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| 1 | Study on early warning index of spatial deformation for high concrete dam显示文摘Owing to the deficiency in early warning for high concrete dam,a formula was established to characterize the deformation behavior of high concrete dam as a whole.The early warning index of spatial deformation was calculated by low probability principle on the basis of the deformation entropy formula proposed.The steps were as follows.Firstly,the probability method was utilized to define the degree of order and degree of chaos for each survey point.Secondly,the weight distribution among the survey points was calculated by projection pursuit analysis.Thirdly,the formula of holistic deformation entropy,which can represent the degree of order of high concrete dam,was established on the basis of synergetics and information entropy.Lastly,the early warning index of deformation entropy was computed by low probability method based on series of calculated deformation entropy values.An example showed that the dynamic property of deformation entropy is in accordance with both environmental variables and deflection deformation.Moreover,deformation entropy can be used to improve warning ability and safety management for high concrete dam. | LEI Peng CHANG XiaoLin XIAO Feng ZHANG GuiJin SU HuaiZhi | 2011 | Science China(Technological Sciences)2011，54，6： | 23 |
| 2 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 3 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 4 | Comparison of microwave assisted extraction with hot reflux extraction in acquirement and degradation of anthocyanin from powdered blueberry显示文摘Acquirement and degradation kinetics of anthocyanin from powdered blueberry were studied to analyze the degradation reason and improve the yield of anthocyanin under microwave assisted extraction(MAE)conditions.Hot reflux extraction(HRE)method was employed as a reference with MAE to discriminate the influences of the microwave irradiation under the same extraction temperature at 30℃-70℃.Ethanol was selected as extraction solvent.Microwave volumetric heating improves the diffusion and solubility of anthocyanin within powdered blueberry particles in the pre-heating period.The kinetic coefficients,in terms of delivery kinetic and diffusion kinetic,are lower in MAE than that in HRE.Four anthocyanins including delphinidin,cyanidin,malvidin and pelaronidin were detected in the anthocyanin extracts from blueberry.Delphinidin,cyaniding,and pelargonidin contents significantly decrease,but malvidin was unchanged in MAE.Anthocyanin yield increases with elevating extraction temperatures,but anthocyanin degradation occurred at 41.2℃.The acquirement amount of anthocyanin is lower than its degradation amount when microwave extraction temperature is higher than 53.6℃.The self-aggregation of anthocyanin molecules and degradation results in the reduction of anthocyanin yield extracted from blueberry powder.In MAE,microwave volumetric heating results in the rapidly elevated temperature in pre-heating stage and generation of internal pressure to improve the acquirement of anthocyanin and the non-thermal effect from microwave field may weak the effect of temperature to decline the degradation of anthocyanin to monomer.The non-thermal microwave irradiation has pronounced effects compared to the effects of temperature on the structure changes of anthocyanin molecules at extraction temperature below 50℃.In HRE,convection mode of heat transfer in extraction system form the non-uniform distribution of temperature in the extraction vials to decrease the acquirement yield of anthocyanin from the blueberry powder.The research results provide valuable data to optimize extraction temperature for high extraction yield and bioactivity of anthocyanin in microwave extraction process. | Sun Yu Xue Hongkun Liu Chenghai Liu Chai Su Xiaolin Zheng Xianzhe | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 7 |
