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| 1 | Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke:the first multicentre,phase III trial in China显示文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients. | Huaguang Zheng Yi Yang Huisheng Chen Chuanling Li Yangkun Chen Fu-Dong Shi Li Yang Xiaoping Cui Zuneng Lu Yanling Liang Songbiao Cui Anding Xu Yiqing Wu Yaqing Sun Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，3： | 4 |
| 2 | Selective catalytic hydrogenation of naphthalene to tetralin over a NiMo/Al2O3 catalyst显示文摘The selective catalytic hydrogenation of naphthalene to high-value tetralin was systematically investigated.A series of Al2O3 catalysts containing different active metals(Co,Mo,Ni,W)were prepared by incipient wetness impregnation.The effects of different active metals forms(oxidation,reduction,sulfuration)and reaction conditions on naphthalene hydrogenation were investigated and the catalysts were characterized by XRD,XPS,BET,NH3-TPD and SEM.Especially,Ni-Mo/Al2O3 was first used in this reactive system.The results show that the oxidative4%Ni O-20%MoO3/Al2O3 is the best catalyst for the preparation of tetralin.The conversion of naphthalene and the selectivity of tetralin can reach 95.62%and 99.75%respectively at 200℃,8 h and 6 MPa.Compared with reduced and sulfureted 4%Ni O-20%MoO3/Al2O3 catalysts,oxidative 4%Ni O-20%MoO3/Al2O3 has a well dispersed and uniform monolayer of the active metals,larger pore volume and size,and larger total acidity.NiO-MoO3/Al2O3 has a synergistic effect between NiO activity and MoO3 selectivity. | Xiaoping Su Pu An Junwen Gao RuchengWang Yujuan Zhang Xi Li Yangkun Zhao Yongqi Liu Xiaoxun Ma Ming Sun | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 4 |
| 3 | Fuzzy Random Reliability Analysis of Blocky Rock-Mass in Slopes显示文摘Slope stability assessment is a geotechnical problem characterized by many sources of uncertainty. In clas- sical reliability analysis, only the randomness of uncertainties is taken into account but the fuzziness of them is ignored. In this paper, a fuzzy probability approach and a fuzzy JC method are presented for the reliability analysis. The two methods have been applied to stability analysis of a certain slope of permanent ship lock in the Three-Gorges Project. The results obtained from these two methods are basically the same. However, compared with the fuzzy probability means, the fuzzy JC method can reflect the real situation better because it uses a fuzzy-based analysis applied to not only limit state equation but also mechanical parameters. | YANGKun ZHANGXin | 2005 | Journal of China University of Mining and Technology2005，15，2： | 3 |
| 4 | HER2 gene status and the relationship with p21 protein expression in gastric cancer显示文摘我们瞄准了到分析的目的有在胃的癌的 p21 蛋白质表示的 HER2 基因地位和它的关系。在 situ 杂交(鱼) 和 immunohistochemistry (IHC ) 的方法荧光技术被用来在胃的癌症的 59 种情况中检测 HER2 基因地位和 p53 蛋白质。HER2 基因扩大率的结果鱼察觉是 16.9%(10/59 ) ,在没有拷贝数字获得的 49 种情况中的 HER2 基因扩大和基因扩大是 49.2% 的一个总数(29/59 ) 。HER2 蛋白质表示是 42.4%(25/59 ) ,在有 +++ 的病人的 HER2 基因扩大率,, ++ HER2 蛋白质表示在有 + HER2 蛋白质表示的病人是 3/3 和 5/8,它是 2/14,有重要差别(P < 0.05 ) 。p21 蛋白质表示率是 49.2%(29/59 ) , HER2 基因扩大率和 p21 蛋白质表示在肿瘤侵略深度有重要差别,淋巴节点转移(P < 0.05 ) ;在组织学的类型的有的不统计的意义,变老,性差别(P > 0.05 ) 。结论 HER2 基因扩大率和基因拷贝数字断然与 p21 蛋白质表示, HER2 基因地位和联合察觉能提供的 p21 蛋白质的表示有关联在胃的癌症转移,病人条件开发和预后的引用值,它能也指导单个治疗的临床的开发。 | Yongjie Li Yangkun Wang Xianwei Zhang Fulin Li Nianlong Meng Xutao Yuan Jinsheng Song | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 5 | Vibrational characteristics of rotating soft cylinders显示文摘Rotating structural components are omnipresent in engineering structures and natural world. This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cylinders rotating with respect to the axis of symmetry based on the nonlinear elasticity and linear incremental theories. The formulations indicate that the biasing deformation, instantaneous elastic moduli, and incremental equations of motion strongly depend on the rotating speed. The characteristic equation for the natural frequency is derived using the state-space method and approximate laminate technique.The numerical examples included in this work demonstrate that the centrifugal and Coriolis forces might have significant effects on the vibrational characteristics of the cylinder. Results of this work will benefit the design and control of novel engineering systems with rotating soft cylinders or shafts. | Kecheng Li Yinnan Zhang Haifei Zhan Yangkun Du Chaofeng Li | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 2 |
| 6 | Health-related quality of life in the family caregivers of stroke survivors显示文摘 | Yangkun Chen Jinyan Lu Ka Sing Wong Vincent C.T. Mok Gabor S. Ungvari Wai Kwong Tang | 2010 | International Journal of Rehabilitation Research2010，，3： | 2 |
