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| 1 | Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ显示文摘AIM: To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis,spontaneous abortion,allo-and xeno-graft rejection by mediating 'immune coagulation'. METHODS: Tumor tissues from 133 patients with six types of distinct cancers and the animal tumor tissues from human hepatocellular carcinoma (HCC) model on nude mice (established from high metastasis HCC cell line MHCC97LM6) were obtained. RESULTS: Hfgl2 was detected in tumor tissues from 127 out of 133 patients as well as tumor tissues collected from human HCC nude mice. Hfgl2 was highly expressed both in cancer cells and interstitial inflammatory cells including macrophages,NK cells,and CD8+ T lymphocytes and vascular endothelial cells. Hfgl2 mRNA was localized in cells that expressed hfgl2 protein. Fibrin (nogen) co-localization with hfgl2 expression was determined by dual immunohistochemical staining. In vitro,IL-2 and IFN-γ increased hfgl2 mRNA by 10-100 folds and protein expression in both THP-1 and HUVEC cell lines. One-stage clotting assays demonstrated that THP-1 and HUVEC cells expressing hfgl2 had increased procoagulant activity following cytokines stimulation. CONCLUSION: The hfg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction. | Kai Su Fang Chen Wei-Ming Yan Qi-Li Zeng Li Xu Dong Xi Bin Pi Xiao-Ping Luo Qin Ning | 2008 | World Journal of Gastroenterology2008，14，39： | 20 |
| 2 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 3 | Multiple constraints QoS multicast routing optimization algorithm in MANET based on GA显示文摘Usually multiple quality of service (QoS) guarantees are required in most multicast applications. This paper presents a multiple con-straints algorithm for multicast traffic engineering in mobile ad hoc networks (MANET). The proposed algorithm is a new version of multiple constraints QoS multicast routing optimization algorithm in MANET based on genetic algorithm (MQMGA). The proposed MQMGA can optimize the maximum link utilization, the cost of the multicast tree, the selection of the long-life path, the average delay and the maximum end-to-end delay. Experimental result shows that the approach is efficient, has promising performance in multicast traffic engineering and for evaluating the route stability in dynamic mobile networks. | Baolin Sun Shangchao Pi Chao Gui Yue Zeng Bing Yan Wenxiang Wang Qianqing Qin | 2008 | Progress in Natural Science:Materials International2008，18，3： | 6 |
| 4 | Bibliometric profile of neurogenic bladder in the literature:a 20-year bibliometric analysis显示文摘Neurogenic bladder is a dysfunction of the lower urinary tract caused by nervous system disorder.We investigated the trends in publication of articles under the topic 'neurogenic bladder' using bibliometric analysis.Articles on neurogenic bladder,published between 1995 and 2014,were retrieved from the ISI Web of Science citation database.We analyzed the search results for authors,countries,institutions,journals,and top-cited papers.A total of 1,904 articles were retrieved.There was a small increase in the number of articles on neurogenic bladder from 1995(n = 43) to 2014(n = 117).The USA was the leading country in the total number of articles(n = 598).However,the number of publications from China has rapidly increased,and China was ranked second in 2014.Emmanuel Chartier-Kastler(n = 65) was the most productive author,and University of Paris VI(Paris 6)(n = 61) was the most productive institution.The Journal of Urology published the greatest number of articles on this topic(n = 285).Articles on neurogenic bladder were often published in a professional journal under the category Urology & Nephrology,Neurosciences & Neurology,or Rehabilitation.Visualization analysis based on co-citation networks was conducted using Cite Space III.Visualization analysis revealed that the hot spots in neurogenic bladder were botulinum toxin-A,prazosin,bethanechol,and afferent pathways.These findings provide new insight into the publication trends and hot spots in neurogenic bladder. | Yuan Gao Bo Qu Yan Shen Xiao-jing Su Xiao-yan Dong Xue-mei Chen Yu-hong Zhou Hong-ying Pi | 2015 | Neural Regeneration Research2015，10，5： | 4 |
| 5 | A NEW UNSUPERVISED CLASSIFICATION ALGORITHM FOR POLARIMETRIC SAR IMAGES BASED ON FUZZY SET THEORY显示文摘In this letter, a new method is proposed for unsupervised classification of terrain types and man-made objects using POLarimetric Synthetic Aperture Radar (POLSAR) data. This technique is a combi-nation of the usage of polarimetric information of SAR images and the unsupervised classification method based on fuzzy set theory. Image quantization and image enhancement are used to preprocess the POLSAR data. Then the polarimetric information and Fuzzy C-Means (FCM) clustering algorithm are used to classify the preprocessed images. The advantages of this algorithm are the automated classification, its high classifica-tion accuracy, fast convergence and high stability. The effectiveness of this algorithm is demonstrated by ex-periments using SIR-C/X-SAR (Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar) data. | Fu Yusheng Xie Yan Pi Yiming Hou Yinming | 2006 | Journal of Electronics(China)2006，23，4： | 2 |
