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| 1 | Ultrasensitive detection of cancer biomarker microRNA by amplification of fluorescence of lanthanide nanoprobes显示文摘癌症 biomarker microRNAs (miRNAs ) 的敏感察觉具有为癌症诊断和治疗的重要重要性。尽管如此,在存在 miRNA 生物鉴定的察觉敏感被 miRNA 的结构的特征严重地限制(包括小长度和高顺序相同) 因为大多数这些方法基于目标扩大。此处,我们经由 nanoprobe 的唯一的策略向低丰富的 miRNA 的敏感、特定的察觉汇报一条新奇途径提高溶解的荧光扩大,展示分子的烽火结构的一根俘获探针在被设计。借助于这策略, miRNA-21 与象 1.38 fM 一样低的察觉限制从 10 fM 在一个线性范围被检测到 100 下午。最新发达的生物传感器的高选择被对一个目标的好歧视与单个底的失配表明。而且,这试金被用于低于 10.1% 在 90.2%-108% 的范围和变化的系数与恢复增加进胎儿的牛的浆液样品的 miRNA-21 的察觉,显示它到在新窗户中的 RNA 免疫分析和早癌症 diagnosis.Open | Lianyu Lu Datao Tu Yan Liu Shanyong Zhou Wei Zheng Xueyuan Chen | 2018 | Nano Research2018，11，1： | 6 |
| 2 | A strategy for accurate detection of glucose in human serum and whole blood based on an upconversion nanoparticles-polydopamine nanosystem显示文摘 | Yan Liu Datao Tu Wei Zheng Lianyu Lu Wenwu You Shanyong Zhou Ping Huang Renfu Li Xueyuan Chen | 2018 | Nano Research2018，11，6： | 5 |
| 3 | 'Chameleon-like' optical behavior of lanthanide-doped fluoride nanoplates for multilevel anti-counterfeiting applications显示文摘Lanthanide-based luminescent anti-counterfeiting materials are widely used in various kinds of products.However,the emission color of traditional lanthanide-based luminescent materials usually remains nearly unaltered upon different excitation lights,which may only work for single-level anti-counterfeiting.Herein,the NaYbF4∶2%Er@NaYF4 core/shell nanoplates (NPs) with 'chameleon-like' optical behavior are developed.These NPs display single-band red or green downshifting (DS) emission upon excitation at 377 or 490 nm,respectively.Upon 980 nm excitation,the color of upconversion (UC) emission can be finely tuned from green to yellow,and to red with increasing the excitation power density from 0.1 to 4.0 W/cm^2.The proposed materials readily integrate the advantages of excitation wavelength-dependent DS single-band emissions and sensitive excitation power-dependent UC multicolor emissions in one and the same material,which has never been reported before.Particularly,the proposed NPs exhibit excellent performance as security labels on trademark tag and security ink on painting,thus revealing the great potential of these lanthanide-doped fluoride NPs in multilevel anti-counterfeiting applications. | Wenwu You Datao Tu Renfu Li Wei Zheng Xueyuan Chen | 2019 | Nano Research2019，12，6： | 3 |
| 4 | A facile "ship-in-a-bottle" approach to construct nanorattles based on upconverting lanthanide-doped fluorides显示文摘格格声结构由于唯一的 core@void@shell 体系结构和函数的集成是对 nanomaterials 的设计和申请的大兴趣的一个话题。此处,我们开发了一个新奇 ship-in-a-bottle 方法制作 upconverting (UC ) 由把做 lanthanide 的氟化物合并到空 mesoporous 的光 nanorattles 硅石。nanorattles 的尺寸和氟化物的充满的数量能很好被控制。另外,硅石壳的修正(与苯撑和胺组) 并且有效 UC 氟化物的变化(NaYF 4:Yb,Er, NaLuF 4:Yb,Er, NaGdF 4:Yb,Er 和 LiYF 4:Yb,Er) 乐意地被完成。产生 nanorattles 展出了一个高能力和反癌症药 doxorubicin (纪录影片) 的 pH 依赖的版本。而且,我们由从 UC 氟化物利用精力转移过程到纪录影片在 proof-of-concept 监视 UC 药版本采用了这些 nanorattles,因此作为有效癌症 theranostic 揭示 nanorattles 的大潜力代理人。 | Shan Lu Datao Tu Xingjun Li Renfu Li Xueyuan Chen | 2016 | Nano Research2016，9，1： | 3 |
| 5 | Highly efficient luminescent Ⅰ-Ⅲ-Ⅵ semiconductor nanoprobes based on template-synthesized CuInS2 nanocrystals显示文摘CuInS2 semiconductor nanocrystals (NCs) exhibit large absorption coefficient, size-dependent photoluminescence and low toxicity, making them excellent candidates in a variety of bioapplications. However, precise control of both their composition and morphology to improve the luminescent efficiency remains a great challenge via conventional direct synthesis. Herein, we present a novel low-temperature template synthesis of highly efficient luminescent CuInS2 nanoprobes from