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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Research progresses on Cherenkov and transit-time high-power microwave sources at NUDT显示文摘Research progresses on Cherenkov and transit-time high-power microwave(HPM)sources in National University of Defense Technology(NUDT)of China are presented.The research issues are focused on the following aspects.The pulse-shortening phenomenon in O-type Cerenkov HPM devices is suppressed.The compact coaxial relativistic backward-wave oscillators(RBWOs)at low bands are developed.The power efficiency in M-Type HPM tubes without guiding magnetic field increased.The power capacities and power efficiencies in the triaxial klystron amplifier(TKA)and relativistic transit-time oscillator(TTO)at higher frequencies increased.In experiments,some exciting results were obtained.The X-band source generated 2 GW microwave power with a pulse duration of 110 ns in 30 Hz repetition mode.Both L-and P-band compact RBWOs generated over 2 GW microwave power with a power efficiency of over 30%.There is approximately a 75% decline of the volume compared with that of conventional RBWO under the same power capacity conditions.A 1.755 GHz MILO produced 3.1 GW microwave power with power efficiency of 10.4%.A 9.37 GHz TKA produced the 240 MW microwave power with the gain of 34 dB.A 14.3 GHz TTO produced 1 GW microwave power with power efficiency of 20%. | Jiande Zhang Xingjun Ge Jun Zhang Juntao He Yuwei Fan Zhiqiang Li Zhenxing Jin Liang Gao Junpu Ling Zumin Qi | 2016 | Matter and Radiation at Extremes2016，1，3： | 7 |
| 3 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 4 | Seismic response analysis of continuous rigid frame bridge considering canyon topography effects under incident SV waves显示文摘To evaluate the importance of the canyon topography effects on large structures, based on a rigid frame bridge across a 137-m-deep and 600-m-wide canyon, the seismic response of the canyon site is analyzed using a two-dimensional finite element model under different seismic SV waves with the assumptions of vertical incidence and oblique incidence to obtain the ground motions, which are used as the excitation input on the pier foundations of the bridge with improved large mass method. The results indicate that canyon topography has significant influences on the ground motions in terms of incident angle. The peak ground acceleration values vary greatly from the bottom of the canyon to the upper corners. Under vertical incident SV waves, at the upper corners of canyon the peak ground accelerations greatly increase; whereas the peak ground accelerations diminish at the bottom corners of canyon. Under oblique incident SV waves, the shaking of the canyon slope perpendicular to the incidence direction is much more severe than that of the opposite side of canyon. And the ground surface has been characterized by larger deformations in the case of oblique incident waves. It is also concluded that the low piers and frame of the continuous rigid frame bridge are more sensitive to the multi-support seismic excitations than the flexible high piers. The canyon topography as well as the oblique incidence of the waves brings the continuous rigid frame bridge severe responses, which should be taken into account in bridge design. | Guoliang Zhou Xiaojun Li Xingjun Qi | 2010 | Earthquake Science2010，23，1： | 7 |
| 5 | The Sorption Isosteric Heats of Rough Rice in China显示文摘 | Xingjun Li Zidan Wu Hui Lu | 2011 | Journal of Life Sciences2011，5，1： | 4 |
| 6 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 7 | A facile "ship-in-a-bottle" approach to construct nanorattles based on upconverting lanthanide-doped fluorides显示文摘格格声结构由于唯一的 core@void@shell 体系结构和函数的集成是对 nanomaterials 的设计和申请的大兴趣的一个话题。此处,我们开发了一个新奇 ship-in-a-bottle 方法制作 upconverting (UC ) 由把做 lanthanide 的氟化物合并到空 mesoporous 的光 nanorattles 硅石。nanorattles 的尺寸和氟化物的充满的数量能很好被控制。另外,硅石壳的修正(与苯撑和胺组) 并且有效 UC 氟化物的变化(NaYF 4:Yb,Er, NaLuF 4:Yb,Er, NaGdF 4:Yb,Er 和 LiYF 4:Yb,Er) 乐意地被完成。产生 nanorattles 展出了一个高能力和反癌症药 doxorubicin (纪录影片) 的 pH 依赖的版本。而且,我们由从 UC 氟化物利用精力转移过程到纪录影片在 proof-of-concept 监视 UC 药版本采用了这些 nanorattles,因此作为有效癌症 theranostic 揭示 nanorattles 的大潜力代理人。 | Shan Lu Datao Tu Xingjun Li Renfu Li Xueyuan Chen | 2016 | Nano Research2016，9，1： | 3 |
| 8 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 9 | The development of machine learning-based remaining useful life prediction for lithium-ion batteries显示文摘Lithium-ion batteries are the most widely used energy storage devices,for which the accurate prediction of the remaining useful life(RUL)is crucial to their reliable operation and accident prevention.This work thoroughly investigates the developmental trend of RUL prediction with machine learning(ML)algorithms based on the objective screening and statistics of related papers over the past decade to analyze the research core and find future improvement directions.The possibility of extending lithium-ion battery lifetime using RUL prediction results is also explored in this paper.The ten most used ML algorithms for RUL prediction are first identified in 380 relevant papers.Then the general flow of RUL prediction and an in-depth introduction to the four most used signal pre-processing