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| 1 | Ligustrazine monomer against cerebral ischemia/reperfusion injury显示文摘Ligustrazine(2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease.The mechanism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present.This study summarizes its protective effect,the optimum time window of administration,and the most effective mode of administration for clinical treatment of cerebral ischemia/reperfusion injury.We examine the effects of ligustrazine on suppressing excitatory amino acid release,promoting migration,differentiation and proliferation of endogenous neural stem cells.We also looked at its effects on angiogenesis and how it inhibits thrombosis,the inflammatory response,and apoptosis after cerebral ischemia.We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury.The time window of ligustrazine administration is limited.The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine,CXC137 and CXC195 after cerebral ischemia were better than ligustrazine. | Hai-jun Gao Peng-fei Liu Pei-wen Li Zhuo-yan Huang Feng-bo Yu Ting Lei Yong Chen Ye Cheng Qing-chun Mu Hai-yan Huang | 2015 | Neural Regeneration Research2015，10，5： | 48 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | The levels, sources and reactivity of volatile organic compounds in a typical urban area of Northeast China显示文摘Air concentrations of volatile organic compounds(VOCs) were continually measured at a monitoring site in Shenyang from 20 August to 16 September 2017. The average concentrations of alkanes, alkenes, aromatics and carbonyls were 28.54, 6.30, 5.59 and9.78 ppbv, respectively. Seven sources were identified by the Positive Matrix Factorization model based on the measurement data of VOCs and CO. Vehicle exhaust contributed the most(36.15%) to the total propene-equivalent concentration of the measured VOCs,followed by combustion emission(16.92%), vegetation emission and secondary formation(14.33%), solvent usage(10.59%), petrochemical industry emission(9.89%), petrol evaporation(6.28%), and liquefied petroleum gas(LPG) usage(5.84%). Vehicle exhaust, solvent usage and combustion emission were found to be the top three VOC sources for O_3 formation potential, accounting for 34.52%, 16.55% and 11.94%, respectively. The diurnal variation of the total VOCs from each source could be well explained by their emission characteristics,e.g., the two peaks of VOC concentrations from LPG usage were in line with the cooking times for breakfast and lunch. Wind rose plots of the VOCs from each source could reveal the possible distribution of the sources around the monitoring site. The O_3 pollution episodes during the measurement period were found to be coincident with the elevation of VOCs, which was mainly due to the air parcel from the southeast direction where petrochemical industry emission was found to be dominant, suggesting that the petrochemical industry emission from the southeast was probably a significant cause of O_3 pollution in Shenyang. | Zhuobiao Ma Chengtang Liu Chenglong Zhang Pengfei Liu Can Ye Chaoyang Xue Di Zhao Jichen Sun Yiming Du Fahe Chai Yujing Mu | 2019 | Journal of Environmental Sciences2019，31，5： | 12 |
| 4 | Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer显示文摘To flourish,cancers greatly depend on their surrounding tumor microenvironment(TME),and cancer-associated fibroblasts(CAFs)in TME are critical for cancer occurrence and progression because of their versatile roles in extracellular matrix remodeling,maintenance of sternness,blood vessel formation,modulation of tumor metabolism,immune response,and promotion of cancer cell proliferation,migration,invasion,and therapeutic resistance.CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta,phosphoinositide 3-kinase/AKT/mammalian target of rapamycin,mitogen-activated protein kinase,Wnt,Janus kinase/signal transducers and activators of transcription,epidermal growth factor receptor,Hippo,and nuclear factor kappa-light-chain-enhancer of activated B cells,etc.,signaling pathways.These signals in CAFs exhibit their own special characteristics during the cancer progression