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| 1 | RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor显示文摘The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory,metabolic and neurodegenerative diseases,but medications targeting the NLRP3 inflammasome are not available for clinical use.RRx-001 is a well-tolerated anticancer agent currently being investigated in phase III clinical trials,but its effects on inflammatory diseases are not known.Here,we show that RRx-001 is a highly selective and potent NLRP3 inhibitor that has strong beneficial effects on NLRP3-driven inflammatory diseases.RRx-001 inhibits the activation of the canonical,noncanonical,and alternative NLRP3 inflammasomes but not the AIM2,NLRC4 or Pyrin inflammasomes.Mechanistically,RRx-001 covalently binds to cysteine 409 of NLRP3 via its bromoacetyl group and therefore blocks the NLRP3-NEK7 interaction,which is critical for the assembly and activation of the NLRP3 inflammasome.More importantly,RRx-001 treatment attenuates the symptoms of lipopolysaccharide(LPS)-induced systemic inflammation,dextran sulfate sodium(DSS)-induced colitis and experimental autoimmune encephalomyelitis(EAE)in mice.Thus,our study identifies RRx-001 as a new potential therapeutic agent for NLRP3-driven diseases. | Yun Chen Hongbin He Bolong Lin Yun Chen Xianming Deng Wei Jiang Rongbin Zhou | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 2 | Annealing behavior of a modified 5083 aluminum alloy显示文摘 | Shuangping Lin Zuoren Nie Hui Huang Bolong Li | 2009 | Materials and Design2009，，3： | 2 |
| 3 | Annealing behavior of a modified 5083 aluminum alloy显示文摘 | Shuangping Lin Zuoren Nie Hui Huang Bolong Li | 2009 | Materials and Design2009，，3： | 1 |
| 4 | Optimized PEF treatment for antioxidant polypeptides with MW 10–30<ce:hsp sp='0.25'/>kDa and preliminary analysis of structure change显示文摘 | Ke Wang Jia Wang Ping Zhao Songyi Lin Bolong Liu Jingbo Liu Gregory Jones Hsiang-Chi Huang | 2012 | International Journal of Biological Macromolecules2012，，5： | 1 |
| 5 | Growth and Physiological Response of Organs of Phragmites australis to Different Water Compensation in Degraded Wetlands显示文摘To study the effect of different water compensation on growth and physiology of reed in degraded wetlands,three water treatments in the field were conducted to test the height and photosynthesis of reed,the ions and soluble sugar contents of different organs.In the controls(without extra water compensation for 10 years),the height of reed was only 50 cm,the net photosynthetic rate,stomatal conductance,the intercellular CO2 concentration and transpiration rate were very low.The contents of Na + and Clin rhizome were higher than those in other organs.Discontinuous water compensation(continuous for 8 years,then stopped for 2 years)increased the height(2.1-fold),the net photosynthetic rate(41.8%),stomatal conductance(1.8-fold),transpiration rate(1.3-fold)of reed(Phragmites australis),and decreased the content of Na + (62.3%)and Cl- (71.1%)of rhizome significantly.Continuous water compensation(continuous for 10 years)increased the height(3.2-fold),the net photosynthetic rate(104%),stomatal conductance(2.4-fold),transpiration rate(1.5-fold)of reed,and decreased Na + (82.5%)and Cl - (64.7%)contents in rhizome, then accumulated the K+ ,H2PO4-,SO42- and soluble sugar contents significantly in rhizome.Interrupting water compensation led to the decrease of height(25.3%),the net photosynthetic rate(30.7%),stomatal conductance(17.3%) and increase of Na + (1.16-fold)in rhizome when comparing to the continuous water compensation.These results showed that recovering the degraded reed wetlands needed continuous water compensation yearly to promote reed growth.The organs of reed had corresponding physiological response characteristic to the different water compensation condition.Under long-time dry and waterlogging condition,the rhizomes both helped reed to adapt located environment,by enriching the ions such as Na+ ,Cl- ,and K+ ,H2PO4-,SO42- ,respectively. | LI Xiaoyu LIU Xingtu LI Xiujun LIN Jixiang WEN Bolong | 2012 | 湿地科学2012，10，1： | 1 |
| 6 | Chiral self-assembly of terminal alkyne and selenium clusters organic–inorganic hybrid显示文摘The on-surface self-assembly of inorganic atomic clusters and organic molecules offers significant opportunities to design novel hybrid materials with tailored functionalities.By adopting the advantages from both inorganic and organic components,the hybrid self-assembly molecules have shown great potential in future optoelectrical devices.Herein,we report the co-deposition of 4,8-diethynylbenzo[1,2-d-4,5-d0]bisoxazole(DEBBA)and Se atoms to produce a motif-adjustable organic–inorganic hybrid self-assembly system via the non-covalent interactions.By controlling the coverage of Se atoms,various chiral molecular networks containing Se,Se_(6),Se_(8),and terminal alkynes evolved on the Ag(111)surface.In particular,with the highest coverage of Se atoms,phase segregation into alternating one-dimensional chains of non-covalently bonded Se_(8) clusters and organic ligands has been noticed.The atom-coverage dependent evolution of self-assembly structures reflects the remarkable structural adaptability of Se clusters as building blocks based on the spontaneous resize to reach the maximum non-covalent interactions.This work has significantly extended the possibilities of flexible control in self-assembly nanostructures to enable more potential functions for broad applications. | Zhi Chen Tao Lin Haohan Li Mingzi Sun Chenliang Su Bolong Huang Kian Ping Loh | 2022 | Nano Research2022，15，3： | 0 |
