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| 1 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 2 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 3 | Fast approximate matching of binary codes with distinctive bits显示文摘 | Chenggang Clarence YAN Hongtao XIE Bing ZHANG Yanping MA Qiong DAI Yizhi LIU | 2015 | Frontiers of Computer Science2015，9，5： | 3 |
| 4 | Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers.The total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical efficacy.Safety assessments were also performed.RESULTS:Of the 165 enrolled patients,147 completed the clinical observation.There was no difference in baseline between the two groups.The total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,respectively.No statistical difference was found between the two groups(P>0.05).Additionally,ESR and CRP were similar in both groups(P>0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P>0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P>0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects. | Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 5 | RECOVERY A POSTERIORI ERROR ESTIMATES FOR GENERAL CONVEX ELLIPTIC OPTIMAL CONTROL PROBLEMS SUBJECT TO POINTWISE CONTROL CONSTRAINTS显示文摘一个 posteriori 错误为一般凸的最佳的控制问题有限元素近似估计的 Superconvergence 和恢复在这份报纸被调查。我们获得有限元素答案的 superconvergence 性质,并且由使用 superconvergence 结果,我们得到一个 posteriori 错误估计在一些整齐条件下面是 asymptotically 准确的恢复。一些数字例子被提供验证理论结果。[从作者抽象] | Yanping Chen Yao Fu Huanwen Liu Yongquan Dai Huayi Wei | 2009 | Journal of Computational Mathematics2009，27，4： | 2 |
| 6 | Identification of two novel missense WFS1 mutations,H696Y and R703H,in patients with non-syndromic low-frequency sensorineural hearing loss显示文摘Non-syndromic 低频率的 sensorineural 听觉损失(LFSNHL ) 是听见在频率, 2000 Hz 主要被影响的损失的一种不平常的类型。迄今为止,在二基因, DIAPH1 和 WFS1 的不同变化,被发现了与 LFSNHL 被联系。这里,我们与 postlingual 和进步 LFSNHL 报导一个五产生的中国家庭。我们在在标记 SNP_A-2167174 和 D4S431 之间的染色体 4p16 上印射疾病地点到 2.5 Mb 区域,与 DFNA6/14/38 地点重叠。候选人基因定序揭示了异质接合的 c.2086C > 在 exon 的 T 替换 8 WFS1,在 Wolframin (WFS1 ) 的 C 终点导致 p.H696Y 替换。另外,我们执行了在 37 个分散的病人, WFS1 屏蔽的 mutational 750 岁,与 LFSNHL。我们检测了异质接合的 c.2108G > 在 exon 的替换 8 WFS1,在一个病人导致 p.R703H 替换。在 WFS1 的 H696 和 R703 高度越过种类被保存,包括人,猩猩,老鼠,老鼠,和青蛙(Xenopus ) 。顺序分析表明了 c.2086C 的缺席 > T 或 c.2108G > 在在中国背景的 200 个无关的控制题目之中的 WFS1 基因的 A 替换,支持他们代表的假设原因的变化,和不稀罕的多型性。我们的数据为为 LFSNHL 建立更好的 genotypephenotype 关联提供另外的分子、临床的信息。 | Yi Sun Jing Cheng Yanping Lu Jianzhong Li Yu Lu Zhanguo Jin Pu Dai Rongguang Wang Huijun Yuan | 2011 | Journal of Genetics and Genomics2011，38，2： | 2 |
| 7 | Variation of high-molecular-weight glutenin subunits and glutenin macropolymer particle distribution in wheat grains produced under different water regimes显示文摘The components and contents of high-molecular-weight glutenin subunits(HMW-GS) in wheat grains affect glutenin macropolymer(GMP) size, which is considered an important flour quality trait in wheat. Four wheat cultivars(Shiluan 02-1, Yannong 24, Jinan 17 and Lumai 21) with different end-use qualities were used to investigate the HMW-GS and GMP contents, and the GMP particle distributions in grain produced under irrigated and rainfed conditions. The percent volume of GMP particles and the contents of HMW-GS and GMP were affected by genotype and soil water. Genotype × soil water interaction was significant only for GMP particles <12 μm and >100 μm in the growing season of 2010–2011. Irrigated and rainfed conditions had different influences on the GMP particle distribution in the four cultivars. Compared to irrigated treatment, the rainfed