and have the potential to be targeted for anticancer therapy.Therefore,a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to fully realize the pivotal roles of CAFs in cancers.Herein,in this review,we will summarize the enormous amounts of findings on the signals mediating crosstalk of CAFs with cancer cells and its related targets or trials.Further,we hypothesize three potential targeting strategies,including,namely,epithelial-mesenchymal common targets,sequential target perturbation,and crosstalk-directed signaling targets,paving the way for CAF-directed or host cell-directed antitumor therapy. | Fanglong Wu Jin Yang Junjiang Liu Ye Wang Jingtian Mu Qingxiang Zeng Shuzhi Deng Hongmei Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 9 |
| 5 | Epidemiology of urticaria in China:a population-based study显示文摘Background:Urticaria is a common skin disease characterized by episodes of wheals,and it has a negative effect on patients’quality of life.Large-scale population-based epidemiological studies of urticaria are scarce in China.The aim of this survey was to determine the prevalence,clinical forms,and risk factors of urticaria in the Chinese population.Methods:This survey was conducted in 35 cities from 31 provinces,autonomous regions,and municipalities of China.Two to three communities in each city were selected in this investigation.Participants completed questionnaires and received dermatological examinations.We analyzed the prevalence,clinical forms,and risk factors of urticaria.Results:In total,44,875 questionnaires were distributed and 41,041 valid questionnaires were collected(17,563 male and 23,478 female participants).The lifetime prevalence of urticaria was 7.30%,with 8.26%in female and 6.34%in male individuals(P<0.05).The point prevalence of urticaria was 0.75%,with 0.79%in female and 0.71%in male individuals(P<0.05).Concomitant angioedema was found in 6.16%of patients.Adults had a higher prevalence of urticaria than adolescents and children.Living in urban areas,exposure to pollutants,an anxious or depressed psychological status,a personal and family history of allergy,thyroid diseases,and Helicobacter pylori infection were associated with a higher prevalence of urticaria.Smoking was correlated with a reduced risk of urticaria.Conclusion:This study demonstrated that the lifetime prevalence of urticaria was 7.30%and the point prevalence was 0.75%in the Chinese population;women had a higher prevalence of urticaria than men.Various factors were correlated with urticaria. | Jiaqing Li Dandan Mao Shuoshuo Liu Ping Liu Jing Tian Chenhong Xue Xiaojing Liu Ruiqun Qi Bingxue Bai Jianjun Nie Siqi Ye Yu Wang Yuye Li Qing Sun Juan Tao Shuping Guo Hong Fang Jianqin Wang Qiri Mu Quanzhong Liu Yan Ding Jianzhong Zhang | 2022 | Chinese Medical Journal2022，，11： | 6 |
| 6 | Toward emerging gallium oxide semiconductors:A roadmap显示文摘Owing to the advantages of ultra-wide bandgap and rich material systems,gallium oxide(Ga_(2)O_(3))has emerged as a highly viable semiconductor material for new researches.This article mainly focuses on the growth processes,material characteristics,and applications of Ga_(2)O_(3).Compared with single crystals and the epitaxial growth of other wide-bandgap semiconductors,large-size and high-quality��-Ga_(2)O_(3) single crystals can be efficiently grown with a low cost,making them highly competitive.Thanks to the availability of high-quality single crystals,epi-taxial films,and rich material systems,high-performance semiconductor devices based on Ga_(2)O_(3) go through a booming development in recent years.The defects and interfaces of Ga_(2)O_(3) are comprehensively analyzed owing to their significant influence on practical applications.In this study,the two most common applications of Ga_(2)O_(3) materials are introduced.The high breakdown electric field,high working temperature,and excellent Baliga’s figure-of-merit of Ga_(2)O_(3) represent an inspiring prospect for power electronic devices.In addition,the excellent absorption in deep-ultraviolet band provides new ideas for optoelectronic detectors and ensures the dramatic progress.Finally,the summary,challenges,and prospects of the Ga_(2)O_(3) materials and devices are presented and discussed. | Yuan Yuan Weibing Hao Wenxiang Mu Zhengpeng Wang Xuanhu Chen Qi Liu Guangwei Xu Chenlu Wang Hong Zhou Yanni Zou Xiaolong Zhao Zhitai Jia Jiandong Ye Jincheng Zhang Shibing Long Xutang Tao Rong Zhang Yue Hao | 2021 | Fundamental Research2021，1，6： | 5 |
