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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 3 | Maximal capacity nonorthogonal pulse shape modulation显示文摘To improve spectral utilization of communication system, a novel nonorthogonal pulse shape modulation(NPSM) based on prolate spheroidal wave function(PSWF) is proposed. The modulation employs nonorthogonal PSWF pulses to transmit information and it shows a higher capacity than traditional orthogonal modulations. The NPSM capacity under the constraint of finite input alphabet, which is determined by parameters of PSWF pulse, is derived. An optimization model for maximal capacity of NPSM is constructed and an exhaustive self-adapting gradient search algorithm for the model is proposed. A practical NPSM scheme with the maximal capacity is obtained by this search algorithm and it is proved to be superior to orthogonal signaling in the capacity. Our theoretical analysis is validated by numerical simulations and practical tests, and the results show that NPSM outperforms orthogonal modulations in the capacity and has a lower Peak-to-Average Power Ratio. | Chen Zhaonan Wang Hongxing Liu Xiguo Zhong Peilin | 2015 | Chinese Journal of Aeronautics2015，28，6： | 8 |
| 4 | Effects of Single and Repeated Exposure to a 50-Hz 2-mT Electromagnetic Field on Primary Cultured Hippocampal Neurons显示文摘The prevalence of domestic and industrial electrical appliances has raised concerns about the health risk of extremely low-frequency magnetic fields(ELF-MFs). At present, the effects of ELF-MFs on the central nervous system are still highly controversial, and few studies have investigated its effects on cultured neurons. Here, we evaluated the biological effects of different patterns of ELF-MF exposure on primary cultured hippocampal neurons in terms of viability, apoptosis, genomic instability,and oxidative stress. The results showed that repeated exposure to 50-Hz 2-mT ELF-MF for 8 h per day after different times in culture decreased the viability and increased the production of intracellular reactive oxidative species in hippocampal neurons. The mechanism was potentially related to the up-regulation of Nox2 expression.Moreover, none of the repeated exposure patterns had significant effects on DNA damage, apoptosis, or autophagy, which suggested that ELF-MF exposure has no severe biological consequences in cultured hippocampal neurons. | Ying Zeng Yunyun Shen Ling Hong Yanfeng Chen Xiaofang Shi Qunli Zeng Peilin Yu | 2017 | Neuroscience Bulletin2017，33，3： | 6 |
| 5 | Research advances in unsupported Pt-based catalysts for electrochemical methanol oxidation显示文摘Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical shortfalls, especially the undesirable activity and durability issues of electrocatalysts toward methanol oxidation reaction. In light of these challenges, the inherent advantages of unsupported Pt based nanostructures demonstrate their great potentials as durable and efficient electrocatalysts for direct methanol fuel cells. This review will summarize recent achievements of unsupported Pt-based electrocatalysts toward methanol oxidation, with highlighting the interactions between the performance and structure tailoring and composition modulating. At last, a perspective is proposed for the upcoming challenges and possible opportunities to further prompt the practical application of unsupported Pt-based electrocatalysts for direct methanol fuel cells. | Xin Long Tian Lijuan Wang Peilin Deng Yu Chen Bao Yu Xia | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 6 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 7 | 数字减影脑血管造影术对伴发眩晕的后循环缺血患者血管异常病因分析显示文摘目的通过数字减影脑血管造影术(DSA)对伴发眩晕的后循环缺血(PCI)患者的头颈部血管进行检查,分析其血管异常病因,掌握其发病规律。方法对138例伴发眩晕的PCI患者入院后给予详细的影像学检查,包括MRI、DSA,分析患者血管异常与PCI的因果关系。结果 138例患者,诊断为椎基底动脉系统短暂性缺血发作者89例、椎基底动脉系统脑梗死49例,综合所有的影像学检查结果分析,椎基底动脉血管异常者86例,考虑与PCI病因有关,有12例患者明确有心脏病心房颤动,考虑与后循环脑梗死病因有关,其余40例患者病因不明确。结论伴发眩晕的PCI患者的血管异常病因为:①椎基底动脉系统血管变异;②椎基底动脉系统血管狭窄或闭塞导致的后循环出现低灌注状态或脑梗死。 | 胡沛霖 陈树波 王文胜 李喜朋 周建峰 胡岩芳 HU Peilin CHEN Shubo,WANG Wensheng LI Xipeng,ZHOU Jian feng HU Yanfang | 2012 | 临床荟萃2012，27，6： | 4 |
| 8 | Mechanical properties and microstructure analysis of refilling friction stir welding on 2219 aluminum alloy显示文摘The 2219 aluminum alloy under refilling friction stir welding (RF-FSW) was investigated. The micrographs showed that the bead could be divided into six zones, and the grain size and shape were greatly different in these zones. According to the microstructure analysis, the weld nugget zone and the shoulder stirring zone consisted of equiaxed grains, while the grains in the heat affected zone were seriously coarsened. It was obvious that bending deformation occurred in the thermo-mechanically affected zone. According to the microhardness analysis, the lowest hardness of the weld was at the thermo-mechanically affected zone, and the microhardness increased with the retraction of the stir-pin. The tensile strength and elongation of the bead were 70% and 80% of the base metal, respectively. The tensile strength was slightly different for the stable stage and the retraction stage, while the elongation decreased in the retraction stage. The mechanical properties and microstructure responded to different retraction speed were analyzed, and it showed that the elongation decreased with increasing retraction speed. | Peilin LI Zhongfeng XU Chun YU Hao LU Junshan YAO Guoyu CHEN | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，3： | 3 |
