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| 1 | Interpretation of breast cancer screening guideline for Chinese women显示文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China. | Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao | 2019 | Cancer Biology & Medicine2019，16，4： | 10 |
| 2 | Long-term outcomes in patients with ypT0 rectal cancer after neoadjuvant chemoradiotherapy and curative resection显示文摘Objective: For patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy(NCRT), significant pathological response of the primary tumor has been proposed to identify candidates for organ preservation. However, this does not address metastatic lymph nodes in the mesorectum. The aim of this study was to assess the incidence of lymph node metastases in ypT0 patients treated with NCRT and curative resection and to explore risk factors associated with survival.Methods: This was a retrospective study of patients with ypT0 rectal cancer after NCRT and curative resection at a tertiary care center in China from 2005 to 2014.Results: A total of 60(18.6%) patients who underwent surgery after NCRT and achieved ypT0 were enrolled in this study; one patient was excluded owing to lack of follow-up. Of these 59 patients, lymph node metastases were found in the mesorectum(ypT0N+) in eight(13.6%) patients. After a median follow-up of 52 months, 5-year recurrence-free survival(82.7% vs. 62.5%, P=0.014) and overall survival(OS)(90.9% vs. 70.0%, P=0.032) were much higher in ypN0 than yp N+ patients. Multivariate analyses showed that ypN+ status(P=0.009) and perioperative blood transfusion(BT)(P=0.001) were significantly independent risk factors associated with recurrence; however, no factor was correlated with 5-year OS.Conclusions: Patients with ypT0N0 rectal cancer can achieve excellent long-term outcomes; however, positive lymph nodes or tumor deposits can still be found in 13.6% of ypT0 patients. Nodal positivity in the mesorectum and perioperative BT are independent risk factors for recurrence. | Zhao Lu Pu Cheng Fu Yang Zhaoxu Zheng Xishan Wang | 2018 | Chinese Journal of Cancer Research2018，30，2： | 8 |
| 3 | Safety and survival outcomes of transanal natural orifice specimen extraction using prolapsing technique for patients with middle-to low-rectal cancer显示文摘Objective:The transanal approach to specimen collection,combined with the prolapsing technique,is a wellestablished and minimally invasive surgery for treating rectal cancer.However,reports on outcomes for this approach are sparse.We compared short-and long-term outcomes of conventional laparoscopic surgery(CLS)vs.transanal natural orifice specimen extraction(NOSE)using the prolapsing technique for patients with middle-to low-rectal cancer.Methods:From January 2013 to December 2017,we enrolled consecutive patients with middle-to low-rectal cancer undergoing laparoscopic anterior resection.Totally,50 patients who underwent transanal NOSE using the prolapsing technique were matched with 50 patients who received CLS.Clinical parameters and survival outcomes between the two groups were compared.Results:Estimated blood loss(29.70±29.28 vs.52.80±45.09 mL,P=0.003),time to first flatus(2.50±0.79 vs.2.86±0.76,P=0.022),time to liquid diet(3.62±0.64 vs.4.20±0.76 d,P<0.001),and the need for analgesics(22%vs.48%,P=0.006)were significantly lower for the NOSE group compared to the CLS group.The incidences of overall complications and fecal incontinence were comparable in both groups.After a median follow-up of 44.52 months,the overall local recurrence rate(6%vs.5%,P=0.670),3-year disease-free survival(86.7%vs.88.0%,P=0.945)and 3-year overall survival(95.6%vs.96.0%,P=0.708),were not significantly different.Conclusions:For total laparoscopic rectal resection,transanal NOSE using the prolapsing technique is effective and safe,and associated with less trauma and pain,a faster recovery,and similar survival outcomes compared to CLS. | Zhao Lu Haipeng Chen Mingguang Zhang Xu Guan Zhixun Zhao Zheng Jiang Zheng Liu Zhaoxu Zheng Xishan Wang | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 4 | Retreatment of a patient who presented with synchronous multiple primary colorectal carcinoma: report of a case显示文摘It is well known that one-stage resection of synchronous multiple primary colorectal carcinoma is an ideal choice if the patient's physical condition is not bad. Detailed examination of the whole intestinal tract is very important for patients with colorectal cancer, which could prevent