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| 1 | Pre-and intraoperative predictors of acute kidney injury after liver transplantation显示文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors. | Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 2 | Multiple metastases to the small bowel from large cell bronchial carcinomas显示文摘AIM: Metastases from lung cancer to gastrointestinal tract are not rare atpostmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual.METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 μm thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117.RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells,were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine.CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected. | Davor Tomas Mario Ledinsky Mladen Belicza Bozo Kru(s|ˇ)lin | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 3 | Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage显示文摘Cross-sectional study of 75 consecutive patients presenting with acute symptomatic posterior vitreous detachment(ASPVD) and vitreous hemorrhage was conducted at University Eye Clinic,University Hospital 'Sveti Duh',Zagreb,Croatia.To check ultrasound reliability in detecting retinal tears in patients with ASPVD,transpalpebral ultrasound of the eye and the orbit was performed followed by fundus examination initially and in 6 wk period.In 13(17%) patients membranous lesion with ultrasound characteristics of retinal tear was detected.Ophthalmoscopy confirmed the diagnosis in 8/13 patients.In 62/75 patients neither ultrasound nor clinical examination revealed retinal tear.Sensitivity of ultrasound examination was 100%,specificity 92%,positive predictive value 62% and negative predictive value 100%.Ultrasound proved to be a reliable and accurate method for detection of retinal tears in ASPVD.Given the high sensitivity and negative predictive value,negative result on B-scan ultrasound excludes the probability of the retinal tear with a high degree of certainty. | Biljana Kuzmanovic Elabjer Mladen Busic Ana Biscan Tvrdi Daliborka Miletic Damir Bosnar Mirjana Bjelos | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 3 |
| 4 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 5 | Off-pump extraanatomic aortic bypass for the treatment of complex aortic coarctation and hy- poplastic aortic arch 显示文摘 | Florian SS Pascal AB Mladen P | 2008 | Ann Thorac Surg2008，85，2： | 1 |
| 6 | A simulation and testing laboratory for addressing power quality issues in power systems显示文摘 | All Abur Mladen Kezunovie | 1999 | IEEE Trans on Power Systems1999，14，1： | 1 |
| 7 | High-speed fault detection and classification with neural nets显示文摘 | Mladen Kezunovic Igor Rikalo | 1995 | Electric power system research1995，34，2： | 1 |
| 8 | High Estimated Likelihood Ratio Might Be Insufficient in a DNA-lead Process of Identification of War Victims显示文摘 | SNJEZANA DZIJAN DRAGAN PRIMORAC MLADEN MARCIKIC | 2005 | Croatica Chemica ACTA2005，78，3： | 1 |
| 9 | Cloud computing-issues, research and implementations显示文摘 | Mladen A V | 2008 | Journal of Computing and Information Technology2008，16，4： | 1 |
| 10 | Cloud computing-issues,research and implementations显示文摘 | Mladen A Vouk | 2008 | Journal of Computing and Information Technology-CIT 162008，，4： | 1 |
| 11 | Ganglia/Nerve Fibers Ratio Correlates with the Need for Surgery in Patients Diagnosed with Hirschsprung’s Disease Allied Disorder (HAD)显示文摘 | Iva Gasparovic Drazen Kovac Mladen Persic Irena Slavic Harry Nikolic Nives Jonjic | 2011 | Fetal & Pediatric Pathology2011，，6： | 1 |
| 12 | The FEM-BEM analysis of complex grounding systems显示文摘 | Mladen Trlep Anton Hamler Marko Jasenik | 2003 | IEEE Trans on Magnetics2003，39，3： | 1 |
| 13 | The simulation of the soil ionization phenomenon around the grounding system by the finite element method显示文摘 | Anton H Mladen T | 2006 | IEEE Transactions on Magnetic2006，42，4： | 1 |
| 14 | The Role of Host Lymphoid Population in the Response of Mouse EMT6Tumor to photodynamic Therapy 显示文摘 | Mladen korbelick Groazd krosl | 1996 | Cancer Research1996，15，： | 1 |
| 15 | Numerically assisted analysis of fiat and corrugated plate solar collectors thermal per- formances显示文摘 | Damir Dovic Mladen Andrassy | 2012 | Solar Energy2012，86，9： | 1 |
| 16 | A new analysis method for early detection and prevention of cascading events显示文摘 | SONG Hongbiao MLADEN K | 2006 | Electric Power Systems Research2006，77，8： | 1 |
| 17 | A new method for classification and characterization of voltage sags 显示文摘 | Mladen Kezunovic Yuan Liao | 2001 | Electric Power Systems Research2001，58，1： | 1 |
| 18 | Correlation of two methods for determination of cathepsin D in breast carcinoma (immunohistochemistry and ELISA in cytosol)显示文摘 | Uasminka Jaki? Razumovi? Ranka Romi? Stojkovi? Mladen Petrove?ki Stjepan Gamulin | 1997 | Breast Cancer Research and Treatment1997，，2： | 1 |
| 19 | A longitudinal assessment of college student engagement in good practices in undergraduate education显示文摘 | Mladen Koljatic George D. Kuh | 2001 | Higher Education2001，，3： | 1 |
| 20 | A simulation and testing laboratory for addressing power quality issues in power systems显示文摘 | All Abur Mladen Kezunovic | 1999 | IEEE Trans on Power Systems1999，14，1： | 1 |
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