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| 1 | Clinical analysis and follow-up study of chronic active Epstein-Barr virus infection in 53 pediatric cases显示文摘背景长期的活跃 Epstein-Barr 病毒感染(CAEBV ) 以前被报导了有时与一堂好攻击的临床的功课被联系。在大陆中国小儿科的病人的 CAEBV 的特征大部分是 unreported。这调查的主要目的是在孩子认出 CAEBV 的临床的特征并且探索它的诊断标准和风险 factors.Methods A 回顾的学习与 CAEBV 在 53 个小儿科的病人(36 个男孩和 17 个女孩) 上被执行进入北京孩子在 2003 和 2007 之间的医院。所有他们的医药记录被考察并且分析。为每个病人,人口统计,临床,实验室数据和结果被收集。独立样品的 t 测试被用于在 CAEBV 的发作的年龄从 2 个月到 14.6 年的统计 analysis.Results (平均数(5. | LU Gen XIE Zheng-de ZHAO Shun-ying YE Ling-jun WU Run-hui LIU Chun-yan YANG Shuang JIN Ying-kang SHEN Kun-ling | 2009 | Chinese Medical Journal2009，，3： | 36 |
| 2 | A study on relationship of nitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis显示文摘AIM To study relationship of injury induced bynitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis.METHODS The values of plasma nitric oxide(P-NO),plasma vitamin C(P-VC),plasma vitamin E(P-VE),plasma β-carotene(P-β-CAR),plasmalipoperoxides(P-LPO),erythrocyte superoxidedismutase(E-SOD),erythrocyte catalase(E-CAT),erythrocyte glutathione peroxidase(E-GSH-Px)activities and erythrocyte lipoperoxides(E-LPO)level in 77 patients with chronic cholecystitisand 80 healthy control subjects were determined,differences of the above average values betweenthe patient group and the control group anddifferences of the average values betweenpreoperative and postoperative patients wereanalyzed and compared,linear regression andcorrelation of the disease course with the abovedetermination values as well as the stepwiseregression and correlation of the course with thevalues were analyzed.RESULTS Compared with the control group,theaverage values of P-NO,P-LPO,E-LPO weresignificantly increased(P<0.01),and of P-VC, P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdecreased(P<0.01)in the patient group.Theanalysis of the linear regression and correlationshowed that with prolonging of the course,thevalues of P-NO,P-LPO and E-LPO in the patientswere gradually ascended and the values of P-VC,P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdescended(P<0.01).The analysis of thestepwise regression and correlation indicated thatthe correlation of the course with P-NO,P-VE andP-β-CAR values was the closest.Compared withthe preoperative patients,the average values of P-NO,P-LPO and E-LPO were significantlydecreased(P<0.01)and the average values of P-VC,E-SOD,E-CAT and E-GSH-Px in postoperativepatients increased(P<0.01)in postoperativepatients.But there was no significant difference inthe average values of P-VE,P-β-CAR preoperativeand postoperative patients.CONCLUSION Chronic cholecystitis could inducethe increase of nitric oxide,oxidation,peroxidation and lipoperoxidation. | Jun Fu Zhou Dong Cai You Gen Zhu Jin Lu Yang Cheng Hong Peng Yang Hai Yu | 2000 | World Journal of Gastroenterology2000，6，4： | 36 |
| 3 | Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China显示文摘背景 Epstein-Barr 联系病毒的 hemophagocytic lymphohistiocytosis (EBV-HLH ) 的临床的特征大部分是在在中国的大陆的小儿科的病人的 unreported。这研究的主要目的是在孩子认出 EBV-HLH 的临床的特征并且探索它的预后和风险 factors.Methods A 回顾的学习与 EBV-HLH 在 78 个小儿科的病人上被执行进入北京孩子在 2003 和 2008 之间的医院。所有病人的医药记录被考察并且分析。为每个病人,人口统计,临床,实验室和结果信息被收集。统计分析经由 multivariate 和 univariate analysis.Results 被进行发作的年龄在 1-2 年之间达到顶点,男孩们是更多半发达的 EBV-HLH。EBV-HLH 与 EBV 原子抗原(EBNA ) 主要在血清学的模式发生了积极(70.5%) 。疾病的全面命运是 56.7% 。39 死亡(30.8%) 中的 12 个在诊断以后在 2 个月以内很快死了。 Multivariate 分析揭示了那不收到化疗( P=0.002 ), 4 星期在诊断( P=0.004 )以前的病,并且白朊铺平< 20 g/L ( P=0.045 )显著地预言增加的命运 risk.Conclusions EBV-HLH 是有与 EBNA 主要在血清学的模式发生的高命运率的严重疾病积极。化疗和及时诊断的早开始显著地改进幸存率。实际策略应该集中于减少早死亡的可能性的。 | JIN Ying-kang XIE Zheng-de YANG Shuang LU Gen SHEN Kun-ling | 2010 | Chinese Medical Journal2010，，11： | 30 |
| 4 | Effect of lipid on proliferation and activation of rat hepatic stellate cells(Ⅰ)显示文摘INTRODUCTIONDespitetheearlycontroversyovertheprimarycelularsourceofextracelularmatrixproteinsinliverfibrosis,compelinginvitro... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao, FAN Zhu Ping and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 18 |
| 5 | Mutations in the perforin gene in children with hemophagocytic lymphohistiocytosis显示文摘 | LU Gen XIE Zheng-de SHEN Kun-ling YE Ling-jun WU Run-hui LIU Chun-yan JIN Ying-kang YANG Shuang | 2009 | Chinese Medical Journal2009，，23： | 16 |
