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| 1 | Effects of electroacupuncture and Chinese kidney-nourishing medicine on polycystic ovary syndrome in obese patients显示文摘OBJECTIVE: To explore the effect of electroacupuncture and Chinese kidney-nourishing medicine on insulin (INS), adiponectin (APN), leptin (LEP), and glucolipid metabolism of obese patients with polycystic ovary syndrome (PCOS). METHODS: Sixty-seven obese PCOS patients were randomly divided into two groups. Thirty-three patients in the acupuncture-medicine group were treated three times a week with electroacupuncture at the Tianshu (ST 25), Zhongwan (CV 12), Qihai (CV 6), Sanyinjiao (SP 6), Geshu (BL 17), and Cil-iao (BL 32) acupoints. They also took the Chinese drug, Tiankui capsule, for 3 months as a course of treatment. Point-taking and treatment in the electroacupuncture group of 34 patients was the same as those in the acupuncture-medicine group. We observed and compared the changes in the obesity-related indexes of body weight (BW), body mass index (BMI), and waist-hip ratio (WHR), as well as fasting plasma glucose (FPG), fasting insulin (FINS), APN, and LEP. RESULTS: BW, BMI, WHR, and FINS decreased and insulin sensitivity index (ISI) and APN were higher in the acupuncture-medicine group than in the electroacupuncture group (P<0.01). There was no obvious difference in LEP between the two groups (P>0.05). CONCLUSION: Acupuncture combined with medicine is better than just electroacupuncture for obese PCOS patients by improving obesity-related indexes, insulin sensitivity, and APN level. This indicates that acupuncture-medicine therapy is worth clinical popularization. | Liqing Yu Yanjun Liao Huangan Wu Jimeng Zhao Luyi Wu Yin Shi Jianqiao Fang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 15 |
| 2 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 3 | Performance enhancement of perovskite-sensitized mesoscopic solar cells using Nb-doped TiO2 compact layer显示文摘Perovskite 太阳能电池是常规光电的设备的最有希望的选择之一,并且广泛的研究集中于设备优化进一步改进他们的表演。TiO 2 的紧缩的层通常在 perovskite 太阳能电池被使用阻止到达做氟的符号的听氧化物电极接近洞。在这贡献,我们用做的 Nb 设计了 TiO 2 协议层,它与 10.26% 的力量变换效率(PCE ) 导致了太阳能电池,它比有一样的配置的设备的高,但是包含太古的 TiO 2 协议层(PCE =9.22%) 。设备表演改进被归因于减少的选择接触抵抗并且增加了源于做的 Nb 的费用再结合抵抗,它被阻抗光谱学大小揭示。发达策略为 perovskite 太阳能电池强调接口优化的重要性。 | Xiong Yin Yanjun Guo Zhaosheng Xue Peng Xu Meng He Bin Liu | 2015 | Nano Research2015，8，6： | 9 |
| 4 | Treatment of coke plant wastewater by A/O fixed biofilm system显示文摘Coke plant wastewater was treated by an anaerobic–aerobic (A/O) biofilm system. A lab-scale experiment, during which semi-soft media were packed in both the anaerobic and the aerobic reactors, was carried out. The influence parameters, such as HRT, C/N ratio, OLR, and the recycling flow rate on the performance of the system, were studied. The results showed that a sufficient carbon source was important to the performance of bio-degradation system. The COD removal rate increased from 64.15% to 83.28% by raising C/N in wastewater from 2.5 (no ex-ternal carbon source) to 5. But the effluent COD concentration was still a little higher than the discharge standard. In order to make it meet the discharge standard, a deep treatment, coagula-tion, was applied, which was proved as an effective method. Then the effluent COD concentra-tion can be brought to lower than 200 mg·L?1. The NH4-N removal rate in this system was sat-isfactory, being higher than 99%. In addition, it was almost not affected by both C/N ratio and coagulation treatment. The results show that the system is feasible to treat coke plant wastewa-ter. | YU Zhaoxiang QI Rong YIN Yanjun | 2005 | Science China Chemistry2005，48，5： | 8 |
| 5 | Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through Sirt1显示文摘Perioperative hyperglycemia is a common metabolic disorder in clinic settings.Hyperglycemia leads to endothelial inflammation,endothelial cell apoptosis,and dysfunction,thus resulting in endothelial injury.Propofol(2,6-diisopropylphenol)is a widely used intravenous anesthetic in clinic settings.Our previous study indicated that propofol inhibits mitochondrial reactive oxygen species(ROS)production via down-regulation of phosphatase A2(PP2A)expression,inhibition of Ser36-p66shc dephosphorylation and mitochondrial translocation,thus improving high glucose-induced endothelial injury.The expression of p66shc was inhibited by propofol in hyperglycemic human umbilical vein endothelial cells(HUVECs).However,the mechanism by which propofol inhibits p66shc expression in hyperglycemic HUVECs is still obscure.In the