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| 1 | Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening显示文摘Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals.This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation.However,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define.In tomato,fruit development and ripening are a complex process that involves epigenetic control.We have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr fruits.We compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 genes.Differentially methylated regions were found for some of these genes.Virus-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr fruits.These results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant. | Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng Zhang Silin Zhong Paul Hunter Mahmut Tor Yiguo Hong | 2018 | Science China(Life Sciences)2018，61，2： | 3 |
| 2 | D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration显示文摘Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the elderly.However,an effective therapy for this disease is lacking.Here,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE cells.Surprisingly,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein.The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model.These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD. | Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 4 | Sutureless primary repair of colonic perforation with a degradable stent in a porcine model of fecal peritonitis显示文摘 | Kun Liu Hong Yu Minghui Zhang Yichen Yu Yifan Wang Xiujun Cai | 2012 | International Journal of Colorectal Disease2012，，12： | 1 |
| 5 | Toward practical quantum key distribution using telecom components显示文摘The BB84 protocol[1],as the first and the most well-known quantum key distribution(QKD)protocol,has opened up an era of secure commu-nication using quantum methods,by providing information-theoretical secure key distribution[2].In the 2000s,continuous-variable QKD(CV-QKD)was proposed as an alternative approach,and it is now going through a booming period because of its compatibility with the tele-com industry[3]. | Hong Guo Zhengyu Li Song Yu Yichen Zhang | 2021 | Fundamental Research2021，1，1： | 1 |
| 6 | Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosis显示文摘 | Mei‐JieJou Tsung‐IPeng Pai‐ZuYu Shuo‐BinJou Russel J.Reiter Jin‐YiChen Hong‐YuehWu Chih‐ChunChen Lee‐FenHsu | 2007 | Journal of Pineal Research2007，，4： | 1 |
| 7 | Deep Active Learning for Solvability Prediction in Power Systems显示文摘Traditional methods for solvability region analysis can only have inner approximations with inconclusive conservatism and handle limited types of power flow models.In this letter,we propose a deep active learning framework for solvability prediction in power systems.Compared with passive learning where the training is performed after all instances are labeled,active learning selects most informative instances to be labeled and therefore significantly reduces the size of the labeled dataset for training.In the active learning framework,the acquisition functions,which correspond to different sampling strategies,are defined in terms of the on-the-fly posterior probability from the classifier.First,the IEEE 39-bus system is employed to validate the proposed framework,where a two-dimensional case is illustrated to visualize the effectiveness of the sampling method followed by the high-dimensional numerical experiments.Then,the Northeast Power Coordinating Council(NPCC)140-bus system is used to validate the performance on large-scale power systems. | Yichen Zhang Jianzhe Liu Feng Qiu Tianqi Hong Rui Yao | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，6： | 0 |
| 8 | Survey on rain removal from videos or a single image显示文摘Rain can cause performance degradation of outdoor computer vision tasks.Thus,the exploration of rain removal from videos or a single image has drawn considerable attention in the field of image processing.Recently,various deraining methodologies have been proposed.However,no comprehensive survey work has yet been conducted to summarize existing deraining algorithms and quantitatively compare their generalization ability,and especially,no off-the-shelf toolkit exists for accumulating and categorizing recent representative methods for easy performance reproduction and deraining capability evaluation.In this regard,herein,we present a comprehensive overview of existing video and single image deraining methods as well as reproduce and evaluate current state-of-the-art deraining methods.In particular,these approaches