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| 1 | Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells显示文摘越来越多的研究建议了 type-2 糖尿病导致的 methylglyoxal (MGO ) 与 Parkinson 的疾病(PD ) 有关。然而,很少对分子的机制被知道。在这研究,我们在 neuroblastoma SH-SY5Y 房间探索了 MGO 毒性。MGO 的 Neurotoxicity 被 mitochondrial 膜潜力, malondialdehyde,和 methylthiazoletetrazolium 试金测量。多巴胺, 3,4-dihydroxyphenylacetic 酸(DOPAC ) ,和 1-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (salsolinol ) 的层次被液体 chromatographymass spectrometry/mass spectrometry 检测。酷氨酸 hydroxylase (TH ) 和多巴胺 transporter (DAT ) 的表情被反向的 transcriptase 聚合酶链反应和西方的污点分析检测。当多巴胺, DOPAC,和内长的神经毒素 salsolinol 的层次也增加了时,结果证明 MGO 在 SH-SY5Y neuroblastoma 房间在 TH 和 DAT 表情导致了增加。Aminoguanidine (AG ) 是 MGO 的一个禁止者。AG 能减少,这被发现反应的氧种类(ROS ) 水平由 MGO 导致了,但是不能禁止 TH, DAT 和多巴胺的增加。多巴胺, DOPAC 和 salsolinol 层次的增加能导致高 ROS 和 mitochondrial 损坏。当 MGO 在糖尿病的功课期间被增加时,这研究建议多巴胺引起的 ROS 能贡献 dopaminergic 神经原的损坏。 | Bingjie Xie Fankai Lin Lei Peng Kaleem Ullah Hanyan Wu Hong Qing Yulin Deng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 2 | Digital surface model applied to unmanned aerial vehicle based photogrammetry to assess potential biotic or abiotic effects on grapevine canopies显示文摘Accurate data acquisition and analysis to obtain crop canopy information are critical steps to understand plant growth dynamics and to assess the potential impacts of biotic or abiotic stresses on plant development.A versatile and easy to use monitoring system will allow researchers and growers to improve the follow-up management strategies within farms once potential problems have been detected.This study reviewed existing remote sensing platforms and relevant information applied to crops and specifically grapevines to equip a simple Unmanned Aerial Vehicle(UAV)using a visible high definition RGB camera.The objective of the proposed Unmanned Aerial System(UAS)was to implement a Digital Surface Model(DSM)in order to obtain accurate information about the affected or missing grapevines that can be attributed to potential biotic or abiotic stress effects.The analysis process started with a three-dimensional(3D)reconstruction from the RGB images collected from grapevines using the UAS and the Structure from Motion(SfM)technique to obtain the DSM applied on a per-plant basis.Then,the DSM was expressed as greyscale images according to the halftone technique to finally extract the information of affected and missing grapevines using computer vision algorithms based on canopy cover measurement and classification.To validate the automated method proposed,each grapevine row was visually inspected within the study area.The inspection was then compared to the digital assessment using the proposed UAS in order to validate calculations of affected and missing grapevines for the whole studied vineyard.Results showed that the percentage of affected and missing grapevines was 9.5%and 7.3%,respectively from the area studied.Therefore,for this specific study,the abiotic stress that affected the experimental vineyard(frost)impacted a total of 16.8%of plants.This study provided a new method for automatically surveying affected or missing grapevines in the field and an evaluation tool for plant growth conditions,which can be implemented for other uses such as canopy management,irrigation scheduling and other precision agricultural applications. | Su Baofeng Xue Jinru Xie Chunyu Fang Yulin Song Yuyang Sigfredo Fuentes | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 3 |
| 3 | Glial U87 cells protect neuronal SH-SY5Y cells from indirect effect of radiation by reducing oxidative stress and apoptosis显示文摘最近的研究在 neurodegeneration 表明了放射的间接效果的角色。然而,在对放射的间接效果的 neuroprotection 的 glial 房间的角色仍然不是清楚的,尽管他们被知道在中央神经系统在压力条件下面保护神经原。我们的学习证明放射的那间接效果增加了进一步提高关键 apoptotic 蛋白质的表示并且导致 neuronal 房间死亡的氧化压力。我们也在一个 transwell 合作文化系统面对 glial 房间在 neuronal 房间上调查了放射的间接效果,当我们的分析集中于 neuronal 房间时。当间接放射和 neuroprotective 效果的来源被各种各样的端点分析,照耀的调节房间的中等 ICCM 被使用。导致 ICCM 的反应氧化种类水平显著地在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被减少,这被观察,它可能帮助维持 mitochondrial 膜潜力的正直。抗氧化剂酶 superoxide dismutase 和抗氧化剂谷胱甘肽的增加的层次在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被观察。而且,有 glial 房间的合作文化禁止导致 ICCM 的 apoptotic 蛋白质的表示,这也被观察,即在 SH-SY5Y 房间的 Bax,细胞色素 c,和 caspase-3。因此,在合作文化系统 glial,房间可以由减少导致 ICCM 的氧化压力和 apoptotic 死亡保护 neuronal SH-SY5Y 房间,这能被推测。 | Yasmeen Saeed Bingjie Xie JinXu Abdur Rehman Ma Hong Qing Hong Yulin Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 2 |
