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| 1 | 吸烟和高脂血症是冠状动脉痉挛的重要危险因子显示文摘目的 探讨临床上具有心绞痛样胸痛发作但无显著冠状动脉狭窄患者胸痛的病因 ,并甄别与冠状动脉痉挛相关的临床危险因子。方法 对 2 75例临床上具有心绞痛发作但冠状动脉造影无显著冠状动脉狭窄患者进行乙酰胆碱试验 ,以冠状动脉狭窄程度达到 90 %以上伴胸痛发作和 /或心电图缺血性改变为冠状动脉痉挛的诊断标准。Logistic回归强迫引入法分析冠状动脉痉挛与性别、年龄、高血压、糖尿病、吸烟、血脂代谢紊乱和心电图活动平板试验结果的关系 ,并根据乙酰胆碱试验结果分组比较左室射血分数和舒张末期压力。结果 2 71例资料完整的患者中乙酰胆碱试验的阳性率为 38% ,Logistic回归分析表明 ,吸烟和高脂血症分别使冠状动脉痉挛的优势比 (OR)值增加 4 2倍和 2 3倍 ,糖尿病与冠状动脉痉挛呈显著负相关 ,冠状动脉痉挛对左室功能无明显影响。结论 冠状动脉痉挛是冠状动脉造影正常的心绞痛患者的重要病因之一 ,吸烟和高脂血症是冠状动脉痉挛的重要危险因子。 | 向定成 Franz Xaver Kleber | 2002 | 中华心血管病杂志2002，30，4： | 101 |
| 2 | Smoking and hyperlipidemia are important risk factors for coronary artery spasm显示文摘To investigate the role of coronary artery spasm in the etiology of chest pain lacking significant coronary stenosis and to identify the clinical risk factors related to coronary artery spasm Methods Two hundred and seventy five patients with chest pain, but without significant coronary artery stenosis underwent the intracoronary acetylcholine test Coronary artery spasm was diagnosed while coronary artery stenosis increased to 90% and was accompanied by the usual chest pain with or without ischemic changes on electrocardiogram Logistic regression was employed to investigate the relationships between coronary artery spasm and sex, age, hypertension, diabetes mellitus, smoking, hyperlipidemia and results of electrocardiographic treadmill stress te st Left ventricular ejection fraction and end diastolic pressure were compared between spasm group and non-spasm group Results Coronary artery spasm was detected in 103 out of 271 patients, a rate of 38% Logistic regression analysis showed that smoking and hyperlipidemia increased the relative risk of coronary artery spasm 4 2 times and 2 3 times, respectively There was a significantly negative relationship between diabetes mellitus and coronary artery spasm Furthermore, there was no coronary artery spasm detected in left ventricular ejection fraction and end diastolic pressure Conclusions Coronary artery spasm was one of the important etiological factors for patients with chest pain but no coronary artery stenosis Smoking and hyperlipidemia were the main clinical risk factors for coronary artery | 向定成 Franz Xaver Kleber | 2003 | Chinese Medical Journal2003，，4： | 12 |
| 3 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 4 | 病态窦房结综合征患者非典型性胸痛的临床意义显示文摘目的探讨病态窦房结综合征患者非典型性胸痛的病因及临床意义。方法 对34例临床诊断为病态窦房结综合征且需安装心脏永久起搏器、同时伴有非典型性胸痛的患者,在行心脏永久起搏器植入术的同时或术前和术后行冠状动脉造影术,分析冠状动脉病变及左心室功能,其中21例在冠状动脉造影时行乙酰胆碱试验。结果31例患者冠状动脉均正常或狭窄程度<50%,3例患者冠状动脉狡窄程度>75%,但在心动过缓患者可见冠状动脉血流速度明显缓慢。部分患者左心室明显扩大、左心室射血分数足室壁运动降低,9例乙酰胆碱试验阳性。无严重冠状动脉病变者多在起搏器植入术后或合并钙拮抗剂治疗后胸痛消失。结论 病态窦房结综合征患者的非典型性胸痛多数不具有严重冠状动脉病变基础,可能与心动过缓所导致的冠状动脉血流缓慢或冠状动脉痉挛有关,在安装起搏器和服用钙拮抗剂后胸痛多缓解。 | 向定成 Franz Xaver Kleber 马骏 邱建 何建新 龚志华 辛达临 | 2004 | 中华老年心脑血管病杂志2004，6，4： | 4 |
| 5 | 重量轻且成本低的陶瓷合金制动盘显示文摘在转向架其它零部件的重量有所减轻的同时,采用传统制动盘设计的零部件重量的比例却有了上升。一种先进的含有陶瓷成份的铝合金则提供了减轻制动盘重量和改善其性能仿机会。 | Xaver Wirth 于慧娟 | 1996 | 国外机车车辆工艺1996，，2： | 2 |
| 6 | ISOBAR制动闸片提高了盘形制动器的性能显示文摘德国铁路公司的ICE3高速列车与早期ICE列车的四个制动盘相比,它在每根轴上只装两个制动盘,使用一种改善了接触模式的先进制动闸片,可以降低噪声并使能量吸收能力提高了50%。 | XAVER WIRTH 林素贞 | 1998 | 国外机车车辆工艺1998，，3： | 2 |