present study,we mainly examined how propofol inhibited high glucose-induced p66shc expression in HUVECs.Compared with 5 mM glucose treatment,high glucose increased p66shc expression and decreased sirt1 expression,which was inhibited by propofol treatment.Moreover,EX527(a sirt1 inhibitor)reversed the effect of propofol against high glucose-induced p66shc expression.However,EX527 did not reverse the effects of propofol against high glucose-induced ROS accumulation,endothelial inflammation,and apoptosis.Furthermore,when cells were incubated with propofol,EX527,and FTY720(a PP2A activator)simultaneously,the effects of propofol against high glucose-induced ROS accumulation,inflammation,and apoptosis were reversed.Our results suggested that propofol inhibited high glucose-induced p66shc expression via upregulation of sirt1 expression in hyperglycemic HUVECs.Moreover,propofol protects against high glucose-mediated ROS accumulation and endothelial injury via both inhibition of p66shc expression and dephosphorylation of Ser36-p66shc. | Jing Wang Jie Qi Qichao Wu Hui Jiang Yuehao Yin Yan Huanx Yanjun Zhao Minmin Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 5 |
| 6 | Photocatalytic H2 Evolution on TiO2 Assembled with Ti3C2 MXene and Metallic 1T-WS2 as Co-catalysts显示文摘The biggest challenging issue in photocatalysis is efficient separation of the photoinduced carriers and the aggregation of photoexcited electrons on photocatalyst’s surface.In this paper,we report that double metallic co-catalysts Ti3C2 MXene and metallic octahedral(1T)phase tungsten disulfide(WS2)act pathways transferring photoexcited electrons in assisting the photocatalytic H2 evolution.TiO2 nanosheets were in situ grown on highly conductive Ti3C2 MXenes and 1T-WS2 nanoparticles were then uniformly distributed on TiO2@Ti3C2 composite.Thus,a distinctive 1T-WS2@TiO2@Ti3C2 composite with double metallic co-catalysts was achieved,and the content of 1T phase reaches 73%.The photocatalytic H2 evolution performance of 1T-WS2@TiO2@Ti3C2 composite with an optimized 15 wt%WS2 ratio is nearly 50 times higher than that of TiO2 nanosheets because of conductive Ti3C2 MXene and 1T-WS2 resulting in the increase of electron transfer efficiency.Besides,the 1T-WS2 on the surface of TiO2@Ti3C2 composite enhances the Brunauer–Emmett–Teller surface area and boosts the density of active site. | Yujie Li Lei Ding Shujun Yin Zhangqian Liang Yanjun Xue Xinzhen Wang Hongzhi Cui Jian Tian | 2020 | Nano-Micro Letters2020，12，1： | 4 |
| 7 | Establishment of an Objective Standard for the Definition of Binary Tropical Cyclones in the Western North Pacific显示文摘To develop an objective standard for defining binary tropical cyclones(BTCs)in the western North Pacific(WNP),two best-track datasets,from the China Meteorological Administration and the Joint Typhoon Warning Center,were adopted for statistical analyses on two important characteristics of BTCs-two TCs approaching each other,and counterclockwise spinning.Based on the high consistency between the two datasets,we established an objective standard,which includes a main standard for defining BTCs and a secondary standard for identifying typical/atypical BTCs.The main standard includes two requirements:two coexisting TCs are a pair of BTCs if(i)the separation distance is≤1800 km,and(ii)this separation maintains for at least 12 h.Meanwhile,the secondary standard defines a typical BTC as one for which there is at least one observation when the two TCs approach each other and spin counterclockwise simultaneously.Under the standard,the ratio of typical BTCs increases as the BTC duration increases or the minimum distance between the two TCs decreases.Then,using the JTWC dataset,it was found that there are 505 pairs of BTCs during the period 1951−2014,including 328 typical BTCs and 177 atypical BTCs,accounting for 65.0%and 35.0%of the total,respectively.In addition,a study of two extreme phenomena-the maximum approaching speed and the maximum counterclockwise angular velocity in typical BTCs-shows that the configuration of the circulation conditions and the distribution of the BTCs favor the formation of these extreme phenomena. | Fumin REN Yanjun XIE Biwen YIN Mingyang WANG Guoping LI | 2020 | Advances in Atmospheric Sciences2020，37，11： | 3 |
