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| 1 | Characterization of Multi-scale Morphology and Superhydrophobicity of Water Bamboo Leaves and Biomimetic Polydi- methylsiloxane (PDMS) Replicas显示文摘 | Huiying Guan Zhiwu Han Huina Cao Shichao Niu Zhihui Qian Junfeng Ye Luquan Ren | 2015 | Journal of Bionic Engineering2015，12，4： | 8 |
| 2 | Plasmon enhancement for Vernier coupled single-mode lasing from ZnO/Pt hybrid microcavities显示文摘开发单个模式操作并且改进放射激光以便保证 microlasers 和 nanolasers 的实际适用性的表演是必要的。在这份报纸,有 ZnO microcomb 的改变的 nanoscaled 空气差距的二六角形的 microteeth 被用来构造联合耳语画廊洞。这被做完成没有要求任何复杂或复杂的操作完成与 nanoscale 精确放,基于游标效果放射激光的一个稳定的单个模式。光获得和相应紫外放射激光表演通过结合磅 nanoparticles 的局部性的表面电浆子极大地被改进。ZnO/Pt 混合 microcavities 完成了单个模式与更高的方面模式抑制比率和更低的阀值放射激光的紧张的七倍的改进。导致了这改进的机制详细被描述了。 | Yueyue Wang Feifei Qin Junfeng Lu Jitao Li Zhu Zhu Qiuxiang Zhu Ye Zhu Zengliang Shi Chunxiang Xu | 2017 | Nano Research2017，10，10： | 5 |
| 3 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 4 | Angle-dependent discoloration structures in wing scales of Morpho menelaus butterfly显示文摘The Morpho butterfly is famous for its typical structural color and has increasingly attracted the interest of scholars in a wide variety of research fields. Herein, it was found that the color of Morpho menelaus butterfly wings is not only structure-based but also viewing-angle-dependent. Firstly, the discoloration effect of this typical butterfly was confirmed by a series of experiments. Then, the general form, arrangements, and geometrical dimensions of the scales were observed using a stereomicroscope. Scanning electron microscopy was also used to examine the two-dimensional morphologies and structures of a single scale. Afterwards, one model with the optimized three-dimensional profile of the structure was described using Pro-engineer software. The associate model was then analyzed to reconstruct the process between the incident light and the model surface. Finally, the mechanism of the angle-dependent discoloration effect was analyzed by theoretical calculation and optical simulation. Different light propagation paths and the length of the incident light at different angles caused destructive or constructive interference between the light reflected from the different layers. The different spectra of the reflected light make the wings appear with different structural colors, thereby endowing the angle-dependent discoloration effect. The consistency of the calculation and simulation results confirms that these structures possess an excellent angle-dependent discoloration effect. This functional 'biomimetic structure' would not only be of great scientific interest but could also have a great impact in a wide range of applications such as reflective displays, credit card security, and military stealth technology. | NIU ShiChao LI Bo YE JunFeng MU ZhengZhi ZHANG JunQiu LIU Yan HAN ZhiWu | 2016 | Science China(Technological Sciences)2016，59，5： | 4 |
| 5 | In tegrative iTRAQ-based proteomic and transcriptomic analysis reveals the accumulation patter ns of key metabolites associated with oil quality during seed ripening of Camellia oleifera显示文摘Camellia oleifera(C.oleifera)is one of the four major woody oil-bearing crops in the world and has relatively high ecological,economic,and medicinal value.Its seeds undergo a series of complex physiological and biochemical changes during ripening,which is mainly manifested as the accumulation and transformation of certain metabolites closely related to oil quality,especially flavonoids and fatty acids.To obtain new insights into the underlying molecular mechanisms,a parallel analysis of the transcriptome and proteome profiles of C.oleifera seeds at different maturity levels was conducted using RNA sequencing(RNA-seq)and isobaric tags for relative and absolute quantification(iTRAQ)complemented with gas chromatography-mass spectrometry(GC-MS)data.A total of 16,530 transcripts and 1228 proteins were recognized with significant differential abundances in pairwise comparisons of samples at various developmental stages.Among these,317 were coexpressed with a poor correlation,and most were involved in metabolic processes,including fatty acid metabolism,a-linolenic acid metabolism,and glutathione metabolism.In addition,the content of total flavonoids decreased gradually with seed maturity,and the levels of fatty acids generally peaked at the fat accumulation stage;these results basically agreed with the regulation patterns of genes or proteins in the corresponding pathways.The expression levels of proteins annotated as upstream candidates of phenylalanine ammonia-lyase(PAL)and chalcone synthase(CHS)as well as their cognate transcripts were positively correlated with the variation in the flavonoid content,while shikimate O-hydroxycinnamoyltransferase(HCT)-(encoding