|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 3 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 4 | A facile "ship-in-a-bottle" approach to construct nanorattles based on upconverting lanthanide-doped fluorides显示文摘格格声结构由于唯一的 core@void@shell 体系结构和函数的集成是对 nanomaterials 的设计和申请的大兴趣的一个话题。此处,我们开发了一个新奇 ship-in-a-bottle 方法制作 upconverting (UC ) 由把做 lanthanide 的氟化物合并到空 mesoporous 的光 nanorattles 硅石。nanorattles 的尺寸和氟化物的充满的数量能很好被控制。另外,硅石壳的修正(与苯撑和胺组) 并且有效 UC 氟化物的变化(NaYF 4:Yb,Er, NaLuF 4:Yb,Er, NaGdF 4:Yb,Er 和 LiYF 4:Yb,Er) 乐意地被完成。产生 nanorattles 展出了一个高能力和反癌症药 doxorubicin (纪录影片) 的 pH 依赖的版本。而且,我们由从 UC 氟化物利用精力转移过程到纪录影片在 proof-of-concept 监视 UC 药版本采用了这些 nanorattles,因此作为有效癌症 theranostic 揭示 nanorattles 的大潜力代理人。 | Shan Lu Datao Tu Xingjun Li Renfu Li Xueyuan Chen | 2016 | Nano Research2016，9，1： | 3 |
| 5 | Particle swarm optimization and its application to seismic inversion of igneous rocks显示文摘In order to improve the fine structure inversion ability of igneous rocks for the exploration of underlying strata, based on particle swarm optimization(PSO), we have developed a method for seismic wave impedance inversion. Through numerical simulation, we tested the effects of different algorithm parameters and different model parameterization methods on PSO wave impedance inversion, and analyzed the characteristics of PSO method. Under the conclusions drawn from numerical simulation, we propose the scheme of combining a cross-moving strategy based on a divided block model and high-frequency filtering technology for PSO inversion. By analyzing the inversion results of a wedge model of a pitchout coal seam and a coal coking model with igneous rock intrusion, we discuss the vertical and horizontal resolution, stability and reliability of PSO inversion. Based on the actual seismic and logging data from an igneous area, by taking a seismic profile through wells as an example, we discuss the characteristics of three inversion methods, including model-based wave impedance inversion, multi-attribute seismic inversion based on probabilistic neural network(PNN) and wave impedance inversion based on PSO.And we draw the conclusion that the inversion based on PSO method has a better result for this igneous area. | Yang Haijun Xu Yongzhong Peng Gengxin Yu Guiping Chen Meng Duan Wensheng Zhu Yongfeng Cui Yongfu Wang Xingjun | 2017 | International Journal of Mining Science and Technology2017，27，2： | 3 |
| 6 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 7 | Fully integrated hybrid microwave photonic receiver显示文摘Microwave photonic receivers are a promising candidate in breaking the bandwidth limitation of traditional radio-frequency(RF)receivers.To further balance the performance superiority with the requirements regarding size,weight,and power consumption(SWa P),the implementation of integrated microwave photonic microsystems has been considered an upgrade path.However,up to now,to the best of our knowledge,chip-scale fully integrated microwave photonic receivers have not been reported due to the limitation of material platforms.In this paper,we report a fully integrated hybrid microwave photonic receiver(FIH-MWPR)obtained by comprising the indium phosphide(In P)laser chip and the monolithic silicon-on-insulator(SOI)photonic circuit into the same substrate based on the low-coupling-loss micro-optics method.Benefiting from the integration of all optoelectronic components,the packaged FIH-MWPR exhibits a compact volume of 6 cmand low power consumption of 1.2 W.The FIH-MWPR supports a wide operation bandwidth from 2 to 18 GHz.Furthermore,its RF-link performance to down-convert the RF signals to the intermediate frequency is experimentally characterized by measuring the link gain,the noise figure,and the spurious-free dynamic range metrics across the whole operation frequency band.Moreover,we have utilized it as a de-chirp receiver to process the broadband linear frequencymodulated(LFM)radar echo signals at different frequency bands(S-,C-,X-,and Ku-bands)and successfully demonstrated its high-resolution-ranging capability.To the best of our knowledge,this is the first realization of a chip-scale broadband fully integrated microwave photonic receiver,which is expected to be an important step in demonstrating the feasibility of all-integrated microwave photonic microsystems oriented to miniaturized application scenarios. | JIACHEN LI SIGANG YANG HONGWEI CHEN XINGJUN WANG MINGHUA CHEN WEIWEN ZOU | 2022 | Photonics Research2022，10，6： | 2 |