treatment had higher accumulations of HMW-GS and GMP, especially in cultivars Yannong 24, Jinan 17 and Lumai 21. Rainfed conditions also increased the proportion of large size particles of GMP, indicating that different water regimes had an effect on grain quality. According to correlation coefficients(r), the contents of HMW-GS and GMP in grains were negatively correlated with the volume of <12 μm GMP particles, but positively correlated with GMP particles >100 μm. | Zhongmin Dai Yanping Yin Yong Li Li Cao Zhenlin Wang | 2013 | The Crop Journal2013，1，1： | 2 |
| 8 | Use of GFP to trace the colonization of Lactococcus lactis WH-C1 in the gastrointestinal tract of mice 显示文摘 | Wang Yanping Wang Jingrui Dai Weili | 2011 | Journal of Microbi- ological Methods2011，86，3： | 1 |
| 9 | Selective Trace Enrichment of Acidic Pharmaceuticals in Real Water and Sediment Samples Based on Solid-Phase Extraction Using Multi-templates Molecularly Imprinted Polymers 显示文摘 | DUAN Yanping DAI Chaomeng ZHANG Yalei | 2013 | AnalChimActa2013，758，3： | 1 |
| 10 | Axonal and Dendritic Changes are Associated with Diabetic Encephalopathy in Rats: An Important Risk Factor for Alzheimer's Disease显示文摘 | Yanping Zhou Yi Luo Jiapei Dai | 2012 | Journal of Alzheimer's Disease2012，，4： | 1 |
| 11 | Prevalence of neural tube defect pregnancies in China and the impact of gestational age of the births from 2006 to 2008: a hospital-based study显示文摘 | Jun Zhu Xiaohong Li Yanping Wang Dezhi Mu Li Dai Guangxuan Zhou Qi Li He Wang Juan Liang | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，9： | 1 |
| 12 | First-principles study of point defects and Si site preference in Al 3 Ti显示文摘 | Guoliang Zhu Yongbing Dai Da Shu Yanping Xiao Yongxiang Yang Jun Wang Baode Sun Rob Boom | 2011 | Computational Materials Science2011，，9： | 1 |
| 13 | Maternal mortality in China, 1996–2005显示文摘 | Juan Liang Jun Zhu Li Dai Xiaohong Li Mingrong Li Yanping Wang | 2010 | International Journal of Gynecology and Obstetrics2010，，2： | 1 |
| 14 | Reverse engineering in CAD model reconstruction of customized artificial joint 显示文摘 | Lin Yanping Wang Chengtao Dai Kerong | 2005 | Medical Engineering & Physics2005，27，2： | 1 |
| 15 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China显示文摘 | Biyan He Minhan Dai Weidong Zhai Lifang Wang Kejian Wang Junhui Chen Jianrong Lin Aiqin Han Yanping Xu | 2009 | Marine Chemistry2009，，1： | 1 |
| 16 | Functional Mutation of SMAC / DIABLO , Encoding a Mitochondrial Proapoptotic Protein, Causes Human Progressive Hearing Loss DFNA64显示文摘 | Jing Cheng Yuhua Zhu Sudan He Yanping Lu Jing Chen Bing Han Marco Petrillo Kazimierz O. Wrzeszczynski Shiming Yang Pu Dai Suoqiang Zhai Dongyi Han Michael Q. Zhang Wei Li Xuezhong Liu Huawei Li Zheng-Yi Chen Huijun Yuan | 2011 | The American Journal of Human Genetics2011，，1： | 1 |
| 17 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China 显示文摘 | He Biyan Dai Minhan Zhai Weidong Wang Lifang Wang Kejian Chen Junhui Lin Jianrong Han Aiqin Xu Yanping | 2010 | Mar Chem2010，119，14： | 1 |
