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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Cancer incidence and mortality in China, 2014显示文摘Background: National Central Cancer Registry of China(NCCRC) updated nationwide cancer statistics using population-based cancer registry data in 2014 collected from all available cancer registries.Methods: In 2017, 449 cancer registries submitted cancer registry data in 2014, among which 339 registries' data met the criteria of quality control and were included in analysis. These cancer registries covered 288,243,347 population, accounting for about 21.07% of the national population in 2014. Numbers of nationwide new cancer cases and deaths were estimated using calculated incidence and mortality rates and corresponding national population stratified by area, sex, age group and cancer type. The world Segi's population was applied for agestandardized rates.Results: A total of 3,804,000 new cancer cases were diagnosed, the crude incidence rate was 278.07/100,000(301.67/100,000 in males, 253.29/100,000 in females) and the age-standardized incidence rate by world standard population(ASIRW) was 186.53/100,000. Calculated age-standardized incidence rate was higher in urban areas than in rural areas(191.6/100,000 vs. 179.2/100,000). South China had the highest cancer incidence rate while Southwest China had the lowest incidence rate. Cancer incidence rate was higher in female for population between20 to 54 years but was higher in male for population younger than 20 years or over 54 years. A total of 2,296,000 cancer deaths were reported, the crude mortality rate was 167.89/100,000(207.24/100,000 in males,126.54/100,000 in females) and the age-standardized mortality rate by world standard population(ASMRW) was106.09/100,000. Calculated age-standardized mortality rate was higher in rural areas than in urban areas(110.3/100,000 vs. 102.5/100,000). East China had the highest cancer mortality rate while North China had the lowest mortality rate. The mortality rate in male was higher than that in female. Common cancer types and major causes of cancer death differed between age group and sex.Conclusions: Heavy cancer burden and its disparities between area, sex and age group pose a major challenge to public health in China. Nationwide cancer registry plays a crucial role in cancer prevention and control. | Wanqing Chen Kexin Sun Rongshou Zheng Hongmei Zeng Siwei Zhang Changfa Xia Zhixun Yang He Li Xiaonong Zou Jie He | 2018 | Chinese Journal of Cancer Research2018，30，1： | 832 |
| 3 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 4 | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘 | Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang | 2013 | Cell Research2013，23，2： | 36 |
| 5 | The immunotherapeutic effect of dendritic cells vaccine modified with interleukin-18 gene and tumor cell lysate on mice with pancreatic carcinoma显示文摘AIM:To estimate the effect of a therapeutic vaccine against pancreatic carcinoma based on dendritic cell(DC)vaccine modified with tumor lysate and Interleukin-18 gene.METHODS:The BALB/C mice model of pancreatic arcinoma was induced with DMBA,DCvaccine was construted through pulsed with tumor lysate and transfected by the recombinant adenoviral vector encoding IL-18gene.The immnotherapeutic effects of DC vaccine on mice with pancreatic carcinoma were assessed (divided intoD-IL18-Lysate group,DC-Lysate group,DC-IL18 group,DC group,PBSgroup).RESULTS:After vaccination of the DC vaccine,the concentration of IL-18and IFN-γwere 2161±439ng·L^-1and435±72ng·L^-1inDC-IL18-Lysate group and there was significant difference compared with other groups(P<0.01)After vaccination of the DCcvaccine,the transplanted tumors were observed on 30days inDC-Lysate groups.on 16daysinDC-IL18groups.on3days in control group,but mice remained tumor-free for at least50days in DC-IL18-Lysate group and there was significant difference between DC-IL18-Lysate group and other groups(P<0.01).The median survival exceeds62days in DC-IL18-Lysate group.But the