| 5 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 6 | High-peak-power temporally shaped nanosecond fiber laser immune to SPM-induced spectral broadening显示文摘High-peak-power transform-limited narrow-linewidth nanosecond all-fiber lasers are desired in a range of applications.However,their linewidths will be broadened by self-phase modulation(SPM).We propose a novel concept that generates transform-limited laser pulses by temporally shaping the pulse seed.The impact of the pulse shape on SPM-induced spectral broadening was studied numerically and experimentally.It was found theoretically that the square-shape pulsed laser is immune to SPM-induced spectral broadening.Based on this principle,we built a high-peak-power,linearly polarized,square-shape nanosecond all-fiber laser in a master oscillator power amplifier(MOPA)configuration.Stimulated Brillouin scattering(SBS)limited peak powers of 4.02 kW,5.06 kW,6.52 kW and 9.30 kW were obtained at pulse widths of 8 ns,7 ns,6 ns and 5 ns.Thanks to the square-shape pulsed seed,the linewidths at maximum peak power remained at 129.5 MHz,137.6 MHz,156.2 MHz and 200.1 MHz,respectively,close to the transform-limited values of110.8 MHz,126.6 MHz,147.7 MHz and 177.3 MHz. | Rongtao Su Pengfei Ma Pu Zhou Zilun Chen Xiaolin Wang Yanxing Ma Jian Wu Xiaojun Xu | 2019 | High Power Laser Science and Engineering2019，7，2： | 4 |
| 7 | Growth of covellite crystal onto azurite surface during sulfurization and its response to flotation behavior显示文摘In this work,the growth of copper sulfide crystal onto azurite surfaces during sulfurization and its response to flotation are investigated.Filed emission scanning electron microscopy-energy dispersive X-ray spectroscopy(FESEM) and X-ray diffraction(XRD) studies confirmed that the sulfurization of azurite is not limited to the mineral surface,but rather penetrates into the bulk to form covellite crystal(synCuS),creating favorable conditions for the stable adsorption of xanthate and greatly promoting the azurite flotation.Additionally,as demonstrated by X-ray photoelectron spectroscopy(XPS) and time of flight secondary ion mass spectrometry(TOF-SIMS) analyses,a redox reaction occurred during this process,and Cu(Ⅱ) onto the mineral surface was reduced to Cu(Ⅰ).Correspondingly,reduced S^(2-) was oxidized to(S_(2))^(2-),(S_n)^(-2),and even to deeper oxidation state S~0,(S_(x)O_(y))^(n-) and SO_(4)^(2-).Excess sodium sulfide strengthens copper sulfide to form onto the azurite surface,and provides enough raw material for crystal copper sulfide to grow,resulting in the formation of 'flake-like' covellite with a better crystallinity.However,the floatability of azurite decreased dramatically under this condition,because the generated massive colloidal copper sulfide in flotation pulp deteriorates the flotation environment,resulting in a decreased effective adsorption of collector onto azurite surfaces. | Jinpeng Cai Peilun Shen Dianwen Liu Xiaolin Zhang Jianjun Fang Chao Su Xingcai Yu Jiangli Li Han Wang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 4 |
| 8 | Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway显示文摘Adiponectin,an adipokine synthesized and secreted majorly by adipose tissue,is reported to exert cardioprotective properties via anti-inflammation and antiapoptosis.Lipopolysaccharide(LPS)is a common inflammation and apoptosis inducer of cardiomyocytes.However,few studies have reported the roles of adiponectin on LPS-induced inflammation as well as apoptosis of H9c2 cells,and the possible mechanisms of these effects.In the present study,we found that adiponectin significantly relieved LPS-induced cytotoxicity including decreased viability and elevated LDH release,inhibited LPS-triggered inflammation,which is evidenced by increases in release of TNF-α,IL-1β as well as IL-6,and attenuated the enhanced rates of apoptotic cells as well as increased caspase-3 activity caused by LPS in H9c2 cells.In addition,our data demonstrated that adiponectin upregulated AMP-activated protein kinase(AMPK)activation of H9c2 cells with or without LPS administration.Moreover,we found that blocking AMPK pathway by compound c attenuated the protective effects of adiponectin against the cytotoxicity,inflammatory response,and apoptosis of H9c2 cells resulted from LPS.Our observations bring novel insights for understanding the mediatory role of AMPK pathway implicated in the protective effects of adiponectin against LPS-induced cardiotoxicity. | Rui Hao Guoying Su Xiaolin Sun Xiangran Kong Cuiying Zhu Guohai Su | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 4 |
