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| 1 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 2 | Contrastive Consensus Graph Learning for Multi-View Clustering显示文摘Dear Editor,This letter proposes a contrastive consensus graph learning model for multi-view clustering.Graphs are usually built to outline the correlation between multi-model objects in clustering task,and multiview graph clustering aims to learn a consensus graph that integrates the spatial property of each view. | Shiping Wang Xincan Lin Zihan Fang Shide Du Guobao Xiao | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，11： | 1 |
| 3 | BitVault: a highly reliable distributed data retention platform显示文摘 | Zhang Zheng Lian Qiao Lin Shiding | 2007 | Operating Systems Review2007，41，2： | 1 |
| 4 | Low-temperature superplasticity of ZK40 magnesium alloy processed using equal channel angular pressing显示文摘Microstructure evolution and superplastic behaviors of ZK40 magnesium alloy were investigated in the temperature range of 473~623 K. Transmission electron microscopy (TEM) was used to study the microstructure changes, twinning occurred significantly after being processed by equal channel angular pressing (ECAP) for one pass through the die, the mean grain size was 5.6μm. Finer grains can be obtained after further processing through ECAP, the average grain size of the alloy processed by ECAP for three passes was as low as 0.8 μm; this alloy exhibited low temperature superplasticity at 473~523 K, elongations obtained at the same initial strain rate of 1×10-3 s-1 were 260% at 473 K and 612% at 523 K, respectively. Corresponding values for the ZK40 alloy processed by ECAP for only one pass were 124% at 473 K and 212% at 523 K, respectively; poor superplastic behavior of this material was related to the long-range stresses associated with the non-equilibrium grain boundaries within the coarse grains. The incompatibility between fine and coarse grains was thought to be unfavorable to the improvement of superplasticity. | Li LIN Lijia CHEN Wei WU ZHENG Liu Teng LIU Shiding WU | 2004 | China Foundry2004，1，1： | 0 |
| 5 | Grafting of protein-protein binding sites显示文摘A strategy for grafting protein-protein binding sites is described. Firstly, key interactionresidues at the interface of ligand protein to be grafted are identified and suitable positions in scaffold protein for grafting these key residues are sought. Secondly, the scaffold proteins are superposed onto the ligand protein based on the corresponding Cα and Cβ atoms. The complementarity between the scaffold protein and the receptor protein is evaluated and only matches with high score are accepted. The relative position between scaffold and receptor proteins is adjusted so that the interface has a reasonable packing density. Then the scaffold protein is mutated to corresponding residues in ligand protein at each candidate position. And the residues having bad steric contacts with the receptor proteins, or buried charged residues not involved in the formation of any salt bridge are mutated. Finally, the mutated scaffold protein in complex with receptor protein is co-minimized by Charmm. In addition, we | Shide Liang Lan Xiao Fenglou Mao Lin Jiang Yuzhen Han Luhua Lai | 2000 | Chinese Science Bulletin2000，45，18： | 0 |
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