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| 1 | Therapeutic effect of natural melanin from edible fungus Auricularia auricula on alcohol-induced liver damage in vitro and in vivo显示文摘This study explored the therapeutic effects of Auricularia auricula melanin(AAM)on alcoholic liver damage in vitro and in vivo.Human normal liver L02 cells were pre-treated with ethanol and then treated with AAM to explore the therapeutic effect of AAM on ethanol-induced hepatocyte injury.The results show that AAM signifi cantly elevated the cell viability,ameliorated the cell morphology,reduced the ROS and increased the GSH/GSSG of ethanol-pretreated L02 cells.Then,mice were administered with ethanol to induce acute alcoholic liver damage,and administered with AAM to further study the therapeutic effect of AAM on alcoholic liver damage in mice.As a result,AAM reduced the levels of ALT,AST,TG,and MDA,increased the levels of ADH,SOD,and CAT in liver damage mice.The therapeutic effect of AAM may be related to inhibition of CYP2E1 expression and activation of Nrf2 and its downstream antioxidase.The research enriched the bioactivity of AAM and provided some ideas for the development of melanin-related health foods. | Ruolin Hou Xin Liu Xiaoping Wu Mingfeng Zheng Junsheng Fu | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 2 | Template-free synthesis and characterization of K-phillipsite for use in potassium extraction from seawater显示文摘K-phillipsite was prepared using a hydrothermal method.Soluble glass and sodium aluminate were used as raw materials in the absence of an organic template,investigations regarding the K^+ ions were conducted at room temperature to determine the ion-exchange capacity in the seawater sample and the selectivity coefficient of the mixed K^+-Na^+solution.The sample was characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),and energy dispersion spectroscopy(EDS).The K^+ ionexchange capacity is 51 mg/g in seawater and the selectivity coefficient is 75.1 in the mixed K^+-Na^+solution.The sample has a selectivity preference for K^+,and therefore can be used to selectively extract potassium from seawater.The sample composed of Si,Al,K,Na,and O exhibits a cross-like shape and is a typical K-phillipsite structure. | Jin Hou Junsheng Yuan Jia Xu Yunpeng Fu Chunxia Meng | 2013 | Particuology2013，11，6： | 3 |
| 3 | Mating System of Tricholoma giganteum显示文摘Microscopical examination demonstrated that Tricholoma giganteum basidia bear 4 basidiospores. Mating tests revealed that T. giganteum has a tetra-polar, heterothallic mating system. New types of factor B (Br) occurred as a result of recombination within the B-type mating factor. | FU Junsheng CAI Yanshan KE Lina LIN Shaoxia DENG Youjin XIE Baogui | 2007 | 食用菌学报2007，14，3： | 3 |
| 4 | The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics显示文摘Trametes lactinea mycelia polysaccharides(TLMPS)have a wide range of bioactivities.The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of TLMPS and its protective effects on a mouse model of alcoholic liver injury.TLMPS protected the liver against alcohol-induced injury,as evidenced by the reduced alcohol-induced elevation of the liver index,serum biochemical indices,and maintenance of hepatic morphology.Potential mechanisms were analyzed using transcriptome and metabolome analyses.The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis,drug metabolism,and metabolism of xenobiotics by cytochrome P450.The metabolome analysis revealed that TLMPS significantly regulated specific metabolites in the liver,including organic acids,lipids,nucleosides,and organic oxygen compounds.KEGG enrichment analysis revealed the signifi cant involvement of different metabolites in choline metabolism,ATP-binding cassette transporters,and glycerophospholipid metabolism.Assessment of the changes in gene expression and metabolites revealed the significantly different expression of several genes encoding key enzymes and metabolites in choline metabolism pathway.The collective fi ndings confi rmed that choline metabolism plays an important role in the protective effects of TLMPS against acute alcoholic liver injury. | Jinbin Hao Liyun Ye Guoliang Meng Yanjiao Song Junsheng Fu Xiaoping Wu | 2021 | Food Science and Human Wellness2021，10，4： | 2 |
| 5 | Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway显示文摘 | Shih-Hui Li Junsheng Fu Dara Nall Watkins Rakesh K. Srivastava Sharmila Shankar | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 6 | Experimental investigation on the invert stability of operating railway tunnels with different drainage systems using 3D printing technology显示文摘In recent years, the invert anomalies of operating railway tunnels in water-rich areas occur frequently,which greatly affect the transportation capacity of the railway lines. Tunnel drainage system is a crucial factor to ensure the invert stability by regulating the external water pressure(EWP). By means of a threedimensional(3D) printing model, this paper experimentally investigates the deformation behavior of the invert for the tunnels with the traditional drainage