|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Heavy metal accumulation by panicled goldenrain tree(Koelreuteria paniculata) and common elaeocarpus(Elaeocarpus decipens) in abandoned mine soils in southern China显示文摘Phytoremediation can be used as a sustainable technology for mine spoil remediation to remove heavy metals.This study investigated the concentration of 7 heavy metal contamination in soil and plant samples at an abandoned mine site.We found that,after vegetation remediation at the abandoned mine site,the reduction rates for 7 heavy metals were in the range of 4.2%-86%,where reduction rates over 50% were achieved for four heavy metals(Zn,Mn,Cd,Ni).Transfer coeffcients of the panicled goldenrain tree(Koelreuteria paniculata Laxm) and the common elaeocarpus(Elaeocarpus decipens) for Zn,Mn,Ni,and Co were more than 1.Enrichment coeffcients of both trees for Mn were higher than 1.Our results suggest that the panicled goldenrain tree and the common elaeocarpus tree may act as accumulators in remediation.Moreover,the woody vegetation remediation in abandoned mining areas play an important role in improving scenery besides removing heavy metal from contaminated soil. | TIAN Dalun ZHU Fan YAN Wende Fang Xi XIANG Wenhua DENG Xiangwen WANG Guangjun PENG Changhui | 2009 | Journal of Environmental Sciences2009，21，3： | 11 |
| 3 | Impacts of changed litter inputs on soil CO_2 efflux in three forest types in central south China显示文摘Climate change is expected to cause the alteration of litter production in forests,which may result in substantial changes in soil CO2 efflux (FCO2) process as litter represents a major pathway of carbon from vegetation to the soils.In this study,we conducted an aboveground litter manipulation experiment to examine the influence of litter addition and exclusion on soil FCO2 in Camphor tree,Masson pine,and mixed Camphor tree and Masson pine forests in central south China.Litter input manipulation included three treatments:non-litter input (litter exclusion),double litter input (litter addition),and natural litter input (control).On average,litter exclusion significantly reduced soil FCO2 rate by approximately 39%,24% and 22% in Camphor tree forests,the Mixed forests,and Masson pine forests,respectively.On a yearly basis,double litter addition significantly increased soil CO2 by 12% in the Mixed forests (P=0.02) but not in both Camphor tree and Masson pine forests (P>0.05),when compared with their corresponding control treatments.However,litter addition increased soil FCO2 rates in the months of June-August in Camphor tree and Masson pine forests,coinciding with high soil temperature of summer conditions.Litter exclusion reduced soil FCO2 more than litter addition increased it in the study sites.Responses of soil respiration to litter input treatments varied with forest types.Litter input treatments did not alter the seasonal patterns of soil temperature and soil water content.Our results indicated that changes in aboveground litter as a result of global climate change and/or forest management have a great potential to alter soil respiration and soil carbon balance in forest ecosystems. | YAN WenDe CHEN XiaoYong TIAN DaLun PENG YuanYing WANG GuangJun ZHENG Wei | 2013 | Science China(Technological Sciences)2013，56，3： | 11 |
| 4 | Geochronology, Geochemistry and Sr-Nd-Pb-Hf Isotopes of No. I Complex from the Shitoukengde Ni–Cu Sulfide Deposit in the Eastern Kunlun Orogen, Western China: Implications for the Magmatic Source, Geodynamic Setting and Genesis显示文摘The Shitoukengde Ni-Cu deposit, located in the Eastern Kunlun Orogen, comprises three mafic–ultramafic complexes, with the No. I complex hosting six Ni-Cu orebodies found recently. The deposit is hosted in the small ultramafic bodies intruding Proterozoic metamorphic rocks. Complexes at Shitoukengde contain all kinds of mafic-ultramafic rocks, and olivine websterite and pyroxene peridotite are the most important Ni-Cu-hosted rocks. Zircon U-Pb dating suggests that the Shitoukengde Ni-Cu deposit formed in late Silurian(426–422 Ma), and their zircons have εHf(t) values of-9.4 to 5.9 with the older T_(DM1) ages(0.80–1.42 Ga). Mafic-ultramafic rocks from the No. I complex show the similar rare earth and trace element patterns, which are enriched in light rare earth elements and large ion lithophile elements(e.g., K, Rb, Th) and depleted in heavy rare earth elements and high field strength elements(e.g., Ta, Nb, Zr, Ti). Sulfides from the deposit have the slightly