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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 4 | Hierarchical sodium-rich Prussian blue hollow nanospheres as high-performance cathode for sodium-ion batteries显示文摘最近,因为他们的好骑车表演,低费用,和环境友好,普鲁士的蓝色和它的类似物(PBA ) 为钠离子电池作为阴极材料吸引了巨大的注意。然而,他们仍然受不了与联系的运动问题固态钠离子的散开在充电和分泌物期间处理表演,它导致低特定的能力和差的率。在这个工作,有层次空体系结构的新奇的钠铁 hexacyanoferrate nanospheres 被一个灵巧的模板方法为钠离子电池作为阴极材料制作了。由于唯一的空范围形态学,钠铁 hexacyanoferrate nanospheres 能为钠离子提供大量活跃地点和高散开动力学,因此交付高度特定的能力(142 mAh/g ) ,一个优异的率能力,和优秀骑车稳定性。而且,钠插入 / 抽取机制被学习了由在 situ X 光检查衍射,它在充电和分泌物过程期间提供进一步的卓见进钠铁 hexacyanoferrate nanosphere 阴极材料的水晶结构变化。 | Xiao Tang Hao Liu Dawei Su Peter H. L. Notten Guoxiu wang | 2018 | Nano Research2018，11，8： | 9 |
| 5 | The First Case of New Variant COVID-19 Originating in the United Kingdom Detected in a Returning Student—Shanghai Municipality,China,December 14,2020显示文摘On December 14,2020,a 23-year-old female returning from the United Kingdom(UK)via airplane was tested by the laboratory of Shanghai Customs using nose swab to test for coronavirus disease 2019(COVID-19).At 20:30 on December 14,Shanghai CDC received notification from the Shanghai Customs that the patient tested positive for COVID-19.By 22:00,the patient was transported by ambulance from the isolation point to the fever clinic of Jiading District Central Hospital.Due to travel history from the UK and abnormalities in nucleic acid test results. | Hongyou Chen Xiaoyan Huang Xiang Zhao Yang Song Peter Hao Hui Jiang Xi Zhang Chen Fu | 2021 | China CDC weekly2021，3，1： | 9 |
| 6 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 7 | Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell transplantation显示文摘Background:Acute myeloid leukemia(AML) with t(8;21) is a heterogeneous disease.Identifying AML patients with t(8;21) who have a poor prognosis despite achieving remission is important for determining the best subsequent therapy.This study aimed to evaluate the impact of Wilm tumor gene-1(WT1) transcript levels and cellular homolog of the viral oncogene v-KIT receptor tyrosine kinase(C-KIT) mutations at diagnosis,and RUNXTRUNX1T1 transcript levels after the second consolidation chemotherapy cycle on outcomes.Methods:Eighty-eight AML patients with t(8;21) who received chemotherapy only or allogeneic hematopoietic stem cell transplantation(allo-HSCT) were included.Patients who achieved remission,received two or more cycles of consolidation chemotherapy,and had a positive measureable residual disease(MRD) test result(defined as <3-log reduction in RUNX1-RUNX1T1 transcript levels compared to baseline) after 2-8 cycles of consolidation chemotherapy were recommended to receive allo-HSCT.Patients who had a negative MRD test result were recommended to receive further chemotherapy up to only 8 cycles.WT1 transcript levels and C-KIT mutations at diagnosis,and RUNX1-RUNX1T1 transcript levels after the second consolidation chemotherapy cycle were tested.Results:Patients who had a C-KIT mutation had significantly lower WTl transcript levels than patients who did not have a C-KIT mutation(6.7%± 10.6%vs.19.5%± 19.9%,P < 0.001).Low WTl transcript levels(<5.0%) but not C-KIT mutation at diagnosis,a positive MRD test result after the second cycle of consolidation chemotherapy,and receiving only chemotherapy were independently associated with high cumulative incidence of relapse in all patients(hazard ratio[HR]= 3.53,2.30,and 11.49;95%confidence interval[CI]1.64-7.62,1.82-7.56,and 4.43-29.82;P = 0.002,0.034,and <0.001,respectively);these conditions were also independently associated with low leukemia-free survival(HR =3.71,2.33,and 5.85;95%CI 1.82-7.56,1.17-4.64,and 2.75-12.44;P < 0.001,0.016,and <0.001,respectively) and overall survival(HR = 3.50,2.32,and 4.34;95%CI 1.56-7.82,1.09-4.97,and 1.98-9.53;P = 0.002,0.030,and <0.001,respectively) in all patients.Conclusions:Testing for WTl transcript levels at diagnosis in patients with AML and t(8;21) may predict outcomes in those who achieve remission.A randomized study is warranted to determine whether allo-HSCT can improve prognosis in these patients. | Ya-Zhen Qin Yu Wang Hong-Hu Zhu Robert Peter Gale Mei-Jie Zhang Qian Jiang Hao Jiang Lan-Ping Xu Huan Chen Xiao-Hui Zhang Yan-Rong Liu Yue-Yun Lai Bin Jiang Kai-Yan Liu Xiao-Jun Huang | 2016 | Chinese Journal of Cancer2016，35，7： | 7 |