| 8 | Multiplexed intracellular detection based on dual-excitation/dualemission upconversion nanoprobes显示文摘Multiplexed intracellular detection is desirable in biomedical sciences for its higher eficiency and accuracy compared to the single-analyte detection.However,it is very challenging to construct nanoprobes that possess multiple fluorescent signals to recognize the different intracellular species synchronously.Herein,we proposed a novel dual-excitation/dual-emission upconversion strategy for multiplexed detection through the design of upconversion nanoparticles(UCNP)loaded with two dyes for sensitization and quenching of the upconversion luminescence(UCL),respectively.Based on the two independent energy transfer processes of near-infrared(NIR)dye IR845 to UCNP and UCNP to visible dye PAPS-Zn,CIO-and Zn2+were simultaneously detected with a limit of detection(LOD)of41.4 and 10.5 nM,respectively.By tilizing a purpose built 830/980 nm dual-laser confocal microscope,both intrinsic and exogenous CIO and Zn2+in live MCF-7 cells have been accurately quantified.Such dual-excitation/dual-emission ratiometric UCL detection mode enables not only monitoring multiple intracellular analytes but also eliminating the detection deviation caused by inhomogeneous probe distribution in cells.Through modulation of NIR dye and visible dye with other reactive groups,the nanoprobes can be extended to analyze various intraellular species,which provides a promising tool to study the biological activities in live cells and diagnose diseases. | Jianxi Ke Shan Lu Zhuo Li Xiaoying Shang Xingjun Li Renfu Li Datao Tu Zhuo Chen Xueyuan Chen | 2020 | Nano Research2020，13，7： | 2 |
| 9 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 10 | Thermodynamic database of the phase diagrams in the Mg-Al-Zn-Y-Ce system显示文摘The Mg-Al-Zn-Y-Ce system is one of the key systems for designing high-strength Mg alloys. The purpose of the present article is to develop a thermodynamic database for the Mg-Al-Zn-Y-Ce multicomponent system to design Mg alloys using the calculation of phase diagrams (CALPHAD) method, where the Gibbs energies of solution phases such as liquid, fcc, bcc, and hcp phases were described by the subregular solution model, whereas those of all the compounds were de- scribed by the sublattice model. The thermodynamic parameters describing Gibbs energies of the different phases in this database were evaluated by fitting the experimental data for phase equilibria and thermodynamic properties. On the basis of this database, a lot of information concerning stable and metastable phase equilibria of isothermal and vertical sections, mo- lar fractions of constituent phases, the liquidus projection, etc., can be predicted. This database is expected to play an im- portant role in the design of Mg alloys. | LIU Xingjun WANG Cuiping WEN Mingzhong CHEN Xing PAN Fusheng | 2006 | Rare Metals2006，25，5： | 2 |
| 11 | Design of large-displacement asymmetric piezoelectric microgripper based on flexible mechanisms显示文摘The output displacement of the traditional symmetrical microgripper is large,but its micro-components or parts are easily damaged due to the uneven force exerted on the left and right jaws of the gripper.The output force of the traditional asymmetric microgripper is stable.However,its output displacement is small,typically half the output displacement of the symmetric microgripper.To solve these problems,in this study,we designed a large-displacement asymmetric microgripper.First,we calculated the relationship between the theoretical input and output variables based on their geometric relationship.Then,we analyzed the performance of the microgripper using finite element software.Lastly,we used a piezoelectric actuator as the input driver of the microgripper.The errors associated with the theoretical and simulated output displacements were 7.05%and 9.24%,respectively.At 150 V of driving voltage,the maximum output displacement was 224μm,and the actual magnificationwas 11.2 times.Microparts can be gripped in parallel and stably,which confirms the validity of the design. | Xiaodong Chen Siya Hu Zilong Deng Jinhai Gao Xingjun Gao | 2019 | Nanotechnology and Precision Engineering2019，2，4： | 2 |
| 12 | Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway显示文摘尽管螺旋体 interrogans 是不能的作为它的碳 / 精力利用葡萄糖,采购原料, L 的 LA_1437 基因。interrogans serovar Lai 潜在地编码组 III glucokinase (GLK ) 。L。interrogans GLK (LiGLK ) 不同类地在 Escherichia 表示了 coli 被净化并且证明了是有它 12.3 的特定的活动的 homodimeric 酶 ? 桴 ? 慰瑲慩?? 潤慭湩愠摮渠牯慭?? 整浲湩獵? 獩猠潨瑲牥琠慨 ? 偁 ? 湡 ??? 戠 ? 桴 ? 敲獡湯漠 ? 敧敮映慲敭桳晩 ? 畭慴楴湯搠牵湩? | Qing Zhang Yunyi Zhang Yi Zhong Jun Ma Nanqiu Peng Xingjun Cao Chen Yang RongZeng Xiaokui Guo Guoping Zhao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 1 |
