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| 1 | Effects of electroacupuncture at Guanyuan(CV 4)or Sanyinjiao(SP 6)on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice显示文摘OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8(SAMP8)were divided into three groups: the disease model,EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1(SAMR1)were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone(FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determinethe HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze(MWM) test.RESULTS:(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels(P < 0.01), and an increase in Gn RH, LH and FSH levels(P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group(P < 0.05). In contrast,Gn RH and LH and FSH levels were reduced(P <0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining Gn RH levels(P < 0.01).(b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day5 compared with the disease model group(P <0.05), whereas the EA-Guanyuan treatment group showed no significant difference.CONCLUSION: EA can regulate hormone(E2, FSH,LH, Gn RH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory. | Wang Jing Cheng Kai Qin Zhuo Wang Yanping Zhai Lijing You Min Wu Juanjiao | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 8 |
| 2 | Regulation of non-classical immune parameters in immune thrombocytopenic purpura mice by a spleen-invigorating,qi-replenishing and blood-containing formula显示文摘Objective:This study investigated the regulatory effect of non-classical immune parameters on immune thrombocytopenic purpura(ITP)mice by a spleen-invigorating,qi-replenishing and blood-containing formula(SQBF).Method:A total of 80 BALB/c mice were randomly divided into four equal groups(20 mice each):control group,model group,prednisone group and spleen-invigorating,qi-replenishing and blood-containing(SQBF)group.Mice in the model group,prednisone group,and SQBF group were administered anti-platelet serum to induce ITP.The dynamic variations of platelet counts in ITP mice were measured with an automatic blood analyzer before modeling and 48 h,and 8,12 and 15 days following APS injection.Levels of b-endorphin(b-EP),vasoactive intestinal peptide(VIP)and salivary IgA(SIgA)were detected by enzyme-linked immunosorbent assay(ELISA)on 15th day of experiment.Results:SQBF enhanced peripheral blood platelet counts in ITP mice similar to that of prednisone,and both groups showed a statistically significant response compared with the model group(P<.01).The SQBF significantly decreased b-EP levels compared with the model and prednisone intervention groups(P<.05),significantly increased the levels of VIP and SIgA in ITP mice compared with the model group(P<.05)and had significant protective effects on the thymus of ITP mice compared with the model group(P<.01).Conclusions:The SQBF had a similar effect to prednisone with regards to enhancing peripheral blood platelet counts in ITP mice.Furthermore,it decreased b-EP levels and increased VIP and SIgA,and protected the thymus.This shows that,on base of the brain-gut axis functions,some non-classical immune vascular active factors or neurotransmitters are also involved in immune responses,and also have relationship with the onset of ITP and bleeding and/or hemostasis.It needs further study to determine whether a change in these active factors is related to immediate hemostasis. | Tiantian Li Hao He Li Hou Yue Xu Xiaoyong Wu Yanping Sun Lei Zheng Zhixiong Chen Xinyi Chen Bei Qin | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，2： | 6 |