system(TDS) widely used in China and its optimized drainage system(ODS) with bottom drainage function. Six test groups with a total of 110 test conditions were designed to consider the design factors and environmental factors in engineering practice,including layout of the drainage system, blockage of the drainage system and groundwater level fluctuation. It was found that there are significant differences in the water discharge, EWP and invert stability for the tunnels with the two drainage systems. Even with a dense arrangement of the external blind tubes, TDS was still difficult to eliminate the excessive EWP below the invert, which is the main cause for the invert instability. Blockage of drainage system further increased the invert uplift and aggravated the track irregularity, especially when the blockage degree is more than 50%. However, ODS can prevent these invert anomalies by reasonably controlling the EWP at tunnel bottom. Even when the groundwater level reached 60 m and the blind tubes were fully blocked, the invert stability can still be maintained and the railway track experienced a settlement of only 1.8 mm. Meanwhile, the on-site monitoring under several rainstorms further showed that the average EWP of the invert was controlled within 84 k Pa, while the maximum settlement of the track slab was only 0.92 mm, which also was in good agreement with the results of model test. | Linyi Li Junsheng Yang Jinyang Fu Shuying Wang Cong Zhang Maolong Xiang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 1 |
| 7 | Potential Ecological Risk Assessment of Heavy Metal Pollution in Sediments of the Yangtze River Within the Wanzhou Section, China显示文摘 | Chuan Fu Jinsong Guo Jie Pan Junsheng Qi Weisheng Zhou | 2009 | 2009 (1-3)2009，，1： | 1 |
| 8 | Determination of the Concentration of Chlorella vulgaris Beij by Visible Spectrophotometer显示文摘[Objective]This study aimed to provide technical parameters for large-scale production and industrial development of Chlorella vulgaris Beij.[Method]By using 721 visible spectrophotometer,the transmitted light intensity of different concentrations of C.vulgaris liquid under different wavelengths was measured to normalize the absorbance data,thus determining the optimal wavelength for the growth of C.vulgaris and the concentration of C.vulgaris liquid under the optimal wavelength.The regression equation of absorbance at the optimal wavelength and C.vulgaris concentration was obtained to derive the formula between equivalent concentration C and transmitted light intensity I,thus calculating the equivalent concentration of 0.25-fold C.vulgaris liquid under different transmittance.[Result]The transmitted light intensity of C.vulgaris reached the peak at 670 nm,indicating that 670 nm is the optimal wavelength for measuring C.vulgaris concentration.The regression equation between absorbance and C.vulgaris concentration was y=-1.479 7+0.987x,with a correlation coefficient of 0.991,suggesting a high correlation between these two factors.The formula of equivalent concentration C and transmitted light intensity I was C=-ln(I/I0)/LK,where L indicates the optical path length(cuvette width)and K indicates the average cross-sectional area of C.vulgaris cells.[Conclusion]It is feasible to investigate indirectly the concentration of C.vulgaris with a spectrophotometer,which can be used to determine the optimal dehydration time of C.vulgaris. | Zhixu ZHAO Jingyang PAN Liangbo WU Wei ZHANG Junsheng XU Yugui CHEN Zhide FU | 2015 | Agricultural Biotechnology2015，4，2： | 0 |
| 9 | Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway显示文摘Hepatocellular carcinoma(HCC)is one of the common most malignant tumors.This study aimed to determine the in vitro and in vivo anticancer activity of cordycepin and elucidate its mechanism of action.The results of in vitro and in vivo studies revealed that cordycepin inhibited proliferation and migration in HepG-2 cells and inhibited the growth of HepG-2 xenograft-bearing nude mice by inducing apoptosis.Transcriptome sequencing analysis revealed a total of 403 differential genes,which revealed that cordycepin may play an anti-HCC role by regulating Hippo signaling pathway.The regulatory effects of cordycepin on the Hippo signaling pathway was further investigated using a YAP1 inhibitor.The results demonstrated that cordycepin upregulated the expression of MST1 and LAST1,and subsequently inhibited YAP1,which activated the Hippo signaling pathway.This in turn downregulated the expression of GBP3 and ETV5,and subsequently inhibited cell proliferation and migration.Additionally,YAP1 regulated the expression of Bax and Bcl-2,regulated the mitochondrial apoptotic pathway,and induced apoptosis by upregulating the expression of the caspase-3 protein.In summary,this study reveals that cordycepin exerts its anti-hepatocarcinoma effect through regulating Hippo signaling pathway,and GBP3 and ETV5 may be potential therapeutic targets for hepatocarcinoma. | Xiaomin Li Qing Liu Songyu Xie Xiaoping Wu Junsheng Fu | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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