.PVS has a bimodal distribution in the population,affecting children and adults.Congenital PVS is the usual PVS type in children,which sometimes develops after cardiothoracic surgery.Acquired PVS,in turn,is the most common PVS type in adults.A review of the relevant literature has shown that PVS after radiofrequency ablation of atrial fibrillation is the most common,as well as that caused by compression of proliferative fibrous tissues or tumor in the mediastinum(eg,PVS caused by fibrosing mediastinitis,lung tumors,metastases,etc).This article provides a comprehensive review of PVS in terms of embryology and anatomy,etiology and triggers,classification,clinical symptoms and signs,treatment,and prognosis,intending to promote the understanding and treatment of this disease. | Mengfei Jia Juan Wang Kaiyu Jiang Hongling Su Yu Li Zhaoxia Guo Hai Zhu Aqian Wang Xin Pan Yunshan Cao | 2023 | Cardiology Discovery2023，3，2： | 0 |
| 13 | A lightweight data-voting strategy for triple-modular redundant control computers显示文摘Triple-modular redundancy(TMR), a well-known methodology for improving the reliability of computer systems, has been used for onboard control computers in many safety-critical space applications. In this paper, a lightweight data-voting strategy for TMR control computer is proposed, in which an additional straightforward input voting stage is added, so that determination of the maximum admissible deviation for output matching, as required by traditional strategies, can be avoided. The lightweight strategy is a practical data-voting solution for the TMR control computer that exploits the characteristics of the data of the control computer. The addition of input voting, in both the value and time domains, can ensure that the outputs of non-faulty machines are exactly equal, and the bitwise output matching of the TMR control computer can be performed. The new data-voting strategy has been optimized according to the actual application conditions in spacecraft control systems, and has been adopted for the TMR control computer of the Chang’e-5 Return Spacecraft. The results of the ground experiments and successful on-orbit application have demonstrated the advantages of the new data-voting strategy for TMR control computer. | LIU Bo YANG MengFei WANG Yong YUAN Li LIU ChaoWei XU Jian YU Dan HU HongKai FENG Dan | 2022 | Science China(Technological Sciences)2022，65，2： | 0 |
| 14 | Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering显示文摘The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural tissues.Aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair.We here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin regeneration.The future use of aligned structures in tissue engineering is also discussed. | Kejie Lu Ying Qian Jiaxing Gong Ziyu Zhu Jun Yin Liang Ma Mengfei Yu Huiming Wang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
| 15 | Engineered Vasculature for Organ-on-a-Chip Systems显示文摘Organ-on-a-chip technology,a promising three-dimensional(3D)dynamic culture method,ensures accu-rate and efficient cell culture and has great potential for replacing animal models in preclinical testing.The circulatory system,the most abundant organ in the human body,plays a crucial role in oxygen exchange and mass transfer,which is the determining factor for the survival of tissues and organs.Thus,it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological functions.This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology,which offers even better possibilities of dupli-cating physiology and disease characteristics.In addition,we review the different steps of a vascularized organ-on-a-chip fabrication process,including structure fabrication and tissue construction using differ-ent biofabrication strategies.Finally,we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture. | Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang | 2022 | Engineering2022，8，2： | 0 |
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