| 7 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 8 | Risk Evaluation on Logistics Finance of Agricultural Products Based on Fuzzy-AHP Model显示文摘The development of logistics finance business for agricultural products is the best way to realize the common interests of logistics enterprises,small and medium-sized agricultural product enterprises and financial institutions,which will contribute to the development of China's new socialist rural economy and the construction of ' two-oriented society'. As the agricultural products have some special attributes,it's easy to create the risk in carrying out the logistics finance business. The paper constructs a risk evaluation indicator system for logistics finance of agricultural product,and uses the Fuzzy-AHP model to evaluate. The results show that the comprehensive risk level is normal risk,which shows that third-party logistics enterprises can carry out the logistics financial business of agricultural products,but the risks from logistics enterprises and agricultural collateral need to be prevented. | Yan PANG Yangkun XIA | 2015 | Asian Agricultural Research2015，7，9： | 2 |
| 9 | GuoLishu等汽毫电子机械制动系统设计与仿真显示文摘 | YangKun 李静 | 2008 | 农业机械学报2008，，： | 1 |
| 10 | Properties of WC-Co ceramic coatings of ultra-fine grain prepared by electrothermal explosion method 显示文摘 | Liu Zongde YangKun DuanPeng | 2004 | Key Engineering Materials2004，，： | 1 |
| 11 | 显示文摘 | KangXinting(康新婷) YangKun(杨坤) ChiYudi(迟煜頔)etal | 2012 | 稀有金属材料与工程2012，41，2： | 1 |
| 12 | 显示文摘 | YANGKun ZENGLi-bo LEIJun-feng etal(杨琨 曾立波 雷俊峰 等) | | 华中科技大学学报0，，： | 1 |
| 13 | Electromechanical modeling of eye fatigue detecting using flexible piezoelectric sensors显示文摘Eye fatigue has attracted significant interest due to its potential harm to human daily activities. An ultrathin flexible piezoelectric sensor was currently designed and fabricated to detect eye fatigue by deforming together with the eyelid epidermis. Herein we develop a theoretical model to illustrate the correlation between the eyelid motion and the signals output by the piezoelectric sensor. The theoretical predictions on the eyelid motion based on the measured electrical output agree well with the in vivo observations in experiment. A simple scaling law is established to evaluate the impacts of different parameters on the function ability of the flexible piezoelectric sensor. The results may provide useful guidelines for designing and optimizing similar devices for alike biological motions. | Chaofeng LU Shuang WU Yangyang ZHANG Yangkun DU | 2018 | Science China(Information Sciences)2018，61，6： | 1 |
| 14 | EffectofhumicacidsonphysicochemicalpropertyandCd(II)sorptionofmultiwalledcarbonnanotubes显示文摘 | TianXiaoli LiTingting YangKun etal | 2012 | Chemosphere2012，89，11： | 1 |
| 15 | Genomic characterisation of a lentogenic Newcastle disease virus strain HX01 isolated from sick pigs in China显示文摘 | Shengli Chen Huafang Hao Xinglong Wang Enqi Du Haijin Liu Tao Yang Yangkun Liu Xiangjing Fu Peng Zhang Zengqi Yang | 2013 | Virus Genes2013，，2： | 1 |
| 16 | Modeling on monitoring the growth and rupture assessment of saccular aneurysms显示文摘The unpredictable rupture of saccular aneurysms especially of the intracerebral aneurysm is a knotty problem that always results in high mortality.Traditional diagnosis of medical images,which gives the aneurysm size and compares with a speculated critical size from clinical statistics,was demonstrated inadequate to forecasting rupture.Here,we propose a new detecting strategy that uses a dielectric elastomer(DE)capacitance sensor to monitor the growth of saccular aneurysms and deliver both the wall stress and geometric parameters.Based on the elastic growth theory together with the finite deformation analyses,the correlation between the real-time output capacitance of the DE sensor and the wall stress and/or geometry of an aneurysm is derived.Compared to clinic statistics and biomechanics simulations,the wall stress and geometric size may be used as combined indicators to assess the rupture risk of a saccular aneurysm.Numerical results show that an output relative capacitance of 30 indicates a high risk of rupture.Finally,the sensitivity and resolution of the DE sensor are proved adequately high for monitoring the growth state and evaluating the rupture risk of a saccular aneurysm. | Yangkun Du Chaofeng Lu | 2017 | Theoretical & Applied Mechanics Letters2017，7，2： | 1 |
| 17 | 1 Association study ofastrocyte- derived protein SIOOB gene polymorphlsms with major depressive dis- order in Chinese individuals 显示文摘 | YangKun XieGuangrong HuYiqiu eta | 2009 | Can J Psychiat2009，54，5： | 1 |
| 18 | 显示文摘 | YANGKun(杨昆) | 2009 | 中国激光2009，，11： | 1 |
| 19 | Diageneses and Their Influences on Reservoir Properties of Chang 2 Oil Member in Renshan Region, Zhidan Oilfield, Ordos Basin显示文摘1 Introduction Yanchang Formation in Upper Triassic,Ordos basin contains the most abundant hydrocarbon resources in North China(Wang et al.,2014).The sandstones are the most important oil-bearing reservoirs in | YANG Kang ZHOU Xue LI Hong XIE Wei DONG Yangkun LIU Yongjie SONG Shijun ZHAO Leizhao | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 20 | 显示文摘 | KangXinting(康新婷) YangKun(杨坤) | 2012 | 稀有金属材料与工程2012，41，2： | 1 |
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