| 8 | Diagnostic performance of magnetic resonance venography in the detection of recanalization in patients with chronic cerebral venous sinus thrombus显示文摘在服的静脉的湾穴血栓(CVST ) 的长期的阶段的背景,开运河能导致迥异的先生外观。我们试图有希望地在这研究有希望地评估了的 CVST.Methods 的开运河的评估调查磁性的回声 venography (MRV ) 的诊断精确性 2-dimensional time-of-flight (2D-TOF ) 的诊断表演在 32 个连续病人的 MRV 在期间一三 -- 到为 CVST 的六月的后续。2D-TOF MRV 和数字 substraction angiography (DSA ) 被承担。当没有复杂并发症,参考 standard.Results MRV 和 DSA 在所有 32 个病人被完成,在 recanalized 血栓的察觉的 2D-TOF MRV 的诊断精确性用 DSA 被评估。敏感,特性,积极预兆的价值,和为一个部分基础上的开运河的察觉的 2D-TOF MRV 的否定预兆的价值是91%( 62/68 ),93%( 37/40 ),95%( 62/65 ),并且86%( 37/43 ) respectively.Conclusion 2D-TOF MRV 为 recanalized CVST 片断的诊断提供高敏感和特性。 | SUN Ying ZHENG Dong-you JI Xun-ming Peter WEALE WU Hao JIANG Li-dan YANG Li-zhuang | 2009 | Chinese Medical Journal2009，，20： | 7 |
| 9 | Two Reemergent Cases of COVID-19—Hebei Province,China,January 2,2021显示文摘On January 2,2021,2 cases of coronavirus disease 2019(COVID-19)were identified in 2 cities of Hebei Province,and genomic sequencing suggested that the cases likely resulted from the same origin.The first case(Patient A)was identified as positive at 12∶18 in Shijiazhuang City,the capital of Hebei Province,and the second case(Patient B)was identified as positive at 21∶00 in Xingtai City. | Shunxiang Qi Xiang Zhao Peter Hao Nankun Liu George F.Gao Yang Song Wenbo Xu Qi Li | 2021 | China CDC weekly2021，3，2： | 7 |
| 10 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 11 | COVID-19 Cases Spread Through the K350 Train-Jilin and Heilongjiang Provinces,China,January 2021显示文摘As of 16∶00 on January 13,2021,95 positive cases of coronavirus disease 2019(COVID-19)were reported in Suihua City of Heilongjiang Province and an additional 35 cases have been linked across 7 cities in 3 provinces:Qiqihar City(7 cases),Mudanjiang City(4 cases),Harbin City(3 cases),and Yichun City(1 case)of Heilongjiang Province;Changchun City(9 cases)and Tonghua City(6 cases)of Jilin Province;and Weihai City of Shandong Province(1 case). | Lei Zhou Laishun Yao Peter Hao Chao Li Qinglong Zhao Huiling Dong Jinhua Dou Shengnan Wang George F.Gao Qun Li Biao Huang | 2021 | China CDC weekly2021，3，8： | 5 |
| 12 | Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs显示文摘 | Zhiyuan Fan Peter Y. Li Junjie Deng Stephen C. Bady Hao Cheng | 2018 | Nano Research2018，11，10： | 5 |
| 13 | Time Synchronization for Transmission Substations Using GPS and IEEE 1588显示文摘Time synchronization systems that utilize the global navigation satellite systems(GNSS)are widely used in the monitoring,control,and protection of transmission networks.They ensure that phasor measurement units(PMUs)can accurately monitor voltage phase angles,increase the accuracy of fault locators,enhance the capabilities of disturbance recorders,and allow differential feeder protection to use re-routable communication networks.However,concern about the reliability of GNSS receivers used in intelligent electronic devices(IEDs)have been reported;problems include mal-operations of differential protection,erroneous satellite timing/location messages,inappropriate installations,and blocking of satellite signals due to illegal use of GNSS jammers in vehicles.Utilities now require a timing system less dependent on the use of low cost GNSS receivers integrated into IEDs,but one that uses Grandmaster clocks,slave and transparent clocks,and an Ethernet communication network.The IEEE 1588-2008 synchronization protocol uses the Ethernet to disseminate a global time reference around a substation.A future substation will probably include duplicate 1588 grandmasters,each incorporating stable oscillators with GNSS and terrestrial receivers,in conjunction with a 1588 compliant Ethernet data network with slave and transparent clocks,and redundancy boxes for interfacing with IEDs.Although IEEE 1588 protocol is promising for future substation automation systems,its performance and impact has to be fully evaluated before it can be used in real substations.This paper describes how an IEEE 1588 time synchronization