genes had the opposite pattern.The increase in the abundance of proteins and mRNAs corresponding to alcohol dehydrogenase(ADH)was associated with a reduction in linoleic acid synthesis.Using weighted gene coexpression network analysis(WGCNA),we further identi fied six unique modules related to flavonoid,oil,and fatty acid anabolism that contained hub genes or proteins similar to transcription factors(TFs),such as MADS intervening keratin-like and C-terminal(MIKC_MAD s),type-B authentic response regulator(ARR-B),and basic helix-loop-helix(bH〔H).Finally,based on the known metabolic pathways and WGCNA combined with the correlation analysis,fi ve coexpressed transcripts and proteins composed of cinnamyl-alcohol dehyd rogenases(CADs),caffeicacid 3-O-methyltransferase(COMT),fl avonol synthase(FLS),and 4-coumarate:CoA ligaas(4CL)were screened out.With this exploratory multiomics dataset,our results presented a dynamic picture regarding the maturation process of C.oleifera seeds on Hainan Island,not only revealing the temporal specific expression of key candidate genes and proteins but also providing a scientific basis for the genetic improvement of this tree species. | Zhouchen Ye Jing Yu Wuping Yan Junfeng Zhang Dongmei Yang Guanglong Yao Zijin Liu Yougen Wu Xilin Hou | 2021 | Horticulture Research2021，8，1： | 3 |
| 6 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 7 | Electrochemical deposition of Au–Pt alloy particles with cauliflower-like microstructures for electrocatalytic methanol oxidation显示文摘 | Weichun Ye Huanhuan Kou Qinze Liu Junfeng Yan Feng Zhou Chunming Wang | 2011 | International Journal of Hydrogen Energy2011，，5： | 1 |
| 8 | CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis显示文摘 | Tianxia Jiang Jie Zhuang Hongxia Duan Yongting Luo Qiqun Zeng Kelong Fan Huiwen Yan Di Lu Zhongde Ye Junfeng Hao Jing Feng Dongling Yang Xiyun Yan | 2012 | Blood2012，，11： | 1 |
| 9 | Synthesis of ZnSnanoparticles via Hydrothermal process assisted by mi- croemulsion technique显示文摘 | Jun Liu Junfeng Ma Ye Liu | 2009 | Journal of Alloys and Compounds2009，489，12： | 1 |
| 10 | A method of estimating the Martian neutral atmospheric density at 130 km, and comparison of its results with Mars Global Surveyor and Mars Odyssey aerobraking observations based on the Mars Climate Database outputs显示文摘Profiles of the Martian dayside ionosphere can be used to derive the neutral atmospheric densities at 130 km,which can also be obtained from the Mars Climate Database(MCD)and spacecraft aerobraking observations.In this research,we explain the method used to calculate neutral densities at 130 km via ionosphere observations and three long-period 130-km neutral density data sets at northern high latitudes(latitudes>60°)acquired through ionospheric data measured by the Mars Global Surveyor(MGS)Radio Occultation Experiment.The calculated 130-km neutral density data,along with 130-km density data from the aerobraking observations of the MGS and Mars Odyssey(ODY)in the northern high latitudes,were compared with MCD outputs at the same latitude,longitude,altitude,solar latitude,and local time.The 130-km density data derived from both the ionospheric profiles and aerobraking observations were found to show seasonal variations similar to those in the MCD data.With a negative shift of about 2×10^10 cm^−3,the corrected 130-km neutral densities derived from MCD v4.3 were consistent with those obtained from the two different observations.This result means that(1)the method used to derive the 130-km neutral densities with ionospheric profiles was effective,(2)the MCD v4.3 data sets generally overestimated the 130-km neutral densities at high latitudes,and(3)the neutral density observations from the MGS Radio Science Experiment could be used to calibrate a new atmospheric model of Mars. | JunFeng Qin Hong Zou YuGuang Ye YongQiang Hao JinSong Wang Erling Nielsen | 2020 | Earth and Planetary Physics2020，4，4： | 1 |
| 11 | Template-free and direct electrochemical deposition of hierarchical dendritic gold microstructures: growth and their multiple applications显示文摘 | YE Weichun Y AN Junfeng YE Qian | 2010 | J Phys Chem C2010，114，15： | 1 |