| 6 | How Work Organization Affects the Prevalence of WMSDs: A Case-control Study显示文摘Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables(P<0.1) were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance(P<0.05). The odds ratios(OR) of ‘work changing with season' and ‘sufficient rest time' did not reach 1(0.749 and 0.441, respectively). In addition, ‘sufficient rest time' seemed to be the stronger protective factor according to its higher standardized coefficient. And ‘repetitive work every minute', ‘constantly repetitive work'(every day), ‘shortage of site personnel', and ‘often switching shifts with others' seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required. | LIU Lu CHEN Song Gen TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu | 2015 | Biomedical and Environmental Sciences2015，28，9： | 11 |
| 7 | Oxidative Stress before and after Operation in Patients with Chronic Cholecystitis Containing Gallstone显示文摘To study the relationship of oxidative, antioxidative constituents and antioxidases in blood with chronic cholecystitis containing gallstone, levels of lipoperoxides (LPO), nitric oxide (NO), vitamin C(VC), vitamin E (VE) and β carotene (β CAR) in plasma as well as level of LPO, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH Px) in erythrocytes were investigated by spectrophotometric assay in 107 patients with this condition (PCg) and 100 healthy volunteers (HVs). Compared with HVs group, the average value of LPO and NO in plasma and that of LPO in erythrocytes of PCg group were significantly increased ( P <0.0001), while that of VC, VE and β CAR in plasma and the average activities of SOD, CAT and GSH Px in erythrocytes were significantly decreased ( P <0.0001). Linear regression and correlation analysis for 107 preoperative PCg showed that the value of LPO and NO in plasma and that of LPO in erythrocytes of PCg gradually increased ( P <0.0001), representing a significant linear positive correlation. The value of VC, VE and β CAR in plasma and that of SOD, CAT and GSH Px in erythrocytes of PCg gradually decreased ( P <0.0001), representing a significant linear negative correlation. Stepwise regression and correlation analysis for 107 preoperative PCg suggested that the closest correlation was observed between the course of disease and the value of NO and VC in plasma and that of SOD, GSH Px and LPO in erythrocytes, r =0.7306, F =32.1408, P <0.0001. Compared with the preoperative PCg group, the average value of LPO and NO in plasma and that of LPO in erythrocytes of the postoperative PCg group were significantly decreased ( P <0.0001). Furthermore, the average value of VC in plasma and that of SOD, CAT and GSH Px in erythrocytes of the postoperative PCg group were significantly increased ( P <0.0001), whereas no significant difference was found between their average value of VE and β CAR in plasma. These findings suggested that oxidative stress was an aggravating pathological condition in PCg group. Therefore, we recommend that in treating PCg, antioxidants such as VC, VE, β CAR should be given in order to alleviate their potential oxidative damages. | ZHOU JUN FU , CHEN PENG , YANG JIN LU +, ZHU YOU GEN + PENG CHENG HONG , AND WU YU LIAN The 2nd Affiliated Hospital, Medical College of Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejian | 2000 | Biomedical and Environmental Sciences2000，13，4： | 10 |
| 8 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 9 | Role of free fatty acids in proliferation of rat hepatic stellate cells(Ⅱ)显示文摘INTRODUCTIONAlthoughtheroleofhepatocytesinfatyacidsmetabolismandtransporthavebeendiscusedintensively,fewofthatofHSCwasreporte... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 8 |
| 10 | ABSTRACTS OF CHINESE MEDICAL LITERATURE显示文摘 | Lu Gen, Feng Jiemei,Huang Jian, et al. Guangzhou Institute of Tuberculosis, Guangzhou 510180. Chin J Tuberculosis & Respirat Dis 1995 | 1995 | Chinese Medical Journal1995，，6： | 5 |
| 11 | Performance of compact plastic scintillator strips with wavelength shifting fibers using a photomultiplier tube or silicon photomultiplier readout显示文摘This study presents the design and performance results for compact plastic scintillator strips using a wavelength shifting fiber(WLS-fiber)readout with dimensions of 0.1 m×0.02 m×2 m.This approach was evaluated as a candidate for a cosmic-ray muon detector for the Taishan Antineutrino Observatory(JUNO-TAO).The strips coupled with 3-inch photomultiplier tubes(PMTs)were measured and compared between the single-end and double-end readout options.Additionally,a strip using the double-end option coupling with a silicon photomultiplier(SiPM)was further evaluated and compared with the results obtained using PMTs.The performance of the strips was determined by a detailed survey along their length with a cosmicray muon after detailed characterization of the 3-inch PMTs and SiPMs.The proposed design employing a compact plastic scintillator strip with WLS-fiber coupling to a SiPM provides a good choice for cosmic-ray muon veto detectors,particularly when detector dimensions must be limited. | Min Li Zhi‑Min Wang Cai‑Mei Liu Pei‑Zhi Lu Guang Luo Yuen‑Keung Hor Jin‑Chang Liu Chang‑Gen Yang | 2023 | Nuclear Science and Techniques2023，34，2： | 3 |
