| 1 | A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene显示文摘Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration.The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications.Herein,an epoxy network loading curcumin and Ti3 C2 TxMXenes were developed as a hybrid biomedical patch.The hybrid patch was basically prepared through an epoxy/thiol curing chemistry,and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature.The resulted hybrid patch exhibits shape-morphing capability,multi-substrate adhesion,self-healing ability,and photothermal effects under 980 nm near infrared(NIR).Additionally,the asprepared hybrid patch possesses strong UV-shielding,excellent oxidation resistance(ROS scavenging efficiency was 89.3%in3 min),highly effective antibacterial vitality(more than 99%)against S.aureus and E.coli,and good cytocompatibility.As a proof of concept,the present multifunctional hybrid patch broadens the potential applications in the biomedical field. | ZOU Yang JIN Xin ZHANG XiaoPing KONG XiaoLing ZHANG Qian XIE XianHua LIU ChangJun KE LinNan LIU WenGuang WANG Wei | 2021 | Science China(Technological Sciences)2021，64，12： | 2 |
| 2 | In vitro genotoxicity evaluation and metabolic study of residual glutaraldehyde in animal-derived biomaterials显示文摘Glutaraldehyde(GA)is an important additive that is mainly used in animal-derived biomaterials to improve their mechanical and antimicrobial capacities.However,GA chemical toxicity and the metabolic mechanism remain relatively unknown.Therefore,residual GA has always been a major health risk consideration for animal-derived medical devices.In this study,extracts of three biopatches were tested via the GA determination test and mouse lymphoma assay(MLA).The results showed that dissolved GA was a potential mutagen,which could induce significant cytotoxic and mutagenic effects in mouse lymphoma cells.These toxic reactions were relieved by the S9 metabolic activation(MA)system.Furthermore,we confirmed that GA concentration decreased and glutaric acid was generated during the catalytic process.We revealed GA could be oxidized via cytochrome P450 which was the main metabolic factor of S9.We found that even though GA was possibly responsible for positive reactions of animal-derived biomaterials’biocompatibility evaluation,it may not represent the real situation occurring in human bodies,owing to the presence of various detoxification mechanisms including the S9 system.Overall,in order to achieve a general balance between risk management and practical application,rational decisions based on comprehensive analyses must be considered. | Jianfeng Shi Huan Lian Yuanli Huang Danmei Zhao Han Wang Chunren Wang Jingli Li Linnan Ke | 2020 | Regenerative Biomaterials2020，7，6： | 1 |
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