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| 1 | Therapeutic effect of natural melanin from edible fungus Auricularia auricula on alcohol-induced liver damage in vitro and in vivo显示文摘This study explored the therapeutic effects of Auricularia auricula melanin(AAM)on alcoholic liver damage in vitro and in vivo.Human normal liver L02 cells were pre-treated with ethanol and then treated with AAM to explore the therapeutic effect of AAM on ethanol-induced hepatocyte injury.The results show that AAM signifi cantly elevated the cell viability,ameliorated the cell morphology,reduced the ROS and increased the GSH/GSSG of ethanol-pretreated L02 cells.Then,mice were administered with ethanol to induce acute alcoholic liver damage,and administered with AAM to further study the therapeutic effect of AAM on alcoholic liver damage in mice.As a result,AAM reduced the levels of ALT,AST,TG,and MDA,increased the levels of ADH,SOD,and CAT in liver damage mice.The therapeutic effect of AAM may be related to inhibition of CYP2E1 expression and activation of Nrf2 and its downstream antioxidase.The research enriched the bioactivity of AAM and provided some ideas for the development of melanin-related health foods. | Ruolin Hou Xin Liu Xiaoping Wu Mingfeng Zheng Junsheng Fu | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 2 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 3 | An Overview and Experimental Study of Learning-Based Optimization Algorithms for the Vehicle Routing Problem显示文摘The vehicle routing problem(VRP)is a typical discrete combinatorial optimization problem,and many models and algorithms have been proposed to solve the VRP and its variants.Although existing approaches have contributed significantly to the development of this field,these approaches either are limited in problem size or need manual intervention in choosing parameters.To solve these difficulties,many studies have considered learning-based optimization(LBO)algorithms to solve the VRP.This paper reviews recent advances in this field and divides relevant approaches into end-to-end approaches and step-by-step approaches.We performed a statistical analysis of the reviewed articles from various aspects and designed three experiments to evaluate the performance of four representative LBO algorithms.Finally,we conclude the applicable types of problems for different LBO algorithms and suggest directions in which researchers can improve LBO algorithms. | Bingjie Li Guohua Wu Yongming He Mingfeng Fan Witold Pedrycz | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，7： | 2 |
| 4 | Development of adaptive soft sensor based on statistical identification of key variables显示文摘 | Ma Ming-Da Ko Jing-Wei Wang San-Jang Wu MingFeng Jang Shi Shang Shieh Shyan-Shu Wong David Shan-Hill | | 0，，09： | 1 |
| 5 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations显示文摘 | Hu Zhibin Jin Guangfu Liang Jie Zhang Mingfeng Shen Hongbing Wu Chen Yu Dianke Huang Liming Tan Wen Lin Dongxin Guo Huan Wu Tangchun Qian Ji Lu Daru | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 1 |
| 6 | Performance evaluation of a push mechanism for wlan and mobile network integration显示文摘 | Chang Mingfeng Wu Linyi Lin Yibing | 2006 | IEEE Transactions on Vehicular Technology2006，55，1： | 1 |
| 7 | Intercalation of 7- PGA in Mg/A1 layered double hydroxides: An in situ WAXD and FTIR investigation显示文摘 | Chiang MingFeng Wu Tzong-Ming | 2011 | Appl Clay Sci2011，51，3： | 1 |
| 8 | Improved block truncation coding based on the void-and-cluster dithering approach显示文摘 | Guo Jingming Wu Mingfeng | 2009 | IEEE Trans- actions on Image Processing2009，18，1： | 1 |
| 9 | A high-density intervarietal map of the wheat genome enriched with markers derived from expressed sequence tags显示文摘 | Shulin Xue Zhengzhi Zhang Feng Lin Zhongxin Kong Yong Cao Chunjun Li Hongying Yi Mingfeng Mei Huilan Zhu Jizhong Wu Haibin Xu Dongmei Zhao Dagang Tian Caiqin Zhang Zhengqiang Ma | 2008 | Theoretical and Applied Genetics2008，，2： | 1 |
| 10 | The third family of compact stars with the color-flavor locked quark core显示文摘In this paper,we study the third family of compact stars with the color-flavor locked(CFL)quark core.The relativistic mean field model is used for hadronic matter and the MIT bag model for CFL quark matter.The results of the calculation show a transitional behavior that goes from the hadron star range,through the transition range,into the CFL quark star range.In the transition range,the third family of compact stars with the CFL quark matter core is found in the wide range of the CFL energy gap 100MeV≤<150 MeV.By comparing with early investigations,we argue that the greatest possible third family of compact stars may be the hybrid stars with the CFL quark core. | WANG HongYan LIU GuangZhou WU YaoRui XU Yan ZHU MingFeng BAO Tmurbagan | 2013 | Chinese Science Bulletin2013，58，31： | 1 |
| 11 | Intercalation of r-PGA in Mg-A1 layered double hydroxides : an in situ WAXD and FTIR inves- tigation显示文摘 | CHIANG Mingfeng WU Tzongming | 2011 | Applied Clay Science2011，51，： | 1 |
