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| 1 | 冷冻球囊消融与冷盐水灌注射频消融治疗阵发性心房颤动的长期随访效果比较显示文摘目的探讨阵发性心房颤动(PAF)患者首次采用冷冻球囊消融(CBA)与冷盐水灌注导管射频消融(RFCA)治疗长期随访效果的差异。方法回顾性分析2011年1月至2013年6月首次接受导管消融治疗的PAF患者的住院病历资料、手术记录和门诊随访资料。根据消融方法不同分为CBA组和RFCA组。术后3个月后如有快速型房性心律失常复发的心电学证据判定为消融治疗失败。结果 158例PAF患者纳入研究,其中CBA组103例,RFCA组55例。CBA组与RFCA组术中即刻PVI成功率(98.3%vs 98.1%)和主要并发症发生率(2.9%vs 3.6%)均无明显差异。CBA组X线曝光时间短[20(14,32)min vs 28(16,43)min,P<0.000 1]、X线曝光剂量少[39783(24 528,2 455 559)mGy/cm2vs 63 306(26 478,138 753)mGy/cm2,P=0.000 7]、手术时间短[115(80,151)min vs 159(120,218)min,P<0.000 1]、消融时间短[35(24,55)min vs 49(17,71)min,P=0.000 4]。在(18±8)个月随访期内119例(75.3%)完成随访,消融治疗成功率66.9%(81/121)。消融术后3、6、9、12、24、30个月随访结果显示CBA组成功率依次为95.8%、85.9%、76.1%、69.0%、60.6%、60.6%,RFCA组成功率依次为90.0%、78.0%、78.0%、78.0%、72.0%和72.0%,两组患者消融术后成功率无明显差异。结论 CBA与RFCA治疗PAF手术安全性相似,长期随访效果无差别。 | 刘俊 唐闽 Kaufmann Jan Kriatselis Charalampos Fleck Eckart 李劲宏 方丕华 张澍 | 2014 | 中国心脏起搏与心电生理杂志2014，28，5： | 12 |
| 2 | 新一代冷冻球囊能提高冷冻消融治疗心房颤动的远期疗效显示文摘目的探讨新一代冷冻球囊能否提高冷冻消融治疗心房颤动(简称房颤)的远期疗效。方法回顾性分析2012年1月至2013年6月序贯接受冷冻球囊消融治疗的房颤患者的介入治疗与术后门诊随访资料。根据术中使用球囊类型不同将患者分为第一代(G1)组和第二代(G2)组。术后3个月后的规律门诊随访中如有房颤或心房扑动或房性心动过速复发的心电学证据则判定为冷冻消融治疗失败。术前经胸超声测量左房前后径。结果共105例患者纳入研究,其中G1组57例,G2组48例。G2组术中即刻肺静脉隔离成功率高于G1组[98.7%(150/152)vs 94.6%(174/184),P=0.042 9]。G2组不同肺静脉最低冷冻温度均明显低于G1组(P<0.01),冷冻消融时间[30(16,44)min vs 35(25,55)min,P<0.000 1]、手术时间[105(75,145)min vs 120(80,190)min,P=0.0056]、X线曝光时间[17(13,28)min vs 20(13,32)min,P=0.047 0]均明显低于G1组。G1组1例发生心包积液,G2组4例(8.3%)发生手术相关主要并发症(2例膈神经麻痹,2例短暂性脑缺血发作)。在平均13(5,20)个月随访期内73例完成随访,46例维持窦性心律。G2组冷冻消融术后成功率明显高于G1组[89.3%(25/28)vs 46.7%(21/45),P=0.0002]。生存分析亦证实G2组成功率高于G1组(Log-Rank=5.023 8,P=0.025 0)。复发患者左房内径较大[(48±7)mm vs(44±6)mm,P=0.007 9]。Logistic回归分析显示采用新球囊[RR=9.524(2.511,36.121),P=0.000 9]与冷冻消融成功率提高独立相关。结论采用新一代冷冻球囊冷冻消融治疗房颤不仅能够缩短术中冷冻标测和消融时间,提高即刻肺静脉隔离成功率,还能提高远期随访成功率,但是在早期应用中主要并发症发生率稍高。 | 刘俊 Jan Kaufmann Charalampos Kriatselis Eckart Fleck 张澍 李劲宏 方丕华 | 2014 | 中国心脏起搏与心电生理杂志2014，28，6： | 8 |
| 3 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 4 | 单次冷冻球囊消融治疗心房颤动长期随访效果显示文摘目的分析冷冻球囊消融(CBA)治疗心房颤动(房颤)患者的单中心长期随访效果,探讨影响其疗效的相关临床因素。方法回顾性分析2009年1月至2013年4月接受CBA治疗的房颤患者的住院病历资料、手术记录和门诊随访资料。术前经胸超声测量左心房内径(LAD)。术后3个月后出现的房颤、心房扑动(房扑)、房性心动过速(房速)发作判定为CBA治疗失败。结果 199例房颤接受CBA治疗,术中并发膈神经麻痹3例(1.5%),术后发生心包积液1例(0.5%)、短暂性脑缺血发作1例(0.5%),均自行缓解。在平均(23±14)个月随访中152例患者完成随访,其中65例(42.8%)治疗成功,失败患者中75例(86.2%)为术后12个月内复发。失败患者年龄较大[(62±7)比(52±10),P=0.0379]、LAD较大[(47±7)mm比(43±6)mm,P<0.0001],持续性房颤患者治疗成功率(29.5%)明显低于阵发性房颤患者(48.1%)。Logistic回归分析显示年龄[OR=1.037(1.000,1.076),P=0.0488]和LAD[OR=0.896(0.842,0.953),P=0.005]能独立预测初次CBA治疗效果。结论 CBA治疗房颤安全有效,长期随访效果较好。房性心律失常复发主要发生在术后12个月内。年龄和LAD是预测术后复发的独立危险因素。 | 刘俊 唐闽 Jan Kaufmann Charalampos Kriatselis Eckart Fleck 李劲宏 方丕华 张澍 | 2014 | 中国介入心脏病学杂志2014，22，5： | 7 |
| 5 | 疫苗诱导对猪肺炎支原体的免疫防卫显示文摘疾病防制策略包括调整宿主 (猪 )和入侵者 (猪肺炎支原体 )之间的关系。本文介绍的一种策略是利用免疫接种激活猪的免疫系统。对于猪肺炎支原体的免疫应答 (包括体液、粘膜和细胞介导的各个系统 )非常复杂 ,是当前的热门研究课题。 | 汪秉刚 Robyn Fleck | 2002 | 国外畜牧学(猪与禽)2002，，5： | 3 |