| 4 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 5 | Geochemical Characteristics and Sedimentary Control of Pinghu Formation(Eocene)Coal-bearing Source Rocks in Xihu Depression,East China Sea Basin显示文摘Coal-bearing source rocks of the Pinghu Formation in the Xihu Depression comprise an important material basis of oil and gas resources in the East China Sea Basin.Based on drilling core observation results combined with the analysis and test results of macerals,trace/rare earth elements,and rock pyrolysis,the geochemical characteristics and sedimentary control of coal-bearing source rocks formation are discussed in a high-frequency sequence framework.The results indicate that the macerals composition of the coal-bearing source rocks of the Eocene Pinghu Formation in the Xihu Depression is dominated by vitrinite,with low-medium abundance of exinite and almost no inertinite.The coals and carbonaceous mudstones display higher amounts of total organic carbon(TOC)(14.90%-65.10%),S1+S2(39.24-136.52 mg/g),and IH(191-310 HC/g TOC)respectively,as compared to the mudstones.Organic matter is plotted in typeⅢkerogens and partially in typeⅡ;it is mainly in the low maturity stage.The trace elements results imply that the samples were deposited in a weakly reducing to weakly oxidizing environment and were occasionally affected by seawater.The coal-bearing source rocks were deposited in a relatively oxygen-containing environment.The coal-bearing source rocks development is jointly controlled by the coal accumulation environment,the water conditions affected by ocean currents in offshore basins in China,oxidation-reduction cycles of aqueous media and paleoclimate evolution in a high-frequency sequence framework. | SHEN Yulin QIN Yong CUI Min XIE Guoliang GUO Yinghai QU Zhenghui YANG Tianyang YANG Liu | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 2 |
| 6 | Semi-crosslinked polyacrylamides as high-resolution and dynamic self-coating sieving matrices for protein capillary electrophoresis显示文摘This paper describes non-gel capillary sieving electrophoresis employing semi-crosslinked polyacrylamide as a high performance and low viscous replaceable separation matrix for separation of non-denatured protein separation. Arising from the fine sieving and dynamic coating ability of this polymer, a mixture of basic proteins lysozyme, cytochrome C, ribonuclease A, and trypsin was resolved with excellent reproducibility. Mixing different semi-crosslinked polyacrylamides together further improves the separation. The separtion mechanism was analyzed. With network structure developed to an intermediate state between crosslinked gel and linear polymer solutions, these semi-crosslinked polyacrylamide polymers demonstrate a promise as a new class of size sieving separation medium, not only in capillary electrophoresis, but also in microfluidic chip separation schemes. | ZHOU Jin XU JianDong XIE Yao QU Feng DENG YuLin GENG LiNa | 2008 | Chinese Science Bulletin2008，53，19： | 2 |
| 7 | Detection and recognition of traffic signs based on HSV vision model and shape features显示文摘 | Yixin Chen Yi Xie Yulin Wang | 2013 | Journal of Computers2013，8，5： | 1 |
| 8 | Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Shan Dan Wei Wang Jinghui Ren Yali Li Hua Hu Zhengfeng Xu Tze Kin Lau Jianhong Xie Weihua Zhao Hefeng Huang Jiansheng Xie Luming Sun Xiaohong Zhang Weipeng Wang Shixiu Liao Rong Qiang Jiangxia Cao Qiufang Zhang Yulin Zhou Haiyan Zhu Mei Zhong Yi Guo Linhu | 2012 | Prenat Diagn2012，，13： | 1 |