| 3 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 4 | TWO IMPROVED ALGORITHMS AND IMPLEMENTATION FOR A SINGULARLY PERTURBED PROBLEM ON MOVING MESHES显示文摘这份报纸把一个差别计划用于一个不可思议地使不安的问题。作者由使用能改进数字答案的精确性的理查森推测在动人的网孔方法上提供二个算法。在动人的网孔的传统的算法,起始的网孔是一个一致网孔。作者把它改变到 Bakhvalov-Shishkin 网孔,并且证明它由数字实验改进效率。最后,二个算法的结果被分析。 | Qin ZHOU Yanping CHEN Yin YANG | 2011 | Journal of Systems Science & Complexity2011，24，6： | 4 |
| 5 | Selective recovery of Cu^2+ and Ni^2+ from wastewater using bioelectrochemical system显示文摘作为 bioelectrochemical 系统,微生物引起的燃料房间(MFC ) 和微生物引起的电解房间(MEC ) 被开发有选择地恢复 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” > 从废水的 2+ 个 离子。废水在系统的阴极房间被对待,在哪个 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” >2+ 个 离子被分别地使用 MFC 和 MEC 移开。在起始的 Cu < 啜 class= “ a-plus-plus ” > 500 mg 瀠牥散瑮条 ? 景漠瑵異 ? 慶畬 ? 景椠摮獵牴 ? 湩敶瑳摥戠 ? 的 2+ 集中潈杮? 湯 ?? 捡潡 ? 慔睩湡愠摮愠牢慯? 攠敮杲 ? 牰捩 ? 湡 ? 湩敶瑳敭瑮漠 ? 諗棔娹驺硴超 _ 捥湨汯杯捩污愠瑣癩瑩敩 ? 潦 ? 湩畤瑳祲挠畯摬戠 ? 潰獳扩敬挠湯牴扩瑵牯 ? 湡 ? 牤癩牥 ? 潴琠敨椠摮獵牴慩? 湥牥祧攠晦捩敩据? | Haiping LUO Bangyu QIN Guangli LIU Renduo ZHANG Yabo TANG Yanping HOU | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 4 |
| 6 | A novel method for evaluating the dynamic biocompatibility of degradable biomaterials based on real-time cell analysis显示文摘Degradable biomaterials have emerged as a promising type of medical materials because of their unique advantages of biocompatibility,biodegradability and biosafety.Owing to their bioabsorbable and biocompatible properties,magnesium-based biomaterials are considered as ideal degradable medical implants.However,the rapid corrosion of magnesium-based materials not only limits their clinical application but also necessitates a more specific biological evaluation system and biosafety standard.In this study,extracts of pure Mg and its calcium alloy were prepared using different media based on ISO 10993:12;the Mg^2+ concentration and osmolality of each extract were measured.The biocompatibility was investigated using the MTT assay and xCELLigence real-time cell analysis(RTCA).Cytotoxicity tests were conducted with L929,MG-63 and human umbilical vein endothelial cell lines.The results of the RTCA highly matched with those of the MTT assay and revealed the different dynamic modes of the cytotoxic process,which are related to the differences in the tested cell lines,Mg-based materials and dilution rates of extracts.This study provides an insight on the biocompatibility of biodegradable materials from the perspective of cytotoxic dynamics and suggests the applicability of RTCA for the cytotoxic evaluation of degradable biomaterials. | Xiaoxiao Gai Chenghu Liu Guowei Wang Yang Qin Chunguang Fan Jia Liu Yanping Shi | 2020 | Regenerative Biomaterials2020，7，3： | 3 |
| 7 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
| 8 | Tetrapioid induction of Crassostrea hongkongensis and C.sikamea by inhibiting the polar body 1 release in diploid fertilized eggs显示文摘The production of an all-triploid population by mating tetrapioid males with diploid females is the best and most fundamental method for the large-scale production of triploid oysters.Obtaining a stable tetrapioid population is essential for guaranteed production in industrialized triploid cultivation.C.hongkongensis and C.sikamea are important oyster breeding species in southern China,and have great economic value.However,there are not any published data on inducing tetrapioid C.hongkongensis or C.sikamea.Therefore,we investigated tetrapioid induction in these two oyster species by inhibiting the PB1 release in diploid fertilized eggs using Cytochalasin B(CB)under 31℃,15%o salinity.The results confirmed that the optimal tetrapioid induction conditions for C.hongkongensis were a CB concentration of 0.50 mg/L with induction starting at 9.0 min after fertilization,and stopping at 21.0 min after fertilization;the induction efficiency