are mainly classified into model-and deep-learning-based methods,and more elaborate branches of each method are presented.Inherent abilities,especially generalization performance,of the state-of-the-art methods have been both quantitatively and visually analyzed through thorough experiments conducted on synthetic and real benchmark datasets.Moreover,to facilitate the reproduction of existing deraining methods for general users,we present a comprehensive repository with detailed classification,including direct links to 85 deraining papers,24 relevant project pages,source codes of 12 and 25 algorithms for video and single image deraining,respectively,5 and 10 real and synthesized datasets,respectively,and 7 frequently used image quality evaluation metrics,along with the corresponding computation codes.Research limitations worthy of further exploration have also been discussed for future research along this direction. | Hong WANG Yichen WU Minghan LI Qian ZHAO Deyu MENG | 2022 | Science China(Information Sciences)2022，65，1： | 0 |
| 9 | UAV search-and-rescue planning using an adaptive memetic algorithm显示文摘The use of unmanned aerial vehicles(UAVs) is becoming more commonplace in search-and-rescue tasks,but UAV search planning can be very complex due to limited response time, large search area, and multiple candidate search modes. In this paper, we present a UAV search planning problem where the search area is divided into a set of subareas and each subarea has a prior probability that the target is present in it. The problem aims to determine the search sequence of the subareas and the search mode for each subarea to maximize the probability of finding the target. We propose an adaptive memetic algorithm that combines a genetic algorithm with a set of local search procedures and dynamically determines which procedure to apply based on the past performance of the procedures measured in fitness improvement and diversity improvement during problem-solving. Computational experiments show that the proposed algorithm exhibits competitive performance compared to a set of state-of-the-art global search heuristics, non-adaptive memetic algorithms, and adaptive memetic algorithms on a wide set of problem instances. | Libin HONG Yue WANG Yichen DU Xin CHEN Yujun ZHENG | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，11： | 0 |
| 10 | New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway显示文摘Objective:To clarify the anti-depressive potential mechanisms of Kaixin Powder(KP),a drug that helps to prevent and treat depression and other mentaldiseases,from genome-wide transcriptome profiling.Methods:Transcriptome and KEGG pathway analysis were conducted on the hippocampus of depressed rats,then the differentially expressed genes were validated and serum concentration of lipid parameters were identified by enzymatic assays.Furthermore,high-fat diets induced depression-like behaviors in Syrian golden hamsters were conducted to verify the predicted molecular mechanisms acquired from the transcriptome analysis.Results:Transcriptome results revealed that the 24 differentially expressed genes(DEGs)in chronic mild stress(CMS)rats could be reversed after two weeks of KP treatment.The mechanisms of KP in treating depression firstly involved the regulation of several pathology modules,including lipid metabolism,synapse function and inflammation.KP could regulate imbalances of lipid homeostasis in high-fat diet induced depressive symptoms.Furthermore,it was validated that cholesterol metabolism dysfunction can be ameliorated by KP,which was correlated with upregulation of the AdipoR1-BDNF(brainderived neurotrophic factor)co-regulatory pathway.Conclusion:Taken together,our results demonstrated that KP not only alleviates depression via traditional mental illness targets,but it may also simulates the cholesterol metabolism and adiponectin signaling with multi-target characteristics. | Wenshan Yang Hong Yin Yichen Wang Yuanbo Wang Xia Li Chaochen Wang Ping Liu Yuan Hu | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 11 | The impact of posterior corneal astigmatism on the surgical planning of toric multifocal intraocular lens implantation显示文摘Purpose:To investigate the influence of posterior corneal astigmatism on the prediction accuracy of toric multifocal intraocular lens(IOL)calculation.Methods:The keratometric astigmatism measured by Lenstar LS 900(KCA_(L)),keratometric astigmatism(KCAp)and total corneal astigmatism(TCA)measured by Scheimpflug camera(Pentacam HR)were documented and analyzed accordingly.Three deduction models using different