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| 1 | Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats.Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome.Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment.Simultaneously,P2X 4 receptor immunoreactivity significantly increased in the colon and spinal cord.Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity,and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord.These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord. | Xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang | 2013 | Neural Regeneration Research2013，8，22： | 9 |
| 2 | RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor显示文摘The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory,metabolic and neurodegenerative diseases,but medications targeting the NLRP3 inflammasome are not available for clinical use.RRx-001 is a well-tolerated anticancer agent currently being investigated in phase III clinical trials,but its effects on inflammatory diseases are not known.Here,we show that RRx-001 is a highly selective and potent NLRP3 inhibitor that has strong beneficial effects on NLRP3-driven inflammatory diseases.RRx-001 inhibits the activation of the canonical,noncanonical,and alternative NLRP3 inflammasomes but not the AIM2,NLRC4 or Pyrin inflammasomes.Mechanistically,RRx-001 covalently binds to cysteine 409 of NLRP3 via its bromoacetyl group and therefore blocks the NLRP3-NEK7 interaction,which is critical for the assembly and activation of the NLRP3 inflammasome.More importantly,RRx-001 treatment attenuates the symptoms of lipopolysaccharide(LPS)-induced systemic inflammation,dextran sulfate sodium(DSS)-induced colitis and experimental autoimmune encephalomyelitis(EAE)in mice.Thus,our study identifies RRx-001 as a new potential therapeutic agent for NLRP3-driven diseases. | Yun Chen Hongbin He Bolong Lin Yun Chen Xianming Deng Wei Jiang Rongbin Zhou | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | Coronary heart disease: incidence, risk factors and interventions in Jiaozhou of Shandong province显示文摘 | Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin | 2014 | Chinese Medical Journal2014，，12： | 5 |
| 4 | Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance显示文摘The development of multiple drug resistance(MDR) to chemotherapy and subsequent treatment failures are major obstacles in cancer therapy. An attractive option for combating MDR is inhibiting the expression of P-glycoprotein(P-gp) in tumor cells. Here, we report a novel chemosensitizing agent, XMD8-92,which can down-regulate P-gp. To enhance the specificity of MDR chemotherapy, a promising nanotheranostic micelle system based on poly(ethylene glycol)-blocked-poly(L-leucine)(PEG-b-Leu) was developed to simultaneously carry the anticancer drug doxorubicin, chemosensitizing agent XMD8-92, and superparamagnetic iron oxide nanoparticles(SPIOs). Featured with MDR environmentally responsive dual-targeting capability, controllable drug delivery, and efficient magnetic resonance(MR) imaging characteristics, the prepared nanotheranostics(DXS@NPs) showed outstanding in vitro cytotoxicity on MDR cells(SCG 7901/VCR) with only 53% of cells surviving compared to 90% of DOX-treated cells.Furthermore, efficient tumor inhibition and highly reduced systemic toxicity were exhibited by MDR tumor-bearing mice treated with DXS@NPs. Overall, the environmentally responsive dual-targeting nanotheranostics represent a promising approach for overcoming cancer MDR. | Caixia Yang Xin Pang Weihai Chen Xiaoyong Wang Gan Lin Chengchao Chu Xianzheng Zhang Xianming Deng Xiaoyuan Chen Gang Liu | 2019 | Science Bulletin2019，64，10： | 3 |
| 5 | Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis显示文摘 | Taoling Zeng Qun Wang Jieying Fu Qi Lin Jing Bi Weichao Ding Yikai Qiao Sheng Zhang Wenxiu Zhao Huayue Lin Meilin Wang Binfeng Lu Xianming Deng Dawang Zhou Zhenyu Yin Hong-Rui Wang | 2014 | Cell Reports2014，，3： | 1 |
| 6 | Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc显示文摘 | Priscila Y. Sato Wanda Coombs Xianming Lin Oxana Nekrasova Kathleen J. Green Lori L. Isom Steven M. Taffet Mario Delmar | 2011 | Circulation Research2011，，2： | 1 |
| 7 | Problems of durability and reinforcement measures for underground structures in China显示文摘In this paper,the bolt-and cable-supported structures mainly refer to anchored cables,anchored bolts,soil nails and other commonly used reinforcing and supporting structures in geotechnical engineering,as well as reinforced soil structures in permanent works.They are often used in combination,or formed into composite bolt-and cable-supported structures,with other traditional construction methods and relevant measures.Distinct characteristics of such structures are that they are most often invisible,exposed to more severe underground corrosive environments and with strict durability requirements.A number of serious durability problems of underground structures are discussed and major achievements and advances in China and abroad in terms of durability and reinforcement measures for underground structures are reviewed,followed by comprehensive analyses.Some suggestions for those problems are put forward. | Xianming Zeng Zhenyu Wang Junqi Fan Lin Zhao Dalu Lin Jian Zhao | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，3： | 1 |