medsian surival was 48.6days in DC-Lysate group,33days in DC-IL-18group,17days in PBSgroup.The survival period was obviously prolonged in DC-IL18-Lysate group than in other groups(P<0.05,P<0.01).The weight of pancreatic tumor was0.22±0.083ginDC-IL18-Lysate group,1.45±0.74ginDC-Lysate group,1.89±1.34gin DC-IL18group,3.0±1.6ginDCgroup,2.9±2.0ginPBSgroup and the weight of tumor obviously reduced in DC-IL-18-Lysate group than in other groups(P<0.05,P<0.01).CONCLUSION:DC vaccine modified with tumo lysate and Interleukin-18gene can induce a specific and effective immune response against pancreatic cancinoma,cell. | Zhao-Hui Tang Gao-Song Wu Sheng-Quan Zou Fa-Zhu Qiu Department of Surgery of Tong Ji Hospital Wen-Hong Qiu Department of immunology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China Xiang-Ping Yang Department of Biochemistry,Rheinisch-Westfalische Technische Hochschule(RWTH),D-52074 Aachen,Germany | 2002 | World Journal of Gastroenterology2002，8，5： | 37 |
| 6 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 7 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 8 | Engineering Broad-Spectrum Bacterial Blight Resistance by Simultaneously Disrupting Variable TALE-Binding Elements of Multiple Susceptibility Genes in Rice显示文摘Xanthomonas oryzae pv.oryzae(Xoo),the causal agent of bacterial blight of rice,employs the transcription activator-like effectors(TALEs)to induce the expression of the OsSWEET family of putative sugar transporter genes,which function in conferring disease susceptibility(S)in rice plants.To engineer broadspectrum bacterial blight resistance,we used CRISPR/Cas9-mediated gene editing to disrupt the TALEbinding elements(EBEs)of two S genes,OsSWEETH and OsSWEET14,in rice cv.Kitaake,which harbors the recessive resistance allele of Xa25/OsSWEET13.The engineered rice line MS14K exhibited broadspectrum resistance to most Xoo strains with a few exceptions,suggesting that the compatible strains may contain new TALEs.We identified two PthXo2-like TALEs,Tal5LN18 and Tal7PX061,as major virulence factors in the compatible Xoo strains LN18 and PX061,respectively,and found that Xoo encodes at least five types of PthXo2-like effectors.Given that PthXo2/PthXo2.1 target OsSlVEETf3 for transcriptional activation,the genomes of 3000 rice varieties were analyzed for EBE variationsin the OsSWEET13 promoter,and 10Xa25-like haplotypes were identified.We found that Tal5LN18 and Tal7PX〇6i bind slightly different EBE sequences in the OsSWEET13 promoter to activate its expression.CRISPR/Cas9 technology was then used to generate InDels in the EBE of the OsSWEET13 promoter in MS14K to creat a new germplasm with three edited OsSWEET EBEs and broad-spectrum resistance against all Xoo strains tested.Collectively,our findings illustrate how to disarm TALE-S co-evolved loci to generate broad-spectrum resistance through the loss of effector-triggered susceptibility in plants. | Zhengyin Xu Xiameng Xu Qiang Gong Ziyang Li Ying Li Sai Wang Yangyang Yang Wenxiu Ma Longyu Liu Bo Zhu Lifang Zou Gongyou Chen | 2019 | Molecular Plant2019，12，11： | 29 |
| 9 | Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells显示文摘Emodin (1,3,8-trihydroxy-6-methylanthraquinone) could enhance the sensitivity of tumor cells to arsenic trioxide(As2O3)–induced apoptosis via generation of ROS, but the molecular mechanism has not been elucidated. Here, wecarried out cDNA microarray-based global transcription profiling of HeLa cells in response to As2O3/emodin cotreatment,comparing with As2O3–only treatment. The results showed that the expression of a number of genes was substantiallyaltered at two time points. These genes are involved in different aspects of cell function. In addition to redox regulationand apoptosis, ROS affect genes encoding proteins associated with cell signaling, organelle functions, cell cycle,cytoskeleton, etc. These data suggest that based on the cytotoxicity of As2O3, emodin mobilize every genomic resourcethrough which the As2O3–induced apoptosis is facilitated. | Xiao Jing WANG Jie YANG Hui CANG Yan Qiong ZOU Jing YI | 2005 | Cell Research2005，15，7： | 28 |