| 6 | Degradation of the antibiotic sulfamonomethoxine sodium in aqueous solution by photo-Fenton oxidation显示文摘In this study, photo-Fenton oxidation was applied to degradation of sulfamonomethoxine sodium (SMMS) in aqueous solution. The operation parameters of pH, temperature, and concentrations of H2O2, Fe2+ and SMMS were investigated. The optimum conditions for the photo-Fenton process were determined as follows: [SMMS]=4.53 mg/L, pH 4.0, [H2O2]=0.49 mmol/L, [Fe2+]= 19.51 μmol/L and T=25°C. Under these conditions 98.5% of the SMMS degraded. The kinetics were also studied, and degradation of SMMS by the photo-Fenton process could be described by first-order kinetics. The apparent activation energy was calculated as 23.95 kJ/mol. Mineralization of the process was investigated by measuring the chemical oxygen demand (COD), and the COD decreased by 99% after 120 min. This process could be used as a pretreatment method for wastewater containing sulfamonomethoxine sodium. | SUN JianHui FENG JingLan SHI ShaoHui PI YunQing SONG MengKe SHI Yan | 2012 | Chinese Science Bulletin2012，57，5： | 2 |
| 7 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
| 8 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 9 | Dynamic dead-time controller for synchronous Boost DC-DC converters显示文摘 | W Yan C Pi W Li | 2010 | Electronics Letters2010，46，2： | 1 |
| 10 | Big mitogen-activated protein kinase (BMK1)/ ERK5 protects endothelial cells from apoptosis显示文摘 | Pi X Yan C Berk BC | 2004 | Circ Res2004，94，3： | 1 |
| 11 | Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole,a natural coumarin显示文摘 | Chen Xiao-hong Pi Rong-biao Zou Yan | 2010 | Eur J Pharmacol2010，629，13： | 1 |
| 12 | Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture,and the affected yields under several cell culture treatments显示文摘 | Yan Pi Keji Jiang Rong Hou | 2010 | Biocell2010，34，3： | 1 |
| 13 | Special magnetic phenomena in heavily doped La_(0.7-x)Dy_xSr_(0.3)MnO_3 system显示文摘The magnetism in heavily Dy doped La0.7-xDyxSr0.3MnO3(0.40≤x≤0.70)system is studied in this paper.The M-T relation seems to be complicated with the increase of x.For sample with x=0.40,AFM behavior exists at T≤TN and M-T curves under zero field cooling(ZFC)and field cooling(FC)exhibit typical behavior of spincluster glass state above TN.For the sample with x=0.50,the M-T curve under ZFC exhibits a valley at a low temperature while the M-T curve under FC exhibits the negative magnetization below TN.For samples with x=0.60,0.70,their ZFC M-T curves are similar to that of x=0.50,but the FC M-T curves do not exhibit negative values any more.All the peculiar phenomena above are well explained by Néel double-lattice model combined with M-H relation at typical temperatures.The molecular field theory fits well the negative magnetization for x=0.50. | LIU Ning 1,2 ,YAN GuoQing 1,3 ,CAI ZhiRang 1 ,PI Li 2 ,ZHANG Bei 2 &TONG Wei 2 1 Department of Physics,Suzhou College,Suzhou 234000,China 2 Structure Research Laboratory,University of Science and Technology of China,Hefei 230026,China 3 National Laboratory of Solid State Microstructures,Physics Department,Nanjing University,Nanjing 210093,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 1 |
| 14 | Promotion of nicotine biosynthesis in transgenic tobacco'by overexpressing allene oxide cyclase from Hyoscyamus niger显示文摘 | Keji Jiang Yan Pi Rong Hou | 2009 | Planta2009，229，： | 1 |
| 15 | Molecular cloning and expression profile of a jasmonate biosynthetic pathway gene for allene oxide cyclase from Hyoscyamus niger显示文摘 | Keji Jiang Zhihua Liao Yan Pi Zhuoshi Huang Rong Hou Ying Cao Qing Wang Xiaofen Sun Kexuan Tang | 2008 | Molecular Biology2008，，3： | 1 |
| 16 | Minor influence of sub-bowman kerato- mileusis on the posterior corneal surface at early stage 显示文摘 | Yan PI Du Z Wu N | 2013 | Curr Eye Res2013，38，8： | 1 |
| 17 | Recovery of iron oxide concentrate from high-sulfur and low-grade pyrite cinder using an innovative beneficiating process显示文摘 | Binbin He Xike Tian Yan Sun Chao Yang Yanglin Zeng Yanxin Wang Suxin Zhang Zhenbang Pi | 2010 | Hydrometallurgy2010，，2： | 1 |
| 18 | Investigation of microbial community structure in constructed mangrove microcosms receiving wastewater-borne polycyclic aromatic hydrocarbons (PAHs) and polybrominated diphenyl ethers (PBDEs)显示文摘 | Ya-fen Wang Yan Wu Na Pi Nora Fung-yee Tam | 2014 | Environmental Pollution2014，，： | 1 |
| 19 | Periglaucines A- D, anti-HBV and-HIV-1 alkaloids from Pericampylus glaucus 显示文摘 | Yan Menghong Cheng Pi Jiang Zhiyong | 2008 | J Nat Prod2008，71，5： | 1 |
| 20 | Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter显示文摘Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side effects.Post-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD ulcers.In this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine model.PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in vitro.Besides,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in vivo.In a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites.PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation.Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair. | Long-Mei Zhao Mei Gong Rui Wang Qi-Juan Yuan Yi Zhang Jin-Kui Pi Xiu-He Lv Yan Xie Hui-Qi Xie | 2021 | Regenerative Biomaterials2021，8，1： | 1 |
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