| 9 | High mixing effectiveness lobed nozzles and mixing mechanisms显示文摘For a circular lobed nozzle with the exit plane displaced from the center body,adding a central plug at exit or replacing the nozzle with an alternating-lobe nozzle can improve the mixing effectiveness.In this study,numerical investigations of jet mixing in the lobed nozzles with a central plug and alternating-lobe nozzles in pumping operation were conducted.The effects of the central plugs with the wake ranging from attached to separated flow on the mixing were analyzed,along with the mechanism of improving the mixing performance in a'sword'alternating-lobe nozzle.The simulation results reveal that the large-scale mixing rate,which is dominated by streamwise vortices,is related to the intensity of the attainable heat and mass transfer in the streamwise vortices.The effects of the streamwise vortices on the normal vortex ring are virtually a manifestation of the heat and mass transfer/mixing process of the streamwise vortices.The simulation results also show that the central plug with the attached rear-flow performs better in improving the mixing effectiveness and pumping performance;on the contrary,if the rear-flow is separated,more pressure loss will be induced.In particular,a completely separated flow over the rear of the central plug will severely degrade the attainable heat and mass transfer in the streamwise vortices.For the sword alternating-lobe nozzle,wider sword deep troughs help to increase the flux of the secondary stream around the core region and delay the confluence of the primary stream in the region between the deep and shallow troughs.Thus,the mixing is improved in the middle and posterior segments.Compared to the lobed nozzle with a central plug,the improved sword alternating-lobe nozzle can achieve a higher mixing effectiveness with much less pressure loss,which is preferred in situations when the power loss of the engine is restricted. | SHENG ZhiQiang CHEN ShiChun WU Zhe HUANG PeiLin | 2015 | Science China(Technological Sciences)2015，58，7： | 3 |
| 10 | Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice显示文摘Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms.Pathogens employing this strategy are currently threatening global rice production.In the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing regions.The environment-linked variation was not attributable to any known host-related or external factors.Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic compound.ATT,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by B.plantarii up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling cascade.Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues.Mechanisms of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction assays.TroK,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by ATT.Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host's metabolic activity and subsequent signaling interference. | Haruna Matsumoto Yuan Qian Xiaoyan Fan Sunlu Chen Yanxia Nie Kun Qiao Dandan Xiang Xinzhong Zhang Meng Li Bo Guo Peilin Shen Qiangwei Wang Yunlong Yu Tomislav Cemava Mengcen Wang | 2022 | Fundamental Research2022，2，2： | 2 |
| 11 | Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid显示文摘The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)analysis.Here,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and reproducibility.The highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed molecules.At the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy.Further application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L.The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection. | YANG LI HAOLIN CHEN YANXIAN GUO KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO GUO WEN ZHANG HUIQING ZHONG ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU | 2021 | Photonics Research2021，9，6： | 2 |
| 12 | Structure elucidation and in vitro rat intestinal fermentation properties of a novel sulfated glucogalactan from Porphyra haitanensis显示文摘This study was to investigate the structure and rat fecal microbial fermentation properties of a polysaccharide fraction(PHP2)isolated from the red marine alga Porphyra haitanensis.PHP2 was characterized as a sulfated glucogalactan,with a hypothetical backbone structure of→4)Gα(1→6)G4 Sβ(1→4)Glc(1→and a side chain of Man(1→6)Glc.PHP2 had an irregular spherical chain conformation.The 16 S r RNA sequence analysis revealed that PHP2 modulated the rat fecal micro-flora composition,with a similar effect to inulin,changing the dominant genus(Lactobacillus and Escherichia-Shigella)and promoting the growth of organisms that degrade sulfur-containing polysaccharides,such as Desulfovibrio,Ruminococcaceae_UCG-005,and Ruminococcus_2.PHP2 can promote production of acetic,propionic and butyric acid by rat fecal micro-flora.Prediction of metabolic function suggested that PHP2 could modulate cholesterol metabolism.The sulfated glucogalactan fermentation behavior may be associated with its monosaccharide composition,chain branching and chain conformation.PHP2 appeared to have considerable potential as functional food,and was associated with sulfur-containing polysaccharides in general. | Peilin Chen Lu Liu Zirun Cheng Yi Zhang Baodong Zheng Xiaoke Hu Hongliang Zeng | 2023 | Food Science and Human Wellness2023，12，2： | 2 |