techniques in RUL prediction are presented.The research core of common ML algorithms is given first time in a uniform format in chronological order.The algorithms are also compared from aspects of accuracy and characteristics comprehensively,and the novel and general improvement directions or opportunities including improvement in early prediction,local regeneration modeling,physical information fusion,generalized transfer learning,and hardware implementation are further outlooked.Finally,the methods of battery lifetime extension are summarized,and the feasibility of using RUL as an indicator for extending battery lifetime is outlooked.Battery lifetime can be extended by optimizing the charging profile serval times according to the accurate RUL prediction results online in the future.This paper aims to give inspiration to the future improvement of ML algorithms in battery RUL prediction and lifetime extension strategy. | Xingjun Li Dan Yu Vilsen Søren Byg Store Daniel Ioan | 2023 | Journal of Energy Chemistry2023，，7： | 3 |
| 10 | Fully integrated hybrid microwave photonic receiver显示文摘Microwave photonic receivers are a promising candidate in breaking the bandwidth limitation of traditional radio-frequency(RF)receivers.To further balance the performance superiority with the requirements regarding size,weight,and power consumption(SWa P),the implementation of integrated microwave photonic microsystems has been considered an upgrade path.However,up to now,to the best of our knowledge,chip-scale fully integrated microwave photonic receivers have not been reported due to the limitation of material platforms.In this paper,we report a fully integrated hybrid microwave photonic receiver(FIH-MWPR)obtained by comprising the indium phosphide(In P)laser chip and the monolithic silicon-on-insulator(SOI)photonic circuit into the same substrate based on the low-coupling-loss micro-optics method.Benefiting from the integration of all optoelectronic components,the packaged FIH-MWPR exhibits a compact volume of 6 cmand low power consumption of 1.2 W.The FIH-MWPR supports a wide operation bandwidth from 2 to 18 GHz.Furthermore,its RF-link performance to down-convert the RF signals to the intermediate frequency is experimentally characterized by measuring the link gain,the noise figure,and the spurious-free dynamic range metrics across the whole operation frequency band.Moreover,we have utilized it as a de-chirp receiver to process the broadband linear frequencymodulated(LFM)radar echo signals at different frequency bands(S-,C-,X-,and Ku-bands)and successfully demonstrated its high-resolution-ranging capability.To the best of our knowledge,this is the first realization of a chip-scale broadband fully integrated microwave photonic receiver,which is expected to be an important step in demonstrating the feasibility of all-integrated microwave photonic microsystems oriented to miniaturized application scenarios. | JIACHEN LI SIGANG YANG HONGWEI CHEN XINGJUN WANG MINGHUA CHEN WEIWEN ZOU | 2022 | Photonics Research2022，10，6： | 2 |
| 11 | Multiplexed intracellular detection based on dual-excitation/dualemission upconversion nanoprobes显示文摘Multiplexed intracellular detection is desirable in biomedical sciences for its higher eficiency and accuracy compared to the single-analyte detection.However,it is very challenging to construct nanoprobes that possess multiple fluorescent signals to recognize the different intracellular species synchronously.Herein,we proposed a novel dual-excitation/dual-emission upconversion strategy for multiplexed detection through the design of upconversion nanoparticles(UCNP)loaded with two dyes for sensitization and quenching of the upconversion luminescence(UCL),respectively.Based on the two independent energy transfer processes of near-infrared(NIR)dye IR845 to UCNP and UCNP to visible dye PAPS-Zn,CIO-and Zn2+were simultaneously detected with a limit of detection(LOD)of41.4 and 10.5 nM,respectively.By tilizing a purpose built 830/980 nm dual-laser confocal microscope,both intrinsic and exogenous CIO and Zn2+in live MCF-7 cells have been accurately quantified.Such dual-excitation/dual-emission ratiometric UCL detection mode enables not only monitoring multiple intracellular analytes but also eliminating the detection deviation caused by inhomogeneous probe distribution in cells.Through modulation of NIR dye and visible dye with other reactive groups,the nanoprobes can be extended to analyze various intraellular species,which provides a promising tool to study the biological activities in live cells and diagnose diseases. | Jianxi Ke Shan Lu Zhuo Li Xiaoying Shang Xingjun Li Renfu Li Datao Tu Zhuo Chen Xueyuan Chen | 2020 | Nano Research2020，13，7： | 2 |
