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| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 3 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 4 | Signal overcomplete representation and sparse decomposition based on redundant dictionaries显示文摘Decomposing a signal based upon redundan dictionaries is a new method for data representation on sig- nal processing. It approximates a signal with an overcom- plete system instead of an orthonormal basis to provide a sufficient choice for adaptive sparse decompositions. Re- placing the original data with a sparse approximation can result in not only a higher compression ratio, but also greater flexibility in capturing the inherent structure of the natura signals with the redundancy of dictionaries. This paper gives an overview of a series of recent results in this field, and deals with the relationship between sparsity of signal de- composition and incoherence of dictionaries with BP and MP algorithms. The current and future challenges of the dic- tionary construction are discussed. | ZHANG Chunmei YIN Zhongke CHEN Xiangdong XIAO Mingxia | 2005 | Chinese Science Bulletin2005，50，23： | 13 |
| 5 | Dryland Expansion in Northern China from 1948 to 2008显示文摘This study examines the expansion of drylands and regional climate change in northern China by analyzing the variations in aridity index(AI), surface air temperature(SAT), precipitation and potential evapotranspiration(PET) from 1948 to 2008.It is found that the drylands of northern China have expanded remarkably in the last 61 years. The area of drylands of the last 15 years(1994–2008) is 0.65 × 106km2(12%) larger than that in the period 1948–62. The boundary of drylands has extended eastward over Northeast China by about 2° of longitude and by about 1° of latitude to the south along the middleto-lower reaches of the Yellow River. A zonal band of expansion of semi-arid regions has occurred, stretching from western Heilongjiang Province to southern Gansu Province, while shifts to the east of semi-arid regions in dry subhumid regions have also occurred. Results show that the aridity trend of drylands in northern China is highly correlated with the long-term trend of precipitation and PET, and the expansion of semi-arid regions plays a dominant role in the areal extent of drylands, which is nearly 10 times larger than that in arid and subhumid regions. | LI Yue HUANG Jianping JI Mingxia RAN Jinjiang | 2015 | Advances in Atmospheric Sciences2015，32，6： | 12 |
| 6 | Occurrence and Diversity of Marine Yeasts in Antarctica Environments显示文摘A total of 28 yeast strains were obtained from the sea sediment of Antarctica.According to the results of routine identi-fication and molecular characterization,the strains belonged to species of Yarrowia lipolytica,Debaryomyces hansenii,Rhodotorula slooffiae,Rhodotorula mucilaginosa,Sporidiobolus salmonicolor,Aureobasidium pullulans,Mrakia frigida and Guehomyces pullu-lans,respectively.The Antarctica yeasts have wide potential applications in biotechnology,for some of them can produce b-galactosidase and killer toxins. | ZHANG Xue HUA Mingxia SONG Chunli CHI Zhenming | 2012 | Journal of Ocean University of China2012，11，1： | 11 |
| 7 | Middle–Upper Ordovician(Darriwilian–Early Katian) Positive Carbon Isotope Excursions in the Northern Tarim Basin, Northwest China: Implications for Stratigraphic Correlation and Paleoclimate显示文摘Three positive carbon isotope excursions are reported from Middle–Upper Ordovician in Tahe oil-gas field, northern Tarim Basin. Based on conodont biostratigraphy, the Middle Darriwilian Isotope Carbon Excursion(MDICE) and the Guttenberg Carbon Isotope Excursion(GICE) are identified from Darriwilian to Early Katian by the aid of whole-rock carbon isotope data from two well cores. Positive excursion within conodont Pygodus anserinus zone is developed in Early Sandbian, and the fluctuation range is no less than MDICE. Because the range of this excursion in the generalized global carbon isotope curve is short, previous studies paid little attention to it, and named Early Sandbian Isotope Carbon Excursion(ESICE) in this paper. Furthermore, these positive excursions are not directly related to sea level fluctuations and the MDICE and GICE identified in northern Tarim can be globally correlated to that in southern China, North America, South America, and Europe. The Saergan Fm. source rocks of Middle-Upper Ordovician in Kalpin Dawangou outcrop are in accord with the geologic time of MDICE and ESICE, and GICE have strong ties to the source rock of Lianglitag Fm. in basin. Abundant organic carbon burial is an important factor in genesis of positive isotope carbon excursions. Positive oxygen isotope excursion, conodont fauna turnover, decreased conodont total diversity, and the change of sedimentary facies indicated that dramatic changes of paleoceanographic environment of Early-Middle Ordovician in Tarim Basin started from the end of Darriwillian, and an obvious icehouse climate of Late Ordovician occurred in ESICE. | Cunge Liu Guorong Li Dawei Wang Yongli Liu Mingxia Luo Xiaoming Shao | 2016 | Journal of Earth Science2016，27，2： | 9 |