| 13 | Soluble CD163 and CD163 Expression on Monocytes Associated with Chronic Hepatitis B Inflammation and HBsAg Loss显示文摘Background and Aims:Monocyte/macrophage-associat-ed CD163 is an indicator of the severity of liver inflam-mation and cirrhosis,but the difference of soluble CD163(sCD163)levels in chronic hepatitis B(CHB)patients and hepatitis B surface antigen(HBsAg)-loss patients is un-clear.Herein,we aimed to compare the sCD163 levels in CHB patients and HBsAg-loss patients with or without an-tiviral treatment.Methods:sCD163 and CD163 expres-sion on monocytes were compared among four groups,healthy subjects,treatment-naïve CHB patients,sponta-neous HBsAg-loss patients,and treatment-related HBsAg-loss patients.The correlation between sCD163 levels and clinical parameters in CHB patients was analyzed.A group of 80 patients with hepatitis B virus(HBV)infection and liver biopsy were recruited.Results:sCD163 levels were higher in the CHB group than in the other three groups.sCD163 levels were higher in treatment-related HBsAg-loss patients than in spontaneous HBsAg-loss patients.sCD163 levels were negatively correlated with hepatitis B e-antigen(HBeAg)and HBsAg levels in HBeAg-positive patients.Liv-er biopsy results further demonstrated that sCD163 levels were elevated in CHB patients with substantial inflamma-tion(A≥2)or fibrosis(F≥2).The sCD163 model was more sensitive in predicting inflammation than other noninvasive models.Its levels were higher in patients with normal ala-nine aminotransferase levels and significant inflammation(A≥2)than in patients with no or mild inflammation.Con-clusions:sCD163 and CD163 expression on monocytes were associated with CHB inflammation and HBsAg loss,and may be used as markers to predict HBV-specific im-mune activation. | Peilin Xie Bilian Yao Dao Huang Yongyan Chen Qiming Gong Xinxin Zhang | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 2 |
| 14 | Single atomic cobalt electrocatalyst for efficient oxygen reduction reaction显示文摘Robust oxygen reduction reaction(ORR)catalysts are essential for energy storage and conversion devices,but their development remains challenging.Herein,we design a single-atom catalyst featuring isolated Co anchored on nitrogen-doped carbon(Co-SAC/NC)via a highly efficient“plasma-bombing”strategy.With a high loading(up to 2.5wt%),the well-dispersed single Co atoms in Co-SAC/NC give it robust ORR performance in an alkaline medium.It also demonstrates excellent battery performance when implemented as the air-cathode catalyst in a zinc-air battery(ZAB).Theoretical calculations reveal that the Co-N_(4)moiety experiences an“extraction/recovery”structural evolution during the ORR process,and the reaction's rate-determining step is the formation of OOH∗(reaction intermediate).This work provides a new strategy for designing robust ORR catalysts for high-performance ZABs and other energy-conversion devices. | Peng Rao Daoxiong Wu Tian-Jiao Wang Jing Li Peilin Deng Qi Chen Yijun Shen Yu Chen Xinlong Tian | 2022 | eScience2022，2，4： | 2 |
| 15 | Reactive cerium (IV) oxide powders by the homogeneous precipitation method显示文摘 | Chen Peilin Chen I W | 1993 | J Am Ceram Soc1993，76，6： | 1 |
| 16 | Specific Heat Anomaly of Lithium Sodium Niobate at Low Temperature显示文摘A differential scanning calorimetric(DSC)study of the crystal Li_(0.02)Na_(0.98)NbO_(3) was carried out in the temperature range from 120 to 300K.The specific heat changes anomalously at about 180K on cooling and about 260K on heating,implying a first order phase transition.The heat of transition ΔQ=(212±50)J/mol and the corresponding change in entropy AS=0.82J/mol.K.The thermal hysteresis of this transition is about 80K,in agreement with that previously obtained from the dielectric and pyroelectric measurements. | ZHANG Peilin ZHONG Weilie ZHAO Shaoxiang YANG Zhaohe CHEN Huanchu SONG Yongyuan | 1992 | Chinese Physics Letters1992，9，8： | 1 |
| 17 | Sintering of fine oxide powders: Ⅰmicro structural evolution显示文摘 | CHEN Iwei | 1996 | J Am Ceram Soc1996，79，12： | 1 |
| 18 | Periodic solutions for a two-species nonautonomous competition system with diffusion and impulses显示文摘 | Lingzhen Dong Lansun Chen Peilin Shi | 2006 | Chaos Solitons and Fractals2006，，5： | 1 |
| 19 | Microstructural finite element analysis of asphalt mixture using digital image processing 显示文摘 | CHEN Peilin YU Jiangmiao LI Xiaojin | 2006 | Journal of Anhui University of Technology2006，23，3： | 1 |
| 20 | 显示文摘 | Chen Peilin Chen Iwei | 1993 | J Am Ceram Soc1993，76，6： | 1 |
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