higher δ^(34)S values of 1.9–4.3‰ than the mantle(0 ± 2‰). The major and trace element characteristics, and Sr-Nd-Pb and Hf, S isotopes indicate that their parental magmas originated from a metasomatised, asthenospheric mantle source which had previously been modified by subduction-related fluids, and experienced significant crustal contamination both in the magma chamber and during ascent triggering S oversaturation by addition of S and Si, that resulted in the deposition and enrichment of sulfides. Combined with the tectonic evolution, we suggest that the Shitoukengde Ni-Cu deposit formed in the post-collisional, extensional regime related to the subducted oceanic slab break-off after the Wanbaogou oceanic basalt plateau collaged northward to the Qaidam Block in late Silurian. | LI Liang SUN Fengyue LI Bile LI Shijin CHEN Guangjun WANG Wei YAN Jiaming ZHAO Tuofei DONG Jun ZHANG Dexin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 10 |
| 5 | Geometry-dependent springback behaviors of thin-walled tube upon cold bending显示文摘As one kind of key lightweight components with enormous quantities and diversities, the bent tubular parts have attracted in- creasing applications in aerospace, automobile, etc. Thus, how the inevitable springback behaves under different bending specifications should be fully addressed to efficiently achieve the precision forming of various bent tubes. Taking the medium strength thin-walled 6061-T4 Al-alloy tube as the objective, via the deformation theory of plasticity, explicit/implicit FE method and experimental approaches, we explored and clarified the nonlinear springback rules of the tubes and corresponding mechanisms in universal rotary draw bending regarding angular springback and radius growth by deliberately changing the tube diameter D and wall thickness t. The geometry dependent springback behaviors of thin-walled tube upon cold bending are thus revealed: 1) With the increasing of D, the tangent tensile strain increases and the proportional coefficient decreases, which causes the angular springback to decrease, while the radius springback increases due to the larger bending radius. 2) With the increasing of t, the tangent tensile strain decreases and the proportional coefficient increases, resulting in the increase of both angular springback and radius springback. 3) Under the same D/t, the angular springback varies little, while the radius springback increases with the larger diameter D. 4) The D/t can be used as a reasonable nondimensional index to evaluate the springback angle; as to the radius growth, the individual effects of the D and t should be considered. 5) The verification of the above results was conducted by experiments and analytical analysis. | LI Heng YANG He TIAN YuLi LI GuangJun WANG ZhengHua | 2012 | Science China(Technological Sciences)2012，55，12： | 10 |
| 6 | Wheat straw-derived magnetic carbon foams: In-situ preparation and tunable high-performance microwave absorption显示文摘Recently,biomass-derived three-dimensional (3D) porous carbon materials have been gaining more interest as promising microwave absorbers due to their low cost,vast availability,and sustainability.Here,a novel 3D interconnected porous magnetic carbon foams are in-situ synthesized via a combination of sol-gel and carbonization process with wheat straw as the carbon source and FeCl3·6H2O as the magnetic regulating agent.During the process of foams formation,the lignocelluloses from the steam-exploded wheat straw are converted into interconnected carbon sheet networks with hierarchical porous structures,and the precursor FeCl3·6H2O is converted into magnetic nanoparticles uniformly embedded in the porous carbon foams.The generated magnetic nanoparticles are benefit to enhance the interface polarization and magnetic loss ability to improve the efficient complementarities between the dielectric and magnetic loss,thus increasing the impedance matching.The obtained sample treated at 600 ℃ displays the best microwave absorption (MA) performance.It presents a minimal reflection loss (RL) of-43.6 dB at 7.1 GHz and the effective bandwidth (RL <-10 dB) is 3.3 GHz with the thickness of 4.7 mm.The 3D porous structure,multi-interfaces and the synergy of dielectric loss and magnetic loss make great contribution to the outstanding MA performance. | Guangjun Gou Fanbin Meng Huagao Wang Man Jiang Wei Wei Zuowan Zhou | 2019 | Nano Research2019，12，6： | 9 |