| 6 | Alteration of soil microbial communities and water quality in restored wetlands显示文摘 | Deborah A. Bossio Jacob A. Fleck Kate M. Scow Roger Fujii | 2005 | Soil Biology and Biochemistry2005，，6： | 2 |
| 7 | 普罗布考和抗氧化维生素不影响体外实验条件下内皮细胞的白细胞粘附显示文摘为探讨预防动脉粥样硬化的药物普罗布考、维生素C和维生素E是否抑制内皮细胞表面粘附分子表达和白细胞—内皮细胞的粘附 ,以及这种抑制是否通过影响核因子 -κB的活性来实现的 ,在液体流动小室中进行细胞粘附实验 ;用ELISA方法测定内皮细胞粘附分子E -选择素的表达 ;用电泳迁移率分析测定内皮细胞核因子 -κB的活性。经肿瘤坏死因子α刺激的内皮细胞核因子 -κB活性增加 ,粘附分子E -选择素的表达上调 (是基础水平的 3.5倍 ) ,其表面HL6 0细胞的粘附增加 (是基础水平的 4~ 2 6倍 ) ,而抗氧化剂PDTC使所有这些变化都受到抑制。PDTC浓度为 18μmol L时对粘附分子E -选择素的表达呈最大半抑制 ;PDTC浓度为 5 2 μmol L时对内皮细胞表面HL6 0细胞的粘附呈最大半抑制。普罗布考、维生素C和维生素E对肿瘤坏死因子α诱导的粘附分子表达和HL6 0细胞与内皮细胞的粘附没有作用 ;对核因子 -κB的活性没有影响。临床上常用的这三种抗氧化剂并未影响作为动脉粥样硬化始动机制之一的E -选择素介导的白细胞 -内皮细胞粘附水平。 | 黄虔 Grfe M Grafe K Fleck E | 2001 | 中国动脉硬化杂志2001，9，2： | 2 |
| 8 | Finite element analysis of the dynamic response of clamped sandwich beams subjected to loading显示文摘 | Qiu X Deshpande V S Fleck N A | 2003 | European Journal of Mechanics A: Solids2003，22，： | 1 |
| 9 | Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis显示文摘 | Gumey M E Fleck T J Himes C S | 1998 | Neurology1998，50，： | 1 |
| 10 | Effects of transverse air flow on burning rates of rectangular methanol pool fires显示文摘 | Woods J A R Fleck B A Kostiuk L W | 2006 | Combustion and Flame2006，146，12： | 1 |
| 11 | Effect of inclusions and holes on the stiffness and strength of honeycomb 显示文摘 | Chen C Lu T J Fleck N A | 2001 | Mech SCi2001，43，： | 1 |
| 12 | Three-dimensional lamina architecture alters light-harvesting efficiency in Fagus: A leaf-scale analysis显示文摘 | Fleck S Niinemets U Cescatti A | 2003 | Tree Physiology2003，23，9： | 1 |
| 13 | Whole-body CT trauma imaging with adapted and optimized CT angiography of the craniocervical ves- sels: do we need an extra screening examination? 显示文摘 | Langner S Fleck S Kirsch M | 2008 | AJNR Am J Neuroradiol2008，29，10： | 1 |
| 14 | Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease-possible candidates for paradoxical epidemiology?显示文摘 | Busch M Fleck C Wolf G | 2006 | Amino Acids2006，30，3： | 1 |
| 15 | A crystal plasticity model for ferroelectrics 显示文摘 | HUBER J E FLECK N A MCMEEKING R M | 1999 | Ferroelectrics1999，228，： | 1 |
| 16 | New anthracycline antibiotics produced byInter-specific recombinants of streptomycetes 显示文摘 | Ihn W Schlegel B Fleck W F | 1980 | J Antibiot1980，33，： | 1 |
| 17 | Aripiprazole augmentation in treatment-resistant bipolar depression: early response and development of akathisia 显示文摘 | KEMP DE GILMER WS FLECK J | 2007 | Prog Neuropsychopharmacol Biol Psychiatry2007，31，2： | 1 |
| 18 | Increased vascular permeability:a major cause of hypoalbuminaemia in disease and injury显示文摘 | Fleck A Raines G Hawker F | 1985 | Lancet1985，1，8432： | 1 |
| 19 | Single-dose pharmacokinetics of the dipeptidyl peptidase-4 inhibitor alogliptin in subjects with renal impairment显示文摘 | Karim A Fleck P Hetman L | 2008 | Diabetes2008，57，1： | 1 |
| 20 | Albumin metabolismin rheumatoid arthritis显示文摘 | Ballantyne FC Fleck A Dick WC | 1971 | Ann Rheum Dis1971，30，3： | 1 |
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