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| 1 | Heterotic Group Classification of 63 Inbred Lines and Hybrid Purity Identification by Using SSR Markers in Winter Cabbage(Brassica Oleracea L. var. capitata)显示文摘Winter cabbage is an important crop cultivated through winter in the region near the Yangtze River, enabling the supply of fresh cabbage there at that time of year. However, a problem has emerged regarding the newly developed parents of winter cabbage, which is completely different from spring and autumn cabbage, namely, how to combine these parents to breed an elite hybrid. To classify the heterotic groups and improve the efficiency of parent selection in winter cabbage breeding, 20 polymorphic SSR markers were selected to screen 63 winter cabbage inbred lines. Seventeen pairs among the 20 SSR markers amplified polymorphic bands. These primers amplified two to six bands,with an average of 2.8 bands per primer, and a total of 47 polymorphic bands were generated in the 63 inbred lines. These lines included flatheaded morphotype and round-headed morphotype, thus they were separately classified into heterotic groups based on the SSR markers. The flat-headed morphotype contained 21 inbred lines and was classified into three heterotic groups, named Hanchun 4, Jiali, and Dongsheng, in accordance with the representative germplasm contained in each group. The round-headed morphotype contained 42 inbred lines and was classified into five heterotic groups, named Parte, Bejo1039, YK-143, SCA002, and Golden B90. Meanwhile, parent analysis of 20 developed elite combinations showed that their parents were all distributed in different heterotic groups, indicating that the group classification was reasonable,which can provide a basis for further parent selection in winter cabbage breeding. Furthermore, polymorphic SSR primers were successfully used to identify the hybrid purity of three elite varieties. | LI Xing YU Hailong LI Zhiyuan LIU Xiaoping FANG Zhiyuan LIU Yumei YANG Limei ZHUANG Mu LV Honghao ZHANG Yangyong | 2018 | Horticultural Plant Journal2018，4，4： | 11 |
| 2 | Transient Macular Edema after Laser In-Situ Keratomileusis显示文摘Purpose: To investigate the macular changes induced by laser in situ keratomileusisc(LASIK) procedure.Methods: Optical Coherence Tomography(OCT) was used to examine 27 eyes of 15LASIK patients before surgery, and 1 day, 1 week, 1 month after surgery.Results: The mean thick iness of neuroepithelial layer of macula was (195±24)microns, ( 178 ± 16) microns 1 day and 1 month after surgery, respectively, while thebaseline was (174 ± 12)microns. The increase in macular neuroepithelial thickness wascorrelated with the degree of myopia, but not with the duration of suction or thepostoperative BCVA.Conclusion: Mild macular edema is common in the first month following LASIK,especially in high myopia. However, no association with loss of BCVA has beenestablished. | Bin Yang, Zheng Wang, Guofu Huang, Xing Liu, Yunlan Ling, Xiaoping ZhengZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2003 | Eye Science2003，19，1： | 10 |
| 3 | Clinical and genetic findings in a Chinese family with VDR-associated hereditary vitamin D-resistant rickets显示文摘Hereditary vitamin D-resistant rickets(HVDRR) is a rare autosomal recessive disorder characterized by severe rickets,hypocalcemia,hypophosphatemia,secondary hyperparathyroidism,and elevated alkaline phosphatase.This disorder is caused by homogeneous or heterogeneous mutations affecting the function of the vitamin D receptor(VDR),which lead to complete or partial target organ resistance to the action of 1,25-dihydroxy vitamin D.A non-consanguineous family of Chinese Han origin with one affected individual demonstrating HVDRR was recruited,with the proband evaluated clinically,biochemically and radiographically.To identify the presence of mutations in the VDR gene,all the exons and exon–intron junctions of the VDR gene from all family members were amplified using PCR and sequenced.The proband showed rickets,progressive alopecia,hypocalcemia,hypophosphatemia,secondary hyperparathyroidism,and elevated alkaline phosphatase.She also suffered from epilepsy,which is rarely seen in patients with HVDRR.Direct sequencing analysis revealed a homozygous missense mutation c.122G4A(p.C41Y) in the VDR gene of the proband,which is located in the first zinc finger of the DNA-binding domain.Both parents had a normal phenotype and were found to be heterozygous for this mutation.We report a Chinese Han family with one individual affected with HVDRR.A homozygous missense mutation c.122G4A(p.C41Y) in the VDR gene was found to be responsible for the patient's syndrome.In contrast to the results of treatment of HVDRR in other patients,our patient responded well to a supplement of oral calcium and a low dose of calcitriol. | Qianqian Pang Xuan Qi Yan Jiang Ou Wang Mei Li Xiaoping Xing Jin Dong Weibo Xia | 2016 | Bone Research2016，4，1： | 9 |