| 7 | Capillary blood flow in patients with dysmenorrhea treated with acupuncture显示文摘OBJECTIVE: To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into variousTraditional Chinese Medicine(TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu(LI 4), adding other acupoints based on syndrome. Laser speckle was used to compare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu(LI 4) before and during the treatment. Each subject was required to finish the period pain symptoms observation form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxiety scale, and numerical rating scale before and after treatments. RESULTS: After 10 sessions, the symptom scores, pain index(PI), and visual analog scale(VAS) decreased significantly in treatment group. The volume of blood flow in Hegu(LI 4) declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vasomotor amplitude at Hegu(LI 4) increased remarkably. CONCLUSION: Acupuncture can increase the capillary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief. | Tao Huang Lijian Yang Shuyong Jia Xiang Mu Mozheng Wu Hang Ye Weizhe Liu Xinnong Cheng | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 8 | Deer Body Adaptive Threshold Segmentation Algorithm Based on Color Space显示文摘In large-scale deer farming image analysis,K-means or maximum between-class variance(Otsu)algorithms can be used to distinguish the deer from the background.However,in an actual breeding environment,the barbed wire or chain-link fencing has a certain isolating effect on the deer which greatly interferes with the identification of the individual deer.Also,when the target and background grey values are similar,the multiple background targets cannot be completely separated.To better identify the posture and behaviour of deer in a deer shed,we used digital image processing to separate the deer from the background.To address the problems mentioned above,this paper proposes an adaptive threshold segmentation algorithm based on color space.First,the original image is pre-processed and optimized.On this basis,the data are enhanced and contrasted.Next,color space is used to extract the several backgrounds through various color channels,then the adaptive space segmentation of the extracted part of the color space is performed.Based on the segmentation effect of the traditional Otsu algorithm,we designed a comparative experiment that divided the four postures of turning,getting up,lying,and standing,and successfully separated multiple target deer from the background.Experimental results show that compared with K-means,Otsu and hue saturation value(HSV)+K-means,this method is better in performance and accuracy for adaptive segmentation of deer in artificial breeding scenes and can be used to separate artificially cultivated deer from their backgrounds.Both the subjective and objective aspects achieved good segmentation results.This article lays a foundation for the effective identification of abnormal behaviour in sika deer. | Yuheng Sun Ye Mu Qin Feng Tianli Hu He Gong Shijun Li Jing Zhou | 2020 | Computers, Materials & Continua2020，，8： | 5 |
| 9 | Genetic variation of Ardisia crenata in south China revealed by nuclear microsatellite显示文摘Ardisia crenata Sims,one of the most widely distributed Ardisia in the world,is an important ornamental and medicinal plant species.Using seven polymorphic nuclear microsatellite loci,we studied the genetic variation of 20 natural populations of A.crenata across its distribution center in south China.Significant deviation from the Hardy–Weinberg equilibrium in all populations and at all loci were detected,and the fixation index was high (FIS=0.725),indicating that inbreeding may be dominant in the mixed mating system of this self-compatible species.The average genetic