| 8 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 9 | Remarkably improved hydrogen storage properties of nanocrystalline TiO2-modified NaAlH4 and evolution of Ti- containing species during dehydrogenation/hydrogenation显示文摘增加 nanocrystalline TiO 的小数量<潜水艇class=“ a-plus-plus ”> 2 @C ( TiO <潜水艇class=“ a-plus-plus ”>在 nanoporous 碳上支持的 2 )合成戏剧性地减少操作温度并且在 NaAlH 为氢存储改进反应动力学<潜水艇class=“ a-plus-plus ”> 4 。nanocrystalline TiO < 潜水艇 class= “ a-plus-plus ” > 2 @C 合成在 900 AVO 八面体综合了是盖住试剂和生长的赞成过度饱和的选择吸附的结果种。随后, 3D 多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体被 AVO 八面体的简单 thermolysis 经由一个锻烧处理获得。作为为锂电池的阴极材料,多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体阴极在西班牙的北方展出 96 mAsga 盆的一个能力;并且(3 ) Zpy (n ?=? 17 ) , LV 质量从 226 被减少[178;306 ] g 到 220 [169;254 ] g (p ?=? 0.007 ) 在 13 点 ? 桴 ? 畦摮浡湥慴? 牦煥敵据敩 ? 景琠敨猠摥浩湥獴? 敢楳敤琠敨氠湯楧畴楤慮? 湡 ? 牴湡癳牥敳映湵慤敭瑮污映敲畱湥楣獥漠 ? 慥档戠極摬湩 ? 慢敳 ? 湯琠敨愠灭楬畴敤猠数瑣慲愠摮琠敨映潬牯猠数瑣慲? 慲楴?? 剓? 敭桴摯? | Xin Zhang Yongfeng Liu Ke Wang Mingxia Gao Hongge Pan | 2015 | Nano Research2015，8，2： | 8 |
| 10 | Optical generation,detection and non-destructive testing applications of terahertz waves显示文摘Optoelectronic terahertz generation and detection play a key role in the applications of non-destructive testing,which involves different areas such as physics,biological,material science,imaging,explosions detection,astronomy applications,semiconductor technology and superconductiong electronics. In this article,we present a reviewof the principle and performance of typical terahertz sources,detectors and non-destructive testing applications. On this basis,the newdevelopment and trends of terahertz radiation detectors are also discussed. | ZHANG Weili LIANG Dachuan TIAN Zhen HAN Jiaguang GU Jianqiang HE Mingxia OUYANG Chunmei | 2016 | Instrumentation2016，3，1： | 8 |
| 11 | Determination of metastable zone and induction time of analgin for cooling crystallization显示文摘The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol–aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time(t_(ind)) data. Homogeneous nucleation tended to occur when the supersaturation is high, whereas heterogeneous nucleation was more likely to occur when the supersaturation is low. | Ling Zhou Zhao Wang Meijing Zhang Mingxia Guo Shijie Xu Qiuxiang Yin | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 7 |
| 12 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 13 | Longitudinal study of a community hospital integrated model for diabetes management in the Beijing Jingsong community显示文摘Objective:To determine the effects of a community hospital integrated model on the longitu-dinal management of diabetic patients.Methods:Four hundred forty-one patients with type 2 diabetes residing in Jingsong Commu-nity were randomly assigned to intensive and standard groups.Metabolic parameters were meas-ured in the two groups at baseline and after 36 months of management to compare the rate of goal achievement.Results:After comprehensive management,the overall control rate in the intensive group was increased from 2.7%to 9.6%compared with 2.3%-4.5%in the standard group.Specifically,the control rates for fasting plasma glucose,glycosylated hemoglobin,and blood pressure in the intensive group were significantly increased from 54.1%,40.0%,and 68.2%to 85.5%,74.6%,and 89.1%,respectively.The control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of treatment.Conclusion:The community hospital integrated model for longitudinal management effec-tively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes. | Jiandong Zhang Ning Zhuang Mingxia Yuan Lijuan Gao Chuan Bian Huaining Chen Qing Chi Suqing Hui Guiying Li Yanli Su Hongsong Bao Gang Wan Guangran Yang Shenyuan Yuan | 2014 | Family Medicine and Community Health2014，2，1： | 7 |