| 4 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 5 | IDSRadar:a real-time visualization framework for IDS alerts显示文摘Intrusion Detection Systems(IDS) is an automated cyber security monitoring system to sense malicious activities.Unfortunately,IDS often generates both a considerable number of alerts and false positives in IDS logs.Information visualization allows users to discover and analyze large amounts of information through visual exploration and interaction efficiently.Even with the aid of visualization,identifying the attack patterns and recognizing the false positives from a great number of alerts are still challenges.In this paper,a novel visualization framework,IDSRadar,is proposed for IDS alerts,which can monitor the network and perceive the overall view of the security situation by using radial graph in real-time.IDSRadar utilizes five categories of entropy functions to quantitatively analyze the irregular behavioral patterns,and synthesizes interactions,filtering and drill-down to detect the potential intrusions.In conclusion,IDSRadar is used to analyze the mini-challenges of the VAST challenge 2011 and 2012. | ZHAO Ying ZHOU FangFang FAN XiaoPing LIANG Xing LIU YongGang | 2013 | Science China(Information Sciences)2013，56，8： | 5 |
| 6 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 7 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 8 | The Study of Retinal Nerve Fiber Layer Thickness of Normal Eyes Using Scanning Laser Polarimetry显示文摘Purpoe: To evaluate retinal nerve fiber layer (RNFL) thickness measurements in local normal Chinese subjects of different age groups and analyse the correlation of RNFL thickness with age using scanning laser polarimetry (SLP,GDxVCC). To assess the reproducibility of RNFL thickness measurement with GDxVCC. Methods: The RNFL thickness of 67 normal subjects (123 eyes) were measured by GDxVCC. The average TSNIT parameters were calculated. The differences of RNFL thickness between sex,right and left eyes,superior and inferior were compared. The relationship between RNFL thickness and age was analyzed with correlation analysis and linear regression analysis. The intraclass correlation coefficients (ICC) of three images in every eye were calculated. Results: The average peripapillary RNFL thickness at the superior,inferior and whole ellipse regions in 123 eyes of 67 normal subjects were (70.30±6.76)(?)m,(67.35±6.77)(?)m and (56.87±4.53)(?) m,respectively. The average TNSIT standard deviation was 23.68±4.61 and the average inter-eye symmetric value was 0.86±0.11. There were significant difference of RNFL thickness between superior and inferior (t=4.952,P < 0.001). There were significant difference of inferior RNFL thickness and TNSIT standard deviation between right and left eyes (P=0.005 and 0.002),while not significant difference of superior RNFL thickness and whole mean RNFL thickness between right and left eye (P=0.086 and 0.529). There was no significant difference in TSNIT parameters between different genders. There was a slight negative correlation average RNFL thickness in superior sector with age (decreased approximately 0.15 microns per year,P=0.047) in the subjects aged below 60 years old. The ICC values of RNFL thickness were >0.8 in superior,inferior and global. Conclusions: The RNFL thickness can be measured accurately by GDxVCC and the reproducibility of RNFL thickness measurement by GDxVCC is good. There was a slight negative correlation between average RNFL thickness in superior with age. More researches on the effects of age on RNFL thickness by GDxVCC are needed. | Xing Liu Jingjing Huang Jian Ge Yunlan Ling Xiaoping Zheng | 2006 | 眼科学报2006，22，3： | 2 |
| 9 | Silkworm Silk Fibers with Multiple Reinforced Properties Obtained through Feeding Ag Nanowires显示文摘Silkworm silk fbers have been woven into textiles for thousands of years,because of their attractive luster,good mechanical properties,excellent biocompatibility,and large-scale production.With the development of human society,preparation of silk fbers with modifed or enhanced properties are highly desirable for potential applications in structural materials and smart textiles.Herein,we realized the reinforcement of multiple properties of silk fbers by feeding silkworms with Ag nanowire(Ag NW)modifed diets.The obtained silk fbers show obviously enhanced comprehensive mechanical properties,including improved tensile strength,elongation at