| 9 | Full-parameter vision navigation based on scene matching for aircrafts显示文摘Vision navigation based on scene matching between real-time images and a reference image has many advantages over the commonly used inertial navigation system(INS),such as no cumulative measurement errors for long-endurance flight.Recent developments in vision navigation are mainly used for partial navigation parameters measurements,such as the position and the relative velocity,which cannot meet the requirements of completely autonomous navigation.We present the concept,principle and method of full-parameter vision navigation(FPVN)based on scene matching.The proposed method can obtain the three-dimensional(3D)position and attitude angles of an aircraft by the scene matching for multiple feature points instead of a single point in existing vision navigations.Thus,FPVN can achieve the geodetic position coordinates and attitude angles of the aircraft and then the velocity vector,attitude angular velocity and acceleration can be derived by the time differentials,which provide a full set of navigation parameters for aircrafts and unmanned aerial vehicles(UAVs).The method can be combined with the INS and the cumulative errors of the INS can be corrected using the measurements of FPVN rather than satellite navigation systems.The approach provides a completely autonomous and accurate navigation method for long-endurance flight without the help of satellites. | YU QiFeng SHANG Yang LIU XiaoChun LEI ZhiHui LI Xiang ZHU XianWei LIU XiaoLin YANG Xia SU Ang ZHANG XiaoHu ZHANG HongLiang | 2014 | Science China(Information Sciences)2014，57，5： | 3 |
| 10 | Role of ammonium sulfate in sulfurization flotation of azurite:Inhibiting the formation of copper sulfide colloid and its mechanism显示文摘In this study,the role of(NH_(4))_(2)SO_(4)during the sulfurization of azurite and its response to flotation were investigated.The flotation results showed that adding(NH_(4))_(2)SO_(4)prior to sulfurization decreased the formation of colloid in flotation pulp,and the floatability of the suppressed azurite caused by excess sodium sulfide was restored.After adding(NH_(4))_(2)SO_(4)prior to sulfurization,the formation of Cu(NH_(3))_(n) ^(2+)intermediate products changed the path of the sulfurization reaction,which slowed the direct impact of HSon the azurite surface.The nucleation rate was reduced,and the growth of copper sulfide crystal was improved.Covellite(syn,CuS)with larger crystal grains was formed on the azurite surface,thereby enhancing the mechanical stability of copper sulfide products onto the mineral surface.Therefore,the generated copper sulfide colloid significantly reduced,ultimately promoting the effective adsorption of xanthate on the azurite surface. | Jinpeng Cai Chao Su Yinyu Ma Xingcai Yu Rong Peng Jiangli Li Xiaolin Zhang Jianjun Fang Peilun Shen Dianwen Liu | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 11 | A novel coating technology for fast sealing of air leakage in underground coal mines显示文摘Air leakage in underground coal mines presents a serious hazard for coal production and the safety of miners.Coating technology is commonly used as an efficient means for preventing air leakage.To address existing problems with high dust concentrations in large operations involving complex processes and the high cost of traditional coating technology,a novel coating technology that ensures intrinsic safety by utilizing water pressure and wind pressure was developed.This new coating technology was designed to suction and spray,and the technical parameters of its spray performance was also studied.The experimental tests and evaluation indicated the optimum working range is 0.3–0.7 MPa of wind pressure,1.2–10.2 L/min of water quantity,and 1.0–3.5 m of spraying distance.Moreover,this novel coating technology was tested in the Dashuitou Coal Mine in Gansu Province of China.Compared with conventional counterparts,the proposed new technology is safe,efficient,and convenient to operate.During spraying,dust concentrations were kept at less than 10 mg/m3,and the average rebound ratio resilient rate of solid materials was below 13%.After spraying,the average leakage every 100 m was 4 m3/min,and the oxygen volume fraction in the adjacent goaf was approximately 4%,demonstrating excellent air leakage prevention. | Sihua Shao Chunlei Wu Min Hao Xiaolin Song Xueyou Su Weihan Wang Guosheng Li Bobo Shi | 2021 | International Journal of Mining Science and Technology2021，31，2： | 2 |