parameters were compared.Model 1:KCA_(L)+keratometric comeal surgically induced astigmatism(KCSIA,0.30 D@50°);Model 2:KCA_(P)+KCSIA);Model 3:TCA 4-total CSIA(TCSIA,0.23 D@50°).The prediction errors of each model as the difference vector between the actual and the intended residual astigmatism were compared.Results:Seventy-six eyes implanted with toric multifocal IOLs were included in this study.The vector differences of the actual KCSIA and TCSIA were statistically significant in the total sample and against-the-rule(ATR)subgroup(both P<0.05).Model 1 deduced the smallest mean values of prediction error,while that of Model 3 were smaller than that of Model 2,both in the total sample and the ATR subgroups(all P<0.05).Meanwhile,in the total sample and ATR subgroups,the centroid vector magnitudes of Model 3 were smaller than that of Model 1(0.31±0.76 D and 0.39±0.76 D).Conclusions:The calculation of toric multifocal IOL should be individualized especially in the ATR eyes for the impact of PCA on the estimation of the preoperative comeal astigmatism and the CSIA. | Shaochong Bu Yuanfeng Jiang Yichen Gao Xiaomei Bai Xiteng Chen Hong Zhang Fang Tian | 2023 | Advances in Ophthalmology Practice and Research2023，3，1： | 0 |
| 12 | Comparative Analysis of the Evolution of Community Space in Chengdu-Chongqing Region: A Case Study of Main Urban Areas in Chengdu and Chongqing显示文摘Due to the integrated development between Chengdu and Chongqing,there are a large number of residents flowing into the two cities from their surrounding areas,so community renewal is imminent.Because of the similarity in the historical and cultural background of the two places,a comparative analysis of the evolution of community space in Chengdu-Chongqing Region enables Chengdu and Chongqing learn from each other and speed up the pace of renewal.This paper analyzed the evolution of community space in main urban areas of Chengdu and Chongqing.Specifically,the evolution of community space in Chengdu and Chongqing went through three stages.The starting time of community renewal in the two places was very close,but the duration of each stage varied.The second stage of Chengdu continued for a longer time,so its renovation and renewal of the community space was more detailed and thorough,and the emphasis and extension direction of the evolution of the community space were different.The evolution of community space in both Chengdu and Chongqing went through'mechanical renewal of demolition and construction—small-scale gradual renewal',but the path of renewal and development of the community space in Chengdu was faster.This paper,from the perspective of the evolution of community space,put forward the framework and content of community renewal in Chengdu and Chongqing based on community development and elaborated the community research content based on community development. | GAO Wei XIAO Yue HE Yi GUO Zhenni LENG Qinyi LIU Hong KANG Yichen WANG Zhiye ZHU Zeliang WANG Jiamin ZHOU Xu CHAO Yi DONG Hailong MAO Xiao WANG Chensu | 2017 | Journal of Landscape Research2017，9，5： | 0 |
| 13 | Activation of peroxymonosulfate by FeVO_(3-x)for the degradation of carbamazepine:Vanadium mediated electron shuttle and oxygen vacancy modulated interface chemistry显示文摘Fast Fe(III)/Fe(II)circulation in heterogeneous peroxymonosulfate(PMS)activation remains as a bottleneck issue that restricts the development of PMS based advanced oxidation processes.Herein,we proposed a facile ammonia reduction strategy and synthesized a novel FeVO3-x catalysts to activate PMS for the degradation of a typical pharmaceutical,carbamazepine(CBZ).Rapid CBZ removal could be achieved within 10 min,which outperforms most of the other iron or vanadium-based catalysts.Electron paramagnetic resonance analysis and chemical probe experiments revealed SO_(4)^(·-),·OH,O_(2)^(·-)and high valent iron(Fe(IV))were all generated in this system,but SO4·-and Fe(IV)primarily contributed to the degradation of CBZ.Besides,X-ray photoelectron spectroscopy and X-ray adsorption spectroscopy indicated that both the generated low-valent V provides and oxygen vacancy acted as superior electron donors and accelerated internal electron transfer via the unsaturated V-O-Fe bond.Finally,the proposed system also exhibited satisfactory performance in practical applications.This work provides a promising platform in heterogeneous PMS activation. | Leiduo Lai Hongyu Zhou Yichen Hong Mengfan Luo Yang Shi Heng Zhang Zhaokun Xiong Gang Yao Bo Lai | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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