break,tensile modulus,and toughness,which are increased by 37.2%,37.6%,68.3%,and 69.8%,respectively.Furthermore,compared with unmodifed silk,the electrical conductivity and thermal conductivity of modifed silk fbers are improved by 246.4%and 32.1%,respectively.The analysis on the components and structure shows that the incorporated Ag NWs lead to increased content of random coil/α-helix,improved orientation of crystallites,and increased content of Ag compared to pristine silk fbers,which may contribute to the enhanced mechanical,electrical,and thermal properties. | Haojie Lu Muqiang Jian Zhe Yin Kailun Xia Shaoyi Shi Mingchao Zhang Huimin Wang Xiaoping Liang Weigang Ma Xing Zhang Yingying Zhang | 2022 | Advanced Fiber Materials2022，4，3： | 2 |
| 10 | Determination of 3-chloro-1,2-propandiol in soy sauces by capillary eletrophoresis with electrochemical detection 显示文摘 | Xiaoping Xing Yuhua Cao | 2007 | Food Control2007，，18： | 1 |
| 11 | Strategy decision on China's food security in the new era: review of the forum on China's food security and policy显示文摘 | Hu Xiaoping Xing Yan | 2012 | Chinese Rural Economy2012，，1： | 1 |
| 12 | Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma显示文摘 | Lei Zhang Wenfu Lu Xiaoping Miao Deyin Xing Wen Tan Dongxin Lin | 2006 | 中国生物学文摘2006，20，4： | 1 |
| 13 | Biochar-based organic fertilizer application rates for Tetrastigma hemsleyanum planted under Moso bamboo显示文摘The under-forest economy has received increased attention in China.However,little is known about the effects of co-composted biochar on soil and plant biomass in under-forest planting systems.In this study,plant biomass,soil nutrient levels,and bacterial communities were evaluated after application of biochar-based organic fertilizer(BOF,derived from co-composted biochar-compost)at varying rates to soils supporting Tetrastigma hemsleyanum Diels&Gilg planted under a Moso bamboo(Phyllostachys edulis)forest.BOF treatment increased the biomass of T.hemsleyanum.Compared with the control,BOF application significantly increased soil pH and organic carbon(SOC).The high-throughput sequencing results showed significant differences in the Bacteroidetes,Verrucomicrobia,Chlorofexi,and OD1 phyla among all groups.At the genus level,the control group was characterized by a preponderance of Conexibacter.Rhodanobacter was enriched in soils with a 3%BOF application and Steroidobacter and Spirochaeta were the most prominent phyla in the 5%BOF group.There was no biomarker selected in the 1%BOF group at the genus level.In conclusion,BOF application increased the biomass of T.hemsleyanum when intercropped under a Moso bamboo forest;this effect may be due to changes in the soil physicochemical properties and microbial communities after BOF application. | Xiaoping Zhang Guibin Gao Zhizhuang Wu Xing Wen Fangyuan Bian Chuanbao Yang | 2020 | Journal of Forestry Research2020，31，5： | 1 |
| 14 | Geochemical and zircon U-Pb and Hf isotopic study of the Baijuhu@an metaluminous A-type granite: Extension at 125-100 Ma and its tectonic significance for South China 显示文摘 | Wong J Sun Min Xing Guangfu Li Xian-hua Zhao Guochun Wong K Yuan Chao Xia Xiaoping Li Longming Wu Fuyuan | 2009 | Lithos2009，112，34： | 1 |
| 15 | Determination of 3-chloro-1,2-propanediol in soy sauces by capillary electrophoresis with electrochemical detection显示文摘 | Xiaoping Xing Yuhua Cao | 2005 | Food Control2005，，2： | 1 |
| 16 | Copper-Mediated Trifluoromethylation of Terminal Alkynes by S-(Trifluoromethyl)diarylsulfonium Salt显示文摘有 S-(trifluoromethyl ) diarylsulfonium 盐的终端炔属羟的调停铜的 trifluoromethylation 小心地被调查了。反应顺利继续了负担得起 trifluoromethylated 乙炔在对好收益中等。这条途径是一个方便方法综合许多功能的 trifluoromethylated 乙炔。 | Xiaoping Wang Jinhong Lin Chengpan Zhang Jichang Xiao Xing Zheng | 2013 | Chinese Journal of Chemistry2013，31，7： | 1 |
| 17 | Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an atrisk Chinese population 显示文摘 | Miao Xiaoping Xing Deyin Lin Dongxin | 2002 | Cancer Epidemiol Biomarkers Prey2002，11，： | 1 |
| 18 | Stability Analy- sis for CFST Basket Handle Arch Bridge显示文摘 | Xing Fan Zhu Bing Wang Xiaoping | 2009 | Interna- tional Conference on Transportation Engineering ASCE2009，，： | 1 |
| 19 | Comparisons of cognitive function and serum S-100B level between diabetic and non-diabetic patients after the implantation of carotid artery stent (CAS)显示文摘 | Lizhou Wang Xing Li Jie Song Tianpeng Jiang Xiaoping Wu Shi Zhou | 2014 | Neuroscience Letters2014，，： | 1 |
| 20 | Disorder in ball-milled graphite revealed by Raman spectroscopy显示文摘 | Tan Xing Lu Hua Li Liting Hou Xiaoping Hu Shaoxiong Zhou Robert Peter Mladen Petravic Ying Chen | 2013 | Carbon2013，，： | 1 |
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