| 12 | Characterization of Kiwifruit Xyloglucan显示文摘Structural characteristics of xyloglucan are constant in the pericarp cell walls of kiwifruit (Actinidia deliciosa) throughout fruit enlargement and maturation. Most of the xyloglucan (XG) persists in the cell walls of ripe kiwifruit. XG from the pericarp tissues of 36-h ethylene-treated kiwifruit was extracted as hemicellulose Ⅱ (HC-Ⅱ) with 4.28 M KOH containing 0.02% NaBH4, and purified using iodine precipitation and subsequent anion-exchange chromatography. This purifying protocol increased XG purity from 50 mol% in HC-Ⅱ fraction to 62 mol% in the purified XG powder. The molar ratio of glucose: xylose: galactose: fucose in the purified XG was 10: 6.9: 2.1: 0.3. Gel permeation chromatography indicated that purified XG had an average molecular-mass of 161 KDa, a value that exceeds the 95 KDa Mr determined for total polymeric sugars. Sugar linkage analysis confirmed the lack of fucose in the kiwifruit XG, but a small amount of arabinoxylan and low Mr glucomannan remained associated with this fraction. | Xingjun Li Naoki Sakurai Donald J. Nevins | 2009 | Journal of Integrative Plant Biology2009，51，10： | 2 |
| 13 | Role ofβ(FeA1)nanoparticles in abnormal grain growth in the annealing of cast Cu-Al-Mn-Fe shape memory alloys显示文摘In this study,the low-cost production of Cu-AI-Mn-Fe shape memory alloy single crystals exceeding 46 mm by abnormal grain growth was realized only through annealing their cast alloys.The results show that the mis-orientation formed during annealing may be responsible for such abnormal grain growth process.It was con-firmed that this misorientation resulted from the dissolution of bec B(FeAI)nanoparticles during heat treatment at a sufficiently temperature of approximately 1173 K.The rate of migration of the abnormal grain boundary was experimentally measured to be approximately9.3 x 10^-m s^-1within 2 min of the commencement of abnormal grain growth.Additionally,the range of composition of the alloys that can lead to abnormal grain growth was determined.When the Cu-13.0AI-6.5Mn-3.2Fe single crystal close to the[100]direction was deformed to a pre-strain of 12%,full shape recovery happened without any residual strain.At that time,the superelastic strain was approximately 9%.Such a superelastic characteristic remained nearly constant over 50 cycles,showing excellent fatigue resistance.The superelastic properties of the present Cu-13.0AI-6.5Mn-3.2Fe single crystal are compared to those of commercial Ni-Ti-based shape memory alloys.Therefore,it can be considered as a new kind of superelastic material having practical applications.The obtained results should be of great significance in the development of Cu based shape memory alloys.Furthermore,it is expected that a similar microstructure can be designed for the production of more metallic single crystals. | Shuiyuan Yang Xinyu Qing Jixun Zhang Lipeng Guo Shen Hong Mingpei Li Jinbin Zhang Cuiping Wang Xingjun Liu | 2020 | Progress in Natural Science:Materials International2020，30，4： | 2 |
| 14 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 15 | Development and investigation of efficient artificial bee colony algorithm for numerical function optimization 显示文摘 | LI GUOQIANG NIU PEIFENG XIAO XINGJUN | 2012 | Applied Soft Computing2012，12，1： | 1 |
| 16 | Development and investigation of efficient artificial bee colony algorithm for numerical function optimization显示文摘 | Guoqiang Li Peifeng Niu Xingjun Xiao | 2011 | Applied Soft Computing Journal2011，，1： | 1 |
| 17 | Equilibrium moisture content and sorption isosteric heats of five wheat varieties in China显示文摘 | Xingjun Li Zhiyang Cao Zhiyan Wei Qiyan Feng Jinshui Wang | 2010 | Journal of Stored Products Research2010，，1： | 1 |
| 18 | Influence of differ- ent modificatior on structure and mechanical properties of liquid forging aluminum alloy 显示文摘 | Hongbo Li Xingjun Su Chunjie Li | 2012 | Advanced Materials Research2012，549，： | 1 |
| 19 | Fast and stable K-ion storage enabled by synergistic interlayer and pore-structure engineering显示文摘Carbon-based material has been regarded as one of the most promising electrode materials for potassium-ion batteries(PIBs).However,the battery performance based on reported porous carbon electrodes is still unsatisfactory,while the in-depth K-ion storage mechanism remains relatively ambiguous.Herein,we propose a facile“in situ self-template bubbling”method for synthesizing interlayer-tuned hierarchically porous carbon with different metallic ions,which delivers superior K-ion storage performance,especially the high reversible capacity(360.6 mAh·g^(−1)@0.05 A·g^(−1)),excellent rate capability(158.6 mAh·g^(−1)@10.0 A·g^(−1))and ultralong high-rate cycling stability(82.8%capacity retention after 2,000 cycles at 5.0 A·g^(−1)).Theoretical simulation reveals the correlations between interlayer distance and K-ion diffusion kinetics.Experimentally,deliberately designed consecutive cyclic voltammetry(CV)measurements,ex situ Raman tests,galvanostatic intermittent titration technique(GITT)method decipher the origin of the excellent rate performance by disentangling the synergistic effect of interlayer and pore-structure engineering.Considering the facile preparation strategy,superior electrochemical performance and insightful mechanism investigations,this work may deepen the fundamental understandings of carbon-based PIBs and related energy storage devices like sodium-ion batteries,aluminum-ion batteries,electrochemical capacitors,and dual-ion batteries. | Deping Li Qing Sun Yamin Zhang Xinyue Dai Fengjun Ji Kaikai Li Qunhui Yuan Xingjun Liu Lijie Ci | 2021 | Nano Research2021，14，12： | 1 |
| 20 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
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