| 7 | Atomscopic of ripple origins for two-dimensional monolayer transition metal dichalcogenides显示文摘During the development of ultrathin two-dimensional(2D)materials,the appearance of ripples has been widely observed.However,the formation mechanisms and their influences are still rarely investigated,especially their contributions to the electronic structures and optical properties.To compensate for the knowledge gap,we have carried out comprehensive theoretical studies on the monolayer WSe_(2) with a series of ripple structures from 0 to 12Åin different lattice sizes.The sensitivity of the formation energy,band structures,electronic structures,and optical properties to the ripple structures have been performed systematically for the first time.The formation of ripples in Armchair and zigzag simultaneously are more energetically favorable,leading to more flexible optimizations of the optoelectronic properties.The improved charge-locking effect and extension of absorption ranges indicate the significant role of ripple structures.The spontaneous formation of ripples is associated with orbital rearrangements and structural distortions.This leads to the unique charge carrier correlate inversion between W-5d and Se-4p orbitals,resulting in the pinning of the Fermi level.This work has supplied significant references to understand ultrathin 2D structures and benefit their future developments and applications in high-performance optoelectronic devices. | Haitao Yu Mingzi Sun Xiao Wu Cheuk Hei Chan Bolong Huang Zhong Lin Wang | 2024 | Nano Research2024，17，3： | 0 |
| 8 | Engineering the synergistic effect of carbon dots-stabilized atomic and subnanometric ruthenium as highly efficient electrocatalysts for robust hydrogen evolution显示文摘Currently,the most efficient electrocatalyst for the hydrogen evolution reaction(HER)in water dissociation is Pt-based catalyst.Unfortunately,the high cost and less than perfect efficiency hinder wide-range industrial/technological applications.Here,by controlling the treatment temperature of tris(2,2-bipyridine)ruthenium dichloride hexahydrate,synthesis of compounds with novel ruthenium single/dual atoms(Ru S/DAs)mixed with Ru nanoclusters(Ru S/DAs+Ru NCs)and supported by carbon dots is demonstrated.These compounds are shown to be highly efficient and competitive catalysts for hydrogen evolution.Ru S/DAs+Ru NCs exhibit very high activity,with overpotentials of 15 and 40mV at a current density of 10mA/cm2 in 1.0mol/L KOH and 0.5mol/L H2SO4,respectively.Furthermore,the composites are found to possess outstanding stability and rapid HER kinetics.X ray absorption fine structure analysis,supported by density functional theory calculations,shows charge rearrangement in single-atomic Ru,and the Ru dual sites promote active hydrogen adsorption and recombination.Ru S/DAs and Ru NCs demonstrate high electroactivity due to the electroactive Ru 4d orbitals.The introduction of Ru NCs activates the carbon support,providing a high electronic conductivity to transfer electrons from Ru NCs to Ru S/DAs,and facilitates water dissociation for the HER process. | Yuan Liu Ning Chen Weidong Li Mingzi Sun Tong Wu Bolong Huang Xue Yong Qinghua Zhang Lin Gu Haoqiang Song Robert Bauer John S.Tse Shuang-Quan Zang Bai Yang Siyu Lu | 2022 | SmartMat2022，3，2： | 0 |
| 9 | Carboxylated carbon nanotubes with high electrocatalytic activity for oxygen evolution in acidic conditions显示文摘Since most electrocatalysts for oxygen evolution reaction(OER),except for precious metal oxides RuO_(2) and IrO_(2),are unstable in harsh acidic solutions,it is highly desirable to develop high-performance OER electrocatalysts for acidic media,though it is still a big challenge.Herein,we report a simple strategy to produce carboxyl-enriched multiwalled carbon nanotubes(COOH-MWNTs)that exhibit stable and high electrocatalytic activities for OER in acidic solutions,showing an overpotential at a current density of 10 mA cm^(–2) and a Tafel slope as low as of 265 mV and 82 mV dec^(–1),respectively.As far as we are aware,these results represent the best OER performance for metal-free electrocatalysts,even comparable to those of RuO_(2) and IrO_(2).We have further revealed the catalytic mechanism,which involves one electron lose from the COOH-MWNTs catalyst at the beginning of the OER process to trigger H_(2)O molecule oxidation by forming peralcohol,followed by the recapture of one electron from water molecule to oxidize water and to recover the initial state for the COOH-MWNTs catalyst.The unravel of this new OER mechanism is important as it provides new insights into the crucial role of organic functional groups in electrocatalytic processes.Also,the mechanistic understanding can be used to guide the design and development of novel metalfree catalysts for acidic OER electrocatalysis and beyond. | Xin Zhang Wenqing Zhang Jianying Dai Mingzi Sun Jun Zhao Lifei Ji Lin Chen Fanlong Zeng Fengchun Yang Bolong Huang Liming Dai | 2022 | InfoMat2022，4，1： | 0 |
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