patients from receiving repeat treatment to a great extent. We present a case report of a patient with synchronous primary colorectal cancer. Because pre-or intra-operative examination is not sufficient at his first consultation, the patient had undergone multiple operations after receiving chemotherapy, radiotherapy and intestinal stent insertion, which results in peritoneal adhesions formation. The preoperative placement of prophylactic ureteral catheters facilitated recognition of ureters in operation that assure the prevention of ureteral injuries. If not aware of the importance of detailed preoperative examination and standardized treatment can lead to wrong treatment as in this case. Prophylactic ureteral catheters might assist in their immediate recognition. | Zheng Jiang Shan Muhammad Xishan Wang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 5 | Influence of Perioperative Blood Transfusion on Prognosis in Patients with Colon Cancer显示文摘客观:探索起作用的仙子的影响有结肠癌的病人的手术后的幸存上的输血。方法:Univariate 和 multivariateretrospective 分析总共在 10 年的一个时期期间通过手术被对待的 723 个结肠癌病人的在幸存上被执行。结果:Kaplan-Meier 估计显示出起作用的那超过 800 mL 仙子输血幸存预言者。输血显著地影响了病人的预后 40 岁并且更年轻,那些 undergoinghelicoloectomy 左边,那些与乳头状腺癌,那些与大肿瘤(直径≥ 8cm ) ,那些与阶段Ⅰ肿瘤,那些与没有肝转移的淋巴的节点转移和那些。在里面多变量分析仅仅肿瘤地点,操作的 radicality,淋巴的侵略,肝转移,肿瘤侵略的深度和 TNM 舞台保留了他们的 significance.Conclusion:Perioperative 输血是为有到某程度的结肠癌的病人的预示的因素。输血的指示必须严格地被限制,特殊比 40 岁年轻的住院病人与右边损害,乳头状腺癌,大肿瘤(直径≥ 8 厘米) ,阶段Ⅰ肿瘤和淋巴的节点转移或没有肝转移。Butperioperative 输血不能为有阶段Ⅳ疾病并且与远转移的病人是有害的。 | LIANG Han WANG Xiaona WANG Baogui PAN Yuan LIU Ning WANG Dianchang HAO Xishan | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 6 | Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study显示文摘 | Runmei Li Changli Wang Liang Liu Chunjuan Du Shui Cao Jinpu Yu Shizhen Emily Wang Xishan Hao Xiubao Ren Hui Li | 2012 | Cancer Immunology Immunotherapy2012，，11： | 2 |
| 7 | SEM in-situ investigation on fatigue cracking behavior of P/M Rene95 alloy with surface inclusions显示文摘The low-cycle fatigue behavior of powder metallurgy Rene95 alloy containing surface inclusions was investigated by in-situ observation with scanning electron microscopy (SEM). The process of fatigue crack initiation and early stage of propagation behavior indicates that fatigue crack mainly occurs at the interface between the inclusion and the matrix. The effect of inclusion on the fatigue crack initiation and the early stage of crack growth was very obvious. The fatigue crack growth path in the matrix is similar to the shape of inclusion made on the basis of fatigue fracture image analysis. The empiric relation between the surface and inside crack growth length, near a surface inclusion, can be expressed. Therefore, the fatigue crack growth rate or life of P/M Rene95 alloy including the inclusions can be evaluated on the basis of the measurable surface crack length parameter. In addition, the effect of two inclusions on the fatigue crack initiation behavior was investigated by the in-situ observation with SEM. | Xishu Wang Lina Zhang Yanping Zeng Xishan Xie | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 2 |
| 8 | MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7显示文摘 | Qiang Li Chaoxia Zou Chendan Zou Zhongjing Han Haifeng Xiao Huiyan Wei Wei Wang Lei Zhang Xueying Zhang Qingchao Tang Chunjing Zhang Ji Tao Xishan Wang Xu Gao | 2013 | Cancer Letters2013，，： | 1 |
| 9 | Three New Chromone Derivatives Produced by Phomopsis sp. HNY29-2B from Acanthus ilicifolius Linn.显示文摘三新 chromone 衍生物, phomochromenones 交流(1-3 ) ,和一已知的 chaetocyclinone B (4 ) 从 Phomopsis sp 的文化被获得。HNY29-2B 从红树属植物叶板 ilicifolius 悬崖孤立,它从华南海是镇定的。他们的结构被 1 D NMR 和 2 象集体分光镜的数据一样的 D NMR。1 和 2 的绝对配置被电子圆形的二色性(ECD ) 的量化学药品计算分配系列。化合物 3 是拥有唯一的 chromeno 的碱的第三个例子[3,2-c ] pyridine 原子核。在 bioactivity 试金,化合物 4 与 8.13 和 3.59 污穹摥 ? 穩牯歯? 效正愠摮匠穵歵? 楍慹牵 ? 牣獯 ? 潣的 IC 50 价值对人的前列腺癌症房间线(PC-3 和 DU145 房间) 显示出 cytotoxicity 吗? | Bo Ding Zhiyuan Wang Guoping Xia Xishan Huang Fang Xu Wenrui Chen Zhigang She | 2017 | Chinese Journal of Chemistry2017，35，12： | 1 |
| 10 | The concentration of CYFRA 21-1, NSE and CEA in cerebro-spinalfluid can be useful indicators for diagnosis of meningeal carcinomatosis oflung cancer显示文摘 | Peng Wang Yingzhe Piao Xiaohui Zhang Wenliang Li Xishan Hao | 2013 | Cancer Biomarkers2013，，2： | 1 |
| 11 | MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7显示文摘 | Qiang Li Chaoxia Zou Chendan Zou Zhongjing Han Haifeng Xiao Huiyan Wei Wei Wang Lei Zhang Xueying Zhang Qingchao Tang Chunjing Zhang Ji Tao Xishan Wang Xu Gao | 2013 | Cancer Letters2013，，1： | 1 |