| 8 | Supplement and optimization of classical capillary number experimental curve for enhanced oil recovery by combination flooding显示文摘In the middle of the last century,American scientists put forward the concept of capillary number and obtained the relation curve between capillary number and residual oil through experiments.They revealed that the corresponding residual oil saturation decreased with increasing of capillary number;after capillary number reached up to a limit,residual oil saturation would become stable and did not decrease.These important achievements laid a theoretical base for enhanced oil recovery with chemical flooding.On the basis of the theory,scholars developed chemical flooding numerical simulation software UTCHEM.During the numerical simulation study of combination flooding,the authors found that as the capillary number is higher than the limit capillary number,the changes of the residual oil saturation along with the capillary number differ from the classical capillary number curve.Oil displacement experiments prove that there are defects in classic capillary number experimental curve and it is necessary to mend and improve.Capillary number‘calculation’curve is obtained with a method of numerical simulation calculation and a complete description of capillary number curve is provided;On this basis,combination flooding capillary number experimental curve QL is obtained through experiments,which is different from the classical capillary curve;and based on which,an expression of corresponding combination flooding relative permeability curve QL is given and the corresponding relative permeability parameters are determined with experiments.Further oil displacement experiment research recognizes the cause of the singular changes of the capillary number curve.'Combination flooding capillary number experimental curve QL'and'combination flooding relative permeability curve QL'are written in combination flooding software IMCFS,providing an effective technical support for the application of combination flooding technical research. | QI LianQing LIU ZongZhao YANG ChengZhi YIN YanJun HOU JiRui ZHANG Jian HUANG Bo SHI FengGang | 2014 | Science China(Technological Sciences)2014，57，11： | 2 |
| 9 | Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital显示文摘 | Xiang Li Ting Xiao Yuzhen Wang Hongbin Gu Zhiguo Liu Yufeng Jiang Yanjun Liu Zuqian Lu Xiaopin Yang Yin Lan Zhangrong Xu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 10 | ADAM10 overexpression in human non-small cell lung cancer correlateswith cell migration and invasion through the activation of the Notch1 signalingpathway显示文摘 | Jianli Guo Lei He Ping Yuan Peng Wang Yanjun Lu Fangli Tong Yu Wang Yanhua Yin Jun Tian Jun Sun | 2012 | Oncology Reports2012，，： | 1 |
| 11 | Research on influence factors of rock-soil thermal properties by laboratory test显示文摘In order to discover the relation between rock-soil thermal properties and strata during the process of engineering investigation,the authors studied the measuring principle of Thermal Conductivity Scanner( TCS)and measured the thermal properties of 45 drilling samples from Qinghai with TCS in the laboratory. The results show that the specific heat capacity( SHC) decreases while the thermal conductivity( TC) increases with the increase of the depth. With the lithological change,the specific heat capacity and thermal conductivity have the opposite trend. The depth and lithology have a greater influence on the thermal conductivity than the specific heat capacity. | YIN Renchao ZHANG Yanjun WU Fan GAO Ping MEI Zhenzhou | 2014 | Global Geology2014，17，1： | 1 |
| 12 | Complex genetic architecture underlying the plasticity of maize agronomic traits显示文摘Phenotypic plasticity is the ability of a given genotype to produce multiple phenotypes in response to changing environmental conditions.Understanding the genetic basis of phenotypic plasticity and establishing a predictive model is highly relevant to future agriculture under a changing climate.Here we report findings on the genetic basis of phenotypic plasticity for 23 complex traits using a diverse maize population planted at five sites with distinct environmental conditions.We found that latituderelated environmental factors were the main drivers of across-site variation in flowering time traits but not in plant architecture or yield traits.For the 23 traits,we detected 109 quantitative trait loci(QTLs),29 for mean values,66 for plasticity,and 14 for both parameters,and 80%of the QTLs interacted with latitude.The effects of several QTLs changed in magnitude or sign,driving variation in phenotypic plasticity.We experimentally validated one plastic gene,ZmTPS14.1,whose effect was likely mediated by the compensation effect of ZmSPL6 from a downstream pathway.By integrating