| 7 | Tribological evaluation of surface modified H13 tool steel in warm forming of Ti–6Al–4V titanium alloy sheet显示文摘The H13 hot-working tool steel is widely used as die material in the warm forming of Ti–6Al–4V titanium alloy sheet. However, under the heating condition, severe friction and lubricating conditions between the H13 tools and Ti–6Al–4V titanium alloy sheet would cause difficulty in guaranteeing forming quality. Surface modification may be used to control the level of friction force, reduce the friction wear and extend the service life of dies. In this paper, four surface modification methods(chromium plating, TiAlN coating, surface polishing and nitriding treatment)were applied to the H13 surfaces. Taking the coefficient of friction(CoF) and the wear degree as evaluation indicators, the high-temperature tribological behavior of the surface modified H13 steel was experimentally investigated under different tribological conditions. The results of this study indicate that the tribological properties of the TiAlN coating under dry friction condition are better than the others for a wide range of temperature(from room temperature to 500 C), while there is little difference of tribological properties between different surface modifications under graphite lubricated condition, and the variation law of CoF with temperature under graphite lubricated is opposite to that under the dry friction. | Wang Dan Li Heng Yang He Ma Jun Li Guangjun | 2014 | Chinese Journal of Aeronautics2014，27，4： | 9 |
| 8 | Co-delivery of doxorubicin and quercetin via mPEG-PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity显示文摘橡黄素(Que ) 是自然多功能的 bioflavonoid,并且为减少不利副作用并且提高化学疗法的药的反肿瘤功效显示出大潜力。然而,它的临床的申请在生理的系统由于很低的溶解度和结构的不稳定性被限制。此处,我们共同交付由开发 amphiphilic 聚合物包括的 biocompatible nanocarrier 的恐水病的橡黄素和吸水的 doxorubicin (纪录影片) , methoxy poly (乙烯乙二醇) 并且 poly (D, L-lactide-co-glycolide ) 分别地。反肿瘤和这个系统的预防功效被评估在细胞并且动物模型。我们说明的调查结果 Dox-Que nanoparticulate 明确的表达保护了正常脉管的 endothelial 房间免受免费的任何一个或 nanoparticulate 的伤害导致 doxorubicin 的 cytotoxicity 和增加的癌症房间死亡。与免费 doxorubicin 和它的 nanoformulation 相比,用我们的 nanosystem 的橡黄素和 doxorubicin 的合作交货 synergistically 禁止了肿瘤生长,当在浆液维持心脏的功能指示物的正常层次并且在心织物恢复组织病理学说的损坏时。这研究为提高反癌症药功效并且减少 nanoparticulate 表明有希望的策略正常纸巾上的导致化疗的毒性。 | Waseem Akhtar Qureshi Ruifang Zhao Hai Wang Tianjiao Ji Yanping Ding Ayesha Ihsan Ayeesha Mujeeb Guangjun Nie Yuliang Zhao | 2016 | Science Bulletin2016，61，21： | 9 |
| 9 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 10 | Nanoscale pore morphology and distribution of lacustrine shale reservoirs:Examples from the Upper Triassic Yanchang Formation,Ordos Basin显示文摘Pore structure plays an important role in the gas storage and flow capacity of shale gas reservoirs. Fieldemission environmental scanning electron microscopy(FE-SEM) in combination with low-pressure carbon dioxide gas adsorption(CO2GA),nitrogen gas adsorption(N2GA),and high-pressure mercury intrusion(HPMI) were used to study the nanostructure pore morphology and pore-size distributions(PSDs) of lacustrine shale from the Upper Triassic Yanchang Formation,Ordos Basin. Results show that the pores in the shale reservoirs are generally nanoscale and can be classified into four types: organic,interparticle,intraparticle,and microfracture. The interparticle pores between clay particles and organic-matter pores develop most often,l with pore sizes that vary from several to more than 100 nm. Mercury porosimetry analysis shows total porosities ranging between 1.93 and 7.68%,with a mean value of 5.27%. The BET surface areas as determined by N2 adsorption in the nine samples range from 10 to 20 m2/g and the CO2 equivalent surface areas(<2 nm)vary from 18 to 71 m2/g. Together,the HPMI,N2 GA,and CO2 GA curves indicate that the pore volumes are mainly due to pores <100 nm in size. In contrast,however,most of the specific surface areas are provided by the micropores. The total organic carbon(TOC) and clay minerals are the primary controls of the structures of nanoscale pores(especially micropores and mesopores). Micropores are predominantly determined by the content of the TOC,and mesopores are possibly related to the content of clay minerals,particularly the illite-montmorillonite mixed-layer content. | Yang Wang Yanming Zhu Hongyan Wang Guangjun Feng | 2015 | Journal of Energy Chemistry2015，24，4： | 6 |