| 10 | Photodynamic therapy of condyloma acuminata in pregnant women显示文摘 | YANG Yu-guang ZOU Xian-biao ZHAO Hua ZHANG Yun-jie LI Heng-jin | 2012 | Chinese Medical Journal2012，，16： | 28 |
| 11 | Progress in China's Unconventional Oil & Gas Exploration and Development and Theoretical Technologies显示文摘The new century has witnessed a strategic breakthrough in unconventional oil & gas.Hydrocarbon accumulated in micro-/nano-scale pore throat shale systems has become an important domain that could replace current oil & gas resources.Unconventional oil & gas plays an increasingly important role in our energy demand.Tight gas,CBM,heavy oil and asphaltic sand have served as a key domain of exploration & development,with tight oil becoming a 'bright spot' domain and shale gas becoming a 'hotspot' domain.China has made great breakthroughs in unconventional oil & gas resources,such as tight gas,shale gas,tight oil and CBM,and great progress in oil shale,gas hydrate,heavy oil and oil sand.China has an estimated(223-263)×10~8t of unconventional oil resources and(890-1260)×l0^(12)m^3 of gas resources.China has made a breakthrough for progress in unconventional oil & gas study.New progress achieved in fine-grained sedimentary studies related to continental open lacustrine basin large-scale shallow-water delta sand bodies,lacustrine basin central sandy clastic flow sediments and marine-continental fine-grained sediments provide a theoretical basis for the formation and distribution of basin central reservoir bodies.Great breakthroughs have been made in unconventional reservoir geology in respect of research methodology & technology,multi-scale data merging and physical simulation of formation conditions.Overall characterization of unconventional reservoirs via multi-method and multi-scale becomes increasingly popular and facilitates the rapid development of unconventional oil & gas geological theory,method and technology.The formation of innovative,continuous hydrocarbon accumulation theory,the establishment of the framework of the unconventional oil & gas geological theory system,and the determination of the implications,geological feature,formation mechanism,distribution rule and core technology of unconventional oil& gas geological study lays a theoretical foundation for extensive unconventional oil & gas exploration and development.Theories and technologies of unconventional oil & gas exploration and development developed rapidly,including some key evaluation techniques such as 'sweet spot zone' integrated evaluation and a six-property evaluation technique that uses hydrocarbon source,lithology,physical property,brittleness,hydrocarbon potential and stress anisotropy,and some key development &engineering technologies including micro-seismic monitoring,horizontal drilling & completion and 'factory-like' operation pattern, 'man-made reservoir' development,which have facilitated the innovative development of unconventional oil & gas.These breakthroughs define a new understanding in four aspects:①theoretical innovation;② key technologies;③ complete market mechanism and national policy support;and ④ well-developed ground infrastructure,which are significant for prolonging the life cycle of petroleum industry,accelerating the upgrade and development of theories and technologies and altering the global traditional energy structure. | ZOU Caineng YANG Zhi ZHU Rukai ZHANG Guosheng HOU Lianhua WU Songtao TAO Shizhen YUAN Xuanjun DONG Dazhong WANG Yuman WANG Lan HUANG Jinliang WANG Shufang | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 27 |