genetic diversity,environmental variation,and their interaction into a joint model,we could provide site-specific predictions with increased accuracy by as much as 9.9%,2.2%,and 2.6%for days to tassel,plant height,and ear weight,respectively.This study revealed a complex genetic architecture involving multiple alleles,pleiotropy,and genotype-byenvironment interaction that underlies variation in the mean and plasticity of maize complex traits.It provides novel insights into the dynamic genetic architecture of agronomic traits in response to changing environments,paving a practical way toward precision agriculture. | Minliang Jin Haijun Liu Xiangguo Liu Tingting Guo Jia Guo Yuejia Yin Yan Ji Zhenxian Li Jinhong Zhang Xiaqing Wang Feng Qiao Yingjie Xiao Yanjun Zan Jianbing Yan | 2023 | Plant Communications2023，4，3： | 1 |
| 13 | Advancing the pressure sensing performance of conductive CNT/PDMS composite film by constructing a hierarchical-structured surface显示文摘Flexible pressure sensors have attracted wide attention due to their applications to electronic skin,health monitoring,and human-machine interaction.However,the tradeoff between their high sensitivity and wide response range remains a challenge.Inspired by human skin,we select commercial silicon carbide sandpaper as a template to fabricate carbon nanotube(CNT)/polydimethylsiloxane(PDMS)composite film with a hierarchical structured surface(h-CNT/PDMS)through solution blending and blade coating and then assemble the h-CNT/PDMS composite film with interdigitated electrodes and polyurethane(PU)scotch tape to obtain an h-CNT/PDMS-based flexible pressure sensor.Based on in-situ optical images and finite element analysis,the significant compressive contact effect between the hierarchical structured surface of h-CNT/PDMS and the interdigitated electrode leads to enhanced pressure sensitivity and a wider response range(0.1661 kPa^(-1),0.4574 kPa^(-1)and 0.0989 kPa^(-1)in the pressure range of 0–18 kPa,18–133 kPa and 133–300 kPa)compared with planar CNT/PDMS composite film(0.0066 kPa^(-1)in the pressure range of 0–240 kPa).The prepared pressure sensor displays rapid response/recovery time,excellent stability,durability,and stable response to different loading modes(bending and torsion).In addition,our pressure sensor can be utilized to accurately monitor and discriminate various stimuli ranging from human motions to pressure magnitude and spatial distribution.This study supplies important guidance for the fabrication of flexible pressure sensors with superior sensing performance in next-generation wearable electronic devices. | Ye Zhao Taoyu Shen Minyue Zhang Rui Yin Yanjun Zheng Hu Liu Hongling Sun Chuntai Liu Changyu Shen | 2023 | Nano Materials Science2023，5，4： | 1 |
| 14 | Application of adaptive noise cancellation with neural-network-based fuzzy inference system for visual evoked potentials estimation显示文摘 | YIN Haie ZENG Yanjun ZHANG Jianyhua | 2004 | Medical Engineering & Physics2004，26，1： | 1 |
| 15 | Tire Road Friction Coefficient Estimation:Review and Research Perspectives显示文摘Many surveys on vehicle traffic safety have shown that the tire road friction coefficient(TRFC)is correlated with the probability of an accident.The probability of road accidents increases sharply on slippery road surfaces.Therefore,accurate knowledge of TRFC contributes to the optimization of driver maneuvers for further improving the safety of intelligent vehicles.A large number of researchers have employed different tools and proposed different algorithms to obtain TRFC.This work investigates these different methods that have been widely utilized to estimate TRFC.These methods are divided into three main categories:off-board sensors-based,vehicle dynamics-based,and data-driven-based methods.This review provides a comparative analysis of these methods and describes their strengths and weaknesses.Moreover,some future research directions regarding TRFC estimation are presented. | Yan Wang Jingyu Hu Fa’an Wang Haoxuan Dong Yongjun Yan Yanjun Ren Chaobin Zhou Guodong Yin | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 1 |