| 11 | Effects of freeze-drying and spray drying processes on functional properties of phosphorylation of egg white protein显示文摘Egg white protein(EWP)was phosphorylated with Sodium Tripolyphosphate(STP)at pH 4.5.Freeze drying and spray drying were used for drying purpose and the effects of these drying methods on the functional properties were investigated.The functional properties of native and modified proteins were also determined.The results demonstrated that phosphorylation of EWP markedly improved its functional properties,and that it was more effective for the food industry.The freeze-dried STP-EWP powders were superior in terms of solubility,emulsion stability,water holding capacity,oil and water absorption capacity and heat gel strength than spray-dried STP-EWP powders.The results in viscosity showed no significant differences between freeze-dried and spray dried.The spray-dried powders were better in terms of foaming ability and foam stability than freeze-dried powders.However,the spray drying required the longest time to produce.Freeze drying was found to be the best method in terms of production of modified EWP powders with superior functional properties. | Liu Lili Wang Huan Ren Guangyue Duan Xu Li Dan Yin Guangjun | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 6 |
| 12 | Convective high-speed flow and field-aligned high-speed flows explored by TC-1显示文摘From June 1, 2004 to October 31, 2006, a total 465 high-speed flow events are observed by the TC-1 satellite in the near-Earth region (?13 RE < x < ?9 RE, |Y |<10 RE, |Z|<5 RE). Based on the angle between the flow and the magnetic field, the high-speed flow events are further divided into two types, that is, field-aligned high-speed flow (FAHF) in the plasma sheet boundary and convective bursty bulk flow (BBF) in the center plasma sheet. Among the total 465 high-speed flow events, there are 371 FAHFs, and 94 BBFs. The CHF are mainly concentrated in the plasma sheet, the intersection angle between the flow and the magnetic field is larger, the magnetic field intensity is relatively weak. The FHF are mainly distributed near the boundary layer of the plasma sheet, the intersection angle between the flow and magnetic field is smaller, and the magnetic field intensity is relatively strong. The convective BBFs have an important effect on the substorm. | ZHANG LingQian LIU ZhenXing MA ZhiWei W. BAUMJOHANN M.W. DUNLOP WANG GuangJun WANG Xiao H. REME C. CARR | 2008 | Chinese Science Bulletin2008，53，15： | 5 |
| 13 | Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation显示文摘Accumulation and aggregation of β-amyloid(Aβ) peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer's disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity. | Aihua Yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang Chen Wang | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 14 | Reconstruction of linkage maps in the distorted segregation populations of backcross, doubled haploid and recombinant inbred lines显示文摘Non-Mendelian segregation of markers, known as distorted segregation, is a common biological phenomenon. Although segregation distortion affects the estimation of map distances and the results of quantitative trait loci (QTL) mapping, the effects of distorted markers are often ignored in the construction of linkage maps and in QTL mapping. Recently, we have developed a multipoint method via a Hidden Markov chain method to reconstruct linkage maps in an F2 population that corrects for bias of map distances between distorted markers. In this article, the method is extended to cover backcross, doubled haploid and recombinant inbred line (RIL) populations. The results from simulated experiments show that: (1) the degree that two linked segregation distortion loci (SDL) affect the estimation of map distances increases as SDL heritability and interval length between adjacent markers increase, whereas sample size has little effect on the bias; (2) two linked SDL result in the underesti- mation of linkage distances for most cases, overestimation for an additive model with opposite additive effects, and unbiased estimation for an epistatic model with negative additive-by-additive effects; (3) the proposed method can obtain the unbiased estimation of linkage distance. This new method was applied to a rice RIL population with severely distorted segregation to reconstruct the linkage maps, and a bootstrap method was used to obtain 95% confidence intervals of map distances. The results from real data analysis further demonstrate the utility of our method, which provides a foundation for the inheritance analysis of quantitative and viability traits. | ZHU ChengSong WANG FuHua WANG JianFei LI GuangJun ZHANG HongSheng ZHANG YuanMing | 2007 | Chinese Science Bulletin2007，52，12： | 3 |