| 12 | Species and Functions of Rhizobia Growing on Trees and Colonization Mechanisms显示文摘The current research progress in China shows that the tree species of rhizobia that have been found are mainly trees of 11 genera in Papilionaceae,Elaeagnaceae and Mimosaceae,and the rhizobia are mainlyα-rhizobia,which come from multiple genera.Temperature,pH value,NaCl content and antibiotics all affect the growth of tree rhizobia;and different species of rhizobia have different stress resistance,which is related to their living environment.Rhizobium inoculation can promote plant height,biomass,root-to-shoot ratio,and root architecture of trees.We discussed and analyzed the development history and application status of rhizobia research,and prospected their future development directions.In the future,tree rhizobia will surely be used as a means of production to promote efficient agricultural production and sustainable agricultural systems. | Weixin CHEN Xiaolin SHEN Chaoyi YE Yihan SU Chengxiang XU | 2021 | Agricultural Biotechnology2021，10，5： | 1 |
| 13 | Synthesis and Characterization of Fluorescent Starch Using Fluoreseein as Fluorophore:Potential Polymeric Temperature/pH Indicators 显示文摘 | Guan Xiaolin Su Zhixing | 2008 | Polym Adv Technol2008，19，： | 1 |
| 14 | Molecular regulation of vasculogenic mimicry in human uveal melanoma cells: role of helix–loop–helix Id2 (inhibitor of DNA binding 2)显示文摘 | Fan Su Bin Li Jian Wang Xiaolin Xu Ruojin Ren Liaoqing Li Fei Gao Xiaochao Liu | 2009 | Graefe’s Archive for Clinical and Experimental Ophthalmology2009，，3： | 1 |
| 15 | Effects of Shengmai Yin(生脉饮)on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms:a randomized,double blind,multicenter control trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Shengmai Yin(生脉饮,SMY)on visual analogue scale(VAS)for cardiopulmonary symptoms in coronavirus disease 2019(COVID-19)convalescent patients.METHODS:In this randomized,double blind and multicenter controlled trial,a total of 200 COVID-19 convalescent patients who with cardiopulmonary symptoms were enrolled from three medical centers in Hubei,China.These patients were randomized divided into trial group and the control group,100 patients in each one,SMY and its placebo were applied to respectively,for two weeks.VAS of clinical symptoms included shortness of breath,hidrosis,chest distress,palpitation,and dry cough was performed at 0,1,2 weeks.Decrease in VAS of 30%or more was defined as effective,and a reduction in VAS of 0 was defined as curative.RESULTS:A total of 192 completed the study.The VAS of TCM symptoms showed there was no difference in baseline between the two groups.The VAS in both groups was down-regulated,and there was no significant difference in VAS and cure rates at the first and second week between the two groups.There was no significant difference in breath,hidrosis,palpitation,and dry cough between the two groups but SMY treatment for two weeks has remarkable therapeutic effects in chest distress than placebo.CONCLUSIONS:SMY could effectively ameliorate the symptoms of chest distress,and improve the quality of life of the COVID-19 convalescent patients. | AN Xuedong MAO Lina XIA Ping SU Wen WANG Beibei KOU Leiya ZHANG Zequan QI Meng HU Song CHEN Jing LI Xiujuan LIU Jinwei ZHOU Juan QIAO Jie LUO Dan LUO Guangwei YAN Youqin YANG Guiping DONG Dandan ZHOU Wei TAO Junxiu JIN De TONG Xiaolin WEI Li | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 1 |
| 16 | Kilowatt high average power narrow-linewidth nanosecond all-fiber laser显示文摘A high power narrow-linewidth nanosecond all-fiber laser based on the master oscillator power amplifier(MOPA)configuration is demonstrated. A pulsed seed with high repetition rate of 10 MHz was generated by modulating a continuous-wave(CW) single-frequency fiber laser at ~1064 nm by using an electro-optic intensity modulator(EOIM).After multi-stage cascaded power amplification, the average power was boosted to be kilowatt level. The pulses from the main amplifier had a pulse width of ~3 ns and an average/peak power of 913 W/28.6 kW. Further power scaling of the pulses was limited by stimulated Raman scattering(SRS) for the moment, method for SRS suppression and further power scaling was briefly discussed. | Rongtao Su Pu Zhou Xiaolin Wang Rumao Tao Xiaojun Xu | 2014 | High Power Laser Science and Engineering2014，2，1： | 1 |
| 17 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 18 | Oligomer-specific single chain variable fragment antibody attenuates memory deficits and brain amyloid burden in Alzheimer disease transgenic mice显示文摘 | Min Zhao Shaowei Wang Yajing Su Weiwei Zhou Xiaolin Yu Ruitian Liu | 2013 | 中国药理通讯2013，30，2： | 0 |