| 18 | Enhanced degradation of organic contaminants by Fe(Ⅲ)/peroxymonosulfate process with L-cysteine显示文摘The difficulty in Fe(Ⅲ)/Fe(Ⅱ) conversion in the Fe(Ⅲ)/peroxymonosulfate(PMS) process limits its efficiency and application.Herein,L-cysteine(Cys),a green natural organic ligand with reducing capability,was innovatively introduced into Fe(Ⅲ)/PMS to construct an excellent Cys/Fe(Ⅲ)/PMS process.The Cys/Fe(Ⅲ)/PMS process,at room temperature,can degrade a variety of organic contaminants,including dyes,phenolic compounds,and pharmaceuticals.In subsequent experiments with acid orange 7(A07),the AO7 degradation efficiency followed pseudo-first-order kinetic which exhibited an initial 'fast stage' and a second 'slow stage'.The rate constant values ranged depending on the initial Cys,Fe(Ⅲ),PMS,and AO7 concentrations,reaction temperature,and pH values.In addition,the presence of Cl^(-),NO_(3)^(-),and SO_(4)^(2-) had negligible impact while HCO_(3)^(-) and humic acid inhibited the degradation of AO7.Furthermore,radical scavenger experiments and methyl phenyl sulfoxide(PMSO) transformation assay indicated that sulfate radical,hydroxyl radical,and ferryl ion(Fe(Ⅳ)) were the dominant reactive species involved in the Cys/Fe(Ⅲ)/PMS process.Finally,based on the results of gas chromatography-mass spectrometry,several AO7 degradation pathways,including N=N cleavage,hydroxylation,and ring opening were proposed.This study provided a new insight to improve the efficiency of Fe(Ⅲ)/PMS process by accelerating Fe(Ⅲ)/Fe(Ⅱ)cycle with Cys. | Chengdu Qi Yanni Wen Yijie Zhao Yinhao Dai Yanping Li Chenmin Xu Shaogui Yang Huan He | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 19 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 20 | Short-term dynamics of nutrients influenced by upwelling in a small oligotrophic coastal ecosystem,Gan Bay,in the northwest Philippines显示文摘We present a time-series analysis of nutrient and pCO2 (partial pressure of CO2) levels in an oligotrophic coastal ecosystem (Gan Bay), which was likely to be influenced by upwelled subsurface water. Gan Bay is of Currimao Harbor, in the northwest Philippines and is located at the boundary of the South China Sea (SCS). This 42-h time-series observation was conducted in December 2006. In addition to continuous observations of dissolved oxygen (DO) and pCO2, discrete samples were collected at a depth of 5 m every 3 h for measurements of nutrients, including soluble reactive phosphorus (SRP) and inorganic nitrogen (NO3 + NO2 ) in order to examine their dynamics and possible physical and biological controls. We observed remarkably large short-term variations in the surface water, spanning a 10-fold change for SRP (32-330 nM) and from <0.3 lM to 4.3 lM for NO3 + NO2 . DO also varied substantially from a lower end of 171 to 205 lM O2. Surface water pCO2 changed from an equilibrium stage with the atmosphere ( 386 latm) to a stage where it was a significant source for the atmospheric CO2 (seawater pCO2 469 latm). We found that the variation of nutrients was driven neither by tidal mixing nor by biological activities, as was suggested by the variations in the total bacterial abundance and chlorophyll a. Instead, our inverse T-S relationship suggested a two end-member mixing process during the observation period. The N:P ratio throughout the observation period was 13.2, which is characteristic of SCS subsurface and deep waters. Moreover, pCO2 was correlated inversely with the sea surface temperature. It is likely, therefore, that an upwelled subsurface cold water with high nutrients, low-temperature and high-pCO2 existed. It should be noted that this upwelled cold water did not appear to impact the entire observation period (approximately 35 h of 42 h), which might suggest an extremely dynamic nature for this upwelled cold water mass. | Yanping Xu, Minhan Dai, Weidong Zhai, Dongxing Yuan, Jinwen Liu, Zhenyu Sun, Hua Lin, Jingyu Wu State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 0 |
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