diversity within populations was relatively low(HS=0.321).There was significant genetic differentiation among populations(FST=0.583),which may have resulted from a high level of inbreeding and a low level of gene flow.Ardisia crenata in south China can be roughly divided into an eastern group and a western group,consistent with the floristic division of the Sino-Himalayan forest subkingdom and the Sino-Japanese forest subkingdom.There may be separated glacial refugia in each region. | Hong-Ping MU Lan HONG Hong-Lin CAO Zheng-Feng WANG Zhong-Chao LI Hao SHEN Zhang-Ming WANG Wan-Hui YE | 2010 | Journal of Systematics and Evolution2010，48，4： | 4 |
| 10 | Estimating global prevalence,incidence,and outcomes of nonalcoholic fatty liver disease from 2000 to 2021:systematic review and meta-analysis显示文摘Background:The increasing burden of non-alcoholic fatty liver disease(NAFLD)worldwide imposes an emerging public health issue.We perform the current study to estimate the global prevalence,incidence,disease progression,and clinical outcomes of NAFLD.Methods:A systematic search was conducted in Medline,Embase,Web of Science,Google Scholar,and Cochrane CENTRAL that screened articles in English language published from January 2000 to December 2021.NAFLD prevalence,incidence,rate of disease progression,and outcomes were calculated with the DerSimonian-Laird random effects model with arcsine transformation.Results:Our search identified 59,156 records,of which 578 studies fulfilled our inclusion criteria.The overall prevalence of NAFLD was 29.38%(95%confidence interval[CI]28.09-30.69)regardless of the diagnostic techniques.Looking at the group in which the diagnosis was made by ultrasound exclusively,the pooled prevalence was 30.49%(95%CI 29.55-31.43).NAFLD has become more prevalent during the year 2011-2021(31.63%,95%CI 30.23-33.04)compared with year 2000-2010(27.94%,95%CI 26.23-29.69).The pooled estimation of non-alcoholic steatohepatitis prevalence was 8.26%(95%CI 1.13-21.01),46.49%(95%CI 35.93-57.20),and 46.72%(95%CI 37.57-55.98)in general population,NAFLD patients,and severe/morbidly obese patients,respectively.Based on a total of 110,142 newly developed NAFLD patients,the pooled incident rate was estimated as 46.24 cases per 1000 person-years(95%CI 43.21-49.30).In patients with NAFLD,the incident rate of hepatocellular carcinoma was 1.46(95%CI 0.90-2.03)cases per 1000 person-years.The overall pooled estimate of NAFLD related mortality was 23.91(95%CI 13.55-37.18)death per 1000 person-years.Conclusions:The prevalence of NAFLD is increasing globally.It is contributing to poor clinical outcomes including hepatocellular carcinoma and death.Rising awareness and urgent actions are warranted to control the NAFLD pandemic across the globe.Registration:PROSPERO,No.CRD42020171104. | Jiaye Liu Ye Tian Xia Fu Chunyang Mu Menglin Yao Yinyun Ni Yong Liu Zhihui Li | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 11 | Angle-dependent discoloration structures in wing scales of Morpho menelaus butterfly显示文摘The Morpho butterfly is famous for its typical structural color and has increasingly attracted the interest of scholars in a wide variety of research fields. Herein, it was found that the color of Morpho menelaus butterfly wings is not only structure-based but also viewing-angle-dependent. Firstly, the discoloration effect of this typical butterfly was confirmed by a series of experiments. Then, the general form, arrangements, and geometrical dimensions of the scales were observed using a stereomicroscope. Scanning electron microscopy was also used to examine the two-dimensional morphologies and structures of a single scale. Afterwards, one model with the optimized three-dimensional profile of the structure was described using Pro-engineer software. The associate model was then analyzed to reconstruct the process between the incident light and the model surface. Finally, the mechanism of the angle-dependent discoloration effect was analyzed by theoretical calculation and optical simulation. Different light propagation paths and the length of the incident light at different angles caused