In2S3 NCs via a facile cation exchange strategy. The proposed strategy enables synthesis of a series of CuInS2 NCs with broad size tunability from 2.2 to 29.6 nm. Through rationally manipulating the stoichiometry of Cu/In, highly efficient luminescence of CuInS2 with the maximum quantum yield of 28.6% has been achieved, which is about one order of magnitude improvement relative to that of directly synthesized NCs. By virtue of the intense emission of CuInS2 nanoprobes, we exemplify their application in sensitive homogeneous biodetection for an important biomolecule of adenosine triphosphate (ATP) with the limit of detection down to 49.3 nM. Moreover, the CuInS2 nanoprobes are explored for ATP-targeted cancer cell imaging, thus revealing their great potentials in the field of cancer diagnosis and prognosis. | Xian Li Datao Tu Shaohua Yu Xiaorong Song Wei Lian Jiaojiao Wei Xiaoying Shang Renfu Li Xueyuan Chen | 2019 | Nano Research2019，12，8： | 3 |
| 6 | Multiplexed intracellular detection based on dual-excitation/dualemission upconversion nanoprobes显示文摘Multiplexed intracellular detection is desirable in biomedical sciences for its higher eficiency and accuracy compared to the single-analyte detection.However,it is very challenging to construct nanoprobes that possess multiple fluorescent signals to recognize the different intracellular species synchronously.Herein,we proposed a novel dual-excitation/dual-emission upconversion strategy for multiplexed detection through the design of upconversion nanoparticles(UCNP)loaded with two dyes for sensitization and quenching of the upconversion luminescence(UCL),respectively.Based on the two independent energy transfer processes of near-infrared(NIR)dye IR845 to UCNP and UCNP to visible dye PAPS-Zn,CIO-and Zn2+were simultaneously detected with a limit of detection(LOD)of41.4 and 10.5 nM,respectively.By tilizing a purpose built 830/980 nm dual-laser confocal microscope,both intrinsic and exogenous CIO and Zn2+in live MCF-7 cells have been accurately quantified.Such dual-excitation/dual-emission ratiometric UCL detection mode enables not only monitoring multiple intracellular analytes but also eliminating the detection deviation caused by inhomogeneous probe distribution in cells.Through modulation of NIR dye and visible dye with other reactive groups,the nanoprobes can be extended to analyze various intraellular species,which provides a promising tool to study the biological activities in live cells and diagnose diseases. | Jianxi Ke Shan Lu Zhuo Li Xiaoying Shang Xingjun Li Renfu Li Datao Tu Zhuo Chen Xueyuan Chen | 2020 | Nano Research2020，13，7： | 2 |
| 7 | Amine-functional- ized lanthanide-doped KGdF4 nanocrystals as potential optical/ magnetic muhimodal bioprobes 显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2011 | Journal of the American Chemical Society2011，134，2： | 1 |
| 8 | Lanthanide-doped inorganic nanocrystals as luminescent biolabels显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2012 | Combinato-rial Chemistry High Throughput Screening2012，15，7： | 1 |
| 9 | Modulator-directed assembly of hybrid composites based on metalorganic frameworks and upconversion nanoparticles显示文摘Hybrid composites made of metal-organic frameworks(MOFs)and lanthanide-doped upconversion nanoparticles(UCNPs)have attracted considerable interest for their synergistically enhanced functions in various applications such as chemical sensing,photocatalysis,anticounterfeiting and nanomedicine.However,precise assembly of MOF/UCNP hybrid composites with tunable morphologies remains a challenge due to the lack of effective synthetic methods and fundamental understanding of the growth mechanisms.Herein,we propose a