| 12 | Activity maintenance of the excised branches and a case study of NO_2 exchange between the atmosphere and P.nigra branches显示文摘The efficient maintenance of the activity of excised branches is the powerful guarantee to accurately determine gas exchange flux between the detached branches of tall trees and the atmosphere. In this study, the net photosynthetic rate(NPR) of the excised branches and branches in situ were measured simultaneously by using two photosynthetic instruments to characterize the activity of the excised branches of Phyllostachys nigra. The ratio of normalized NPR of excised branches to NPR in situ was used to assess the photosynthetic activity of detached branches. Based on photosynthetic activity, an optimal hydroponics protocol for maintaining activity of excised P. nigra branches was presented:1/8 times the concentration of Gamborg B5 vitamin mixture with p H = 6. Under the best cultivation protocol, photosynthetic activity of excised P. nigra branches could be maintained more than 90% within 6 hr in the light intensity range of 200–2000 μmol/(m2·sec) and temperature range of 13.4–28.7°C. The nitrogen dioxide(NO2) flux differences between in situ and in vitro branches and the atmosphere were compared using double dynamic chambers.Based on the maintenance method of excised branches, the NO2 exchange flux between the excised P. nigra branches and the atmosphere(from-1.01 to-2.72 nmol/(m2·sec) was basically consistent with between the branches in situ and the atmosphere(from-1.12 to-3.16 nmol/(m2 sec)) within 6 hr. Therefore, this study provided a feasible protocol for in vitro measurement of gas exchange between tall trees and the atmosphere for a period of time. | Chun Chen Yuzheng Wang Yuanyuan Zhang Xiaoxiu Lun Chengtang Liu Yujing Mu Chenglong Zhang Pengfei Liu Chaoyang Xue Min Song Can Ye Junfeng Liu | 2019 | Journal of Environmental Sciences2019，31，6： | 1 |
| 13 | Numerical study on the laser ablative Rayleigh-Taylor instability显示文摘The laser ablative Rayleigh-Taylor instability plays an important role in the ignition of inertial refinement fusion.An accurate simulation of this process is important to control the growth of flow instability during the implosion.In this paper,taking the simulations of the hydrodynamics,the laser energy deposition and the electronic thermal conductivity into consideration,a massively parallel laser ablative Rayleigh-Taylor instability code based on Euler method is developed.Some open source codes are used to improve the code development efficiency.The accuracy of the hydrodynamics simulation is tested by an analytical theory about the weakly nonlinear Rayleigh-Taylor instability with double interfaces.The benchmark of an one dimensional heat conductivity is used to test the accuracy of the thermal conductivity simulation.The laser ablative plane target and the laser ablative Rayleigh-Taylor instability are used to test the reliability of the code on the simulation of the whole laser ablative process.It is shown that the confidence of our numerical simulation code is high and the code framework we designed is effective.It can be a basis on studying the problems about the laser ablative instability in inertial refinement fusion. | Zhiyuan Li Lifeng Wang Junfeng Wu Wenhua Ye | 2020 | Acta Mechanica Sinica2020，36，4： | 1 |
| 14 | Afamily of dual-phase-combined zero-current switchingswitched-capacitor converters 显示文摘 | Ye Yuanmao Cheng K W E Liu Junfeng | 2014 | IEEE Transactions onPower Electronics2014，29，8： | 1 |
| 15 | Early Cretaceous intermediate-mafic dykes in the Dabie orogen, eastern China: Petrogenesis and implications for crust-mantle interaction 显示文摘 | Xu Haijin Ma Changqian Song Yanru Zhang Junfeng Ye Kai | 2012 | Lithos2012，154，： | 1 |
| 16 | Advanced Process and Electron Device Technology显示文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years. | Dan Zhang Xiaojing Su Hao Chang Hao Xu Xiaolei Wang Xiaobin He Junjie Li Fei Zhao Qide Yao Yanna Luo Xueli Ma Hong Yang Yongliang Li Zhenhua Wu Yajuan Su Tao Yang Yayi Wei Anyan Du Huilong Zhu Junfeng Li Huaxiang Yin Jun Luo Tianchun Ye Wenwu Wang | 2022 | Tsinghua Science and Technology2022，27，3： | 1 |
| 17 | Dynamic heterogeneity of colorectal cancer during progression revealed clinical risk-associated cell types and regulations in single-cell resolution and spatial context显示文摘Background:Tumor heterogeneity is contributed by tumor cells and the microenvironment.Dynamics of tumor heterogeneity during colorectal cancer(CRC)progression have not been elucidated.Methods:Eight single-cell RNA sequencing(scRNA-seq)data sets of CRC were included.Milo was utilized to reveal the differential abundance of cell clusters during progression.The differentiation trajectory was imputed by using the Palantir algorithm and metabolic states were assessed by using scMetabolism.Three spatial transcription sequencing(ST-seq)data sets of CRC were used to validate cell-type abundances and colocalization.Cancer-associated regulatory hubs were defined as communication networks affecting tumor biological behaviors.Finally,quantitative reverse transcription polymerase chain reaction and immunohistochemistry staining were performed for validation.Results:TM4SF1t,SOX4t,and MKI67t tumor cells;CXCL12t cancer-associated fibroblasts;CD4t resident memory T cells;Treg;IgAt plasma cells;and several myeloid subsets were enriched in stage IV CRC,most of which