| 12 | Analysis of Lymph Node Metastases of 1,526 Cases with Thoracic Esophageal and Cardiac Carcinomas: A Random Sampling Report froni the Fourth Hospital of Hebei Medical University from 1996 to 2004显示文摘OBJECTIVE To summarize the regular pattern and state oflymph node metastasis of patients with esophageal and cardiaccarcinomas,so as to analyze factors influencing lymph nodemetastasis.METHODS Clinical data collected from 1,526 thoracicesophageal and cardiac carcinoma patients who were admitted inthe Fourth Hospital of Hebei Medical University during a periodfrom January 1996 to December 2004,were randomly selectedand an Access Database of the patient's information was set up.Eight clinico-pathologic factors,including the patient's age,tumorlocation and size,pathological classification,the depth of tumorinvasion,vascular tumor embolus (VTE),the state of surroundingorgan encroachment and the status of tumor residues,wereidentified.A correlation between these factors and metastases wasstatistically analyzed using SPSS13.0 software.RESULTS Lymph node metastatic sites from esophagealcarcinomas included the thoracic and abdominal cavity.Lymphnode metastasis from the superior esophageal carcinomasmainly occurred in the neck and thoracic cavity.There was atwo-way lymph node metastasis in the patients with the middleesophageal carcinoma.The inferior esophageal carcinomas mainlymetastasized to the paraesophageal,paragastric cardia,and leftgastric artery lymph nodes.The rate and degree of the metastasisfrom the inferior esophageal carcinomas were significantly highercompared to those of the superior and the middle esophagealcarcinomas (P<0.0125).The degree of abdominal lymph node metastasis fromcarcinomas of the gastric cardia was significantly higher comparedwith that of esophageal carcinomas.In the group with carcinomaof the gastric cardia,the rate and degree of the lymph nodemetastases in the paragastric cardia and left gastric artery weresignificantly higher compared to the group with esophagealcarcinoma (P<0.05).Paraesophageal lymph node metastasis fromcarcinomas of the gastric cardia in the thoracic cavity frequentlyoccurred,too,and the degree of the metastasis was similar to thatof esophageal carcinoma.There was no significant difference inthe rate and degree of the paraesophageal lymph-node metastasisbetween the group with carcinoma of the gastric cardia comparedto those with esophageal carcinoma (P>0.05).Multifactoriallogistic regression analysis showed that the tumor size,depth oftumor encroachment,VTE,and tumor residues could all bringabout obvious impact on lymph-node metastases (P<0.05).CONCLUSION Lymph node metastasis from superioresophageal carcinomas mainly occurs in the neck and thoraciccavity.The middle esophageal carcinomas presented a two-waylymph-node metastasis (both the upwards and the downwards),and the lymph node metastasis from inferior esophagealcarcinomas mainly occurred in the thoracic and abdominal cavities.The metastases of carcinoma of the gastriccardia were most commonly found in the abdominalcavity,with frequent paraesophageal lymph-nodemetastasis.The sufficient attention should be paidto neck lymph node clearance in cases of esophagealcarcinoma.What is of the greatest concern is theclearance of the left gastric artery lymph nodes,andalso in cases of gastric cardia carcinoma,clearance,the paraesophageal lymph nodes.With an increasein the tumor size and depth of tumor encroachment,and occurrence of VTE and tumor residual cells,therisk of lymph node metastasis is significantly raised (P<0.05). | Wei Liu Xishan Hao Yong Chen Haixin Li Shijie Wang Peizhong Wang Hng Jin Liyun Guan Qian Fan Linan Song Yumin Ping Xianli Meng Rui Wang Junfeng Liu Xiaoling Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 1 |
| 13 | Long noncoding RNA HOTAIR involvement in cancer显示文摘 | Yansheng Wu Li Zhang Yang Wang Hui Li Xiubao Ren Feng Wei Wenwen Yu Xudong Wang Lun Zhang Jinpu Yu Xishan Hao | 2014 | Tumor Biology2014，，10： | 1 |
| 14 | Rosiglitazone Suppresses Glioma Cell Growth and Cell Cycle by Blocking the Transforming Growth Factor-Beta Mediated Pathway显示文摘 | Peng Wang Jinpu Yu Qiang Yin Wenliang Li Xiubao Ren Xishan Hao | 2012 | Neurochemical Research2012，，10： | 1 |