| 16 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 17 | Clinical value-oriented research paradigm about inheritance and innovation development of TCM dominant diseases显示文摘Modern medicine has made remarkable achievements in safeguarding people’s life and health,however,it is increasingly found that in the face of complex diseases,selective targeting of single target is often difficult to produce a comprehensive rehabilitation effect,and is prone to induce drug resistance,toxic side effects.Traditional Chinese medicine(TCM)has a long history of clinical application,and its clinical value in the treatment of complex diseases such as cardiovascular and cerebrovascular diseases,digestive diseases,skin diseases,rheumatism and immunity diseases,and adjuvant treatment of tumors has been proven to have obvious advantages.However,its modern research is relatively lagging behind,and in the face of the aging society and the characteristics of the modern disease spectrum,the traditional knowledge-driven research paradigm seems to be stuck in a bottleneck and difficult to make greater breakthroughs.Focusing on the key issues of TCM development in the new era,the clinical value-oriented strategy becomes to be a new research paradigm of TCM inheritance and innovation development,and dominant diseases would be the focus of the TCM inheritance and innovation development,which has been highly valued in recent years by the TCM academia and the relevant national management departments.Based on the clinical value,a series of policies are formulated for the selection and evaluation of the TCM dominant diseases(TCMDD),and exploratory researches about the clinical efficacy characteristics,the modern scientific connotation interpretation were carried out.The clinical value-oriented research paradigm of TCMDD inheritance and innovation development has been initially formed,which is characterized by strong policy support as the guarantee,systematic and standardized selection and evaluation methods as the driving force,scientific and effective research on internal mechanisms as the expansion,and effective clinical guidelines and principles as the transformation,which is of great value in promoting the high-quality development of the industries and undertaking of TCM.In this paper,the main policy support,selection and evaluation methods,therapeutic effect characterization,and modern scientific connotation research strategies of TCMDD in recent years have been comprehensively sorted out,with a view to providing the healthy and benign development of the research on TCMDD. | Dongna Li Hong Guo Lin Niu Qingsheng Yin Yanjun Zhang Pengwei Zhuang | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 18 | Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke显示文摘Ischemic stroke(IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator(r-t PA).Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine(TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates infammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs. | Hanyu Zhang Bowen Jin Xinyu You Pengrong Yi Hong Guo Lin Niu Qingsheng Yin Jiangwei Shi Yanjun Zhang Pengwei Zhuang | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 19 | Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba显示文摘Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of death.Ginkgo biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for centuries.Preclinical studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease models.Of clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia stroke.Here,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and therapy.We highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and others.Finally,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis. | Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 20 | A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs显示文摘Beta-glucan has been shown to have a beneficial effect on gastrointestinal health.This experiment was conducted to investigate the effects ofβ-glucan isolated from Agrobacterium sp.ZX09 on growth performance and intestinal health of weaning pigs.A total of 108 weaned pigs(21 d of age;6.05±0.36 kg)were randomly divided into 3 groups(6 pens/group;6 pigs/pen),and the groups were each treated with the following diets:1)basal diet,2)basal diet supplemented with 20 mg/kg olaquindox,3)basal diet supplemented with 200 mg/kgβ-glucan,for 21 d.Compared with the control group,pigs fed with200 mg/kgβ-glucan had greaterBW,average daily gain and duodenal villus height to crypt depth ratio(P<0.05).Olaquindox increased the duodenal or jejunal villus height of pigs compared withβ-glucan.Compared with the control group,β-glucan tended to increase the occludin mRNA expression in the jejunum(0.05 | Yuliang Wu Xue Li Hongnan Liu Yanjun Du Jian Zhou Lijun Zou Xia Xiong Huilin Huang Zhiliang Tan Yulong Yin | 2021 | Animal Nutrition2021，，4： | 0 |
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