modulator-directed assembly strategy to synthesize a series of ZIF-8@UCNP composites(ZIF-8=zeolitic imidazolate framework-8).The UCNPs densely paved on the surface of ZIF-8 microcrystals and endowed the composites with intense upconversion blue emission,which were verified by steady-state/transient photoluminescence(PL)spectroscopy and single-particle imaging.Ethylenediamine(EDA)was firstly used as a modulator to fine-tune the predominant MOF facets and realized distinct morphologies of the composites.By adjusting the concentration of EDA from 0 to 25 mmol/L,the morphology of the ZIF-8@UCNP composites was tuned from rhombic dodecahedron(RD)to truncated rhombic dodecahedron(TRD),cube with truncated edges(CTE),cube,and finally a unique form of interpenetration twins(IT).The nucleation and growth process of the ZIF-8@UCNP composites was monitored by time-dependent scanning electron microscopy(SEM)images and the formation mechanism was thoroughly revealed.Furthermore,we demonstrated that the strategy for assembly of morphology-controllable ZIF-8@UCNP composites was generally applicable to various UCNPs with different sizes and shapes.The proposed strategy is expected to open up new avenues for the controllable synthesis of MOF/UCNP composites toward diverse applications. | Yanhui Feng Xingjun Li Shan Lu Renfu Li Zhongliang Gong Xiaoying Shang Yifan Pei Wei Zheng Datao Tu Xueyuan Chen | 2023 | Nano Research2023，16，1： | 0 |
| 10 | Lanthanide-Doped Inorganic Nanoprobes for Luminescent Assays of Biomarkers显示文摘Tremendous progress in nanomaterial and nanotechnology has been made in recent years,which greatly contributes to the development of inorganic nanoparticles(NPs)as luminescent probes in diverse biomedical applications.In particular,these luminescent nanoprobes are widely employed for sensitive assays of biomarkers like disease markers.Generally,the luminescent bioassay technologies mainly rely on conventional molecular probes such as lanthanide(Ln3+)chelates or organic dyes,which suffer from inferior photochemical stability,low photobleaching,potential long-term toxicity,or high background noise.In contrast,Ln3+-doped NPs possess distinct physicochemical properties including better photostability,lower toxicity,and superior optical properties like long photoluminescent(PL)lifetime,narrow emission band,and tunable spectral range from the ultraviolet to the second near-infrared(NIR-II),which make them extremely ideal as luminescent nanoprobes.As such,enormous research enthusiasm has been invested in this fascinating field of Ln3+-doped luminescent nanoprobes in recent years.Accordingly,background-free luminescent bioassays with high signal-to-noise have been achieved by employing Ln3+-doped NPs on the basis of their downshifting luminescence(DSL)with a long PL lifetime,NIR-II luminescence with long-wavelength emissions,or upconverting luminescence(UCL)upon NIR excitation.However,there are still key challenges for Ln3+-doped nanoprobes owing to their low brightness and quantum yield,which restrict their biomedical applications.During the past decade,we have explored efficient approaches for the synthesis and design of highly efficient Ln3+-doped nanoprobes toward ultrasensitive luminescent bioassay of disease markers.In this Account,we summarize our most recent endeavors toward the development of inorganic Ln3+-doped NPs as sensitive nanoprobes for luminescent bioassays.First,we overview the approaches of controlled synthesis and optical manipulation to obtain highly efficient Ln3+-doped NPs with desirable optical properties.Second,we survey the design of Ln3+-doped nanoprobes with outstanding water dispersibility and excellent biocompatibility