| 15 | Imaging performance evaluation in depth-of-interaction PET with a new method of sinogram generation:A Monte Carlo simulation study显示文摘In conventional PET systems,the parallax error degrades image resolution and causes image distortion.To remedy this,a PET ring diameter has to be much larger than the required size of field of view(FOV),and therefore the cost goes up.Measurement of depth-of-interaction(DOI)information is effective to reduce the parallax error and improve the image quality.This study is aimed at developing a practical method to incorporate DOI information in PET sinogram generation and image reconstruction processes and evaluate its efficacy through Monte Carlo simulation.An animal PET system with 30-mm long LSO crystals and 2-mm DOI measurement accuracy was simulated and list-mode PET data were collected.A sinogram generation method was proposed to bin each coincidence event to the correct LOR location according to both incident crystal indices and DOI positions of the two annihilation photons.The sinograms were reconstructed with an iterative OSMAPEM(ordered subset maximum a posteriori expectation maximization)algorithm.Two phantoms(a rod source phantom and a Derenzo phantom)were simulated,and the benefits of DOI were investigated in terms of reconstructed source diameter(FWHM)and source positioning accuracy.The results demonstrate that the proposed method works well to incorporate DOI information in data processing,which not only overcomes the image distortion problem but also significantly improves image resolution and resolution uniformity and results in satisfactory image quality. | XIA Yan MA Tianyu LIU Yaqiang SUN Xishan WANG Shi SHAO Yiping | 2011 | Nuclear Science and Techniques2011，22，3： | 1 |
| 16 | Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study显示文摘 | Runmei Li Changli Wang Liang Liu Chunjuan Du Shui Cao Jinpu Yu Shizhen Emily Wang Xishan Hao Xiubao Ren Hui Li | 2012 | Cancer Immunology, Immunotherapy2012，，11： | 1 |
| 17 | Characterization of Natural Killer Cells in the Liver of Young Mice显示文摘OBJECTIVE To determine the quantity and quality of liver NK cells from young and adult mice and compare their characteristics. METHODS C57BL/6 mice were used at 2 weeks (young) and 8 weeks (adult) of age. The percentage and absolute number of NK cells in the liver and spleen were analyzed. The cytotoxicity of NK cells in the liver and spleen against various targets were detected by a 4 h 51Cr-release method. FACScan was used to analyze the expression of CD69, Mac-1, Ly49C/I and CD94 on the NK cells. Perforin mRNA levels were analyzed by the reverse transcription polymerase chain reaction (RT-PCR). RESUTLS The percentages of NK cells in the liver of young and adult mice were similar (11.9%±1.7% vs. 9.9%±1.6%, P>0.05), but the absolute number per liver weight was higher in the young animals (11.6±2.5x105/g vs. 3.4±0.8x105/g, P<0.05). The level of NK cytotoxicity was extremely high in the liver of young compared to adult mice (71.0%±5.5% vs. 23.8%±4.4%, P<0.05), but this difference was not observed in the spleen. Phenotypes of the liver NK cells from young and adult mice were completely different from each other. The liver NK cells from young mice were CD69high Mac-1lowLy49C/ Ilow, whereas NK cells from older mice displayed inverse antigen levels (CD-69low Mac-1high Ly49C/Ihigh). The expression levels of other NK cell-related markers were similar in both groups.The perforin mRNA level in the liver lymphocytes from young mice was consistently greater compared to adult mice. CONCLUSION From 2 to 8 weeks C57BL/6 mice liver NK cells undergo age-associated changes. At 2 weeks of age the liver NK cells showed a high level of NK cytotoxicity and a unique phenotype which was not apparent at 8 weeks of age. | Peng Zhao Jiansheng Guo Guangjun Wang Qiang Chi Dequan Wu Zhaolin Zeng Xuefeng Bai Xishan Hao | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 1 |
| 18 | Preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction:a propensity score matching study of 120 cases(with video)显示文摘Background:Compared with conventional laparoscopic surgery,natural orifice specimen extraction surgery(NOSES)has many advantages.Laparoscopic right colectomy with transvaginal specimen extraction has been reported,but the safety and feasibility of transrectal specimen extraction in male patients with ascending colon cancer remain to be verified.This study aimed to preliminarily evaluate the feasibility and safety of laparoscopic right hemicolectomy with transrectal specimen extraction.Methods:The study was conducted at a single tertiary medical center in China.A total of 494 consecutive patients who underwent laparoscopic right colectomy between September 2018 