| 9 | Studies on novel composites of polyoxymethylene/polyamide 6显示文摘 | Yulin Li Tingxiu Xie Guisheng Yang | 2006 | J Appl Polym Sci2006，99，： | 1 |
| 10 | Applied research of shaped charge technology显示文摘 | Yu Chuan Tong Yanjin Yan Chengli Li Fabo Gui Yulin Zhang Ming Wang Bingren Xie Panhai Li Liangzong | 1999 | International Journal of Impact Engineering1999，，： | 1 |
| 11 | 显示文摘 | Li Yulin Xie Tingxiu Yang Guisheng | 2005 | Journal of Applied Polymer Science2005，95，6： | 1 |
| 12 | Analytical solution for one-dimensional consolidation of clayey soils with a threshold gradient显示文摘 | XIE Kanghe WANG Kun WANG Yulin | 2010 | Computers and Geotechnics2010，37，4： | 1 |
| 13 | Effects of Maleated Styrene (Ethylene-co-Butene)-Styrene on the Morphology, Thermal and Mechanical Properties of Polystyrene/Polyamide 1212 Blends显示文摘 | Yulin Li Tingxiu Xie Guisheng Yang | 2005 | J Appl Polym Sci2005，95，： | 1 |
| 14 | New Discovery of the 341 Ma Gabbro at Xiongcun District in the Southern Margin of Lhasa Terrane, Tibet显示文摘Objective Lhasa terrane has recorded the geologic history concerning the formation and evolution of Paleo-Tethys and the intra-continental convergence in Qinghai–Tibet Plateau(Yin and Harrison,2000).Previous investigations have focused on the initial timing of the India-Asia collision and the Cretaceous–Cenozoic magmatism and sedimentation(Wang Tianyang et al.,2017),however, | LANG Xinghai LIU Dong DENG Yulin TANG Juxing XIE Fuwei YANG Zongyao CUI Zhiwei WANG Xuhui LI Zhijun ZHANG Zhong ZHANG Jinshu HUANG Yong | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 15 | Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Shan Dan Wei Wang Jinghui Ren Yali Li Hua Hu Zhengfeng Xu Tze Kin Lau Jianhong Xie Weihua Zhao Hefeng Huang Jiansheng Xie Luming Sun Xiaohong Zhang Weipeng Wang Shixiu Liao Rong Qiang Jiangxia Cao Qiufang Zhang Yulin Zhou Haiyan Zhu Mei Zhong Yi Guo Linhu | 2012 | Prenat Diagn2012，，13： | 1 |
| 16 | Studies on novel composites of polyoxymethylene/polyamide 6显示文摘 | LI Yulin XIE Tingxiu YANG Guisheng | | 0，，01： | 1 |
| 17 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 18 | Highly doped NaErF_(4)-based nanocrystals for multi-tasking application显示文摘How to engineer single nanocrystal to achieve multiple functions is still a huge challenge.In this work,a novel highly doped rare earth nanocrystal NaErF_(4)@NaGdF_(4)@NaDyF_(4)(Er@Gd@Dy)was designed and fabricated,which exhibits various performances by itself,including the longitudinal(T1)and transverse relaxation time(T2)double-mode magnetic resonance imaging(MRI),upconversion luminescence and down-shifting luminescence.Upon irradiation of 808 nm near-infrared(NIR)light,the upconverted red light can indirectly activate the photo sensitizer Ce6 conjugated on the surface of nanocrystals for photodynamic therapy(PDT).In vivo experiments demonstrate that the nano materials can eradicate notably primary tumors without obvious systematic toxicity.In addition,the longitudinal and transverse relaxation rates of Er@Gd@Dy are 24.83 and 319.86(mmol/L)^(-1)/s,respectively,which are superior to those of the nanocrystals reported previously.Simultaneously,the nanocrystals have the ability to generate NIR-Ⅱlight located at 1530 nm,favorable in bioimaging in deeper tissues.As a consequence,this new nanoplatform will advance the improvement of multimodal imaging guided tumor diagnosis and treatment. | Yulin Xie Qing Chen Man Wang Weilin Chen Zewei Quan Chunxia Li | 2021 | Journal of Rare Earths2021，39，12： | 1 |
| 19 | Effects of Maleated Styrene-( Ethylene-co-Butene )-Styrene on the Morphology and Mechanical and Thermal Properties of Polystyrene/ Polyamide 1212 Blends显示文摘 | Yulin Li Tingxiu Xie Guisheng Yang | 2005 | Journal of Applied Polymer Science2005，95，： | 1 |
| 20 | Detection and recogni- tion of traffic signs based on HSV vision model and shape features显示文摘 | Chen Yixin Xie Yi Wang Yulin | 2013 | Journal of Computers2013，8，5： | 1 |
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