| 8 | Prognostic Role of Heart-type Fatty Acid Binding Protein in Pulmonary Embolism: a Meta-analysis显示文摘 | Mingjie Liu Xia Yuan Xianming Qiu Xiaoxi Shan Dianjie Lin Ling Zhu | 2014 | Thrombosis Research2014，，： | 1 |
| 9 | Design of FPGA Based on Liner Array CCD Driver Circuit 显示文摘 | Tiexi Xu Xianming Xiong Mingjin Lin | 2009 | ICEMI2009，，2： | 1 |
| 10 | Functional formation of heterotypic gap junction channels by connexins-40 and -43显示文摘 | Xianming Lin Qin Xu Richard D Veenstra | 2014 | Channels2014，，5： | 1 |
| 11 | Kinetics and Products Distribution Study on the Catalytic Effect of Zn/HZSM-5 over Pyrolysis of Chlorella through TG-FTIR and Py-GC/MS显示文摘In this study,both the pyrolysis and catalytic pyrolysis behaviour of chlorella were investigated using thermogravimetric analysis combined with Fourier Transform Infrared spectrum(TG-FTIR)and Py-GC/MS.The results of TG indicated the pyrolysis of chlorella was divided into three stages,and the Coats-Redfern kinetic model was used for the analysis and validation of the obtained thermal data.The regression coefficients indicated that the pyrolysis of chlorella was close to second-order reaction.The activation energy of pyrolysis of chlorella and catalytic pyrolysis of chlorella+HZSM-5,chlorella+Zn/HZSM-5 was 61.645,59.080 and 56.808 kJ·mol^(−1),respectively.Combined with the data of FTIR,we found that the addition of the HZSM-5 effectively reduced the activation energy required by pyrolysis;the addition of the Zn/HZSM-5 could not only reduce the activation energy,but also reduce the yield of oxygen-containing compounds,increase the emissions of CO_(2),and facilitate the production of high value-added hydrocarbon products.These results were also verified by Py-GC/MS that the addition of Zn/HZSM-5 could reduce the formation of ketones and aldehydes and increase the production of nitrogen-containing compounds.Thus,through the catalytic pyrolysis of chlorella,the utilization range of chlorella can be expanded,and better bio-oil can be obtained,which will play a crucial role in the selection of available energy in the future. | WANG Lu YE Tao MA Xianming LIN Yan CHEN Juan WANG Fangbin MA Peiyong LIU Jian | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 12 | Teaching Research and Reform of Higher Vocational Medical Education in Guizhou Province of China显示文摘With the development of Guizhou’s economy and society, higher vocational medical education in Guizhou has developed rapidly, making it its mission to cultivate practical and skilled talents oriented to the grassroots and serving for frontline. However, due to the social environment, policy environment and insufficient funding, many difficulties and problems are faced. It is necessary to have a unified management throughout the province, rationally lay out higher vocational colleges and specialties, and promote the healthy and rapid development of medical higher vocational education in Guizhou with advanced concepts, proper policies, and sufficient funds in place, making higher vocational medical education in Guizhou enter a benign development period. | Wan Ding Jicheng Lin Jianhui Yang Xianming Cao Fang Cao Shaomei Lu | 2019 | Journal of Advances in Medicine Science2019，2，2： | 0 |
| 13 | A preliminary study on designing ecological corridors in Xishuangbanna National Nature Reserve with 3S techniques显示文摘This paper is based on the fieldwork in Xishuang-banna Natioanl Nature Reserve in Yunnan Province of China.GPS data of Asian elephants were collected and analyzed with the remote sensing satellite photos of the region to estimate the landform physiognomy of different colors.We also analyzed a series of ecological factors includ-ing altitude,landform,relief,villages and roads which affected the distribution and movement of Asian elephants.The results suggested the possibility of designing and estab-lishing corridors in Xishuangbanna National Nature Reserve to protect the population of wild elephants in the region. | Liu LIN Li ZHANG Limin FENG Xianming GUO Jianwei ZHAO Jianhong DAO | 2008 | Frontiers in Biology2008，3，1： | 0 |
| 14 | Microfluidics-based technologies for the analysis of extracellular vesicles at the single-cell level and single-vesicle level显示文摘Extracellular vesicles(EVs)are membrane vesicles secreted by cells,playing critical roles in mediating intercellular communications for various physiological and pathological processes.Most of the EV analysis is currently performed at the bulk level,obscuring the origin of the EVs and diverse characteristics of the individual extracellular vesicle.Technologies to analyze the extracellular vesicles at the single-cell and single-vesicle levels are needed to evaluate EV comprehensively and decode the heterogeneity underlying EV secretion.Microfluidic platforms that could control and manipulate fluids at the microscale provide an efficient way to achieve the aims.Various microfluidics-based technologies are emerging to realize single-cell EV secretion analysis and single EV analysis,which would be summarized in this mini-review. | Fengjiao Zhu Yahui Ji Jiu Deng Linmei Li Xue Bai Xianming Liu Bingcheng Lin Yao Lu | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 15 | Pacer通过与Stx17相互作用把PI3KC3和HOPS复合物亚基招募到自噬膜泡显示文摘文章简介自噬是基于溶酶体的胞内降解途径,对维持细胞的稳态维持有重要作用。自噬参与生物体发育、免疫反应、代谢调节、细胞凋亡和衰老等多种过程。自噬异常与神经退行性疾病、免疫紊乱等发生密切相关。 | Xiawei Cheng Xiuling Ma Xianming Ding Lin Li Xiao Jiang Zhirong Shen She Chen Wei Liu 龚渭华 孙启明 | 2018 | 科学新闻2018，0，4： | 0 |
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