| 12 | Power Reversal Strategies for Hybrid LCC/MMC HVDC Systems显示文摘Power reversal control strategies for different types of hybrid line-commutated-converter(LCC)/modular multi-level converter(MMC)based high-voltage direct-current(HVDC)systems have been proposed with the consideration of system configurations and MMC’s topologies.The studies show that the full-bridge(FB)MMC gives better performance than half-bridge(HB)MMCs in terms of power reversal in hybrid LCC/MMC systems.The modulation method employed in this paper can achieve a smooth online polarity reversal for hybrid LCC/FB-MMC HVDC systems.Additional DC switches and/or discharging resistors may be needed to reverse the DC polarity of LCC/HB-MMC HVDC systems.Based on the proposed strate-gies,the power reversal processes of the studied systems can be accomplished within several seconds.The speed can be changed according to system operation requirements.The effectiveness of the proposed control strategies has been verified through simulations conducted in PSCAD/EMTDC. | Gen Li Ting An Jun Liang Wei Liu Tibin Joseph Jingjing Lu Marcio Szechtman Bjarne R.Andersen Yuanliang Lan | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 13 | Clinical experience of 3T intraoperative magnetic resonance imaging integrated neurosurgical suite in Shanghai Huashan Hospital显示文摘 | QIU Tian-ming YAO Cheng-jun WU Jin-song PAN Zhi-guang ZHUANG Dong-xiao XU Gen ZHU Feng-ping LU Jun-feng GONG Xiu ZHANG Jie YANG Zhong SHI Jian-bin HUANG Feng-ping MAO Ying ZHOU Liang-fu | 2012 | Chinese Medical Journal2012，，24： | 3 |
| 14 | Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number显示文摘The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were selected.Results showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the wall.For all the roughness locations,the variation trend for the profile loss with the roughness magnitude was similar.In the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,respectively.However,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss instead.By comparison,the leading edge roughness played a dominant role in the boundary layer development and performance variation.To take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively. | Mingyang WANG Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU | 2021 | Chinese Journal of Aeronautics2021，34，3： | 2 |
| 15 | Effect of Non-Axisymmetric End Wall on a Highly Loaded Compressor Cascade in Multi-Conditions显示文摘As an effective method to influence end wall flow field,non-axisymmetric profiled end wall can improve the aerodynamic performance of compressor cascades.For a highly loaded low pressure compressor cascade,called V103,the study found the optimal non-axisymmetric profiled end wall decreases total pressure loss coefficient by 4.57%,5.48%and 3.04%under incidences of–3°,0°,and 3°,respectively,compared with those of the planar end wall.The optimal non-axisymmetric profiled end wall changes the structure of secondary flow in hub region,generating a corner vortex near suction surface,inhibiting the development of the passage vortex towards suction surface and reducing flow separation.When the inlet Mach numbers are 0.62 and 0.72,the total pressure loss coefficient decreases by 3.19%and 4.58%for optimal non-axisymmetric profiled end wall compared with those of the planar end wall.Though optimal non-axisymmetric profiled end wall increases total pressure loss near hub region in blade passage under different inlet Mach numbers,the peak value and region of high loss coefficient above 10%span in blade passage significantly decrease.In addition,different incidences affect the secondary flow streamlines and vortex structure near the cascade hub region,however,different inlet Mach numbers hardly change the secondary flow streamlines and vortex structure.In short,the optimal non-axisymmetric profiled end wall shows better aerodynamic performance than the planar end wall for the highly loaded compressor cascade in multi-conditions. | HUANG Song YANG Chengwu LI Ziliang HAN Ge ZHAO Shengfeng LU Xin’gen | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 16 | A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019显示文摘Human respiratory syncytial virus(RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we performed a molecular epidemiological study during 2015–2019. A total of 964 RSV-positive specimens were identified from 5529 enrolled patients during a multi-center study. RSV