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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | First-principles Study of NiAl Alloyed with Rare Earth Element Ce显示文摘The structural, elastic, and electronic properties of NiAl alloyed with rare earth element (REE) Ce have been investigated by using density functional theory (DFT). It is found that Ce has a strong Al site preference and causes lattice distortion of NiAl. The calculation of elastic constants shows that Ce increased both the hardness and the ductility of NiAl, which could be explained by the formation of new ionic bonds between Al (and Ni) and Ce and the enhancement of covalent bonds in Ni8Al7Ce. Our results are in good agreement with the available experimental data and other theoretical results. | You Wang Junqi He Mufu Yan Chonggui Li Liang Wang YeZhou | 2011 | Journal of Materials Science & Technology2011，27，8： | 5 |
| 3 | Effects of cold metal transfer mode on the reaction layer of wire and arc additive-manufactured Ti-6Al-4V/Al-6.25Cu dissimilar alloys显示文摘Components of Ti and Al dissimilar alloys were obtained by wire and arc additive manufacturing using two cold metal transfer(CMT)modes.Direct current CMT(DC-CMT)mode was used for Ti alloy deposition,and DC-CMT or CMT plus pulse(CMT+P)mode was used for the Al alloy deposition.During deposition of the first Al alloy layer,little and a significant amount of Ti alloy were melted using DC-CMT and CMT+P mode,respectively.TiAl_(3)formed in the reaction layer when DC-CMT mode was used,while TiAl_(3),TiAl,and Ti3Al formed in the reaction layer when CMT+P mode was used.Compared to using DC-CMT mode,more cracks occurred when using CMT+P.The nanohardness of the reaction layer was between that of the Al and Ti alloys,irrespective of the CMT modes.The average tensile strengths of the samples using DC-CMT and CMT+P mode were 108 MPa and 24 MPa,respectively.DC-CMT mode was more suitable for the wire and arc additive manufacturing of Ti/Al dissimilar alloys. | Yinbao Tian Junqi Shen Shengsun Hu Jian Gou Yan Cui | 2021 | Journal of Materials Science & Technology2021，，15： | 4 |
| 4 | Broad area quantum cascade lasers operating in pulsed mode above 100℃ at λ ~ 4.7 μm显示文摘We demonstrate a broad area(400 μm) high power quantum cascade laser(QCL). A total peak power of 62 W operating at room temperature is achieved at λ~ 4.7 μm. The temperature dependence of the peak power characteristic is given in the experiment, and also the temperature of the active zone is simulated by a finite-elementmethod(FEM). We find that the interface roughness of the active core has a great effect on the temperature of the active zone and can be enormously improved using the solid source molecular beam epitaxy(MBE) growth system. | Yue Zhao Fangliang Yan Jinchuan Zhang Fengqi Liu Ning Zhuo Junqi Liu Lijun Wang Zhanguo Wang | 2017 | Journal of Semiconductors2017，38，7： | 3 |
| 5 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 6 | 青海河湟谷地胃癌病理特征及其变化趋势分析(英文)显示文摘Objective: The aim of our study was to discuss changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China in recent 10 years. Methods: A retrospective case-control study was performed on 2379 newly-diagnosed gastric cancer patients. All of them came from Hehuang Valley. The patients were divided into two groups [recent 5 years(R5Y) and late 5 years(L5Y)] from February 2003 to February 2013, and the clinicopathological data were surveyed retrospectively. Results: The constituent ratio of upper 1/3 gastric cancer in R5Y and L5Y was 33.5% and 20.7%, respectively, and it showed a significant difference between the two groups(χ2 = 21.28, P = 0.00). The constituent ratio of squamous carcinoma/adenosquamous carcinoma was 2.7% and 1.6%, respectively, and it also showed a significant difference between two groups(χ2 = 50.91, P = 0.00). The constituent ratio of moderately-poorly differentiated/poorly differentiated gastric carcinoma was 84.2% and 50.2%, respectively, and it showed statistically significant difference(χ2 = 30.28, P = 0.00). The detection rate of early gastric cancer(EGC) was 1.47%(35/2379). The constituent ratio of the types of Borrmann II and Borrmann IV of advanced gastric cancer(AGC) among 2379 cases was 47.6% and 40.8%, respectively, and that still showed statistically significant difference(χ2 = 18.80, P = 0.00). The constituent ratio of diffuse-type of gastric cancer in R5Y and L5Y was 36.2% and 30.8%, respectively, even there was a significant difference(χ2 = 7.49, P = 0.01). Furthermore, there were also significant differences in regional lymph nodes metastasis, perineural infiltration and vascular invasion(P < 0.05). The positive detection rate of HER2, ER and PR was 14.88%, 17.23% and 15.93%, respectively. The constituent ratio of HP in two groups was 43.8% and 36.2% respectively, and it also showed a significant difference(χ2 = 13.51, P = 0.00). Conclusion: The pathogenic sites in gastric cancer change to the upper stomach in Hehuang Valley in recent 10 years, and the detection rate of squamous carcinoma/adenosquamous carcinoma reveals a sharp rise. Borrmann III is still one of the main types of advanced gastric cancer, but the detection rates of Borrmann II and IV are increasing. The main type of gastric cancer is the intestinaltype, but the ratio of diffuse-type is also increasing in recent 10 years. The HP detection rate is 40.65%(967/2379), and it has a slight rise in recent 10 years. The detection rate of poorly differentiated adenocarcinoma is increasing despite the fact that the moderately/moderately-poorly differentiated adenocarcinoma is the main histologic types. High detection rates of lymph nodes metastasis, perineural infiltration and vascular invasion indicate poor prognosis in patients with gastric cancer. There is no change in HER2 positive rate, on the contrary, there are a little increase in ER and PR expression in Hehuang Valley. | Su Yan Bin Li Junqi Wu Dawei Xie Yingcai Ma Yuanzhi Xiong Xuxiang Ma Xinjian Guo Man Dai Daquan Zhang Xinyang Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，2： | 2 |