| 12 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 13 | The global image of the Moon obtained by the Chang'E-1:Data processing and lunar cartography显示文摘The global lunar image of the first phase of Chinese Lunar Exploration Program is the first image that covered all over the surface of the Moon. It will serve as a critical foundation for succeeding exploration and scientific research. In this paper, the acquisition, characteristics, and data quality of Chang'E-1 CCD image data are described in detail. Also described are the methodology and procedure of data processing. According to rule of planetary cartography, the image data have been processed, geometrically corrected, and then mosaicked and merged in a scale of 1:2.5 million. The results of data processing and charting show that the image data of Chang'E-1 CCD and their geometric precision meet the demand of charting a map in the scale of 1:2.5 million. The relative geometric positioning precision of the global image is better than 240 m, and the absolute geometric positioning precision is slightly better than that of the ULCN2005 and Clementine lunar basemap (V2.0). The plane positioning precision is approximately 100-1500 m. This global image proves to be the best global image of the Moon so far in terms of space coverage, image quality, and positioning precision. | LI ChunLai1, LIU JianJun1, REN Xin1, MOU LingLi1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang2, YANG JianFeng2, ZOU XiaoDuan1, WANG Min1, XU Chun1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, LI JunDuo1 & OUYANG ZiYuan11 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China | 2010 | Science China Earth Sciences2010，53，8： | 22 |
| 14 | Linkage Map Construction and Quantitative Trait Loci Analysis for Bolting Based on a Double Haploid Population of Brassica rapa显示文摘早白菜跑(Brassica 敲击 L.) 在春天期间,耕作经常在收获物的收益和质量上有有害效果。引起晚跑的变化是引起节目的白菜的一个主要目的。以便分析固定特点的基因基础, B 的一张遗传图谱。敲击一基于 amplifiedfragment 长度被构造多型性(AFLP ) ,顺序相关的放大多型性(SRAP ) , simplesequencerepeat (SSR ) ,多态的脱氧核糖核酸(RAPD ) 的随机的扩大,和 isozyme 标记。Markeranalysiswas 在线从二个同型结合的父母的 F_1progeny 由小孢子文化获得了的 81 双单倍体(DH ) 上执行了:B。敲 L。ssp, pekinensis (由)( 一根额外早跑的 Chinesecabbage 线) 并且 B。敲 L。ssp。raplfera (公里)( 一根额外迟了的跑的欧洲萝卜线) 。包括 130 AFLP, 123 SRAP, 16 SSR, 43RAPDs 和 14 isozymes 的 326 个标记的一个总数被用来与用在 loci 之间的 2.71 厘米的平均距离盖住 882 厘米的 10 个连接组一起构造一张连锁图。每根 DH 线的跑的特点被跑的索引 undercontrolledconditions 评估。量的特点 loci (QTL ) 分析用多重 QTL 模型 mappingwithMapQTLS.O 软件被进行。控制跑的抵抗的八 QTL 被识别。这些 QTL,为有积极加性效果的 phenotypic 变化的 14.1%to25.2% 的财务,被散布进三个连接组。Theseresults 为近来在白菜繁殖固定特点的帮助 molecularmarker 的选择提供有用信息程序。 | Xu Yang Yang-Jun Yu Feng-Lan Zhang Zhi-Rong Zou Xiu-Yun Zhao De-Shuang Zhang Jia-Bing Xu | 2007 | Journal of Integrative Plant Biology2007，49，5： | 23 |
| 15 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 16 | Homocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox显示文摘血 homocysteine 层次(hyperhomocysteinemia ) 的举起是为心血管的混乱的一个风险因素。homocysteine 由导致动脉粥样硬化的机制之一是在反应的氧种(ROS ) 支持脉管的光滑的肌肉细胞(VSMC ) 的增长依赖的举止。homocysteine 在 VSMC 通过 NAD (P) H oxidases 的激活导致 ROS 的生产,这被显示出。在这研究,我们调查了涉及 NAD (P) H oxidases 的激活的信号 transduction 小径。Homocysteine 在 VSMC 支持了 DNA 合成。由 N-acetyl-l-cysteine (一种抗氧化剂) 和 apocynin (NAD (P) H oxidases 的一个禁止者) 的 ROS 的抑制显著地在 VSMC 堵住了导致 homocysteine 的增长。Homocysteine 在 p38-mitogen-activated 蛋白质 kinase (p38 MAPK ) 的 phosphorylation 导致了快速的增加。p38 MAPK 接着由导致 p47phox 的 phosphorylation 激活 NAD (P) H oxidases,导致 ROS 的产生。ROS 导致了 Akt 的 phosphorylation,它为在 VSMC 的增长可能负责。这些调查结果证明 homocysteine 由激活 p38 MAPK 并且提高 p47phox 的 phosphorylation 在 VSMC 在 NAD (P) H oxidases 的活动导致增加。 | Tong Zou Weihong Yang Zongliu Hou Jiefu Yang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 23 |
| 17 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 18 | A precise velocity field of tectonic deformation in China as inferred from intensive GPS observations显示文摘Active tectonics, e.g., faulting, folding, and rifting are clearly manifested over the vast territory of China. The in-tensive crustal deformation with long-lived structures has given rise to numerous highly-elevated mountains in the western China with the Yangtze and Yellow rivers downstreaming to the east, | LI Qiang YOU XinZhao YANG ShaoMin DU RuiLin QIAO XueJun ZOU Rong WANG Qi | 2012 | Science China Earth Sciences2012，55，5： | 23 |
| 19 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 20 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014，11，4： | 21 |
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