subgroup A(RSV-A) was the predominant subgroup during this research period except in2016. Totally, 535 sequences of the second hypervariable region(HVR-2) of the G gene were obtained. Combined with182 Chinese sequences from GenBank, phylogenetic trees showed that 521 RSV-A sequences fell in genotypes ON1(512),NA1(6) and GA5(3), respectively;while 196 RSV-B sequences fell in BA9(193) and SAB4(3). ON1 and BA9 were the only genotypes after December 2015. Genotypes ON1 and BA9 can be separated into 10 and 7 lineages, respectively. The HVR-2 of genotype ON1 had six amino acid changes with a frequency more than 10%, while two substitutions H258 Q and H266 L were co-occurrences. The HVR-2 of genotype BA9 had nine amino acid substitutions with a frequency more than10%, while the sequences with T290 I and T312 I were all from 2018 to 2019. One N-glycosylation site at 237 was identified among ON1 sequences, while two N-glycosylation sites(296 and 310) were identified in the 60-nucleotide duplication region of BA9. To conclusion, ON1 and BA9 were the predominant genotypes in China during 2015–2019. For the genotypes ON1 and BA9, the G gene exhibited relatively high diversity and evolved continuously. | Xiangpeng Chen Yun Zhu Wei Wang Changchong Li Shuhua An Gen Lu Rong Jin Baoping Xu Yunlian Zhou Aihuan Chen Lei Li Meng Zhang Zhengde Xie | 2021 | Virologica Sinica2021，36，6： | 2 |
| 17 | The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),it has become a global pandemic.The spike(S)protein of etiologic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specifically recognizes human angiotensin-converting enzyme 2(hACE2)as its receptor,which is recently identified as an interferon(IFN)-stimulated gene.Here,we find that hACE2 exists on the surface of exosomes released by different cell types,and the expression of exosomal hACE2 is increased by IFNα/β treatment.In particular,exosomal hACE2 can specifically block the cell entry of SARS-CoV-2,subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo.Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry,exhibiting a potential antiviral strategy. | Junsong Zhang Feng Huang Baijin Xia Yaochang Yuan Fei Yu Guanwen Wang Qianyu Chen Qian Wang Yuzhuang Li Rong Li Zheng Song Ting Pan Jingliang Chen Gen Lu Hui Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 18 | An automatic diagnosis method for the knee meniscus tears in MR images显示文摘 | K(o)se C Gen(c)alio(g)lu O (S)evik U | | 0，，02： | 1 |
| 19 | Role of microRNA let-7 and effect to HMGA2 in esophageal squamous cell carcinoma显示文摘 | Qing Liu Guo-dong Lv Xu Qin Yue-hua Gen Shu-tao Zheng Tao Liu Xiao-mei Lu | 2012 | Molecular Biology Reports2012，，2： | 1 |
| 20 | Different Configurations of Interannual Variability of the Western North Pacific Subtropical High and East Asian Westerly Jet in Summer显示文摘This study investigates the circulation and precipitation anomalies associated with different configurations of the western North Pacific subtropical high(WNPSH)and the East Asian westerly jet(EAJ)in summer on interannual timescales.The in-phase configuration of the WNPSH and EAJ is characterized by the westward(eastward)extension of the WNPSH and the southward(northward)shift of the EAJ,which is consistent with the general correspondence between their variations.The out-of-phase configuration includes the residual cases.We find that the in-phase configuration manifests itself as a typical meridional teleconnection.For instance,there is an anticyclonic(cyclonic)anomaly over the tropical western North Pacific and a cyclonic(anticyclonic)anomaly over the mid-latitudes of East Asia in the lower troposphere.These circulation anomalies are more conducive to rainfall anomalies over the Yangtze River basin and south Japan than are the individual WNPSH or EAJ.By contrast,for the out-of-phase configuration,the mid-latitude cyclonic(anticyclonic)anomaly is absent,and the lower-tropospheric circulation anomalies feature an anticyclonic(cyclonic)anomaly with a large meridional extension.Correspondingly,significant rainfall anomalies move northward to North China and the northern Korean Peninsula.Further results indicate that the out-of-phase configuration is associated with the developing phase of ENSO,with strong and significant sea surface temperature(SST)anomalies in the tropical central and eastern Pacific which occur simultaneously during summer and persist into the following winter.This is sharply different from the in-phase configuration,for which the tropical SSTs are not a necessity. | Xinyu LI Riyu LU Gen LI | 2021 | Advances in Atmospheric Sciences2021，38，6： | 1 |
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