index reached 0.123 under these conditions.The optimal tetrapioid induction conditions for C.sikamea were a CB concentration of 0.50 mg/L,with induction starting at 7.5 min after fertilization and stopping at 18 min after fertilization;the induction efficiency index could be as high as 0.281 under these conditions.However,we confirmed that the tetrapioid rate decreased with larval growth,and no tetrapioids were detected in the juvenile period of either C.hongkongensis or C.sikamea.This may be attributed to the very low survival of the tetrapioid larvae induced by this method,especially as most tetrapioid larvae died during the first three days.In summary,it is simple to directly induce tetrapioid C.hongkongensis and C.sikamea larvae by inhibiting the PB1 release of diploid zygotes,but the low survival rate makes it challenging to obtain viable juvenile tetrapioids. | Yanping Qin Zohaib Noor Xingyou Li Yuehuan Zhang Ziniu Yu Haitao Ma Jun Li Yinyin Zhou Riguan Mo | 2021 | Marine Life Science & Technology2021，3，4： | 1 |
| 9 | Ca^(2+)-dependent TaCCD1 cooperates with TaSAUR215 to enhance plasma membrane H^(+)-ATPase activity and alkali stress tolerance by inhibiting PP2C-mediated dephosphorylation of TaHA2 in wheat显示文摘Alkali stress is a major constraint for crop production in many regions of saline-alkali land.However,little is known about the mechanisms through which wheat responds to alkali stress.In this study,we identified a calcium ion-binding protein from wheat,TaCCD1,which is critical for regulating the plasma membrane(PM)H^(+)-ATPase-mediated alkali stress response.PM H+-ATPase activity is closely related to alkali tolerance in the wheat variety Shanrong 4(SR4).We found that two D-clade type 2C protein phosphatases,TaPP2C.D1 and TaPP2C.D8(TaPP2C.D1/8),negatively modulate alkali stress tolerance by dephosphorylating the penultimate threonine residue(Thr926)of TaHA2 and thereby inhibiting PM H+-ATPase activity.Alkali stress induces the expression of TaCCD1 in SR4,and TaCCD1 interacts with TaSAUR215,an early auxin-responsive protein.These responses are both dependent on calcium signaling triggered by alkali stress.TaCCD1 enhances the inhibitory effect of TaSAUR215 on TaPP2C.D1/8 activity,thereby promoting the activity of the PM H^(+)-ATPase TaHA2 and alkali stress tolerance in wheat.Functional and genetic analyses verified the effects of these genes in response to alkali stress,indicating that TaPP2C.D1/8 function downstream of TaSAUR215 and TaCCD1.Collectively,this study uncovers a new signaling pathway that regulates wheat responses to alkali stress,in which Ca^(2+)-dependent TaCCD1 cooperates with TaSAUR215 to enhance PM H+-ATPase activity and alkali stress tolerance by inhibiting TaPP2C.D1/8-mediated dephosphorylation of PM H+-ATPase TaHA2 in wheat. | Minghan Cui Yanping Li Jianhang Li Fengxiang Yin Xiangyu Chen Lumin Qin Lin Wei Guangmin Xia Shuwei Liu | 2023 | Molecular Plant2023，16，3： | 1 |
| 10 | Investigation of the structural, electronic and mechanical properties of CaO–SiO_(2) compound particles in steel based on density functional theory显示文摘CaO–SiO_(2)compounds compromise one of the most common series of oxide particles in liquid steels, which could significantly affect the service performance of the steels as crack initiation sites. However, the structural, electronic, and mechanical properties of the compounds in CaO–SiO_(2)system are still not fully clarified due to the difficulties in the experiments. In this study, a thorough investigation of these properties of CaO–SiO_(2)compound particles in steels was conducted based on first-principles density functional theory. Corresponding phases were determined by thermodynamic