| 15 | Preparation and characterization of molybdenum powders with copper coating by the electroless plating technique显示文摘Molybdenum powders with a diameter of approximately 3 μm were coated with copper using the electroless plating technique in the pH 12.5-13 and temperature range of 55-75°C. The optimization of the electroless copper bath was evaluated through the combination of process parameters like pH and temperature. The optimized values of pH and temperature were found to be 12.5 and 60°C, respectively, which at-tributes to the bright maroon color of the coating with an increase in weight of 46%. The uncoated and coated powders were subjected to mi-crostructural studies using scanning electron microscope (SEM) and the phases were analyzed using X-ray diffraction (XRD). An attempt was made to understand the growth mechanism of the coating. The diffusion-shrinkage autocatalytic model was suggested for copper growth on the molybdenum surface. | WANG Guangjun WANG Dezhi | 2008 | Rare Metals2008，27，4： | 3 |
| 16 | Influence of Climatic Conditions on Planting of Hami Melon显示文摘Climate warming has made the planting area of Hami melon expand northward to Barry Bakai Town,Altay City,near 47° N. Climate events often induce the occurrence of pests and diseases in crops,affecting the steady production of Hami melon. In 2013,pests and diseases occurred seriously,resulting in low yield and poor quality of Hami melon. Based on the production survey data of Hami melon in recent20 years,the interaction of various meteorological factors in different time and different intervals of various factors was analyzed in this paper to explore the characteristics of the meteorological factors that cause diseases and influence the quality of Hami melon. | Jiangang WANG Min JIANG Yuchao LI Guangjun LI | 2018 | Asian Agricultural Research2018，10，2： | 2 |
| 17 | CuInSe_2 thin films obtained by pulse-plating electrodeposition technique with novel pulse wave显示文摘CuInSe2 films were electrodeposited onto indium tin oxide(ITO) substrate in constant current mode using bell-like wave modulated square wave in aqueous solution.The films obtained at different pulse frequencies were characterized by scanning electron microscopy(SEM),X-ray energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD).UV-Vis-NIR absorption spectro scopy was used to study the optical properties of these films.The results showed that the chalcopyrite phase CuInSe2 films with a smooth surface and stoichiometric composition could be obtained at appropriate pulse frequency.The crystallinity of CuInSe2 films could be further improved after annealing treatment.Despite this,we also found that the films obtained using the pulse-plating electrodeposition technique had a faster deposition rate and better film adhesion ability than that using the traditional CIS electrodeposition technique,which is significant to the low-cost CIS thin film solar cell production. | WANG XiaoLi WANG GuangJun TIAN BaoLi WAN ShaoMing DU ZuLiang | 2010 | Chinese Science Bulletin2010，55，18： | 2 |
| 18 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 19 | Study on the Fire Behavior of Sandwich Wall Panels with GFRP Skins and a Wood-Web Core显示文摘To investigate the temperature field and residual bearing capacity of the sandwich wall panels with GFRP skins and a wood-web core under a fire,three sandwich walls were tested.One of them was used for static load test and the other two for the one-side fire tests.Besides,temperature probe points were set on the sandwich walls to obtain the temperature distribution.Meanwhile,the model of the sandwich wall was established in the finite element software by the method of core material stiffness equivalent.The temperature distribution and performance reduction of materials were also considered.The residual bearing capacity of specimens after fire exposure were simulated considering the effects of web spacing,wall panel thickness and fire exposure time.Because the sandwich wall panels were stressed by eccentric compression after a fire,the residual compressive strength of the wall panel after the fire can be calculated through the eccentric loading analysis.Compared with the numerical results,it can be concluded that the effectiveness of calculation method of residual bearing capacity after fire exposure was proved. | Guangjun Sun Chuting Wang Lu Wang | 2022 | Journal of Renewable Materials2022，10，6： | 2 |
| 20 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员