through surface functional bioconjugation of NPs.By employing these nanoprobes,we propose and exemplify several background-free luminescent bioassay strategies in an effort to suppress the interference of background noise from scattered lights and autofluorescence from biological samples.Third,we highlight the ultrasensitive bioassay of disease markers such as the time-resolved luminescent bioassay,NIR-II luminescent bioassay,and UCL bioassay.Finally,the major challenges,promising emerging trends,and future perspectives on this attractive field are discussed.Through this Account,we aim to offer a series of effective approaches to luminescent bioassay with high sensitivity and excellent specificity based on Ln3+-doped nanoprobes,which may broaden the roadway for clinical bioassays and accelerate the exploration of novel nanoprobes in versatile biomedical applications. | Luping Wang Siyuan Han Chenliang Li Datao Tu Xueyuan Chen | 2023 | Accounts of Materials Research2023，4，2： | 0 |
| 11 | Luminescent nano-bioprobes based on NIR dye/lanthanide nanoparticle composites显示文摘Near-infrared(NIR)light,which has ignorable tissue scattering/absorption,minimal photodamage,and no autofluorescence interference,is highly favorable for bioapplications.NIR dye and lanthanide-doped nanoparticle(LnNP),as representative NIR-excited luminescence probes,have attracted increasing interest due to their unique optical property and low biological toxicity.Design of luminescence probes based on NIR dye/LnNP nanocomposites cannot only integrate the advantages but also achieve additional functions via regulating internal energy transfer pathways.In this review,we focus on the most recent advances in the development of NIR dye/LnNP nanocomposites as potential bioprobes,which cover from their fundamental photophysics to bioapplications,including energy transfer mechanisms,interface engineering(involving binding interaction,distance,and aggregation as key factors),and their applications for dye-sensitized upconversion/downshifting luminescent bioimaging,detection of biomolecules,and NIR-triggered diagnosis and therapy.Some future prospects and efforts toward this active research field are also envisioned. | Shan Lu Jianxi Ke Xingjun Li Datao Tu Xueyuan Chen | 2021 | Aggregate2021，2，5： | 0 |
| 12 | Boosting the Energy Migration Upconversion through Inter-Shell Energy Transfer in Tb^(3+)-Doped Sandwich Structured Nanocrystals显示文摘It remained challenging to fabricate Tb^(3+)-doped lanthanide nanocrystals(NCs)to simultaneously acquire strong energy migration upconversion(EMU)emissions of Tb^(3+)while suppressing the Tm3+UV upconversion emissions that cause background biofluorescence issues in bioapplications based on Tb^(3+)-doped EMU NCs.Herein,we report a novel sandwich structured core@shell@shell scheme for the design of EMU NCs,for example,NaLuF4∶Yb/Gd@NaGdF4∶Tm@NaLuF4∶Tb NCs,wherein Yb^(3+),Tm^(3+),and Tb^(3+)are incorporated separately into the inner core,middle shell,and outer shell,respectively.We found that in the sandwich structured NCs,the effective inter-shell energy transfer from Gd^(3+)in the middle shell to Tb^(3+)in the outer shell accelerated the Yb^(3+)-Tm^(3+)five-photon upconversion and the subsequent Tm^(3+)to Gd^(3+)energy transfer processes,which could eventually lead to almost complete inhibition of Tm^(3+)UV upconversion emissions,concurrent with the strong EMU emissions of Tb^(3+).Our findings might stimulate new concepts for manipulating upconversion emissions of lanthanide NCs. | Dan Xu Jin Xu Xiaoying Shang Shaohua Yu Wei Zheng Datao Tu Renfu Li Xueyuan Chen | 2022 | CCS Chemistry2022，4，6： | 0 |
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