calculation, including gamma dicalcium silicate(γ-C2S), alpha-prime(L) dicalcium silicate(αL′-C2S), alpha-prime(H) dicalcium silicate(αH′-C2S), alpha dicalcium silicate(α-C2S), rankinite(C3S2), hatrurite(C3S), wollastonite(CS), and pseudowollastonite(Ps-CS). The results showed that the calculated crystal structures of the eight phases agree well with the experimental results. All the eight phases are stable according to the calculated formation energies, and γ-C2S is the most stable. O atom contributes the most to the reactivity of these phases. The Young’s modulus of the eight phases is in the range of 100.63–132.04 GPa. Poisson’s ratio is in the range of0.249–0.281. This study provided further understanding concerning the CaO–SiO_(2)compound particles in steels and fulfilled the corresponding property database, paving the way for inclusion engineering and design in terms of fracture-resistant steels. | Chao Gu Ziyu Lyu Qin Hu Yanping Bao | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 1 |
| 11 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 12 | Trends of SARS-CoV-2 Infection in Rural Area in Sentinel Community-Based Surveillance——China,December 2022 to January 2023显示文摘Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and evaluate trends of SARS-CoV-2 infection in rural China among the community population.Methods:Data on SARS-CoV-2 infection among approximately 90,000 participants in rural China were collected by the National Sentinel Community-Based Surveillance(NSCS)system.Participants were tested for SARS-CoV-2 infection(defined as positive for SARS-CoV-2 nucleic acid or antigen)twice weekly from December 16,2022 to January 12,2023.The daily average of newly positive rate and its estimated daily percentage change were calculated to describe the national and regional trends of SARS-CoV-2 infection in rural China.Results:In rural China,the daily average new positive rate of SARS-CoV-2 infection peaked at 4.79%between December 20–22,2022 and then decreased to 0.57%between January 10–12,2023,with an average decrease of 29.95%per round.The peak of new SARS-CoV-2 infection was slightly earlier and lower in North China(5.28%between December 20–22,2022)than in South China(5.63%between December 23–26,2022),and then converged from December 30,2022 to January 2,2023.The peak of 6.09%occurred between December 20–22,2022 in eastern China,while the peak of 5.99%occurred later,between December 27–29,2022,in central China.Conclusions:Overall,the epidemic wave in rural China peaked between December 20–22,2022,and passed quickly following the optimization of prevention and control measures.Currently,SARSCoV-2 infection in community populations in rural China is sporadic. | Wenzhan Jing Fan Ding Yanping Zhang Guoqing Shi Jue Liu Yu Wu Fangyuan Li Wenxin Yan Chenyuan Qin Min Liu Qun Li Wannian Liang | 2023 | China CDC weekly2023，5，11： | 1 |
| 13 | Genome-wide analysis of primary auxin-responsive Aux/IAA gene family in maize (Zea mays. L.)显示文摘 | Yijun Wang Dexiang Deng Yunlong Bian Yanping Lv Qin Xie | 2010 | Molecular Biology Reports2010，，8： | 1 |
| 14 | Reference design of ICRF antenna for EAST显示文摘 | QIN Chengming ZHAO Yanping HIROYUKI O | 2006 | Plasma Sci Technol2006，8，： | 1 |
| 15 | Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model显示文摘 | Jiyang Jin Gaojun Teng Yi Feng Yanping Wu Qindi Jin Yu Wang Zhen Wang Qin Lu Yibo Jiang Shengqi Wang Feng Chen Guy Marchal Yicheng Ni | 2007 | CardioVascular and Interventional Radiology2007，，2： | 1 |
