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| 1 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 2 | An Overview and Experimental Study of Learning-Based Optimization Algorithms for the Vehicle Routing Problem显示文摘The vehicle routing problem(VRP)is a typical discrete combinatorial optimization problem,and many models and algorithms have been proposed to solve the VRP and its variants.Although existing approaches have contributed significantly to the development of this field,these approaches either are limited in problem size or need manual intervention in choosing parameters.To solve these difficulties,many studies have considered learning-based optimization(LBO)algorithms to solve the VRP.This paper reviews recent advances in this field and divides relevant approaches into end-to-end approaches and step-by-step approaches.We performed a statistical analysis of the reviewed articles from various aspects and designed three experiments to evaluate the performance of four representative LBO algorithms.Finally,we conclude the applicable types of problems for different LBO algorithms and suggest directions in which researchers can improve LBO algorithms. | Bingjie Li Guohua Wu Yongming He Mingfeng Fan Witold Pedrycz | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，7： | 2 |
| 3 | Polyester-tethered near-infrared fluorophores confined in colloidal nanoparticles:Tunable and thermoresponsive aggregation and biomedical applications显示文摘Intricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light-harvesting complexes of the photosynthetic systems in nature.However,it remains a challenge to achieve such structural complexity and functionality in synthetic polymer-chromophore systems.Here,we report a series of polyester-tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water,which show tunable J-or H-aggregation excitonic coupling and near-infrared fluorescence by precise control of the polymer chain lengths,composition,and temperature.Moreover,the optimal fluorescence or photothermal effect of the Jaggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy. | Cangjie Yang Wei Zhang Xin Pang Fan Xiao Sandeep Kumar Kalva Yipeng Zhang Manojit Pramanik Leilei Tian Gang Liu Mingfeng Wang | 2023 | Aggregate2023，4，2： | 0 |
| 4 | Epidemiological characteristics and clinical manifestations of pediatric patients with COVID-19 in China: A multicenter retrospective study显示文摘Importance:The Coronavirus disease 2019(COVID-19)global pandemic poses a considerable challenge for pediatricians.Objective:This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China.Methods:This multicenter retrospective study included pediatric patients from 46 hospitals in China,covering 12 provinces and two municipalities.Epidemiological,demographic,clinical,laboratory,treatment,and outcome data were analyzed.Results:In total,211 pediatric patients with COVID-19 were included in this study.The median age was 7.0 years(range:22 days to 18 years).Approximately 16.3%of the patients exhibited asymptomatic infections,23.0%had upper respiratory tract infections,and 60.7%had pneumonia,including two with severe pneumonia and one with critical illness.Approximately 78.7%of the pediatric patients occurred in familial clusters.The most three common symptoms or signs at onset in children with COVID-19 were fever(54.5%),cough(49.3%),and pharyngeal congestion(20.8%).Only 17.6%of the patients presented with decreased lymphocyte count,whereas 13.6%had increased lymphocyte count.Among the patients with pneumonia who exhibited abnormal chest computed tomography findings,18.2%(23/127)of the patients had no other symptoms.Generally,the chest radiographs showed abnormalities that affected both lungs(49.6%);ground-glass opacity(47.2%)was the most common manifestation.The cure and improvement rates were 86.7%(183/211)and 13.3%(28/211),respectively.Only one patient with an underlying condition received invasive mechanical ventilation;none of the patients died.Interpretation:Similar to adults,children of all age groups are susceptible to COVID-19.Fortunately,most pediatric patients have mild symptoms or remain asymptomatic,despite the high incidence of pneumonia.Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults. | Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Jun Liu Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen | 2021 | Pediatric Investigation2021，5，3： | 0 |
| 5 | The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-βsignaling显示文摘Liver fibrosis is a key transformation stage and also a reversible pathological process in various types of chronic liver diseases.However,the pathogenesis of liver fibrosis still remains elusive.Here,we report that the calcium binding protein A11(S100A11)is consistently upregulated in the integrated data from GSE liver fibrosis and tree shrew liver proteomics.S100A11 is also experimentally activated in liver fibrosis in mouse,rat,tree shrew,and human with liver fibrosis.While overexpression of S100A11 in vivo and in vitro exacerbates liver fibrosis,the inhibition of S100A11 improves liver fibrosis.Mechanistically,S100A11 activates hepatic stellate cells(HSCs)and the fibrogenesis process via the regulation of the deacetylation of Smad3 in the TGF-βsignaling pathway.S100A11 physically interacts with SIRT6,a deacetylase of Smad2/3,which may competitively inhibit the interaction between SIRT6 and Smad2/3.The subsequent release and activation of Smad2/3 promote the activation of HSCs and fibrogenesis.Additionally,a significant elevation of S100A11 in serum is observed in clinical patients.Our study uncovers S100A11 as a novel profibrogenic factor in liver fibrosis,which may represent both a potential biomarker and a promising therapy target for treating liver fibrosis and fibrosis-related liver diseases. | Tingting Zhu Linqiang Zhang Chengbin Li Xiaoqiong Tan Jing Liu Huiqin Li Qijing Fan Zhiguo Zhang Mingfeng Zhan Lin Fu Jinbo Luo Jiawei Geng Yingjie Wu Xiaoju Zou Bin Liang | 2022 | Journal of Genetics and Genomics2022，49，4： | 0 |
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