| 14 | Changes in T lymphocyte subsets after severe traumatic brain injury显示文摘BACKGROUND: Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE: To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN: A comparative observation. SETTINGS: Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS: All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score (GCS) was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16–62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group (GCS ranged 14–15 points), including 18 males and 12 females, aging 15–58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury. Informed consents were obtained from all the patients or their relatives. METHODS: ① The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at 1, 3, 7 and 14 days after injury in both groups. ② The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES: Changes of T lymphocytes subsets at 1–14 days after severe and mild or moderate traumatic injury. RESULTS: Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. ① Changes of T lymphocyte subsets: At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group (t =2.77–3.26, P < 0.01), and began to recover at 7 days, which were significantly different from those in the control group (t = 2.06–2.24, P < 0.05), and generally recovered to the normal levels at 14 days (P > 0.05). ② Conditions of pulmonary infections: At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% (22/30), 0, χ2=37.29, P < 0.01]. CONCLUSION: Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period (within 7 days), and they are easily to be accompanied by pulmonary infections. | Yulu Miao Mingxia Zhang Yulin Nie Wan Zhao Bin Huang Zhengming Jiang Shaoxiong Yu Zhibin Huang Hongjin Fu | 2007 | Neural Regeneration Research2007，2，2： | 7 |
| 15 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 16 | Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change显示文摘调整葡萄糖的蛋白质(Grp75 ) 75 是属于热吃惊蛋白质的重要分子的女伴 70 家庭并且在线粒体主要住。Grp75 能保护房间免受葡萄糖剥夺(GD ) 的伤害损害。然而,它由执行这功能的分子的机制是未知的。这里,我们报导 Grp75 能推迟细胞色素 c 的版本,还原剂 apoptosis 由 GD 导致,并且我们也发现 Grp75 能减少 Bax/Bcl-2 基因表示比率并且在这个过程期间禁止 Bax 的 conformational 变化。在结论,这些调查结果建议 Grp75 overexpression 能禁止 GD 导致的 apoptosis。Grp75 禁止了 Bax conformational 变化推迟细胞色素 c 的版本,因此提供保护给对 GD 毒性首先被用作一个神经原模型的 PC12 房间。 | Ling Yang Xiaoyu Liu Jinyu Hao Yunlong Yang Mingxia Zhao Ji Zuo Wen Liu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 6 |
| 17 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 18 | MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。 | Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 6 |
| 19 | Catalytic activity of porous manganese oxides for benzene oxidation improved via citric acid solution combustion synthesis显示文摘Various manganese oxides(MnOx) prepared via citric acid solution combustion synthesis were applied for catalytic oxidation of benzene. The results showed the ratios of citric acid/manganese nitrate in synthesizing process positively affected the physicochemical properties of MnOx, e.g., BET(Brunauer-Emmett-Teller) surface area, porous structure, reducibility and so on, which were in close relationship with their catalytic performance. Of all the catalysts, the sample prepared at a citric acid/manganese nitrate ratio of 2:1(C2M1) displayed the best catalytic activity with T(90)(the temperature when 90% of benzene was catalytically oxidized) of 212 ℃. Further investigation showed that C2M1 was Mn2O3 with abundant nano-pores, the largest surface area and the proper ratio of surface Mn^4+/Mn^3+, resulting in preferable low-temperature reducibility and abundant surface active adsorbed oxygen species. The analysis results of the in-situ Fourier transform infrared spectroscopy(in-situ FTIR) revealed that the benzene was successively oxidized to phenolate, o-benzoquinone, small molecules(such as maleates, acetates, and vinyl), and finally transformed to CO2 and H2O. | Hao Guo Zhixiang Zhang Zhi Jiang Mingxia Chen Hisahiro Einaga Wenfeng Shangguan | 2020 | Journal of Environmental Sciences2020，32，12： | 5 |
| 20 | Photocatalytic energy storage ability of TiO_2-WO_3 composite prepared by wet-chemical technique显示文摘TiO2-WO3 hybrid photocatalysts were prepared using wet-chemical technique, and their energy storage performance was characterized by electrochemical galvanostatic method. TiO2 powder was coupled with WO3 powder, which was used as electron pool and the reductive energy could be stored in. As a result, the prepared TiO2-WO3 had good energy storage ability while pure TiO2 showed no capacity and pure WO3 showed quite low performance. The energy storage ability was affected by the crystal structure of WO3 and calcination temperature. The photocatalyst had better capacity when WO3 had low degree of crystallinity, since its loose structure made it easier for electrons and cations to pass through. The photocatalytic energy storage performance was also affected by the molar ratio of TiO2 to WO3. Energy storage capacity was significantly dependent on the composition, reaching the maximum value at TiO2/WO3 1:1 (mol/mol). | Linglin Cao, Jian Yuan, Mingxia Chen, Wenfeng Shangguan Research Center for Combustion and Environment Technology, Shanghai Jiao Tong University, Shanghai 200240, China. | 2010 | Journal of Environmental Sciences2010，22，3： | 5 |
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