| 7 | Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks显示文摘Plastid-to-nucleus 发信号为响应 environmentaland 的细胞的新陈代谢的协作和调整是必要的植物房间的发展暗示。许多运作后退表明小径被描述了被反应的氧种类,光合作用氧化还原作用不平衡, tetrapyrrole 中介,和 othermetabolic 特点要触发的那 arethought。这里,我们基于 transcriptome 和蛋白质相互作用数据报导元分析。比较 outputof 这些小径揭示在 operationalretrograde 发信号上侵犯的六不同来源刺激的公共和怪癖。我们的学习提供新奇卓见进这些小径的相互影响,支持当还未知的存在 ofan 基因的核心反应模块在测试的所有条件下面正在被调整。我们的分析进一步的 highlightsaffiliated 规章的 cis 元素并且分类 abscisic 酸并且作为涉及反应 cascadesfollowing 的第二等的部件的基于植物生长素的发信号一个 plastidial 信号。我们的学习提供结构的全球分析和不同小径 involvedin plastid-to-nucleus 在这建筑群上发信号和一个新看法的接口细胞的通讯 network.Key 词: | Christine GlaiBer Georg Haberer Iris Finkemeier Thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-Josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer | 2014 | Molecular Plant2014，7，7： | 2 |
| 8 | Screening and characterization of new monoclonal anti-benzopyrene antibodies using automated flow-through microarray technology显示文摘 | Xaver Y.Z. Karsunke Michael Pschenitza Martin Rieger Ekkehard Weber Reinhard Niessner Dietmar Knopp | 2011 | Journal of Immunological Methods2011，，1： | 1 |
| 9 | Clinical impact of programmed cell death ligand 1 expression in colorectal cancer显示文摘 | Raoul A. Droeser Christian Hirt Carsten T. Viehl Daniel M. Frey Christian Nebiker Xaver Huber Inti Zlobec Serenella Eppenberger-Castori Alexander Tzankov Raffaele Rosso Markus Zuber Manuele Giuseppe Muraro Francesca Amicarella Eleonora Cremonesi Michael H | 2013 | European Journal of Cancer2013，，9： | 1 |
| 10 | HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia显示文摘 | Thomas Hackenbeck Karl Xaver Knaup Ruth E. Schietke Johannes Sch?del Carsten Willam Xiaoqing Wu Christina Warnecke Kai-Uwe Eckardt Michael Wiesener | 2009 | Cell Cycle2009，，9： | 1 |
| 11 | High frequen-cy of fumigants and other toxic gases in imported freight contain-ers-an underestimated occupational and community health risk显示文摘 | Xaver Baur’Bemd Poschadel Lygia Therese Budnik | 2010 | Occup Environ Med2010，67，3： | 1 |
| 12 | Occupational risksand challenges of seafaring 显示文摘 | Marcus Oldenburg Xaver Baur Clara Schlaich | 2010 | J Occup Health2010，52，3： | 1 |
| 13 | Pre -oxi- dation of an extremely polluted industrial wastewater by the Fen - ton's reagent显示文摘 | Nora San S M Josep F F Xaver F S | 2003 | J Hazard Mater2003，101，3： | 1 |
| 14 | Chloride dependence of growth in bacteria 显示文摘 | Markus R Xaver S Volker M 2003 | 2003 | FEMS Microbiology Letters2003，225，： | 1 |
| 15 | Transcatheter Closure of Interatrial Communications for Secondary Prevention of Paradoxical Embolism: Single-Center Experience显示文摘 | Leonhard Bruch Anne Parsi Marc Oliver Grad Sascha Rux Telse Burmeister Heike Krebs Franz Xaver Kleber | 2002 | Circulation: Journal of the American Heart Association2002，，24： | 1 |
| 16 | Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe显示文摘 | Rolf Teschke Xaver Glass Johannes Schulze Axel Eickhoff | 2012 | European Journal of Gastroenterology & Hepatology2012，，3： | 1 |
| 17 | Herbal hepatotoxicity by Greater Celandine ( Chelidonium majus ): Causality assessment of 22 spontaneous reports显示文摘 | Rolf Teschke Xaver Glass Johannes Schulze | 2011 | Regulatory Toxicology and Pharmacology2011，，3： | 1 |
| 18 | Glucagon-like pep- tided mobilizes intracellular Ca^2+ and stimmulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cell 显示文摘 | Tsuboi T da Sila Xaver G Holz GG | 2003 | Biochem J2003，369，2： | 1 |
| 19 | Identification of wheat gliadins as an allergen family related to baker’s asthma显示文摘 | Cordula Bittner Britta Grassau Karsten Frenzel Xaver Baur | 2008 | The Journal of Allergy and Clinical Immunology2008，，3： | 1 |
| 20 | Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae显示文摘 | Klug H Xaver M Chaugule VK | 2013 | Molecular Cell2013，50，5： | 1 |
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