| 19 | Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke显示文摘Severe ischemic stroke damages neuronal tissue,forming irregular-shaped stroke cavities devoid of supporting structure.Implanting biomaterials to provide structural and functional support is thought to favor ingrowth of regenerated neuronal networks.Injectable hydrogels capable of in situ gelation are often utilized for stroke repair,but challenged by incomplete gelation and imprecise control over end-macrostructure.Injectable shape-memory scaffolds might overcome these limitations,but are not explored for stroke repair.Here,we report an injectable,photoluminescent,carbon-nanotubes-doped sericin scaffold(CNTs-SS)with programmable shape-memory property.By adjusting CNTs’concentrations,CNTs-SS′recovery dynamics can be mathematically calculated at the scale of seconds,and its shapes can be pre-designed to precisely match any irregular-shaped cavities.Using a preclinical stroke model,we show that CNTs-SS with the customized shape is successfully injected into the cavity and recovers its pre-designed shape to well fit the cavity.Notably,CNTs-SS’near-infrared photoluminescence enables non-invasive,real-time tracking after in vivo implantation.Moreover,as a cell carrier,CNTs-SS not only deliver bone marrow mesenchymal stem cells(BMSCs)into brain tissues,but also functionally promote their neuronal differentiation.Together,we for the first time demonstrate the feasibility of applying injectable shape-memory scaffolds for stroke repair,paving the way for personalized stroke repair. | Jian Wang Xiaolin Li Yu Song Qiangfei Su Xiakeerzhati Xiaohalati Wen Yang Luming Xu Bo Cai Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，7： | 0 |
| 20 | Neuro-11:a new questionnaire for the assessment of somatic symptom disorder in general hospitals显示文摘Background Somatic symptom disorder(SSD)commonly presents in general hospital settings,posing challenges for healthcare professionals lacking specialised psychiatric training.The Neuro-11 Neurosis Scale(Neuro-11)offers promise in screening and evaluating psychosomatic symptoms,comprising 11 concise items across three dimensions:somatic symptoms,negative emotions and adverse events.Prior research has validated the scale’s reliability,validity and theoretical framework in somatoform disorders,indicating its potential as a valuable tool for SSD screening in general hospitals.Aims This study aimed to establish the reliability,validity and threshold of the Neuro-11 by comparing it with standard questionnaires commonly used in general hospitals for assessing SSD.Through this comparative analysis,we aimed to validate the effectiveness and precision of the Neuro-11,enhancing its utility in clinical settings.Methods Between November 2020 and December 2021,data were collected from 731 patients receiving outpatient and inpatient care at Shenzhen People’s Hospital in China for various physical discomforts.The patients completed multiple questionnaires,including the Neuro-11,Short Form 36 Health Survey,Patient Health Questionnaire 15 items,Hamilton Anxiety Scale and Hamilton Depression Scale.Psychiatry-trained clinicians conducted structured interviews and clinical examinations to establish a gold standard diagnosis of SSD.Results The Neuro-11 demonstrated strong content reliability and structural consistency,correlating significantly with internationally recognised and widely used questionnaires.Despite its brevity,the Neuro-11 exhibited significant correlations with other questionnaires.A test-retest analysis yielded a correlation coefficient of 1.00,Spearman-Brown coefficient of 0.64 and Cronbach’sαcoefficient of 0.72,indicating robust content reliability and internal consistency.Confirmatory factor analysis confirmed the validity of the three-dimensional structure(p<0.001,comparative fit index=0.94,Tucker-Lewis index=0.92,root mean square error of approximation=0.06,standardised root mean square residual=0.04).The threshold of the Neuro-11 is set at 10 points based on the maximum Youden’s index from the receiver operating characteristic curve analysis.In terms of diagnostic efficacy,the Neuro-11 has an area under the curve of 0.67. | Silin Zeng Yian Yu Shan Lu Sirui Zhang Xiaolin Su Ge Dang Ying Liu Zhili Cai Siyan Chen Yitao He Xin Jiang Chanjuan Chen Lei Yuan Peng Xie Jianqing Shi Qingshan Geng Rafael H Llinas Yi Guo | 2023 | General Psychiatry2023，36，4： | 0 |
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