destructive or constructive interference between the light reflected from the different layers. The different spectra of the reflected light make the wings appear with different structural colors, thereby endowing the angle-dependent discoloration effect. The consistency of the calculation and simulation results confirms that these structures possess an excellent angle-dependent discoloration effect. This functional 'biomimetic structure' would not only be of great scientific interest but could also have a great impact in a wide range of applications such as reflective displays, credit card security, and military stealth technology. | NIU ShiChao LI Bo YE JunFeng MU ZhengZhi ZHANG JunQiu LIU Yan HAN ZhiWu | 2016 | Science China(Technological Sciences)2016，59，5： | 4 |
| 12 | 3D direct writing and micro detonation of CL-20 based explosive ink containing O/W emulsion binder显示文摘The booming development of DIW technology present an unprecedented prospect in energetic materials field and has attracted great interest due to its relative simplicity and high flexibility of manufacturing.Herein,a novel CL-20 based explosive ink formulation have been developed successfully for MEMS initiation systems via DIW technology.We designed PVA/GAP into an oil-in-water(O/W)emulsion,in the way that the aqueous solution of PVA as water phase,the ethyl acetate solution of GAP as oil phase,the combination of Tween 80 and SDS as emulsifier,BPS as a curing agent of GAP.The ideal formulation with good shear-thinning rheology properties and clear gel point was prepared using only 10 wt%emulsion.The dual-cured network formed during the curing process made the printed sample have good mechanical properties.The printed samples had satisfactory molding effect without cracks or fractures,the crystal form of CL-20 not changed and the thermal stability have improved.Deposition of explosive inks via DIW in micro-scale grooves had excellent detonation performances,which critical detonation size was 1×0.045 mm,detonation velocity was 7129 m/s and when the corner reaching 150°can still detonated stably.This study may open new avenues for developing binder systems in explosive ink formulations. | Zhan-xiong Xie Chong-wei An Bao-yun Ye Jia-qing Mu Chun-yan Li Min-jie Li Song-jin Liu | 2022 | Defence Technology(防务技术)2022，18，8： | 4 |
| 13 | Ethylene Polymerization and Copolymerization with Polar Monomers by Benzothiophene-bridged BPMO-Pd Catalysts显示文摘A series of new bisphosphine-monoxide(BPMO)ligands based on benzothiophene backbone and the corresponding palladium complexes{k2-P(O)(Ph)2-3-PR1R2-C8H4S}PdMeCl{2a:R1=R2=Ph;2b:R1=R2=2-0Me-Ph;2c:R1=R2=2-CF3-Ph;2d:Rl=Ph,R2=2-(2',6'-(OMe)2C6Hz)-C6H4}were synthesized and fully characterized by1H-,13C-,31P-,and 2D-NMR spectroscopy and single-crystal X-ray dfraction.In the presence of Na+B[3,5-(CF3)2C6H3]4(NaBArF),these complexes showed very high activities(up to 2.0 x 10’g-mol-1.h-)for ethylene polymerization.More significantly,these catalysts enabled the copolymerization of ethylene with a broad scope of commercially available polar comonomers such as acrylates,acrylic acid,acrylonitrile,vinyltrialkoxysilane,allyl acetate,and long-chain 6-chloro-1-hexene to give functionalized polyethylene with reasonable catalytic activities(up to 105 g-mol-l.h-)and incorporations(up to 5.3 mol96).This contribution suggests that,besides the modulation of conventionally steric and electronic factors,the connectivity(at dfferent linking positions)of BPMO(P,O)donors to the heteroaryl backbone also greatly infuences the catalyst properties in terms of catalytic activity,polymer branching content,comonomer scope,and comonomer incorporation. | Hong-Liang Mu Jun-Hao Ye Guang-Lin Zhou Kang-Kang Li Zhong-Bao Jian | 2020 | Chinese Journal of Polymer Science2020，38，6： | 4 |