| 12 | Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection显示文摘The worldwide epidemic of coronavirus disease 2019(COVID-19)is ongoing.Rapid and accurate detection of the causative virus SARSCoV-2 is vital for the treatment and control of COVID-19.In this study,the comparative sensitivity of different respiratory specimen types were retrospectively analyzed using 3,552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC(Center for Disease Control and Prevention).Except for bronchoalveolar lavage fluid(BALF),the sputum possessed the highest positive rate(73.4%–87.5%),followed by nasal swabs(53.1%–85.3%)for both severe and mild cases during the first 14 days after illness onset(d.a.o.).Viral RNA could be detected in all BALF samples collected from the severe group within 14 d.a.o.and lasted up to 46 d.a.o.Moreover,although viral RNA was negative in the upper respiratory samples,it was also positive in BALF samples in most cases from the severe group during treatment.Notably,no viral RNA was detected in BALF samples from the mild group.Despite typical ground-glass opacity observed via computed tomographic scans,no viral RNA was detected in the first three or all upper respiratory tract specimens from some COVID-19 patients.In conclusion,sputum is most sensitive for routine laboratory diagnosis of COVID-19,followed by nasal swabs.Detection of viral RNA in BALF improves diagnostic accuracy in severe COVID-19 patients. | Yang Yang Minghui Yang Jing Yuan Fuxiang Wang Zhaoqin Wang Jinxiu Li Mingxia Zhang Jinli Wei Ling Peng Gary Wong Haixia Zheng Weibo Wu Chenguang Shen Mingfeng Liao Kai Feng Jianming Li Qianting Yang Juanjuan Zhao Lei Liu Yingxia Liu | 2020 | The Innovation2020，1，3： | 1 |
| 13 | A high-density intervarietal map of the wheat genome enriched with markers derived from expressed sequence tags显示文摘 | Shulin Xue Zhengzhi Zhang Feng Lin Zhongxin Kong Yong Cao Chunjun Li Hongying Yi Mingfeng Mei Huilan Zhu Jizhong Wu Haibin Xu Dongmei Zhao Dagang Tian Caiqin Zhang Zhengqiang Ma | 2008 | Theoretical and Applied Genetics2008，，2： | 1 |
| 14 | Micromachined Infrared Thermopile Detector Based on a Suspended Film Structure显示文摘The micro-electromechanical system(MEMS)infrared thermopile is the core working device of modern information detection systems such as spectrometers,gas sensors,and remote temperature sensors.We presented two different structures of MEMS infrared thermopiles based on suspended film structures.They both deposited silicon nitride over the entire surface as a passivated absorber layer in place of a separate absorber zone,and the thermocouple strip was oriented in the same direction as the temperature gradient.The same MEMS preparation process was used and finally two different structures of the thermopile were characterized separately for testing to verify the impact of our design on the detector.The test results show that the circular and double-ended symmetrical thermopile detectors have responsivities of 27.932 V/W and 23.205 V/W,specific detectivities of 12.1×10^(7) cm·Hz^(1/2)·W^(-1) and 10.1×10^(7) cm·Hz^(1/2)·W^(-1),and response time of 26.2 ms and 27.06 ms,respectively.In addition,rectangular double-ended symmetric thermopile has a larger field of view than a circular thermopile detector,but is not as mechanically stable as a circular thermopile. | Cheng LEI Yihao GUAN Ting LIANG Xuezhan WU Yuehang BAI Mingfeng GONG Pingang JIA Jijun XIONG | 2023 | Photonic Sensors2023，13，3： | 0 |
| 15 | Differences in olfactory functional connectivity in early-onset depression and late-onset depression显示文摘Background:Late-onset depression(LOD)and early-onset depression(EOD)exhibit different pathological mechanisms and clinical phenotypes,including different extents of olfactory dysfunction.However,the brain abnormalities underlying the differences in ol-factory dysfunction between EOD and LOD remain unclear.Objective:The aim of this study was to compare the functional connectivity(FC)patterns of olfactory regions between EOD patients and LOD patients and examine their relationship with cognitive function.Methods:One hundred and five patients with EOD,101 patients with LOD and 160 normal controls(NCs)were recruited for the present study.Participants underwent clinical assessment,olfactory testing,cognitive assessments,and magnetic resonance imaging.Eight regions of the primary and secondary olfactory regions were selected to investigate olfactory FC.Results:Patients with LOD exhibited decreased odor identification(OI)compared with patients with EOD and NCs.The LOD group exhibited decreased FC compared with the EOD and NC groups when primary and secondary olfactory regions were selected as the regions of interest(the piriform cortex,lateral entorhinal cortex,and orbital-frontal cortex).Additionally,these abnormal olfactory FCs were associated with decreased cognitive function scores and OI,and the FC between the left orbital-frontal cortex and left amygdala was a partial mediator of the relationship between global cognitive scores and OI.Conclusion:Overall,patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD,and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment.The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI. | Ben Chen Mingfeng Yang Meiling Liu Qiang Wang Huarong Zhou Min Zhang Le Hou Zhangying Wu Si Zhang Gaohong Lin Xiaomei Zhong Yuping Ning | 2023 | Psychoradiology2023，3，1： | 0 |