| 16 | Comparison of the removal of monovalent and divalent cations in the microbial desalination cell显示文摘微生物引起的脱盐房间(MDC ) 是一种有希望的技术脱盐水并且同时产生电力。这研究的目的是在 MDC 调查一价、二价的阳离子的脱盐表演,并且讨论离子特征,离子集中,和电的特征的效果。NaCl 的混合的盐答案, MgCl < 潜水艇 class= “ a-plus-plus ” > 2 , KCl,和 CaCl < 潜水艇 class= “ a-plus-plus ” > 有一样的集中的 2 在脱盐房间被使用学习阳离子的移动。结果证明在混合的盐答案,阳离子的电渗析脱盐率是:Ca < 啜 class= “ a-plus-plus ” >2+> Mg < 啜 class= “ a-plus-plus ” >2+> Na < 啜 class= “ a-plus-plus ” >+> K < 啜 class= “ a-plus-plus ” >+ 。更高离子的费用和更小的含水的离子的半径导致了阳离子,离子的费用在比含水的离子的半径更重要的更高的脱盐率。NaCl 和 MgCl 的混合答案 < 潜水艇 class= “ a-plus-plus ” > 有不同集中的 2 在脱盐房间被使用学习离子集中的效果。结果看了那什么时候 Na 的离子集中 < 啜 class= “ a-plus-plus ” >+ 是五分之一个到五次 Mg < 啜 class= “ a-plus-plus ” >2+, 离子集中比电渗析更深刻地影响了分离。与在某个值下面的当前的密度,费用转移效率变得很低,分离是为脱盐负责的主要进程。并且从阳极房间的磷酸盐转移和从阴极房间的钾转移能在 MDC 平衡费用转移的 1%3% 。 | Shanshan CHEN Haiping LUO Yanping HOU Guangli LIU Renduo ZHANG Bangyu QIN | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 1 |
| 17 | DOW CORNING 1-2577 Conformal Coating as an efficient diffusion material for cathode in the microbial fuel cell显示文摘在这研究, DOW CORNING 1-2577 保角的涂层为微生物引起的燃料房间(MFC ) 的阴极散开层被建议。在 MFC,不锈钢网孔阴极使用 DOW CORNING 1-2577 是的保角的涂层 / 碳散开层并且二 poly (dimethylsiloxane )(PDMS ) 有四的 /carbon 散开层和碳布阴极(tetrafluoroethylene )(PTFE ) poly,散开层为比较被构造。在一样的运作的条件下面,有 DOW CORNING 1-2577 的 MFC 保角的涂层 / 碳散开层生产了 1585 | Yanping HO~ Haiping LUO Guangli LIU Renduo ZHANG Yong LUO Bangyu QIN Shanshan CHEN | 2013 | Frontiers of Environmental Science & Engineering2013，7，4： | 1 |
| 18 | Using Traveltime Tomography to Reconstruct Electrical Conductivity显示文摘UsingTraveltimeTomographytoReconstructElectricalConductivityMaNing,HuZhengyi,CaiQin,WangYanpingColegeofElectronicInformation... | Ma Ning Hu Zhengyi Cai Qin Wang Yanping | 1997 | Wuhan University Journal of Natural Sciences1997，2，1： | 0 |
| 19 | Trends of SARS-CoV-2 Infection in Sentinel Community-Based Surveillance After the Optimization of Prevention and Control Measures—China,December 2022-January 2023显示文摘Introduction:On December 7,2022,China implemented the“Ten New Measures”to optimize its prevention and control measures for coronavirus disease 2019(COVID-19).To provide the latest data after the optimization,we evaluated trends of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection among the community population in China.Methods:We utilized data from the National Sentinel Community-Based Surveillance(NSCS)system in China to assess trends of SARS-CoV-2 infection.NSCS is a national community-based surveillance cohort with 0.42 million participants from all 31 provincial-level administrative divisions(PLADs)and Xinjiang Production and Construction Corps(XPCC).Participants were tested for infection twice a week(a total of eight rounds)from December 16,2022 to January 12,2023.SARS-CoV-2 infection was defined as testing positive for SARS-CoV-2 nucleic acid or antigen.We calculated the daily average of newly positive rates of SARS-CoV-2 infection.Results:In this national cohort,the daily average newly positive rate of SARS-CoV-2 infection decreased from 4.13% in Round 1(December 16-19,2022)to 0.69% in Round 8(January 10-12,2023).The epidemic peak occurred in Round 2(December 20-22,2022).Similar trends were observed in urban areas(decreasing from 4.65% to 0.73%),rural areas(decreasing from 2.83% to 0.57%),the eastern region(decreasing from 4.18% to 0.67%),the central region(decreasing from 5.43% to 0.61%),and the western region(decreasing from 3.01%to 0.77%).Conclusions:NSCS data showed that the peak of SARS-CoV-2 infection in China had passed.SARSCoV-2 infection in community populations in China is currently at a low epidemic level. | Jue Liu Fan Ding Yu Wu Wenzhan Jing Wenxin Yan Chenyuan Qin Fangyuan Li Yanping Zhang Min Liu Wannian Liang Qun Li | 2023 | China CDC weekly2023，5，7： | 0 |
| 20 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
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