| 7 | MULTI-SHOP SCHEDULING PROBLEM显示文摘A new concept of multi-shop (M ) is put forward which contains all basic shops including open shop (O), job shop (J ), flow shop (F ) and hybrid flow shop (H ) so that these basic shop can be scheduled together. Several algorithms including ant colony optimization (ACO), most work remaining (MWR), least work remaining (LWR), longest processing time (LPT) and shortest processing time (SPT) are used for scheduling the M. Numerical experiments of the M adopting data of some car and reC series benchmark instances are tested. The results show that the ACO algorithm has better performance for scheduling the M than the other algorithms, if minimizing the makespan ( C m*ax) is taken as the objective function. As a comparison, the separate shops contained in the M are also scheduled by the ACO algorithm for the same objective function, when the completing time of the jobs in the previous shop is taken as the ready time of these jobs in the following shop. The results show that the M has the advantage of shortening the makespan upon separate shops. | HU Yanhai YAN Junqi MA Dengzhe YE Feifan ZHANG Jie | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 2 |
| 8 | EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity显示文摘 | Jun-Fang Zheng Li-Cui Sun Hua Liu Yan Huang Yang Li Junqi He | 2010 | Amino Acids2010，，4： | 1 |
| 9 | Research and development on constraint-based product family design and assembly simulation显示文摘 | JIANG Zuhua YAN Junqi | 2003 | Journal of Materials Processing Technology2003，139，13： | 1 |
| 10 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 11 | VIRTUAL FUEL-PUMP DESIGN显示文摘Some concepts of virtual product are discussed. The key technologies of virtual fuel-pump development are in detail analysed, which include virtual fuel-pump product modeling, intelligent simulation, distributed design environment, and virtual assembly. The virtual fuel-pump development prototype system considers requirement analysis, concept design, injection preferment analysis, detailed design, and assembly analysis. | Jiang Zuhua Yan Junqi School of Mechanical Engineering,Shanghai Jiaotong University,Shanghai 200030,China | 2002 | Chinese Journal of Mechanical Engineering2002，15，1： | 1 |
| 12 | A methodology for smoothing of point cloud data based on anisotropic heat conduc- tion theory显示文摘 | Zhang Xuechang Xi Juntong Yan Junqi | 2006 | The International Journal of Advanced Manufac- turing Technology2006，30，8： | 1 |
| 13 | Production engineering-oriented virtual factory: a planning cell-based approach to manufacturing systems design显示文摘 | ZHAI Wenbin YAN Junqi MA Dengzhe | 2006 | International Journal of Advanced Manufacturing Technology2006，28，910： | 1 |
| 14 | Modeling and processing of functionally graded materials for rapid prototyping显示文摘 | Zhou Manyuan Xi Juntong Yan Junqi | 2004 | Journal of Materials Processing Technology2004，146，3： | 1 |
| 15 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 16 | An asynchronous and synchronous coupling approach in the networked rapid product development显示文摘 | NI Yanrong FAN Feiya YAN Junqi | 2003 | International Journal of Advance Manufacturing Technology2003，22，12： | 1 |
| 17 | Simulation and experimental verification of off-axis fiber Bragg grating bending sensor with high refractive index modulation显示文摘Off-axis FBG simulations were performed in this paper using a finite element method in conjunction with the conformal mapping technique to study the bending sensing characteristics of the off-axis FBG with high index modulation.The refractive index(RI)increase of the grating region is taken into consideration for the mode field simulation.The influences of high RI increase and the offset distance of the grating on the bending sensitivity were analyzed.Off-axis FBGs with different offset distances were fabricated using femtosecond laser with phase mask technique in standard single-mode fiber.The simulation results were verified by the experiment.A bending sensitivity of 0.055 d B/m^(-1) was achieved with an offset distance of 4μm.The simulation and experiment results suggest that the grating offset distance has a greater influence on the sensitivity of the off-axis FBG with high RI modulation than that with low RI modulation.The proposed sensor structure and simulation results can provide suggestion for the design and processing of off-axis FBG bending sensors. | CUI Wei ZHOU Yanfang YAN Zhonghua GUO Junqi YUE Yiting CHEN Hao | 2022 | Optoelectronics Letters2022，18，4： | 1 |
| 18 | Virtual maching based on holographic product modeling显示文摘 | YAN Junqi JIANG Zuhua MA Dengzhe | 2000 | Computer Integrated Manufacturing Systems-CIMS2000，6，5： | 1 |
| 19 | Study on virtual product development and its modeling method显示文摘 | HUANG Bin YAN Junqi JIANG Zuhua | 2002 | Computer Integrated Manufacturing System-CIMS2002，8，4： | 1 |
| 20 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
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