| 16 | An adaptive sliding mode control technology for weld seam tracking显示文摘一个新奇适应滑动模式控制算法被导出处理追踪焊接机器的操纵者的控制问题的缝接,在大规模结构部件焊接的过程期间。建议算法不要求精确动态模型,并且是更实际的。它的坚韧性被 Lyapunov 稳定性理论验证。分析结果证明建议算法启用更好的高精确的追踪性能与比在各种各样的骚乱下面的传统的滑动模式控制算法没有闲聊。 | Jie LIU Youmin HU Bo WU Kaibo ZHOU Mingfeng GE | 2015 | Frontiers of Mechanical Engineering2015，10，1： | 0 |
| 17 | Near-threshold-voltage operation in flash-based high-precision computing-in-memory to implement Poisson image editing显示文摘We propose a NOR flash-based computing-in-memory(CIM)to implement high-precision(32-bit)Poisson image editing,including the gradient operations and Laplace operation.To meet the requirements of image processing,CIM operation schemes and reliabilities are carefully studied and optimized,showing that the power consumption at the near-threshold-voltage(NTV)region can be as low as 40 fJ/bit,which is two orders lower than working at the saturation region.High-temperature retention,as well as various disturbs,are also analyzed.The proposed CIM scheme can be applied as an energy-efficient approach to construct the high-precision image processing accelerator. | Yang FENG Bing CHEN Mingfeng TANG Yueran QI Maoying BAI Chengcheng WANG Hai WANG Xuepeng ZHAN Junyu ZHANG Jing LIU Jixuan WU Jiezhi CHEN | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 18 | Epidemiological characteristics and clinical manifestations of pediatric patients with COVID-19 in China: A multicenter retrospective study显示文摘Importance:The Coronavirus disease 2019(COVID-19)global pandemic poses a considerable challenge for pediatricians.Objective:This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China.Methods:This multicenter retrospective study included pediatric patients from 46 hospitals in China,covering 12 provinces and two municipalities.Epidemiological,demographic,clinical,laboratory,treatment,and outcome data were analyzed.Results:In total,211 pediatric patients with COVID-19 were included in this study.The median age was 7.0 years(range:22 days to 18 years).Approximately 16.3%of the patients exhibited asymptomatic infections,23.0%had upper respiratory tract infections,and 60.7%had pneumonia,including two with severe pneumonia and one with critical illness.Approximately 78.7%of the pediatric patients occurred in familial clusters.The most three common symptoms or signs at onset in children with COVID-19 were fever(54.5%),cough(49.3%),and pharyngeal congestion(20.8%).Only 17.6%of the patients presented with decreased lymphocyte count,whereas 13.6%had increased lymphocyte count.Among the patients with pneumonia who exhibited abnormal chest computed tomography findings,18.2%(23/127)of the patients had no other symptoms.Generally,the chest radiographs showed abnormalities that affected both lungs(49.6%);ground-glass opacity(47.2%)was the most common manifestation.The cure and improvement rates were 86.7%(183/211)and 13.3%(28/211),respectively.Only one patient with an underlying condition received invasive mechanical ventilation;none of the patients died.Interpretation:Similar to adults,children of all age groups are susceptible to COVID-19.Fortunately,most pediatric patients have mild symptoms or remain asymptomatic,despite the high incidence of pneumonia.Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults. | Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Jun Liu Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen | 2021 | Pediatric Investigation2021，5，3： | 0 |
| 19 | Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system显示文摘Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis. | Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 20 | The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-βsignaling显示文摘Liver fibrosis is a key transformation stage and also a reversible pathological process in various types of chronic liver diseases.However,the pathogenesis of liver fibrosis still remains elusive.Here,we report that the calcium binding protein A11(S100A11)is consistently upregulated in the integrated data from GSE liver fibrosis and tree shrew liver proteomics.S100A11 is also experimentally activated in liver fibrosis in mouse,rat,tree shrew,and human with liver fibrosis.While overexpression of S100A11 in vivo and in vitro exacerbates liver fibrosis,the inhibition of S100A11 improves liver fibrosis.Mechanistically,S100A11 activates hepatic stellate cells(HSCs)and the fibrogenesis process via the regulation of the deacetylation of Smad3 in the TGF-βsignaling pathway.S100A11 physically interacts with SIRT6,a deacetylase of Smad2/3,which may competitively inhibit the interaction between SIRT6 and Smad2/3.The subsequent release and activation of Smad2/3 promote the activation of HSCs and fibrogenesis.Additionally,a significant elevation of S100A11 in serum is observed in clinical patients.Our study uncovers S100A11 as a novel profibrogenic factor in liver fibrosis,which may represent both a potential biomarker and a promising therapy target for treating liver fibrosis and fibrosis-related liver diseases. | Tingting Zhu Linqiang Zhang Chengbin Li Xiaoqiong Tan Jing Liu Huiqin Li Qijing Fan Zhiguo Zhang Mingfeng Zhan Lin Fu Jinbo Luo Jiawei Geng Yingjie Wu Xiaoju Zou Bin Liang | 2022 | Journal of Genetics and Genomics2022，49，4： | 0 |
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