were associated with overall survival of patients.Trajectory analysis indicated that tumor cells from patients with advanced-stage CRC were less differentiated,when metabolic heterogeneity showed a highest metabolic signature in terminal states of stromal cells,T cells,and myeloid cells.Moreover,ST-seq validated cell-type abundance in a spatial context and also revealed the correlation of immune infiltration between tertiary lymphoid structures and tumors followed by validation in our cohort.Importantly,analysis of cancer-associated regulatory hubs revealed a cascade of activated pathways including leukocyte apoptotic process,MAPK pathway,myeloid leukocyte differentiation,and angiogenesis during CRC progression.Conclusions:Tumor heterogeneity was dynamic during progression,with the enrichment of immunosuppressive Treg,myeloid cells,and fibrotic cells.The differential state of tumor cells was associated with cancer staging.Assessment of cancer-associated regulatory hubs suggested impaired antitumor immunity and increased metastatic ability during CRC progression. | Haoxian Ke Zhihao Li Peisi Li Shubiao Ye Junfeng Huang Tuo Hu Chi Zhang Ming Yuan Yuan Chen Xianrui Wu Ping Lan | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 18 | SNX16通过独特的膜结合和货物蛋白识别机制调节钙粘蛋白E-cadherin的循环转运显示文摘文章简介上皮细胞钙粘蛋白E-cadherin在胚胎发育、肿瘤发展和细胞编程中都发挥重要作用。然而,对于E-cadherin在细胞内的分选转运,尤其是E-cadherin被内吞后重新回到细胞表面的循环转运机制仍不清楚。 | Jinxin Xu Leilei Zhang Yinghua Ye Yongli Shan Chanjuan Wan Junfeng Wang Duanqing Pei 舒晓东 刘劲松 | 2018 | 科学新闻2018，0，4： | 0 |
| 19 | A cross-type imaging electron spectrometer显示文摘Energetic electron measurement is of great significance to theoretical space physics research and space weather applications.Current energetic electron detectors must cooperate with a spin-stabilized satellite platform to achieve high angular resolution in pitch angle distribution and three-dimensional(3D)imaging measurement of energetic electrons.This article introduces a cross-type quasi-3D imaging electron spectrometer(IES)based on pinhole imaging technology developed in the laboratory.The imager is composed of five imaging units,including a nine-pixel area array Si-PIN detector imaging unit in the middle and four three-pixel linear array Si-PIN detector imaging units placed in a cross-shape around it.The combination of five imaging units forms two orthogonal nine-pixel linear array detectors(with a common pixel in the middle).There are four pixels with a view angle of 20°×20°in the 45°oblique directions of the cross-type detection array.There are 21 imaging pixels in the entire crosstype sensor head,corresponding to 21 directions.Two multichannel integrated preamplifier ASICs are integrated in the sensor head to realize particle signal readout from 21 pixels.With a back-end electronics system,each pixel can achieve high energy resolution detection of 50–600 keV electrons.Radioactive sources and electron accelerators are used to calibrate the cross-type imaging sensor head,and the results demonstrate its good energy and directional detection characteristics(the energy resolution reaches 6.9 keV for the incident 200 keV electron beam).We performed simulations on the imaging sensor head’s ability to measure the electron pitch angle distribution on the three-axis stabilized platform,and the results show that the sensor head can perform quasi-three-dimensional detection of electrons incident within 2πsolid angles on the three-axis stabilized satellite platform,with an average angular resolution of the electron pitch angle distribution of less than 6°. | YE YuGuang ZOU Hong WANG YongFu QIN JunFeng SHI WeiHong ZOU JiQing ZHONG WeiYing ZONG QiuGang FU SuiYan | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 20 | Comprehensive Model Construction and Simulation for Superconducting Electrodynamic Suspension Train显示文摘With the advantages of levitation/guidance self-stability,large levitation gap,and high lift-to-drag ratios,superconducting electrodynamic suspension(SC-EDS)train is becoming a viable candidate for the high-speed and ultra-high-speed rail transportation.In order to provide the basis for designing the optimization and control strategy,this paper establishes a comprehensive model for the SC-EDS train,which considers the dynamics of the bogie and car body in all directions.The obtained model reveals the complex coupling and feedback relationships among the variables,which cannot be described by the existing local models of the SC-EDS train.Simulation examples under different parameters and initial conditions are presented and discussed to demonstrate the potential use of the model given in this paper. | Linfeng Liu Hao Ye Wei Dong Junfeng Cui | 2023 | Complex System Modeling and Simulation2023，3，3： | 0 |
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