testbed is designed,constructed,and tested.Testing involves measuring the time offset when the Ethernet is heavily loaded with other traffic and the holdover capability of 1588 clocks.Additional delay introduced by IEEE 1588 traffic is also measured.As there is limited testing on GPS receivers within the power industry,this paper also uses the testbed to evaluate the steady state and transient behavior of GPS receivers.The results show a 1588 time synchronization system is accurate,secure,and ideally suited for protection and control applications,compared to a timing system merely based on GPS receivers.The information described in this paper should increase a utility’s confidence in applying IEEE 1588 timing in a real substation. | Peter A Crossley Hao Guo Zhao Ma | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 5 |
| 14 | A Case of New Variant COVID-19 First Emerging in South Africa Detected in Airplane Pilot—Guangdong Province,China,January 6,2021显示文摘On January 6,2021,Guangdong CDC successfully isolated the 501Y.V2 variant of coronavirus disease 2019(COVID-19)virus from a throat swab of a patient.The 501Y.V2 variant was first detected in South Africa,and the patient is a 55-year-old male airline pilot of South African nationality.He entered Guangzhou City,the capital of Guangdong Province,from Singapore on the evening of December 8,2020 and was subject to a COVID-19 test. | Fengjuan Chen Bosheng Li Peter Hao Yang Song Wenbo Xu Nankun Liu Chunliang Lei Changwen Ke | 2021 | China CDC weekly2021，3，2： | 5 |
| 15 | Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans. | Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 16 | The Soil-Borne Identity and Microbiome-Assisted Agriculture:Looking Back to the Future显示文摘Looking forward includes looking back every now and then.In 2007,David Weller looked back at 30 years of biocontrol of soil-borne pathogens by Pseudomonas and signified that the progress made over decades of research has provided a firm foundation to formulate current and future research questions.It has been recognized for more than a century that soil-borne microbes play a significant role in plant growth and health.The recent application of high-throughput omics technologies has enabled detailed dissection of the microbial players and molecular mechanisms involved in the complex interactions in plant-associated microbiomes.Here,we highlight old and emerging plant microbiome concepts related to plant disease control,and address perspectives that modern and emerging microbiomics technologies can bring to functionally characterize and exploit plant-associated microbiomes for the benefit of plant health in future microbiome-assisted agriculture. | Peter A.H.M.Bakker Roeland L.Berendsen Johan A.Van Pelt Gilles Vismans Ke Yu Erqin Li Sietske Van Bentum Sanne W.M.Poppeliers Juan J.Sanchez Gil Hao Zhang Pim Goossens Ioannis A.Stringlis Yang Song Ronnie de Jonge CornéM.J.Pieterse | 2020 | Molecular Plant2020，13，10： | 3 |
| 17 | Promoting Artemisinin Biosynthesis in Artemisia annua Plants by Substrate Channeling显示文摘 | Junli Han Hongzhen Wang Selvaraju Kanagarajan Mengshu Hao Annefi Lundgren Peter E. Brodefius | 2016 | Molecular Plant2016，9，6： | 3 |
| 18 | Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice显示文摘Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality.The underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general practice.However,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug resistance.In the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical methods.Moreover,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection. | Xiaotong Ding Qinghan Tang Zeyu Xu Ye Xu Hao Zhang Dongfeng Zheng Shuqin Wang Qian Tan Joanneke Maitz Peter K.Maitz Shaoping Yin Yiwei Wang Jun Chen | 2022 | Burns & Trauma2022，10，1： | 3 |
| 19 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
| 20 | WHO classification of alveolar echinococcosis: Principles and application显示文摘 | Peter Kern Hao Wen Naoki Sato Dominique A. Vuitton Beate Gruener Yinmei Shao Eric Delabrousse Wolfgang Kratzer Solange Bresson-Hadni | 2005 | Parasitology International2005，，： | 2 |
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