| 14 | A NUMERICAL MODEL OF FAR-FIELD COD CONCENTRATION DISTRIBUTION FOR NATURAL RIVER显示文摘A far field numerical model is developed to simulate jet pollution into natural rivers. Its character is to compute the velocity and pollution concentration separately. The velocity is computed by SIMPLEC algorithm in boundary fitted coordinate systems. The pollution concentration distribution is computed by developed QUAL IIm and QAIIL 2D program. The present model was applied to the Xiantao section of the Hanjiang River a tributary of Yangtze River, and Xiangjiang River. The flow field and COD distribution are in good agreement with field data. | Hou Guo xiang, Li Qi, Shi Zhong kun, Chen Cai kan Faculty of Traffic Sci. & Eng., Huazhong University of Science and Technology, Wuhan 430074, P.R.China Ye Ming, Deng Lian mu Yangtze Water Resources Protection Institute, Wuhan 430051, P.R.China | 2000 | Journal of Hydrodynamics2000，12，1： | 3 |
| 15 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 16 | Broadband photodetector of high quality SbS nanowire grown by chemical vapor deposition显示文摘Low dimensional semiconductors can be used for various electronic and optoelectronic devices because of their unique structure and property.In this work,one-dimensional Sb2 S3 nanowires(NWs)with high crystallinity were grown via chemical vapor deposition(CVD)technique on SiO2/Si substrates.The Sb2 S3 NWs exhibited needle-like structures with inclined cross-sections.The lengths of Sb2S3 nanowires changed from 7 to 13μm.The photodetection properties of Sb2 S3 nanowires were comprehensively and systematically characterized.The Sb2S3 photodetectors show a broadband photoresponse ranging from ultraviolet(360 nm)to near-infrared(785 nm).An excellent specific detectivity of 2.1×10^(14)Jones,high external quantum efficiency of 1.5×10^(4)%,sensitivity of 2.2×10^(4)cm^(2)W^(-1)and short response time of less than 100 ms was achieved for the Sb2 S3 NW photodetectors.Moreover,the Sb2S3 NWs showed outstanding switch cycling stability that was beneficial to the practical applications.The high-quality Sb2S3 nanowires fabricated by CVD have great application potential in semiconductor and optoelectronic fields. | Kun Ye Bochong Wang Anmin Nie Kun Zhai Fusheng Wen Congpu Mu Zhisheng Zhao Jianyong Xiang Yongjun Tian Zhongyuan Liu | 2021 | Journal of Materials Science & Technology2021，，16： | 3 |
| 17 | Serious BTEX pollution in rural area of the North China Plain during winter season显示文摘Atmospheric BTEX compounds(benzene, toluene, ethylbenzene and xylenes) in a rural site of the North China Plain(NCP) were preliminarily investigated in winter, and the outdoor concentrations(25.8–236.0 μg/m3) were found to be much higher than those reported in urban regions. The pollution of BTEX inside a farmer's house was even more serious, with combined concentrations of 254.5–1552.9 μg/m3. Based on the ratio of benzene to toluene(1.17 ± 0.34) measured, the serious BTEX pollution in the rural site was mainly ascribed to domestic coal combustion for heating during the winter season. With the enhancement of farmers' incomes in recent years, coal consumption by farmers in the NCP is rapidly increasing to keep their houses warm, and hence the serious air pollution in rural areas of the NCP during winter, including BTEX, should be paid great attention. | Kankan Liu Chenglong Zhang Ye Cheng Chengtang Liu Hongxing Zhang Gen Zhang Xu Sun Yujing Mu | 2015 | Journal of Environmental Sciences2015，27，4： | 2 |
| 18 | Stabilizing the black phase of cesium lead halide inorganic perovskite for efficient solar cells显示文摘Inorganic perovskite cesium lead halide is extensively studied because of its potential in improving the thermal stability of perovskite materials. However, the tolerance factor of this type of perovskite is near the critical value, which leads to phase instability. The optoelectronic active black phases(α,β, and γ phases of CsPbI3) are metastable at room temperature, which can be easily transferred into an optoelectronic inactive yellow phase(δ-CsPbI3). This review highlights recent progress in stabilizing the black phase for efficient and stable perovskite solar cells. | Qiufeng Ye Yang Zhao Shaiqiang Mu Pingqi Gao Xingwang Zhang Jingbi You | 2019 | Science China Chemistry2019，62，7： | 2 |
| 19 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 20 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
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