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您的检索式：作者名="StephenLee"
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| 1 | Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia显示文摘DNA methylation is associated with malignant transformation, but limitations imposed by genetic variability, tumor heterogeneity, availability of paired normal tissues and methodologies for global assessment of DNA methylation have limited progress in understanding the extent of epigenetic events in the initiation and progression of human cancer and in identifying genes that undergo methylation during cancer. We developed a mouse model of T/natural killer acute lymphoblastic leukemia that is always preceded by polyclonal lymphocyte expansion to determine how aberrant promoter DNA methylation and consequent gene silencing might be contributing to leukemic transformation. We used restriction landmark genomic scanning with this mouse model of preleukemia reproducibly progressing to leukemia to show that specific genomic methylation is associated with only the leukemic phase and is not random. We also identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of other human cancers. | LiYu ChunhuiLiu JeffVandeusen BrianBecknell ZunyanDai Yue-ZhongWu AparnaRaval Te-HuiLiu WeiDing CharleneMao ShujunLiu LauraTSmith StephenLee LauraRassenti GuidoMarcucci JohnByrd MichaelACaligiuri ChristophPlass | 2005 | 中国生物学文摘2005，19，4： | 80 |
| 2 | Structure Prediction Based on Hydrophobic to Hydrophilic Volume Ratios in Small Molecule Amphiphilic Organic Crystals显示文摘The structure type for the crystal of 4,4ˊ-bis-(2-hydroxy-ethoxy1)-bipheny1 1hasbeen predicted by using the previously developed interfacial model for small organic molecules .Based on the calculated hydrophobic to hydrophilic volume of 1,this model predicts the crystal structure to be of lamellar or bicontinuous bype,which has been confirmed by the X-ray single-crystal structure analysis(C20H26O6,monoclinic,P21/c,a=16.084(1),b=6.0103(4),c=9.6410(7)?,β=103.014(2)°,V=908.1(1)?°^3,Z=2,Dc=1.325g/cm^3,F(000)=388,μ=0.097mm^-1,MoLα radiation,λ=0.71073?,R=0.0382 and wR=0.0882 with I>2ó(I) for 7121 reflections collected, 1852 unique reflections and 170 parameters. As predicted,the hydrophobic and hydrophilic portions of 1 from in the lamellae.The same interfacial model is applied to other amphilphilic small molecule organic systems for structural type prediction. | Zheng-TaoXu StephenLee | 2002 | Chinese Journal of Structural Chemistry2002，21，6： | 0 |
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