and September 2020 were included.Transrectal specimen extraction was performed in 40 male patients(the NOSES group).Patients in the NOSES group were matched to the conventional laparoscopic group using propensity score matching at a 1:2 ratio.Short-term and long-term outcomes between the two groups were compared and evaluated.Results:Forty patients in the NOSES group and 80 patients in the conventional laparoscopic group were matched for analysis.Baseline characteristics were balanced after propensity matching.The operative features,including operating time,intraoperative bleeding,and the number of harvested lymph nodes,were statistically comparable in both groups.In terms of post-operative recovery,patients in the NOSES group showed preferable outcomes,as evidenced by less post-operative pain and faster return to flatus,defecation,and discharge.The post-operative complications rate,according to the Clavien–Dindo classification system,was similar in both groups.No differences in overall survival or disease-free survival were observed between the two groups.Conclusions:Laparoscopic right colectomy with transrectal specimen extraction is oncologically safe.Compared with conventional laparoscopic right colectomy,it can reduce post-operative pain,accelerate post-operative recovery,shorten the hospital stay,and achieve better cosmetic effect. | Mingguang Zhang Zheng Liu Peng Sun Xiyue Hu Haitao Zhou Zheng Jiang Jianqiang Tang Qian Liu Xishan Wang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 19 | Partial Discharge Characteristics in the Course of Aging within XLPE Insulation显示文摘This paper deals with the experimental study on the correlation between partial discharge (PD) characteristic parameters and corresponding aging degree of insulation in the course of the aging within cross-linked polyethylene (XLPE) insulation. The aging tests were performed on a section of 10 kV transmission cable by means of water needle method. The PD macroscopic characteristic parameters were found to be significantly dependent on the corresponding aging degree of insulation in the course of aging of XLPE, and different kind of aging stage has different characteristics. Beside, there are similar regularity but different PD amplitude in the course of aging of XLPE insulation in different electrolyte, and their insulation life is different. Therefore, according to the changing regularity of the PD macroscopic characteristic parameters within XLPE insulation judging the aging degree of XLPE insulation will be an effective method. | WANG Hongxin CHENG Shukang WEN Xishan FU Duan | 2006 | Wuhan University Journal of Natural Sciences2006，11，2： | 0 |
| 20 | Analysis of Clinicopathologic Features of Esophageal Carcinoma Patients Undergoing Surgery-a Report of 4,329 Cases显示文摘OBJECTIVE To investigate the clinicopathological features of esophageal carcinoma(EC)patients,and to analyze epidemiologic characteristics and the current situation of esophageal cancioma in the southern area of Hebei Province. METHODS A total of 4329 patients with esophageal cancinoma, undergoing surgery in the Fourth Hospital of Hebei Medical University during a period from January 1996 to December 2005, were selected.Collection and statistical analysis of the pathologic data were performed using a SAS 6.0 so ware package. RESULTS Over the past ten years,there has been a tendency for an increase in the mean age of EC onset(P<0.05),a downtrend in the percentage of squamous cancer(SqCa)(P<0.05)and an uptrend in the frequency of small cell carcinoma(P<0.05).In clinical stages,there was a drop in the percentage of Stage-II squamous EC patients(P<0.05),and an increase in that of Stage- IV patients(P<0.05).There were statistical differences in sex,age, pathologic types,depth of infiltration,ratio of stages and lymph node metastasis,etc.among the superior,middle and inferior segments of the EC diseased region(P<0.05). CONCLUSION It was relatively late for the EC patients from this area to see a doctor,resulting in a drop in the ratio of SqCa and an ascensus in that of small cell cancer.However,due to a low incidence of adenocarcinoma,no obvious ascending tendency was found in the frequency of this carcinoma over the past ten years. | Wei Liu Xishan Hao Ying Jin Haixin Li Linan Song Shijie Wang Peizhong Wang Yong Chen Qian Fan Liyun Guan Yumin Ping Xianli Meng Rui Wang Junfeng Liu Xiaoling Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
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