| 13 | Design of a flexible piezoelectric microgripper based on combined amplification principles显示文摘Aiming to address the problem of the low amplification ratio of traditional microgrippers,a two-stage microgripper based on the principle of combined amplification was designed with a high amplification ratio and large displacement,using a simple and compact structure.The relationship between theoretical input variables and output variables were first calculated by a projection theorem.Secondly,the performance of the microgripper was analyzed by finite element analysis(FEA).Finally,the accuracy of the theoretical calculation and FEA was verified experimentally.The results show that the microgripper has high magnification and can be gripped in parallel,with self-adaptability for many irregular shaped micro objects.The actual magnification was 23.2×,which is greater than similar products. | Xiaodong Chen Zilong Deng Siya Hu Jinhai Gao Xingjun Gao | 2019 | Nanotechnology and Precision Engineering2019，2，3： | 1 |
| 14 | Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese显示文摘 | Zuoguang Wang Xiaoyun Peng Yanduo Tao Ya Liu Jieling Liu Xingjun Chen Shaojun Wen Zhaosu Wu | 2009 | Clinical and Experimental Hypertension2009，，4： | 1 |
| 15 | Medium optimization for the production of thermal stable fl-glucanase by Bacillus s ubtilis ZJF- 1 A5 using response surface methodology显示文摘 | Xingjun Tang Guoqing He Qihe Chen | 2004 | Bioresource Technology2004，93，： | 1 |
| 16 | Medium optimization for the production of thermal stable 15-glucanase by Bacillus subtilis ZJF-1AS using response surface methodology 显示文摘 | Tang Xingjun He Guoqing Chen Qihe | 2004 | Bio resource Technology2004，93，： | 1 |
| 17 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 18 | Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2显示文摘The combination of immune checkpoint blockade(ICB)with chemotherapy significantly improves clinical benefit of cancer treatment.Since chemotherapy is often associated with adverse events,concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy.However,whether these ancillary drugs could impede immunotherapy remains unknown.Here,we showed that∆9-tetrahydrocannabinol(THC),the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea,reduced the therapeutic effect of PD-1 blockade.The endogenous cannabinoid anandamide(AEA)also impeded antitumor immunity,indicating an immunosuppressive role of the endogenous cannabinoid system(ECS). | Xinxin Xiong Siyu Chen Jianfei Shen Hua You Han Yang Chao Yan Ziqian Fang Jianeng Zhang Xiuyu Cai Xingjun Dong Tiebang Kang Wende Li Penghui Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 19 | Microwave frequency upconversion employing a coupling-modulated ring resonator显示文摘We present a method to generate a frequency-doubled microwave signal by employing a coupling-modulated ring resonator. Critical coupling is achieved when the resonator intrinsic loss is perfectly balanced by the external coupling enabled by a Mach–Zehnder interferometer coupler. The high suppression of the carrier leads to a clean two-tone optical signal with the frequency interval two times larger than that of the input microwave frequency.The beating of the two-tone signal at a photodiode generates the frequency upconverted microwave signal.A theoretical model is established to analyze the modulation process and the microwave signal generation.Experimental results show that the electrical harmonic suppression ratio is around ~20 dB(29 dB) for an input microwave signal with 5 dBm(10 dBm) power. | YIMING ZHONG LINJIE ZHOU YANYANG ZHOU YUJIE XIA SIQI LIU LIANGJUN LU JIANPING CHEN XINGJUN WANG | 2017 | Photonics Research2017，5，6： | 1 |
| 20 | Enhanced thermoelectric performance in Ti(Fe, Co, Ni)Sb pseudoternary Half-Heusler alloys显示文摘TiFe0.5Ni0.5Sb-based half-Heusler compounds have the intrinsic low lattice thermal conductivity and the adjustable band structure.Inspired by the previously reports to achieve both p-and n-type components by tuning the ratio of Fe and Ni based on the same parent TiFe0.5Ni0.5Sb,we selected Co as the amphoteric dopants to prepare both n-type and p-type pseudo-ternary Ti(Fe,Co,Ni)Sb-based halfHeusler alloys.The carrier concentration,as well as the density of states effective mass was significantly increased by Co doping,contributing to the enhanced power factor of 1.80 mW m^(-1) K^(-2) for n-type TiFe0.3Co_(0.2)Ni_(0.5)Sb and 2.21 mW m^(-1) K^(-2) for p-type TiFe_(0.5)Co_(0.15)Ni_(0.35)Sb at 973 K.Combined with the further decreased lattice thermal conductivity due to the strain field and mass fluctuation scattering induced by alloying Hf on the Ti site,peak ZTs of 0.65 in n-type Ti0.8Hf_(0.2)Fe_(0.3)Co_(0.2)Ni_(0.5)Sb and 0.85 in ptype Ti0.8Hf_(0.2)Fe_(0.5)Co_(0.15)Ni_(0.35)Sb were achieved at 973 K,which is of great significance for the thermoelectric power generation applications. | Qingmei Wang Xiaodong Xie Shan Li Zongwei Zhang Xiaofang Li Honghao Yao Chen Chen Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2021 | Journal of Materiomics2021，7，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员